4JGFA

Crystal structure of the cataract-causing p23t gamma d-crystallin mutant
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
171
structure length
171
Chain Sequence
GKITLYEDRGFQGRHYECSSDHTNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVID
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the cataract-causing P23T gamma D-crystallin mutant.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Gamma-crystallin D
total genus 43
structure length 171
sequence length 171
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-03-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00030 Crystall Beta/Gamma crystallin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 4jgfA02
2.60.20.10 Mainly Beta Sandwich Gamma-B Crystallin; domain 1 Crystallins 4jgfA01
4FD9A 1GAMA 1H4AX 2V2UA 2KP5A 3SNYA 4W9BA 2M3TA 3HZBA 4JGFA 5HT8A 1OKIA 4GCRA 1A5DA 1A7HA 5HT9A 4W9AA 3LWKA 1M8UA 1ELPA 2BV2A 1DSLA 2M3CA 1ZGTA 2G98A 2M3UA 3CW3A 1YHPA 2JDFA 3SO0A 2BB2A 2NBRA 1HA4A 1E7NA 1A45A 1ZWOA 3HZ2A 2KFBA 1ZIRA 2JDGA 1HDFA 1ZIEA 3SO1A 3IAJA 1YTQA 2K1XA 2K1WA 1HK0X 2B1OA 4AKAA 1PRRA 4PSRA 1NPSA 4GR7A 2DADA 4PSPA 3ENUA 4EL6A 1BD7A 1BLBA 3SNZA 1ZIQA 1AMMA 1PRSA 2A5MA 3QK3A 4IAUA 1ZWMA 3I9HA 4NI3A 1AG4A 1GCSA 3ENTA 1I5IA
chains in the Genus database with same CATH superfamily
1H4AX 2KP5A 3SNYA 1G6EA 5HT8A 1A7HA 3HZ2A 2M3CA 1DSLA 3SO0A 1E7NA 1ZIEA 1YTQA 2K1WA 1HK0X 4PSRA 1NPSA 2DADA 1PRSA 1GH5A 4IAUA 1C01A 3ENTA 4W9BA 1OKIA 5HT9A 4W9AA 1M8UA 2BV2A 2M3UA 2JDFA 2BB2A 2NBRA 1ZWOA 1A45A 1ZIRA 2JDGA 3SO1A 2K1XA 1WKTA 1PRRA 4GR7A 4EL6A 1F53A 3SNZA 1ZIQA 2A5MA 3QK3A 1ZWMA 1I5IA 4FD9A 1GAMA 2V2UA 4JGFA 3CW3A 2G98A 1YHPA 2KFBA 3IAJA 4AKAA 4PSPA 1BLBA 1GCSA 2M3TA 3HZBA 4GCRA 1A5DA 3LWKA 1ELPA 1ZGTA 1HA4A 1HDFA 2B1OA 3ENUA 1BD7A 3UJZA 1AMMA 1BHUA 3I9HA 4NI3A 1AG4A
chains in the Genus database with same CATH topology
4FD9A 1GAMA 1H4AX 2V2UA 2KP5A 3SNYA 4W9BA 2M3TA 3HZBA 4JGFA 5HT8A 1OKIA 4GCRA 1A5DA 1A7HA 5HT9A 4W9AA 3LWKA 1M8UA 1ELPA 2BV2A 1DSLA 2M3CA 1ZGTA 2G98A 2M3UA 3CW3A 1YHPA 2JDFA 3SO0A 2BB2A 2NBRA 1HA4A 1E7NA 1A45A 1ZWOA 3HZ2A 2KFBA 1ZIRA 2JDGA 1HDFA 1ZIEA 3SO1A 3IAJA 1YTQA 2K1XA 2K1WA 1HK0X 2B1OA 4AKAA 1PRRA 4PSRA 1NPSA 4GR7A 2DADA 4PSPA 3ENUA 4EL6A 1BD7A 1BLBA 3SNZA 1ZIQA 1AMMA 1PRSA 2A5MA 3QK3A 4IAUA 1ZWMA 3I9HA 4NI3A 1AG4A 1GCSA 3ENTA 1I5IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FD9 A;  1GAM A;  1H4A X;  2V2U A;  2KP5 A;  3SNY A;  4W9B A;  2M3T A;  3HZB A;  4JGF A;  5HT8 A;  1OKI A;  4GCR A;  1A5D A;  1A7H A;  5HT9 A;  4W9A A;  3LWK A;  1M8U A;  1ELP A;  2BV2 A;  1DSL A;  2M3C A;  1ZGT A;  2G98 A;  2M3U A;  3CW3 A;  1YHP A;  2JDF A;  3SO0 A;  2BB2 A;  2NBR A;  1HA4 A;  1E7N A;  1A45 A;  1ZWO A;  3HZ2 A;  2KFB A;  1ZIR A;  2JDG A;  1HDF A;  1ZIE A;  3SO1 A;  3IAJ A;  1YTQ A;  2K1X A;  2K1W A;  1HK0 X;  2B1O A;  4AKA A;  1PRR A;  4PSR A;  1NPS A;  4GR7 A;  2DAD A;  4PSP A;  3ENU A;  4EL6 A;  1BD7 A;  1BLB A;  3SNZ A;  1ZIQ A;  1AMM A;  1PRS A;  2A5M A;  3QK3 A;  4IAU A;  1ZWM A;  3I9H A;  4NI3 A;  1AG4 A;  1GCS A;  3ENT A;  1I5I A; 
#chains in the Genus database with same CATH topology
 1H4A X;  2KP5 A;  3SNY A;  1G6E A;  5HT8 A;  1A7H A;  3HZ2 A;  2M3C A;  1DSL A;  3SO0 A;  1E7N A;  1ZIE A;  1YTQ A;  2K1W A;  1HK0 X;  4PSR A;  1NPS A;  2DAD A;  1PRS A;  1GH5 A;  4IAU A;  1C01 A;  3ENT A;  4W9B A;  1OKI A;  5HT9 A;  4W9A A;  1M8U A;  2BV2 A;  2M3U A;  2JDF A;  2BB2 A;  2NBR A;  1ZWO A;  1A45 A;  1ZIR A;  2JDG A;  3SO1 A;  2K1X A;  1WKT A;  1PRR A;  4GR7 A;  4EL6 A;  1F53 A;  3SNZ A;  1ZIQ A;  2A5M A;  3QK3 A;  1ZWM A;  1I5I A;  4FD9 A;  1GAM A;  2V2U A;  4JGF A;  3CW3 A;  2G98 A;  1YHP A;  2KFB A;  3IAJ A;  4AKA A;  4PSP A;  1BLB A;  1GCS A;  2M3T A;  3HZB A;  4GCR A;  1A5D A;  3LWK A;  1ELP A;  1ZGT A;  1HA4 A;  1HDF A;  2B1O A;  3ENU A;  1BD7 A;  3UJZ A;  1AMM A;  1BHU A;  3I9H A;  4NI3 A;  1AG4 A; 
#chains in the Genus database with same CATH homology
 4FD9 A;  1GAM A;  1H4A X;  2V2U A;  2KP5 A;  3SNY A;  4W9B A;  2M3T A;  3HZB A;  4JGF A;  5HT8 A;  1OKI A;  4GCR A;  1A5D A;  1A7H A;  5HT9 A;  4W9A A;  3LWK A;  1M8U A;  1ELP A;  2BV2 A;  1DSL A;  2M3C A;  1ZGT A;  2G98 A;  2M3U A;  3CW3 A;  1YHP A;  2JDF A;  3SO0 A;  2BB2 A;  2NBR A;  1HA4 A;  1E7N A;  1A45 A;  1ZWO A;  3HZ2 A;  2KFB A;  1ZIR A;  2JDG A;  1HDF A;  1ZIE A;  3SO1 A;  3IAJ A;  1YTQ A;  2K1X A;  2K1W A;  1HK0 X;  2B1O A;  4AKA A;  1PRR A;  4PSR A;  1NPS A;  4GR7 A;  2DAD A;  4PSP A;  3ENU A;  4EL6 A;  1BD7 A;  1BLB A;  3SNZ A;  1ZIQ A;  1AMM A;  1PRS A;  2A5M A;  3QK3 A;  4IAU A;  1ZWM A;  3I9H A;  4NI3 A;  1AG4 A;  1GCS A;  3ENT A;  1I5I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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