4ZGMA

Crystal structure of semaglutide peptide backbone in complex with the glp-1 receptor extracellular domain
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
100
structure length
100
Chain Sequence
TVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Glucagon-like peptide 1 receptor
total genus 23
structure length 100
sequence length 100
ec nomenclature
pdb deposition date 2015-04-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02793 HRM Hormone receptor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.1240.10 Few Secondary Structures Irregular Hormone receptor fold GPCR, family 2, extracellular hormone receptor domain 4zgmA00
1U34A 3C4MA 3L2JA 3H3GA 3C59A 2JNDA 4ZGMA 3C5TA 3N7SA 2JODA 2L27A 2QKHA 3N7RA 4LF3C 3EHSA 3N7PA 4DLOA 3IOLA 3AQFB 3EHTA 2XDGA 5II0A 4DLQA 4HJ0A 2JNCA 4ERSA 3EHUA
chains in the Genus database with same CATH superfamily
1U34A 3C4MA 3L2JA 3H3GA 3C59A 2JNDA 4ZGMA 3C5TA 3N7SA 2JODA 2L27A 2QKHA 3N7RA 4LF3C 3EHSA 3N7PA 4DLOA 3IOLA 3AQFB 3EHTA 2XDGA 5II0A 4DLQA 4HJ0A 2JNCA 4ERSA 3EHUA
chains in the Genus database with same CATH topology
1U34A 3C4MA 3L2JA 3H3GA 3C59A 2JNDA 4ZGMA 3C5TA 3N7SA 2JODA 2L27A 2QKHA 3N7RA 4LF3C 3EHSA 3N7PA 4DLOA 3IOLA 3AQFB 3EHTA 2XDGA 5II0A 4DLQA 4HJ0A 2JNCA 4ERSA 3EHUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1U34 A;  3C4M A;  3L2J A;  3H3G A;  3C59 A;  2JND A;  4ZGM A;  3C5T A;  3N7S A;  2JOD A;  2L27 A;  2QKH A;  3N7R A;  4LF3 C;  3EHS A;  3N7P A;  4DLO A;  3IOL A;  3AQF B;  3EHT A;  2XDG A;  5II0 A;  4DLQ A;  4HJ0 A;  2JNC A;  4ERS A;  3EHU A; 
#chains in the Genus database with same CATH topology
 1U34 A;  3C4M A;  3L2J A;  3H3G A;  3C59 A;  2JND A;  4ZGM A;  3C5T A;  3N7S A;  2JOD A;  2L27 A;  2QKH A;  3N7R A;  4LF3 C;  3EHS A;  3N7P A;  4DLO A;  3IOL A;  3AQF B;  3EHT A;  2XDG A;  5II0 A;  4DLQ A;  4HJ0 A;  2JNC A;  4ERS A;  3EHU A; 
#chains in the Genus database with same CATH homology
 1U34 A;  3C4M A;  3L2J A;  3H3G A;  3C59 A;  2JND A;  4ZGM A;  3C5T A;  3N7S A;  2JOD A;  2L27 A;  2QKH A;  3N7R A;  4LF3 C;  3EHS A;  3N7P A;  4DLO A;  3IOL A;  3AQF B;  3EHT A;  2XDG A;  5II0 A;  4DLQ A;  4HJ0 A;  2JNC A;  4ERS A;  3EHU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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