4MK0G

Crystal structure of g protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
59
structure length
59
Chain Sequence
TASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.
pubmed doi rcsb
molecule keywords Beta-adrenergic receptor kinase 1
molecule tags Signaling protein/inhibitor
source organism Homo sapiens
total genus 14
structure length 59
sequence length 59
ec nomenclature
pdb deposition date 2013-09-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 4mk0G00
1GG2G 3SN6G 5TDHG 5HE1G 3KRXG 2BCJG 4MK0G 1B9XB 5KDOG 3PVWG 1B9YB 1GP2G 4KFMG 3CIKG 3KRWG 5HE0G 5HE3G 3PVUG 5HE2G 4PNKG 1GOTG 2TRCG 2PBIA 1OMWG 3AH8G 3V5WG 1XHMB 1A0RG 1TBGE 3PSCG
chains in the Genus database with same CATH superfamily
1GG2G 3SN6G 5TDHG 5HE1G 3KRXG 2BCJG 4MK0G 1B9XB 5KDOG 3PVWG 1B9YB 1GP2G 4KFMG 3CIKG 3KRWG 5HE0G 5HE3G 1HFES 3PVUG 5HE2G 4PNKG 1GOTG 2TRCG 2PBIA 1OMWG 3AH8G 3V5WG 1XHMB 1A0RG 1IOJA 1TBGE 3PSCG
chains in the Genus database with same CATH topology
1GG2G 3SN6G 5TDHG 5HE1G 3KRXG 2BCJG 4MK0G 1B9XB 5KDOG 3PVWG 1B9YB 1GP2G 4KFMG 3CIKG 3KRWG 5HE0G 5HE3G 3PVUG 5HE2G 4PNKG 1GOTG 2TRCG 2PBIA 1OMWG 3AH8G 3V5WG 1XHMB 1A0RG 1TBGE 3PSCG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GG2 G;  3SN6 G;  5TDH G;  5HE1 G;  3KRX G;  2BCJ G;  4MK0 G;  1B9X B;  5KDO G;  3PVW G;  1B9Y B;  1GP2 G;  4KFM G;  3CIK G;  3KRW G;  5HE0 G;  5HE3 G;  3PVU G;  5HE2 G;  4PNK G;  1GOT G;  2TRC G;  2PBI A;  1OMW G;  3AH8 G;  3V5W G;  1XHM B;  1A0R G;  1TBG E;  3PSC G; 
#chains in the Genus database with same CATH topology
 1GG2 G;  3SN6 G;  5TDH G;  5HE1 G;  3KRX G;  2BCJ G;  4MK0 G;  1B9X B;  5KDO G;  3PVW G;  1B9Y B;  1GP2 G;  4KFM G;  3CIK G;  3KRW G;  5HE0 G;  5HE3 G;  1HFE S;  3PVU G;  5HE2 G;  4PNK G;  1GOT G;  2TRC G;  2PBI A;  1OMW G;  3AH8 G;  3V5W G;  1XHM B;  1A0R G;  1IOJ A;  1TBG E;  3PSC G; 
#chains in the Genus database with same CATH homology
 1GG2 G;  3SN6 G;  5TDH G;  5HE1 G;  3KRX G;  2BCJ G;  4MK0 G;  1B9X B;  5KDO G;  3PVW G;  1B9Y B;  1GP2 G;  4KFM G;  3CIK G;  3KRW G;  5HE0 G;  5HE3 G;  3PVU G;  5HE2 G;  4PNK G;  1GOT G;  2TRC G;  2PBI A;  1OMW G;  3AH8 G;  3V5W G;  1XHM B;  1A0R G;  1TBG E;  3PSC G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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