4LF3C

Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
95
structure length
95
Chain Sequence
MDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
pubmed doi rcsb
molecule tags Immune system
source organism Mus musculus
molecule keywords Fab heavy chain
total genus 25
structure length 95
sequence length 95
chains with identical sequence F
ec nomenclature
pdb deposition date 2013-06-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.1240.10 Few Secondary Structures Irregular Hormone receptor fold GPCR, family 2, extracellular hormone receptor domain 4lf3C00
3EHUA 4ZGMA 3N7PA 3EHTA 4DLQA 4LF3C 4HJ0A 3H3GA 2JODA 3C4MA 2JNDA 2XDGA 3C5TA 3N7SA 3N7RA 5II0A 4ERSA 4DLOA 2L27A 3AQFB 3EHSA 2QKHA 2JNCA 3C59A 1U34A 3IOLA 3L2JA
chains in the Genus database with same CATH superfamily
3EHUA 4ZGMA 3N7PA 3EHTA 4DLQA 4LF3C 4HJ0A 3H3GA 2JODA 3C4MA 2JNDA 2XDGA 3C5TA 3N7SA 3N7RA 5II0A 4ERSA 4DLOA 2L27A 3AQFB 3EHSA 2QKHA 2JNCA 3C59A 1U34A 3IOLA 3L2JA
chains in the Genus database with same CATH topology
3EHUA 4ZGMA 3N7PA 3EHTA 4DLQA 4LF3C 4HJ0A 3H3GA 2JODA 3C4MA 2JNDA 2XDGA 3C5TA 3N7SA 3N7RA 5II0A 4ERSA 4DLOA 2L27A 3AQFB 3EHSA 2QKHA 2JNCA 3C59A 1U34A 3IOLA 3L2JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EHU A;  4ZGM A;  3N7P A;  3EHT A;  4DLQ A;  4LF3 C;  4HJ0 A;  3H3G A;  2JOD A;  3C4M A;  2JND A;  2XDG A;  3C5T A;  3N7S A;  3N7R A;  5II0 A;  4ERS A;  4DLO A;  2L27 A;  3AQF B;  3EHS A;  2QKH A;  2JNC A;  3C59 A;  1U34 A;  3IOL A;  3L2J A; 
#chains in the Genus database with same CATH topology
 3EHU A;  4ZGM A;  3N7P A;  3EHT A;  4DLQ A;  4LF3 C;  4HJ0 A;  3H3G A;  2JOD A;  3C4M A;  2JND A;  2XDG A;  3C5T A;  3N7S A;  3N7R A;  5II0 A;  4ERS A;  4DLO A;  2L27 A;  3AQF B;  3EHS A;  2QKH A;  2JNC A;  3C59 A;  1U34 A;  3IOL A;  3L2J A; 
#chains in the Genus database with same CATH homology
 3EHU A;  4ZGM A;  3N7P A;  3EHT A;  4DLQ A;  4LF3 C;  4HJ0 A;  3H3G A;  2JOD A;  3C4M A;  2JND A;  2XDG A;  3C5T A;  3N7S A;  3N7R A;  5II0 A;  4ERS A;  4DLO A;  2L27 A;  3AQF B;  3EHS A;  2QKH A;  2JNC A;  3C59 A;  1U34 A;  3IOL A;  3L2J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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