3N7PA

Crystal structure of the ectodomain complex of the cgrp receptor, a class-b gpcr, reveals the site of drug antagonism
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
100
structure length
100
Chain Sequence
EDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism.
pubmed doi rcsb
molecule tags Membrane protein
source organism Homo sapiens
molecule keywords Calcitonin gene-related peptide type 1 receptor
total genus 18
structure length 100
sequence length 100
chains with identical sequence B, C, J
ec nomenclature
pdb deposition date 2010-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02793 HRM Hormone receptor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.1240.10 Few Secondary Structures Irregular Hormone receptor fold GPCR, family 2, extracellular hormone receptor domain 3n7pA00
3EHSA 2L27A 4DLQA 2JODA 3N7SA 2QKHA 4HJ0A 3H3GA 3IOLA 4LF3C 3C4MA 3EHUA 3AQFB 2JNCA 3N7PA 3C59A 2XDGA 4ZGMA 2JNDA 5II0A 1U34A 3L2JA 4ERSA 3C5TA 3EHTA 3N7RA 4DLOA
chains in the Genus database with same CATH superfamily
3EHSA 2L27A 4DLQA 2JODA 3N7SA 2QKHA 4HJ0A 3H3GA 3IOLA 4LF3C 3C4MA 3EHUA 3AQFB 2JNCA 3N7PA 3C59A 2XDGA 4ZGMA 2JNDA 5II0A 1U34A 3L2JA 4ERSA 3C5TA 3EHTA 3N7RA 4DLOA
chains in the Genus database with same CATH topology
3EHSA 2L27A 4DLQA 2JODA 3N7SA 2QKHA 4HJ0A 3H3GA 3IOLA 4LF3C 3C4MA 3EHUA 3AQFB 2JNCA 3N7PA 3C59A 2XDGA 4ZGMA 2JNDA 5II0A 1U34A 3L2JA 4ERSA 3C5TA 3EHTA 3N7RA 4DLOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EHS A;  2L27 A;  4DLQ A;  2JOD A;  3N7S A;  2QKH A;  4HJ0 A;  3H3G A;  3IOL A;  4LF3 C;  3C4M A;  3EHU A;  3AQF B;  2JNC A;  3N7P A;  3C59 A;  2XDG A;  4ZGM A;  2JND A;  5II0 A;  1U34 A;  3L2J A;  4ERS A;  3C5T A;  3EHT A;  3N7R A;  4DLO A; 
#chains in the Genus database with same CATH topology
 3EHS A;  2L27 A;  4DLQ A;  2JOD A;  3N7S A;  2QKH A;  4HJ0 A;  3H3G A;  3IOL A;  4LF3 C;  3C4M A;  3EHU A;  3AQF B;  2JNC A;  3N7P A;  3C59 A;  2XDG A;  4ZGM A;  2JND A;  5II0 A;  1U34 A;  3L2J A;  4ERS A;  3C5T A;  3EHT A;  3N7R A;  4DLO A; 
#chains in the Genus database with same CATH homology
 3EHS A;  2L27 A;  4DLQ A;  2JOD A;  3N7S A;  2QKH A;  4HJ0 A;  3H3G A;  3IOL A;  4LF3 C;  3C4M A;  3EHU A;  3AQF B;  2JNC A;  3N7P A;  3C59 A;  2XDG A;  4ZGM A;  2JND A;  5II0 A;  1U34 A;  3L2J A;  4ERS A;  3C5T A;  3EHT A;  3N7R A;  4DLO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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