4TTCA

Crystal structure of homo sapiens iodotyrosine deiodinase bound to fmn and mono-iodotyrosine (mit)
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
220
structure length
220
Chain Sequence
VEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTVH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Switch between One- and Two-electron Chemistry of the Human Flavoprotein Iodotyrosine Deiodinase Is Controlled by Substrate.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Iodotyrosine dehalogenase 1
total genus 62
structure length 220
sequence length 220
chains with identical sequence B, C, D, E, F
ec nomenclature ec 1.21.1.1: Iodotyrosine deiodinase.
pdb deposition date 2014-06-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00881 Nitroreductase Nitroreductase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.109.10 Alpha Beta 3-Layer(aba) Sandwich NADH Oxidase NADH Oxidase 4ttcA01
1OO6A 3E10A 5HDJA 2BKJA 3KOQA 3HZNA 2WQFA 1YWQA 3GH8A 4DN2A 3QDLA 1YLUA 3TNZA 3BM1A 1ICRA 3X21A 4XOMA 3GBHA 1KQDA 2IFAA 4QLXA 3E39A 4BN9A 1VKWA 2ISLA 4BN8A 1BKJA 3GB5A 1OONA 3H4OA 3EK3A 3PXVA 3GFAA 3X22A 4QLYA 1NOXA 3KWKA 1ICVA 5J6CA 2B67A 5HEIA 1V5ZA 3EO8A 3N2SA 3HOIA 4BN7A 2I7HA 2R01A 4G8SA 1OOQA 4TTBA 2WZWA 3BEMA 3GR3A 3M5KA 1F5VA 4TTCA 3GAGA 5KO8A 2FREA 2ISKA 5KRDA 1DS7A 4XOQA 3GE6A 1YLRA 3G14A 1ZCHA 3BM2A 3GE5A 1NECA 3TO0A 2H0UA 4XOOA 2WZVA 3EOFA 4BN6A 1V5YA 4BNBA 1IDTA 4EO3A 3OF4A 1KQBA 2YMVA 4URPA 1ICUA 2HAYA 3GFDA 3HJ9A 2ISJA 1VFRA 3EO7A 5KO7A 1YKIA 3K6HA 1KQCA 1OO5A
chains in the Genus database with same CATH superfamily
1OO6A 3E10A 5HDJA 2BKJA 3KOQA 3HZNA 2WQFA 1YWQA 3GH8A 4DN2A 3QDLA 1YLUA 3TNZA 3BM1A 1ICRA 3X21A 4XOMA 3GBHA 1KQDA 2IFAA 1J6RA 4QLXA 3E39A 4BN9A 1VKWA 2ISLA 4BN8A 1BKJA 3GB5A 1OONA 3H4OA 3EK3A 3PXVA 3GFAA 3X22A 4QLYA 1NOXA 3KWKA 1ICVA 5J6CA 2B67A 5HEIA 1V5ZA 3EO8A 3N2SA 3HOIA 4BN7A 2I7HA 2R01A 4G8SA 1OOQA 4TTBA 2WZWA 3BEMA 3GR3A 3M5KA 1F5VA 4TTCA 3GAGA 5KO8A 2FREA 2ISKA 5KRDA 1DS7A 4XOQA 3GE6A 1YLRA 3G14A 1ZCHA 3BM2A 3GE5A 1NECA 3TO0A 2H0UA 4XOOA 2WZVA 3EOFA 4BN6A 1V5YA 4BNBA 1IDTA 4EO3A 3OF4A 1KQBA 2YMVA 4URPA 1ICUA 2HAYA 3GFDA 3HJ9A 2ISJA 1VFRA 3EO7A 5KO7A 1YKIA 3K6HA 1KQCA 1OO5A
chains in the Genus database with same CATH topology
1OO6A 3E10A 5HDJA 2BKJA 3KOQA 3HZNA 2WQFA 1YWQA 3GH8A 4DN2A 3QDLA 1YLUA 3TNZA 3BM1A 1ICRA 3X21A 4XOMA 3GBHA 1KQDA 2IFAA 1J6RA 4QLXA 3E39A 4BN9A 1VKWA 2ISLA 4BN8A 1BKJA 3GB5A 1OONA 3H4OA 3EK3A 3PXVA 3GFAA 3X22A 4QLYA 1NOXA 3KWKA 1ICVA 5J6CA 2B67A 5HEIA 1V5ZA 3EO8A 3N2SA 3HOIA 4BN7A 2I7HA 2R01A 4G8SA 1OOQA 4TTBA 2WZWA 3BEMA 3GR3A 3M5KA 1F5VA 4TTCA 3GAGA 5KO8A 2FREA 2ISKA 5KRDA 1DS7A 4XOQA 3GE6A 1YLRA 3G14A 1ZCHA 3BM2A 3GE5A 1NECA 3TO0A 2H0UA 4XOOA 2WZVA 3EOFA 4BN6A 1V5YA 4BNBA 1IDTA 4EO3A 3OF4A 1KQBA 2YMVA 4URPA 1ICUA 2HAYA 3GFDA 3HJ9A 2ISJA 1VFRA 3EO7A 5KO7A 1YKIA 3K6HA 1KQCA 1OO5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OO6 A;  3E10 A;  5HDJ A;  2BKJ A;  3KOQ A;  3HZN A;  2WQF A;  1YWQ A;  3GH8 A;  4DN2 A;  3QDL A;  1YLU A;  3TNZ A;  3BM1 A;  1ICR A;  3X21 A;  4XOM A;  3GBH A;  1KQD A;  2IFA A;  4QLX A;  3E39 A;  4BN9 A;  1VKW A;  2ISL A;  4BN8 A;  1BKJ A;  3GB5 A;  1OON A;  3H4O A;  3EK3 A;  3PXV A;  3GFA A;  3X22 A;  4QLY A;  1NOX A;  3KWK A;  1ICV A;  5J6C A;  2B67 A;  5HEI A;  1V5Z A;  3EO8 A;  3N2S A;  3HOI A;  4BN7 A;  2I7H A;  2R01 A;  4G8S A;  1OOQ A;  4TTB A;  2WZW A;  3BEM A;  3GR3 A;  3M5K A;  1F5V A;  4TTC A;  3GAG A;  5KO8 A;  2FRE A;  2ISK A;  5KRD A;  1DS7 A;  4XOQ A;  3GE6 A;  1YLR A;  3G14 A;  1ZCH A;  3BM2 A;  3GE5 A;  1NEC A;  3TO0 A;  2H0U A;  4XOO A;  2WZV A;  3EOF A;  4BN6 A;  1V5Y A;  4BNB A;  1IDT A;  4EO3 A;  3OF4 A;  1KQB A;  2YMV A;  4URP A;  1ICU A;  2HAY A;  3GFD A;  3HJ9 A;  2ISJ A;  1VFR A;  3EO7 A;  5KO7 A;  1YKI A;  3K6H A;  1KQC A;  1OO5 A; 
#chains in the Genus database with same CATH topology
 1OO6 A;  3E10 A;  5HDJ A;  2BKJ A;  3KOQ A;  3HZN A;  2WQF A;  1YWQ A;  3GH8 A;  4DN2 A;  3QDL A;  1YLU A;  3TNZ A;  3BM1 A;  1ICR A;  3X21 A;  4XOM A;  3GBH A;  1KQD A;  2IFA A;  1J6R A;  4QLX A;  3E39 A;  4BN9 A;  1VKW A;  2ISL A;  4BN8 A;  1BKJ A;  3GB5 A;  1OON A;  3H4O A;  3EK3 A;  3PXV A;  3GFA A;  3X22 A;  4QLY A;  1NOX A;  3KWK A;  1ICV A;  5J6C A;  2B67 A;  5HEI A;  1V5Z A;  3EO8 A;  3N2S A;  3HOI A;  4BN7 A;  2I7H A;  2R01 A;  4G8S A;  1OOQ A;  4TTB A;  2WZW A;  3BEM A;  3GR3 A;  3M5K A;  1F5V A;  4TTC A;  3GAG A;  5KO8 A;  2FRE A;  2ISK A;  5KRD A;  1DS7 A;  4XOQ A;  3GE6 A;  1YLR A;  3G14 A;  1ZCH A;  3BM2 A;  3GE5 A;  1NEC A;  3TO0 A;  2H0U A;  4XOO A;  2WZV A;  3EOF A;  4BN6 A;  1V5Y A;  4BNB A;  1IDT A;  4EO3 A;  3OF4 A;  1KQB A;  2YMV A;  4URP A;  1ICU A;  2HAY A;  3GFD A;  3HJ9 A;  2ISJ A;  1VFR A;  3EO7 A;  5KO7 A;  1YKI A;  3K6H A;  1KQC A;  1OO5 A; 
#chains in the Genus database with same CATH homology
 1OO6 A;  3E10 A;  5HDJ A;  2BKJ A;  3KOQ A;  3HZN A;  2WQF A;  1YWQ A;  3GH8 A;  4DN2 A;  3QDL A;  1YLU A;  3TNZ A;  3BM1 A;  1ICR A;  3X21 A;  4XOM A;  3GBH A;  1KQD A;  2IFA A;  1J6R A;  4QLX A;  3E39 A;  4BN9 A;  1VKW A;  2ISL A;  4BN8 A;  1BKJ A;  3GB5 A;  1OON A;  3H4O A;  3EK3 A;  3PXV A;  3GFA A;  3X22 A;  4QLY A;  1NOX A;  3KWK A;  1ICV A;  5J6C A;  2B67 A;  5HEI A;  1V5Z A;  3EO8 A;  3N2S A;  3HOI A;  4BN7 A;  2I7H A;  2R01 A;  4G8S A;  1OOQ A;  4TTB A;  2WZW A;  3BEM A;  3GR3 A;  3M5K A;  1F5V A;  4TTC A;  3GAG A;  5KO8 A;  2FRE A;  2ISK A;  5KRD A;  1DS7 A;  4XOQ A;  3GE6 A;  1YLR A;  3G14 A;  1ZCH A;  3BM2 A;  3GE5 A;  1NEC A;  3TO0 A;  2H0U A;  4XOO A;  2WZV A;  3EOF A;  4BN6 A;  1V5Y A;  4BNB A;  1IDT A;  4EO3 A;  3OF4 A;  1KQB A;  2YMV A;  4URP A;  1ICU A;  2HAY A;  3GFD A;  3HJ9 A;  2ISJ A;  1VFR A;  3EO7 A;  5KO7 A;  1YKI A;  3K6H A;  1KQC A;  1OO5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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