5TB5B

Crystal structure of full-length farnesylated and methylated kras4b in complex with pde-delta (crystal form i - with partially disordered hypervariable region)
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
150
structure length
150
Chain Sequence
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta.
pubmed doi rcsb
molecule tags Oncoprotein
source organism Homo sapiens
molecule keywords GTPase KRas
total genus 45
structure length 150
sequence length 150
chains with identical sequence D
ec nomenclature
pdb deposition date 2016-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF05351 GMP_PDE_delta GMP-PDE, delta subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.50.40 Mainly Beta Distorted Sandwich Coagulation Factor XIII; Chain A, domain 1 GMP phosphodiesterase, delta subunit 5tb5B00
4JHPB 3T5IA 5E80A 4GOKC 4JV6B 1KSHB 5F2UA 4JVBB 3GQQA 1KSJB 4GOJC 5TARB 1KSGB 3RBQA 5L7KA 5TB5B 4JV8B 5E8FA 4JVFB 3T5GB
chains in the Genus database with same CATH superfamily
4JHPB 4GOKC 5F2UA 5HGUA 4GBOA 3GQQA 3KYSA 4LN0A 4ALRA 3JUAA 1KSJB 1RHOA 1QVYA 3EIIA 3RBQA 4RE1A 5ACFA 5TB5B 3L15A 1FSOA 4EISA 5ACJA 4D7UA 5ACGA 4JVFB 3T5IA 5FTZA 4JVBB 2JHUA 2JHYA 1FSTA 5TARB 5HNOA 2BENA 2JHVA 5HNPA 2XWXA 4D7VA 2JHTA 2JHXA 4OY8A 1DOAB 2R5OA 1DS6B 2JHWA 5ACIA 5EMWA 2YETA 5IJUA 4A02A 4B5QA 5DQ8A 1FT0A 4QI8A 3EJAA 4MAIA 3UAMA 4ALSA 1GDFA 1KSGB 4MAHA 4OY7A 5L7KA 4JV8B 5EMVA 4EISB 1FT3A 4FMRA 5DQEA 4ALQA 4F38B 3T5GB 4ALEA 5E80A 5ACHA 4JV6B 1KSHB 2YOWA 3ZUDA 2YOYA 4ALCA 1AJWA 2JHZA 2JHSA 2BEMA 5FOHA 4GOJC 5AA7A 2YOXA 4ALTA 4EIRA 1HH4D 2VTCA 5FJQA 4OY6A 2LHSA 2BXWA 1KMTA 2JI0A 5E8FA
chains in the Genus database with same CATH topology
4JHPB 3T5IA 5E80A 4GOKC 4JV6B 1KSHB 5F2UA 4JVBB 3GQQA 1KSJB 4GOJC 5TARB 1KSGB 3RBQA 5L7KA 5TB5B 4JV8B 5E8FA 4JVFB 3T5GB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JHP B;  3T5I A;  5E80 A;  4GOK C;  4JV6 B;  1KSH B;  5F2U A;  4JVB B;  3GQQ A;  1KSJ B;  4GOJ C;  5TAR B;  1KSG B;  3RBQ A;  5L7K A;  5TB5 B;  4JV8 B;  5E8F A;  4JVF B;  3T5G B; 
#chains in the Genus database with same CATH topology
 4JHP B;  4GOK C;  5F2U A;  5HGU A;  4GBO A;  3GQQ A;  3KYS A;  4LN0 A;  4ALR A;  3JUA A;  1KSJ B;  1RHO A;  1QVY A;  3EII A;  3RBQ A;  4RE1 A;  5ACF A;  5TB5 B;  3L15 A;  1FSO A;  4EIS A;  5ACJ A;  4D7U A;  5ACG A;  4JVF B;  3T5I A;  5FTZ A;  4JVB B;  2JHU A;  2JHY A;  1FST A;  5TAR B;  5HNO A;  2BEN A;  2JHV A;  5HNP A;  2XWX A;  4D7V A;  2JHT A;  2JHX A;  4OY8 A;  1DOA B;  2R5O A;  1DS6 B;  2JHW A;  5ACI A;  5EMW A;  2YET A;  5IJU A;  4A02 A;  4B5Q A;  5DQ8 A;  1FT0 A;  4QI8 A;  3EJA A;  4MAI A;  3UAM A;  4ALS A;  1GDF A;  1KSG B;  4MAH A;  4OY7 A;  5L7K A;  4JV8 B;  5EMV A;  4EIS B;  1FT3 A;  4FMR A;  5DQE A;  4ALQ A;  4F38 B;  3T5G B;  4ALE A;  5E80 A;  5ACH A;  4JV6 B;  1KSH B;  2YOW A;  3ZUD A;  2YOY A;  4ALC A;  1AJW A;  2JHZ A;  2JHS A;  2BEM A;  5FOH A;  4GOJ C;  5AA7 A;  2YOX A;  4ALT A;  4EIR A;  1HH4 D;  2VTC A;  5FJQ A;  4OY6 A;  2LHS A;  2BXW A;  1KMT A;  2JI0 A;  5E8F A; 
#chains in the Genus database with same CATH homology
 4JHP B;  3T5I A;  5E80 A;  4GOK C;  4JV6 B;  1KSH B;  5F2U A;  4JVB B;  3GQQ A;  1KSJ B;  4GOJ C;  5TAR B;  1KSG B;  3RBQ A;  5L7K A;  5TB5 B;  4JV8 B;  5E8F A;  4JVF B;  3T5G B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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