5TARB

Crystal structure of farnesylated and methylated kras4b in complex with pde-delta (crystal form ii - with ordered hypervariable region)
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
148
structure length
148
Chain Sequence
AKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta.
pubmed doi rcsb
molecule tags Oncoprotein
source organism Homo sapiens
molecule keywords GTPase KRas
total genus 42
structure length 148
sequence length 148
ec nomenclature
pdb deposition date 2016-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF05351 GMP_PDE_delta GMP-PDE, delta subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.50.40 Mainly Beta Distorted Sandwich Coagulation Factor XIII; Chain A, domain 1 GMP phosphodiesterase, delta subunit 5tarB00
5L7KA 4GOKC 5E8FA 3T5IA 4GOJC 4JHPB 4JVFB 5F2UA 1KSHB 5TARB 3GQQA 4JVBB 3RBQA 4JV6B 1KSGB 4JV8B 5E80A 1KSJB 3T5GB 5TB5B
chains in the Genus database with same CATH superfamily
4MAIA 3EJAA 5L7KA 4F38B 2YOYA 4ALRA 3KYSA 4EISB 4B5QA 5EMWA 1FT0A 1HH4D 1DS6B 5F2UA 5EMVA 2LHSA 4GBOA 2JHTA 2BXWA 3UAMA 2YETA 5ACJA 4D7VA 5E8FA 2JHWA 1GDFA 2JHZA 2JHYA 2JI0A 2YOXA 1FSTA 3GQQA 4JVBB 2VTCA 4JV6B 1DOAB 3JUAA 5IJUA 5AA7A 5FOHA 4ALEA 4OY8A 4OY6A 4ALCA 4GOKC 2R5OA 4EISA 1KMTA 1FT3A 2JHXA 4FMRA 1RHOA 4QI8A 5FJQA 2XWXA 4GOJC 4JHPB 4JVFB 5HGUA 4RE1A 4D7UA 5ACIA 3L15A 5TARB 3RBQA 1KSGB 1KSJB 4MAHA 5TB5B 2JHSA 2BEMA 3EIIA 1AJWA 4OY7A 3T5IA 2BENA 5ACHA 3ZUDA 5HNOA 5DQEA 5ACGA 4ALTA 5HNPA 2YOWA 2JHVA 1QVYA 5ACFA 4EIRA 4ALSA 5FTZA 4A02A 1KSHB 4ALQA 1FSOA 4JV8B 5E80A 2JHUA 5DQ8A 4LN0A 3T5GB
chains in the Genus database with same CATH topology
5L7KA 4GOKC 5E8FA 3T5IA 4GOJC 4JHPB 4JVFB 5F2UA 1KSHB 5TARB 3GQQA 4JVBB 3RBQA 4JV6B 1KSGB 4JV8B 5E80A 1KSJB 3T5GB 5TB5B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L7K A;  4GOK C;  5E8F A;  3T5I A;  4GOJ C;  4JHP B;  4JVF B;  5F2U A;  1KSH B;  5TAR B;  3GQQ A;  4JVB B;  3RBQ A;  4JV6 B;  1KSG B;  4JV8 B;  5E80 A;  1KSJ B;  3T5G B;  5TB5 B; 
#chains in the Genus database with same CATH topology
 4MAI A;  3EJA A;  5L7K A;  4F38 B;  2YOY A;  4ALR A;  3KYS A;  4EIS B;  4B5Q A;  5EMW A;  1FT0 A;  1HH4 D;  1DS6 B;  5F2U A;  5EMV A;  2LHS A;  4GBO A;  2JHT A;  2BXW A;  3UAM A;  2YET A;  5ACJ A;  4D7V A;  5E8F A;  2JHW A;  1GDF A;  2JHZ A;  2JHY A;  2JI0 A;  2YOX A;  1FST A;  3GQQ A;  4JVB B;  2VTC A;  4JV6 B;  1DOA B;  3JUA A;  5IJU A;  5AA7 A;  5FOH A;  4ALE A;  4OY8 A;  4OY6 A;  4ALC A;  4GOK C;  2R5O A;  4EIS A;  1KMT A;  1FT3 A;  2JHX A;  4FMR A;  1RHO A;  4QI8 A;  5FJQ A;  2XWX A;  4GOJ C;  4JHP B;  4JVF B;  5HGU A;  4RE1 A;  4D7U A;  5ACI A;  3L15 A;  5TAR B;  3RBQ A;  1KSG B;  1KSJ B;  4MAH A;  5TB5 B;  2JHS A;  2BEM A;  3EII A;  1AJW A;  4OY7 A;  3T5I A;  2BEN A;  5ACH A;  3ZUD A;  5HNO A;  5DQE A;  5ACG A;  4ALT A;  5HNP A;  2YOW A;  2JHV A;  1QVY A;  5ACF A;  4EIR A;  4ALS A;  5FTZ A;  4A02 A;  1KSH B;  4ALQ A;  1FSO A;  4JV8 B;  5E80 A;  2JHU A;  5DQ8 A;  4LN0 A;  3T5G B; 
#chains in the Genus database with same CATH homology
 5L7K A;  4GOK C;  5E8F A;  3T5I A;  4GOJ C;  4JHP B;  4JVF B;  5F2U A;  1KSH B;  5TAR B;  3GQQ A;  4JVB B;  3RBQ A;  4JV6 B;  1KSG B;  4JV8 B;  5E80 A;  1KSJ B;  3T5G B;  5TB5 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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