4MK0G

Crystal structure of g protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
59
structure length
59
Chain Sequence
TASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.
pubmed doi rcsb
molecule keywords Beta-adrenergic receptor kinase 1
molecule tags Signaling protein/inhibitor
source organism Homo sapiens
total genus 14
structure length 59
sequence length 59
ec nomenclature
pdb deposition date 2013-09-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 4mk0G00
3PVWG 1B9XB 5KDOG 1B9YB 3CIKG 3SN6G 5HE3G 3V5WG 4MK0G 3KRXG 3PVUG 3AH8G 5HE2G 3PSCG 1GOTG 2TRCG 5TDHG 1GP2G 1OMWG 5HE1G 4PNKG 5HE0G 3KRWG 1A0RG 2PBIA 1GG2G 4KFMG 1XHMB 2BCJG 1TBGE
chains in the Genus database with same CATH superfamily
3PVWG 1B9XB 5KDOG 1B9YB 3CIKG 3SN6G 5HE3G 3V5WG 4MK0G 3KRXG 3PVUG 1HFES 3AH8G 5HE2G 3PSCG 1GOTG 2TRCG 5TDHG 1GP2G 1OMWG 5HE1G 4PNKG 5HE0G 1IOJA 3KRWG 1A0RG 2PBIA 1GG2G 4KFMG 1XHMB 2BCJG 1TBGE
chains in the Genus database with same CATH topology
3PVWG 1B9XB 5KDOG 1B9YB 3CIKG 3SN6G 5HE3G 3V5WG 4MK0G 3KRXG 3PVUG 3AH8G 5HE2G 3PSCG 1GOTG 2TRCG 5TDHG 1GP2G 1OMWG 5HE1G 4PNKG 5HE0G 3KRWG 1A0RG 2PBIA 1GG2G 4KFMG 1XHMB 2BCJG 1TBGE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PVW G;  1B9X B;  5KDO G;  1B9Y B;  3CIK G;  3SN6 G;  5HE3 G;  3V5W G;  4MK0 G;  3KRX G;  3PVU G;  3AH8 G;  5HE2 G;  3PSC G;  1GOT G;  2TRC G;  5TDH G;  1GP2 G;  1OMW G;  5HE1 G;  4PNK G;  5HE0 G;  3KRW G;  1A0R G;  2PBI A;  1GG2 G;  4KFM G;  1XHM B;  2BCJ G;  1TBG E; 
#chains in the Genus database with same CATH topology
 3PVW G;  1B9X B;  5KDO G;  1B9Y B;  3CIK G;  3SN6 G;  5HE3 G;  3V5W G;  4MK0 G;  3KRX G;  3PVU G;  1HFE S;  3AH8 G;  5HE2 G;  3PSC G;  1GOT G;  2TRC G;  5TDH G;  1GP2 G;  1OMW G;  5HE1 G;  4PNK G;  5HE0 G;  1IOJ A;  3KRW G;  1A0R G;  2PBI A;  1GG2 G;  4KFM G;  1XHM B;  2BCJ G;  1TBG E; 
#chains in the Genus database with same CATH homology
 3PVW G;  1B9X B;  5KDO G;  1B9Y B;  3CIK G;  3SN6 G;  5HE3 G;  3V5W G;  4MK0 G;  3KRX G;  3PVU G;  3AH8 G;  5HE2 G;  3PSC G;  1GOT G;  2TRC G;  5TDH G;  1GP2 G;  1OMW G;  5HE1 G;  4PNK G;  5HE0 G;  3KRW G;  1A0R G;  2PBI A;  1GG2 G;  4KFM G;  1XHM B;  2BCJ G;  1TBG E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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