4ZGMA

Crystal structure of semaglutide peptide backbone in complex with the glp-1 receptor extracellular domain
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
100
structure length
100
Chain Sequence
TVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Glucagon-like peptide 1 receptor
total genus 23
structure length 100
sequence length 100
ec nomenclature
pdb deposition date 2015-04-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02793 HRM Hormone receptor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.1240.10 Few Secondary Structures Irregular Hormone receptor fold GPCR, family 2, extracellular hormone receptor domain 4zgmA00
2QKHA 3N7RA 4DLOA 3N7SA 3L2JA 5II0A 2JNDA 2XDGA 3EHUA 4ZGMA 3C59A 3EHSA 3IOLA 4HJ0A 3C4MA 4DLQA 3AQFB 4LF3C 2L27A 3N7PA 1U34A 2JNCA 4ERSA 2JODA 3C5TA 3H3GA 3EHTA
chains in the Genus database with same CATH superfamily
2QKHA 3N7RA 4DLOA 3N7SA 3L2JA 5II0A 2JNDA 2XDGA 3EHUA 4ZGMA 3C59A 3EHSA 3IOLA 4HJ0A 3C4MA 4DLQA 3AQFB 4LF3C 2L27A 3N7PA 1U34A 2JNCA 4ERSA 2JODA 3C5TA 3H3GA 3EHTA
chains in the Genus database with same CATH topology
2QKHA 3N7RA 4DLOA 3N7SA 3L2JA 5II0A 2JNDA 2XDGA 3EHUA 4ZGMA 3C59A 3EHSA 3IOLA 4HJ0A 3C4MA 4DLQA 3AQFB 4LF3C 2L27A 3N7PA 1U34A 2JNCA 4ERSA 2JODA 3C5TA 3H3GA 3EHTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QKH A;  3N7R A;  4DLO A;  3N7S A;  3L2J A;  5II0 A;  2JND A;  2XDG A;  3EHU A;  4ZGM A;  3C59 A;  3EHS A;  3IOL A;  4HJ0 A;  3C4M A;  4DLQ A;  3AQF B;  4LF3 C;  2L27 A;  3N7P A;  1U34 A;  2JNC A;  4ERS A;  2JOD A;  3C5T A;  3H3G A;  3EHT A; 
#chains in the Genus database with same CATH topology
 2QKH A;  3N7R A;  4DLO A;  3N7S A;  3L2J A;  5II0 A;  2JND A;  2XDG A;  3EHU A;  4ZGM A;  3C59 A;  3EHS A;  3IOL A;  4HJ0 A;  3C4M A;  4DLQ A;  3AQF B;  4LF3 C;  2L27 A;  3N7P A;  1U34 A;  2JNC A;  4ERS A;  2JOD A;  3C5T A;  3H3G A;  3EHT A; 
#chains in the Genus database with same CATH homology
 2QKH A;  3N7R A;  4DLO A;  3N7S A;  3L2J A;  5II0 A;  2JND A;  2XDG A;  3EHU A;  4ZGM A;  3C59 A;  3EHS A;  3IOL A;  4HJ0 A;  3C4M A;  4DLQ A;  3AQF B;  4LF3 C;  2L27 A;  3N7P A;  1U34 A;  2JNC A;  4ERS A;  2JOD A;  3C5T A;  3H3G A;  3EHT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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