5DQ8A

Crystal structure of human transcription factor tead2 in complex with flufenamic acid
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
225
structure length
193
Chain Sequence
GLGTARLQLVEFSAFVEPQRHLFVHISQLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords Transcriptional enhancer factor TEF-4
total genus 47
structure length 193
sequence length 225
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF17725 YBD YAP binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.50.80 Mainly Beta Distorted Sandwich Coagulation Factor XIII; Chain A, domain 1 Coagulation Factor XIII; Chain A, domain 1 5dq8A00
5EMVA 3L15A 3KYSA 5DQEA 4RE1A 5HGUA 5DQ8A 4LN0A 3JUAA 5EMWA
chains in the Genus database with same CATH superfamily
4MAIA 5IJUA 5FTZA 5HNOA 2JHYA 1HH4D 2BXWA 5DQ8A 1DOAB 1RHOA 4GOJC 2JHZA 3EIIA 5DQEA 3RBQA 4RE1A 1FSTA 5EMWA 1AJWA 2VTCA 4B5QA 2XWXA 1KSGB 4QI8A 2YETA 1KSJB 4ALQA 5ACHA 5TB5B 4JV6B 4EIRA 5ACGA 4OY7A 1FSOA 5ACIA 2R5OA 5EMVA 4JVBB 2BENA 3T5GB 1FT0A 1GDFA 3JUAA 4ALTA 4F38B 5E80A 2JHSA 5ACFA 2JHTA 2YOXA 4A02A 1FT3A 5F2UA 4D7VA 4JHPB 1KSHB 4ALEA 2JHWA 3KYSA 1KMTA 4D7UA 5ACJA 3GQQA 4OY8A 1DS6B 5AA7A 5FJQA 5E8FA 1QVYA 2JHVA 5FOHA 2BEMA 4ALCA 4ALSA 2JHXA 2JHUA 2YOYA 2LHSA 4LN0A 3EJAA 5HNPA 4GBOA 3L15A 5TARB 2YOWA 4JV8B 4GOKC 4ALRA 5HGUA 3T5IA 4EISA 5L7KA 2JI0A 4FMRA 3UAMA 3ZUDA 4OY6A 4JVFB 4MAHA 4EISB
chains in the Genus database with same CATH topology
3KYSA 4MAIA 5ACHA 4D7UA 5ACJA 4EIRA 2YETA 5ACGA 4LN0A 5ACIA 3EJAA 5EMVA 3L15A 5DQ8A 3JUAA 3EIIA 5DQEA 5ACFA 5FOHA 5HGUA 4RE1A 4EISA 4D7VA 5EMWA 4FMRA 2VTCA 4B5QA 3ZUDA 4MAHA 4EISB 4QI8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EMV A;  3L15 A;  3KYS A;  5DQE A;  4RE1 A;  5HGU A;  5DQ8 A;  4LN0 A;  3JUA A;  5EMW A; 
#chains in the Genus database with same CATH topology
 4MAI A;  5IJU A;  5FTZ A;  5HNO A;  2JHY A;  1HH4 D;  2BXW A;  5DQ8 A;  1DOA B;  1RHO A;  4GOJ C;  2JHZ A;  3EII A;  5DQE A;  3RBQ A;  4RE1 A;  1FST A;  5EMW A;  1AJW A;  2VTC A;  4B5Q A;  2XWX A;  1KSG B;  4QI8 A;  2YET A;  1KSJ B;  4ALQ A;  5ACH A;  5TB5 B;  4JV6 B;  4EIR A;  5ACG A;  4OY7 A;  1FSO A;  5ACI A;  2R5O A;  5EMV A;  4JVB B;  2BEN A;  3T5G B;  1FT0 A;  1GDF A;  3JUA A;  4ALT A;  4F38 B;  5E80 A;  2JHS A;  5ACF A;  2JHT A;  2YOX A;  4A02 A;  1FT3 A;  5F2U A;  4D7V A;  4JHP B;  1KSH B;  4ALE A;  2JHW A;  3KYS A;  1KMT A;  4D7U A;  5ACJ A;  3GQQ A;  4OY8 A;  1DS6 B;  5AA7 A;  5FJQ A;  5E8F A;  1QVY A;  2JHV A;  5FOH A;  2BEM A;  4ALC A;  4ALS A;  2JHX A;  2JHU A;  2YOY A;  2LHS A;  4LN0 A;  3EJA A;  5HNP A;  4GBO A;  3L15 A;  5TAR B;  2YOW A;  4JV8 B;  4GOK C;  4ALR A;  5HGU A;  3T5I A;  4EIS A;  5L7K A;  2JI0 A;  4FMR A;  3UAM A;  3ZUD A;  4OY6 A;  4JVF B;  4MAH A;  4EIS B; 
#chains in the Genus database with same CATH homology
 3KYS A;  4MAI A;  5ACH A;  4D7U A;  5ACJ A;  4EIR A;  2YET A;  5ACG A;  4LN0 A;  5ACI A;  3EJA A;  5EMV A;  3L15 A;  5DQ8 A;  3JUA A;  3EII A;  5DQE A;  5ACF A;  5FOH A;  5HGU A;  4RE1 A;  4EIS A;  4D7V A;  5EMW A;  4FMR A;  2VTC A;  4B5Q A;  3ZUD A;  4MAH A;  4EIS B;  4QI8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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