1CFAA

Solution structure of a semi-synthetic c5a receptor antagonist at ph 5.2, 303k, nmr, 20 structures
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
71
structure length
71
Chain Sequence
MLQKKIEEIAAKYKHSVVKKCCYDGASVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.
pubmed rcsb
molecule keywords COMPLEMENT 5A SEMI-SYNTHETIC ANTAGONIST
molecule tags Immune system/inhibitor
source organism Homo sapiens
total genus 14
structure length 71
sequence length 71
ec nomenclature
pdb deposition date 1996-09-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01821 ANATO Anaphylotoxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.91.20 Mainly Alpha Up-down Bundle Influenza Virus Matrix Protein; Chain A, domain 1 Anaphylotoxins (complement system) 1cfaA00
4HWJA 3KLSA 2A73B 2B39A 3CU7A 1C5AA 4P3BA 3HQBA 4FXKB 3HQAA 4P3AA 4WB2A 4UU9C 4HW5A 4WB3A 4I6OA 1CFAA 5JPNB 4P39A 1KJSA 5B4PB
chains in the Genus database with same CATH superfamily
4IQ4A 4HWJA 3KLSA 2B39A 2A73B 3CU7A 4FXGB 1C5AA 4P3BA 2Z16A 3HQBA 1EA3A 4FXKB 3HQAA 4P3AA 4WB2A 5JPMB 4UU9C 1AA7A 4HW5A 4WB3A 4I6OA 1CFAA 5JPNB 4PUSA 4P39A 3MD2A 5CQEA 3VDXA 1KJSA 4ITVA 5B4PB 4D9JA
chains in the Genus database with same CATH topology
4HWJA 3KLSA 2A73B 2B39A 3CU7A 1C5AA 4P3BA 3HQBA 4FXKB 3HQAA 4P3AA 4WB2A 4UU9C 4HW5A 4WB3A 4I6OA 1CFAA 5JPNB 4P39A 1KJSA 5B4PB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HWJ A;  3KLS A;  2A73 B;  2B39 A;  3CU7 A;  1C5A A;  4P3B A;  3HQB A;  4FXK B;  3HQA A;  4P3A A;  4WB2 A;  4UU9 C;  4HW5 A;  4WB3 A;  4I6O A;  1CFA A;  5JPN B;  4P39 A;  1KJS A;  5B4P B; 
#chains in the Genus database with same CATH topology
 4IQ4 A;  4HWJ A;  3KLS A;  2B39 A;  2A73 B;  3CU7 A;  4FXG B;  1C5A A;  4P3B A;  2Z16 A;  3HQB A;  1EA3 A;  4FXK B;  3HQA A;  4P3A A;  4WB2 A;  5JPM B;  4UU9 C;  1AA7 A;  4HW5 A;  4WB3 A;  4I6O A;  1CFA A;  5JPN B;  4PUS A;  4P39 A;  3MD2 A;  5CQE A;  3VDX A;  1KJS A;  4ITV A;  5B4P B;  4D9J A; 
#chains in the Genus database with same CATH homology
 4HWJ A;  3KLS A;  2A73 B;  2B39 A;  3CU7 A;  1C5A A;  4P3B A;  3HQB A;  4FXK B;  3HQA A;  4P3A A;  4WB2 A;  4UU9 C;  4HW5 A;  4WB3 A;  4I6O A;  1CFA A;  5JPN B;  4P39 A;  1KJS A;  5B4P B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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