3PVWG

Bovine grk2 in complex with gbetagamma subunits and a selective kinase inhibitor (cmpd103a)
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
60
structure length
60
Chain Sequence
SIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
pubmed doi rcsb
molecule tags Transferase/signaling protein/inhibitor
source organism Bos taurus
molecule keywords Beta-adrenergic receptor kinase 1
total genus 12
structure length 60
sequence length 60
ec nomenclature
pdb deposition date 2010-12-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 3pvwG00
1GP2G 3AH8G 4KFMG 1XHMB 1B9XB 5HE2G 3PVWG 1B9YB 4PNKG 1GG2G 3CIKG 5KDOG 3KRWG 1A0RG 1OMWG 3V5WG 5HE3G 2BCJG 1TBGE 2TRCG 1GOTG 5HE0G 3PSCG 3SN6G 5HE1G 4MK0G 2PBIA 3PVUG 5TDHG 3KRXG
chains in the Genus database with same CATH superfamily
1GP2G 3AH8G 4KFMG 1XHMB 1B9XB 1HFES 5HE2G 3PVWG 1B9YB 1IOJA 4PNKG 1GG2G 3CIKG 5KDOG 3KRWG 1A0RG 1OMWG 3V5WG 5HE3G 2BCJG 1TBGE 2TRCG 1GOTG 5HE0G 3PSCG 3SN6G 5HE1G 4MK0G 2PBIA 3PVUG 5TDHG 3KRXG
chains in the Genus database with same CATH topology
1GP2G 3AH8G 4KFMG 1XHMB 1B9XB 5HE2G 3PVWG 1B9YB 4PNKG 1GG2G 3CIKG 5KDOG 3KRWG 1A0RG 1OMWG 3V5WG 5HE3G 2BCJG 1TBGE 2TRCG 1GOTG 5HE0G 3PSCG 3SN6G 5HE1G 4MK0G 2PBIA 3PVUG 5TDHG 3KRXG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GP2 G;  3AH8 G;  4KFM G;  1XHM B;  1B9X B;  5HE2 G;  3PVW G;  1B9Y B;  4PNK G;  1GG2 G;  3CIK G;  5KDO G;  3KRW G;  1A0R G;  1OMW G;  3V5W G;  5HE3 G;  2BCJ G;  1TBG E;  2TRC G;  1GOT G;  5HE0 G;  3PSC G;  3SN6 G;  5HE1 G;  4MK0 G;  2PBI A;  3PVU G;  5TDH G;  3KRX G; 
#chains in the Genus database with same CATH topology
 1GP2 G;  3AH8 G;  4KFM G;  1XHM B;  1B9X B;  1HFE S;  5HE2 G;  3PVW G;  1B9Y B;  1IOJ A;  4PNK G;  1GG2 G;  3CIK G;  5KDO G;  3KRW G;  1A0R G;  1OMW G;  3V5W G;  5HE3 G;  2BCJ G;  1TBG E;  2TRC G;  1GOT G;  5HE0 G;  3PSC G;  3SN6 G;  5HE1 G;  4MK0 G;  2PBI A;  3PVU G;  5TDH G;  3KRX G; 
#chains in the Genus database with same CATH homology
 1GP2 G;  3AH8 G;  4KFM G;  1XHM B;  1B9X B;  5HE2 G;  3PVW G;  1B9Y B;  4PNK G;  1GG2 G;  3CIK G;  5KDO G;  3KRW G;  1A0R G;  1OMW G;  3V5W G;  5HE3 G;  2BCJ G;  1TBG E;  2TRC G;  1GOT G;  5HE0 G;  3PSC G;  3SN6 G;  5HE1 G;  4MK0 G;  2PBI A;  3PVU G;  5TDH G;  3KRX G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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