5DQ8A

Crystal structure of human transcription factor tead2 in complex with flufenamic acid
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
225
structure length
193
Chain Sequence
GLGTARLQLVEFSAFVEPQRHLFVHISQLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords Transcriptional enhancer factor TEF-4
total genus 47
structure length 193
sequence length 225
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF17725 YBD YAP binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.50.80 Mainly Beta Distorted Sandwich Coagulation Factor XIII; Chain A, domain 1 Coagulation Factor XIII; Chain A, domain 1 5dq8A00
3JUAA 4LN0A 3KYSA 5EMWA 5HGUA 3L15A 5EMVA 5DQEA 4RE1A 5DQ8A
chains in the Genus database with same CATH superfamily
4OY8A 5TARB 5ACHA 5HNPA 3KYSA 1KSGB 4MAIA 5ACJA 2JHZA 3GQQA 1DOAB 1HH4D 1KSJB 4JVFB 4JVBB 4ALTA 4JHPB 2R5OA 2VTCA 2JHVA 4ALRA 4ALSA 3EJAA 5ACFA 4MAHA 1FSTA 4ALCA 4JV8B 5HNOA 2JHTA 4EIRA 4OY6A 2JHXA 1KSHB 1FT0A 2JI0A 4GOKC 1QVYA 4RE1A 2BEMA 5TB5B 5FJQA 3T5IA 2YOWA 2JHUA 5FOHA 4FMRA 4D7UA 4D7VA 5L7KA 1RHOA 3JUAA 1DS6B 3RBQA 5AA7A 3EIIA 4A02A 4F38B 2JHYA 2BXWA 2YOYA 1GDFA 2LHSA 5EMVA 4QI8A 2YETA 4OY7A 3L15A 5ACIA 4B5QA 5IJUA 1KMTA 5ACGA 5DQEA 5DQ8A 3ZUDA 5E80A 4ALEA 2YOXA 5HGUA 3T5GB 4EISB 2XWXA 1AJWA 5EMWA 1FSOA 5FTZA 4LN0A 4GBOA 4EISA 1FT3A 4JV6B 5F2UA 5E8FA 4GOJC 2JHSA 2JHWA 2BENA 3UAMA 4ALQA
chains in the Genus database with same CATH topology
4EISB 5ACHA 3KYSA 4MAIA 5EMWA 5ACJA 5EMVA 4RE1A 4LN0A 4QI8A 5FOHA 4EISA 4FMRA 2YETA 4D7UA 4B5QA 3L15A 5ACIA 4D7VA 2VTCA 5ACGA 3EJAA 5ACFA 5DQEA 5DQ8A 4MAHA 3JUAA 3ZUDA 3EIIA 5HGUA 4EIRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3JUA A;  4LN0 A;  3KYS A;  5EMW A;  5HGU A;  3L15 A;  5EMV A;  5DQE A;  4RE1 A;  5DQ8 A; 
#chains in the Genus database with same CATH topology
 4OY8 A;  5TAR B;  5ACH A;  5HNP A;  3KYS A;  1KSG B;  4MAI A;  5ACJ A;  2JHZ A;  3GQQ A;  1DOA B;  1HH4 D;  1KSJ B;  4JVF B;  4JVB B;  4ALT A;  4JHP B;  2R5O A;  2VTC A;  2JHV A;  4ALR A;  4ALS A;  3EJA A;  5ACF A;  4MAH A;  1FST A;  4ALC A;  4JV8 B;  5HNO A;  2JHT A;  4EIR A;  4OY6 A;  2JHX A;  1KSH B;  1FT0 A;  2JI0 A;  4GOK C;  1QVY A;  4RE1 A;  2BEM A;  5TB5 B;  5FJQ A;  3T5I A;  2YOW A;  2JHU A;  5FOH A;  4FMR A;  4D7U A;  4D7V A;  5L7K A;  1RHO A;  3JUA A;  1DS6 B;  3RBQ A;  5AA7 A;  3EII A;  4A02 A;  4F38 B;  2JHY A;  2BXW A;  2YOY A;  1GDF A;  2LHS A;  5EMV A;  4QI8 A;  2YET A;  4OY7 A;  3L15 A;  5ACI A;  4B5Q A;  5IJU A;  1KMT A;  5ACG A;  5DQE A;  5DQ8 A;  3ZUD A;  5E80 A;  4ALE A;  2YOX A;  5HGU A;  3T5G B;  4EIS B;  2XWX A;  1AJW A;  5EMW A;  1FSO A;  5FTZ A;  4LN0 A;  4GBO A;  4EIS A;  1FT3 A;  4JV6 B;  5F2U A;  5E8F A;  4GOJ C;  2JHS A;  2JHW A;  2BEN A;  3UAM A;  4ALQ A; 
#chains in the Genus database with same CATH homology
 4EIS B;  5ACH A;  3KYS A;  4MAI A;  5EMW A;  5ACJ A;  5EMV A;  4RE1 A;  4LN0 A;  4QI8 A;  5FOH A;  4EIS A;  4FMR A;  2YET A;  4D7U A;  4B5Q A;  3L15 A;  5ACI A;  4D7V A;  2VTC A;  5ACG A;  3EJA A;  5ACF A;  5DQE A;  5DQ8 A;  4MAH A;  3JUA A;  3ZUD A;  3EII A;  5HGU A;  4EIR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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