3PVWG

Bovine grk2 in complex with gbetagamma subunits and a selective kinase inhibitor (cmpd103a)
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
60
structure length
60
Chain Sequence
SIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
pubmed doi rcsb
molecule tags Transferase/signaling protein/inhibitor
source organism Bos taurus
molecule keywords Beta-adrenergic receptor kinase 1
total genus 12
structure length 60
sequence length 60
ec nomenclature
pdb deposition date 2010-12-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 3pvwG00
4KFMG 2PBIA 1OMWG 1GG2G 1B9XB 1XHMB 1A0RG 5KDOG 3KRXG 5HE2G 1TBGE 1GP2G 3SN6G 1B9YB 2TRCG 3PVWG 3KRWG 3V5WG 4PNKG 3CIKG 3PSCG 5HE1G 1GOTG 5HE0G 2BCJG 5HE3G 5TDHG 3AH8G 4MK0G 3PVUG
chains in the Genus database with same CATH superfamily
4KFMG 2PBIA 1OMWG 1GG2G 1B9XB 1IOJA 1XHMB 3PVUG 1A0RG 5KDOG 3KRXG 5HE2G 1GP2G 3SN6G 1B9YB 2TRCG 3PVWG 3KRWG 3V5WG 4PNKG 3CIKG 3PSCG 5HE1G 1GOTG 5HE0G 2BCJG 5HE3G 5TDHG 1HFES 3AH8G 4MK0G 1TBGE
chains in the Genus database with same CATH topology
4KFMG 2PBIA 1OMWG 1GG2G 1B9XB 1XHMB 1A0RG 5KDOG 3KRXG 5HE2G 1TBGE 1GP2G 3SN6G 1B9YB 2TRCG 3PVWG 3KRWG 3V5WG 4PNKG 3CIKG 3PSCG 5HE1G 1GOTG 5HE0G 2BCJG 5HE3G 5TDHG 3AH8G 4MK0G 3PVUG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KFM G;  2PBI A;  1OMW G;  1GG2 G;  1B9X B;  1XHM B;  1A0R G;  5KDO G;  3KRX G;  5HE2 G;  1TBG E;  1GP2 G;  3SN6 G;  1B9Y B;  2TRC G;  3PVW G;  3KRW G;  3V5W G;  4PNK G;  3CIK G;  3PSC G;  5HE1 G;  1GOT G;  5HE0 G;  2BCJ G;  5HE3 G;  5TDH G;  3AH8 G;  4MK0 G;  3PVU G; 
#chains in the Genus database with same CATH topology
 4KFM G;  2PBI A;  1OMW G;  1GG2 G;  1B9X B;  1IOJ A;  1XHM B;  3PVU G;  1A0R G;  5KDO G;  3KRX G;  5HE2 G;  1GP2 G;  3SN6 G;  1B9Y B;  2TRC G;  3PVW G;  3KRW G;  3V5W G;  4PNK G;  3CIK G;  3PSC G;  5HE1 G;  1GOT G;  5HE0 G;  2BCJ G;  5HE3 G;  5TDH G;  1HFE S;  3AH8 G;  4MK0 G;  1TBG E; 
#chains in the Genus database with same CATH homology
 4KFM G;  2PBI A;  1OMW G;  1GG2 G;  1B9X B;  1XHM B;  1A0R G;  5KDO G;  3KRX G;  5HE2 G;  1TBG E;  1GP2 G;  3SN6 G;  1B9Y B;  2TRC G;  3PVW G;  3KRW G;  3V5W G;  4PNK G;  3CIK G;  3PSC G;  5HE1 G;  1GOT G;  5HE0 G;  2BCJ G;  5HE3 G;  5TDH G;  3AH8 G;  4MK0 G;  3PVU G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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