5TB5B

Crystal structure of full-length farnesylated and methylated kras4b in complex with pde-delta (crystal form i - with partially disordered hypervariable region)
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
150
structure length
150
Chain Sequence
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta.
pubmed doi rcsb
molecule tags Oncoprotein
source organism Homo sapiens
molecule keywords GTPase KRas
total genus 45
structure length 150
sequence length 150
chains with identical sequence D
ec nomenclature
pdb deposition date 2016-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF05351 GMP_PDE_delta GMP-PDE, delta subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.50.40 Mainly Beta Distorted Sandwich Coagulation Factor XIII; Chain A, domain 1 GMP phosphodiesterase, delta subunit 5tb5B00
1KSJB 4JHPB 4JV6B 5E8FA 3RBQA 4JV8B 4GOJC 5TARB 3GQQA 5TB5B 4JVFB 3T5GB 3T5IA 4JVBB 1KSHB 4GOKC 1KSGB 5F2UA 5E80A 5L7KA
chains in the Genus database with same CATH superfamily
5ACFA 3UAMA 4OY6A 5E8FA 5FJQA 5EMVA 4JV8B 5ACJA 3JUAA 3GQQA 1HH4D 5TB5B 1AJWA 1FSTA 4OY8A 5EMWA 5FOHA 4ALEA 1KSHB 4GBOA 2XWXA 4ALQA 4ALTA 5E80A 1RHOA 1KSJB 4JV6B 4MAIA 3EIIA 4GOJC 4ALCA 2YETA 4LN0A 4F38B 2JHTA 5FTZA 4B5QA 4D7VA 1DS6B 2JI0A 2JHXA 5HGUA 2VTCA 3L15A 2YOXA 4ALSA 2LHSA 5DQ8A 1KSGB 5F2UA 2YOWA 5DQEA 3KYSA 4MAHA 3RBQA 1KMTA 2JHSA 4EIRA 4QI8A 4JVFB 4D7UA 5ACGA 3T5IA 4JVBB 4RE1A 5HNPA 4GOKC 1FSOA 2JHUA 1DOAB 4FMRA 2R5OA 2BEMA 4JHPB 5ACHA 2JHVA 5IJUA 3ZUDA 1QVYA 2JHYA 4A02A 1GDFA 4OY7A 5TARB 5ACIA 2BXWA 2JHZA 4ALRA 1FT0A 2BENA 2YOYA 3T5GB 1FT3A 4EISA 3EJAA 2JHWA 5HNOA 5L7KA 4EISB 5AA7A
chains in the Genus database with same CATH topology
1KSJB 4JHPB 4JV6B 5E8FA 3RBQA 4JV8B 4GOJC 5TARB 3GQQA 5TB5B 4JVFB 3T5GB 3T5IA 4JVBB 1KSHB 4GOKC 1KSGB 5F2UA 5E80A 5L7KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KSJ B;  4JHP B;  4JV6 B;  5E8F A;  3RBQ A;  4JV8 B;  4GOJ C;  5TAR B;  3GQQ A;  5TB5 B;  4JVF B;  3T5G B;  3T5I A;  4JVB B;  1KSH B;  4GOK C;  1KSG B;  5F2U A;  5E80 A;  5L7K A; 
#chains in the Genus database with same CATH topology
 5ACF A;  3UAM A;  4OY6 A;  5E8F A;  5FJQ A;  5EMV A;  4JV8 B;  5ACJ A;  3JUA A;  3GQQ A;  1HH4 D;  5TB5 B;  1AJW A;  1FST A;  4OY8 A;  5EMW A;  5FOH A;  4ALE A;  1KSH B;  4GBO A;  2XWX A;  4ALQ A;  4ALT A;  5E80 A;  1RHO A;  1KSJ B;  4JV6 B;  4MAI A;  3EII A;  4GOJ C;  4ALC A;  2YET A;  4LN0 A;  4F38 B;  2JHT A;  5FTZ A;  4B5Q A;  4D7V A;  1DS6 B;  2JI0 A;  2JHX A;  5HGU A;  2VTC A;  3L15 A;  2YOX A;  4ALS A;  2LHS A;  5DQ8 A;  1KSG B;  5F2U A;  2YOW A;  5DQE A;  3KYS A;  4MAH A;  3RBQ A;  1KMT A;  2JHS A;  4EIR A;  4QI8 A;  4JVF B;  4D7U A;  5ACG A;  3T5I A;  4JVB B;  4RE1 A;  5HNP A;  4GOK C;  1FSO A;  2JHU A;  1DOA B;  4FMR A;  2R5O A;  2BEM A;  4JHP B;  5ACH A;  2JHV A;  5IJU A;  3ZUD A;  1QVY A;  2JHY A;  4A02 A;  1GDF A;  4OY7 A;  5TAR B;  5ACI A;  2BXW A;  2JHZ A;  4ALR A;  1FT0 A;  2BEN A;  2YOY A;  3T5G B;  1FT3 A;  4EIS A;  3EJA A;  2JHW A;  5HNO A;  5L7K A;  4EIS B;  5AA7 A; 
#chains in the Genus database with same CATH homology
 1KSJ B;  4JHP B;  4JV6 B;  5E8F A;  3RBQ A;  4JV8 B;  4GOJ C;  5TAR B;  3GQQ A;  5TB5 B;  4JVF B;  3T5G B;  3T5I A;  4JVB B;  1KSH B;  4GOK C;  1KSG B;  5F2U A;  5E80 A;  5L7K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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