4TTCA

Crystal structure of homo sapiens iodotyrosine deiodinase bound to fmn and mono-iodotyrosine (mit)
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
220
structure length
220
Chain Sequence
VEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTVH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
source organism Homo sapiens
publication title A Switch between One- and Two-electron Chemistry of the Human Flavoprotein Iodotyrosine Deiodinase Is Controlled by Substrate.
pubmed doi rcsb
molecule keywords Iodotyrosine dehalogenase 1
total genus 62
structure length 220
sequence length 220
chains with identical sequence B, C, D, E, F
ec nomenclature ec 1.21.1.1: Iodotyrosine deiodinase.
pdb deposition date 2014-06-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00881 Nitroreductase Nitroreductase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.109.10 Alpha Beta 3-Layer(aba) Sandwich NADH Oxidase NADH Oxidase 4ttcA01
3E10A 4BN8A 3GFAA 3X22A 3TO0A 3BEMA 1OO6A 3X21A 2BKJA 1YKIA 2FREA 4QLXA 5J6CA 3GE5A 2I7HA 1BKJA 5KRDA 2ISKA 2ISLA 4XOQA 1ICVA 3HOIA 2IFAA 1IDTA 3GH8A 5KO8A 3KOQA 2WZWA 1OO5A 3N2SA 3GE6A 2ISJA 3KWKA 1KQDA 3GAGA 4BN6A 1OONA 3EO8A 3EO7A 1KQBA 1ZCHA 4DN2A 3GB5A 1YLRA 2HAYA 4BN7A 1YLUA 3TNZA 5KO7A 3GBHA 4TTBA 1V5ZA 2H0UA 3EOFA 2R01A 1OOQA 4BNBA 4XOOA 3BM2A 3HJ9A 3GFDA 3H4OA 1NOXA 2YMVA 5HEIA 2WZVA 3HZNA 4TTCA 3E39A 1VFRA 4XOMA 1VKWA 1F5VA 3EK3A 3OF4A 3GR3A 1V5YA 4BN9A 4G8SA 4EO3A 2WQFA 3K6HA 2B67A 3G14A 1ICUA 1NECA 3PXVA 4URPA 1DS7A 3BM1A 3QDLA 3M5KA 4QLYA 1ICRA 1YWQA 5HDJA 1KQCA
chains in the Genus database with same CATH superfamily
3E10A 4BN8A 3GFAA 3X22A 3TO0A 3BEMA 1OO6A 3X21A 2BKJA 1YKIA 2FREA 4QLXA 5J6CA 3GE5A 2I7HA 1BKJA 5KRDA 2ISKA 2ISLA 4XOQA 1ICVA 3HOIA 2IFAA 1IDTA 3GH8A 5KO8A 3KOQA 2WZWA 1OO5A 3N2SA 3GE6A 2ISJA 3KWKA 1KQDA 3GAGA 4BN6A 1OONA 3EO8A 3EO7A 1KQBA 1ZCHA 4DN2A 3GB5A 1YLRA 2HAYA 4BN7A 1YLUA 3TNZA 5KO7A 3GBHA 4TTBA 1V5ZA 2H0UA 3EOFA 2R01A 1OOQA 4BNBA 4XOOA 3BM2A 3HJ9A 3GFDA 3H4OA 1NOXA 2YMVA 5HEIA 2WZVA 3HZNA 4TTCA 3E39A 1VFRA 4XOMA 1VKWA 1F5VA 3EK3A 3OF4A 3GR3A 1V5YA 4BN9A 4G8SA 4EO3A 2WQFA 3K6HA 2B67A 3G14A 1ICUA 1NECA 3PXVA 4URPA 1DS7A 3BM1A 3QDLA 3M5KA 4QLYA 1ICRA 1YWQA 5HDJA 1J6RA 1KQCA
chains in the Genus database with same CATH topology
3E10A 4BN8A 3GFAA 3X22A 3TO0A 3BEMA 1OO6A 3X21A 2BKJA 1YKIA 2FREA 4QLXA 5J6CA 3GE5A 2I7HA 1BKJA 5KRDA 2ISKA 2ISLA 4XOQA 1ICVA 3HOIA 2IFAA 1IDTA 3GH8A 5KO8A 3KOQA 2WZWA 1OO5A 3N2SA 3GE6A 2ISJA 3KWKA 1KQDA 3GAGA 4BN6A 1OONA 3EO8A 3EO7A 1KQBA 1ZCHA 4DN2A 3GB5A 1YLRA 2HAYA 4BN7A 1YLUA 3TNZA 5KO7A 3GBHA 4TTBA 1V5ZA 2H0UA 3EOFA 2R01A 1OOQA 4BNBA 4XOOA 3BM2A 3HJ9A 3GFDA 3H4OA 1NOXA 2YMVA 5HEIA 2WZVA 3HZNA 4TTCA 3E39A 1VFRA 4XOMA 1VKWA 1F5VA 3EK3A 3OF4A 3GR3A 1V5YA 4BN9A 4G8SA 4EO3A 2WQFA 3K6HA 2B67A 3G14A 1ICUA 1NECA 3PXVA 4URPA 1DS7A 3BM1A 3QDLA 3M5KA 4QLYA 1ICRA 1YWQA 5HDJA 1J6RA 1KQCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E10 A;  4BN8 A;  3GFA A;  3X22 A;  3TO0 A;  3BEM A;  1OO6 A;  3X21 A;  2BKJ A;  1YKI A;  2FRE A;  4QLX A;  5J6C A;  3GE5 A;  2I7H A;  1BKJ A;  5KRD A;  2ISK A;  2ISL A;  4XOQ A;  1ICV A;  3HOI A;  2IFA A;  1IDT A;  3GH8 A;  5KO8 A;  3KOQ A;  2WZW A;  1OO5 A;  3N2S A;  3GE6 A;  2ISJ A;  3KWK A;  1KQD A;  3GAG A;  4BN6 A;  1OON A;  3EO8 A;  3EO7 A;  1KQB A;  1ZCH A;  4DN2 A;  3GB5 A;  1YLR A;  2HAY A;  4BN7 A;  1YLU A;  3TNZ A;  5KO7 A;  3GBH A;  4TTB A;  1V5Z A;  2H0U A;  3EOF A;  2R01 A;  1OOQ A;  4BNB A;  4XOO A;  3BM2 A;  3HJ9 A;  3GFD A;  3H4O A;  1NOX A;  2YMV A;  5HEI A;  2WZV A;  3HZN A;  4TTC A;  3E39 A;  1VFR A;  4XOM A;  1VKW A;  1F5V A;  3EK3 A;  3OF4 A;  3GR3 A;  1V5Y A;  4BN9 A;  4G8S A;  4EO3 A;  2WQF A;  3K6H A;  2B67 A;  3G14 A;  1ICU A;  1NEC A;  3PXV A;  4URP A;  1DS7 A;  3BM1 A;  3QDL A;  3M5K A;  4QLY A;  1ICR A;  1YWQ A;  5HDJ A;  1KQC A; 
#chains in the Genus database with same CATH topology
 3E10 A;  4BN8 A;  3GFA A;  3X22 A;  3TO0 A;  3BEM A;  1OO6 A;  3X21 A;  2BKJ A;  1YKI A;  2FRE A;  4QLX A;  5J6C A;  3GE5 A;  2I7H A;  1BKJ A;  5KRD A;  2ISK A;  2ISL A;  4XOQ A;  1ICV A;  3HOI A;  2IFA A;  1IDT A;  3GH8 A;  5KO8 A;  3KOQ A;  2WZW A;  1OO5 A;  3N2S A;  3GE6 A;  2ISJ A;  3KWK A;  1KQD A;  3GAG A;  4BN6 A;  1OON A;  3EO8 A;  3EO7 A;  1KQB A;  1ZCH A;  4DN2 A;  3GB5 A;  1YLR A;  2HAY A;  4BN7 A;  1YLU A;  3TNZ A;  5KO7 A;  3GBH A;  4TTB A;  1V5Z A;  2H0U A;  3EOF A;  2R01 A;  1OOQ A;  4BNB A;  4XOO A;  3BM2 A;  3HJ9 A;  3GFD A;  3H4O A;  1NOX A;  2YMV A;  5HEI A;  2WZV A;  3HZN A;  4TTC A;  3E39 A;  1VFR A;  4XOM A;  1VKW A;  1F5V A;  3EK3 A;  3OF4 A;  3GR3 A;  1V5Y A;  4BN9 A;  4G8S A;  4EO3 A;  2WQF A;  3K6H A;  2B67 A;  3G14 A;  1ICU A;  1NEC A;  3PXV A;  4URP A;  1DS7 A;  3BM1 A;  3QDL A;  3M5K A;  4QLY A;  1ICR A;  1YWQ A;  5HDJ A;  1J6R A;  1KQC A; 
#chains in the Genus database with same CATH homology
 3E10 A;  4BN8 A;  3GFA A;  3X22 A;  3TO0 A;  3BEM A;  1OO6 A;  3X21 A;  2BKJ A;  1YKI A;  2FRE A;  4QLX A;  5J6C A;  3GE5 A;  2I7H A;  1BKJ A;  5KRD A;  2ISK A;  2ISL A;  4XOQ A;  1ICV A;  3HOI A;  2IFA A;  1IDT A;  3GH8 A;  5KO8 A;  3KOQ A;  2WZW A;  1OO5 A;  3N2S A;  3GE6 A;  2ISJ A;  3KWK A;  1KQD A;  3GAG A;  4BN6 A;  1OON A;  3EO8 A;  3EO7 A;  1KQB A;  1ZCH A;  4DN2 A;  3GB5 A;  1YLR A;  2HAY A;  4BN7 A;  1YLU A;  3TNZ A;  5KO7 A;  3GBH A;  4TTB A;  1V5Z A;  2H0U A;  3EOF A;  2R01 A;  1OOQ A;  4BNB A;  4XOO A;  3BM2 A;  3HJ9 A;  3GFD A;  3H4O A;  1NOX A;  2YMV A;  5HEI A;  2WZV A;  3HZN A;  4TTC A;  3E39 A;  1VFR A;  4XOM A;  1VKW A;  1F5V A;  3EK3 A;  3OF4 A;  3GR3 A;  1V5Y A;  4BN9 A;  4G8S A;  4EO3 A;  2WQF A;  3K6H A;  2B67 A;  3G14 A;  1ICU A;  1NEC A;  3PXV A;  4URP A;  1DS7 A;  3BM1 A;  3QDL A;  3M5K A;  4QLY A;  1ICR A;  1YWQ A;  5HDJ A;  1J6R A;  1KQC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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