1CFAA

Solution structure of a semi-synthetic c5a receptor antagonist at ph 5.2, 303k, nmr, 20 structures
Total Genus 14
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
71
structure length
71
Chain Sequence
MLQKKIEEIAAKYKHSVVKKCCYDGASVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.
pubmed rcsb
molecule tags Immune system/inhibitor
source organism Homo sapiens
molecule keywords COMPLEMENT 5A SEMI-SYNTHETIC ANTAGONIST
total genus 14
structure length 71
sequence length 71
ec nomenclature
pdb deposition date 1996-09-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01821 ANATO Anaphylotoxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.91.20 Mainly Alpha Up-down Bundle Influenza Virus Matrix Protein; Chain A, domain 1 Anaphylotoxins (complement system) 1cfaA00
3HQAA 2B39A 4WB3A 5JPNB 4HWJA 5B4PB 3KLSA 3CU7A 4HW5A 3HQBA 4FXKB 4UU9C 1CFAA 2A73B 1KJSA 4P3BA 4I6OA 4P3AA 1C5AA 4P39A 4WB2A
chains in the Genus database with same CATH superfamily
3HQAA 2B39A 5CQEA 4ITVA 5JPNB 4WB3A 1EA3A 4HWJA 4FXGB 3KLSA 3CU7A 4HW5A 5B4PB 4D9JA 3HQBA 4FXKB 4IQ4A 4UU9C 1CFAA 2A73B 3VDXA 5JPMB 1KJSA 4P3BA 4PUSA 1AA7A 4I6OA 4P3AA 2Z16A 1C5AA 3MD2A 4P39A 4WB2A
chains in the Genus database with same CATH topology
3HQAA 2B39A 4WB3A 5JPNB 4HWJA 5B4PB 3KLSA 3CU7A 4HW5A 3HQBA 4FXKB 4UU9C 1CFAA 2A73B 1KJSA 4P3BA 4I6OA 4P3AA 1C5AA 4P39A 4WB2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HQA A;  2B39 A;  4WB3 A;  5JPN B;  4HWJ A;  5B4P B;  3KLS A;  3CU7 A;  4HW5 A;  3HQB A;  4FXK B;  4UU9 C;  1CFA A;  2A73 B;  1KJS A;  4P3B A;  4I6O A;  4P3A A;  1C5A A;  4P39 A;  4WB2 A; 
#chains in the Genus database with same CATH topology
 3HQA A;  2B39 A;  5CQE A;  4ITV A;  5JPN B;  4WB3 A;  1EA3 A;  4HWJ A;  4FXG B;  3KLS A;  3CU7 A;  4HW5 A;  5B4P B;  4D9J A;  3HQB A;  4FXK B;  4IQ4 A;  4UU9 C;  1CFA A;  2A73 B;  3VDX A;  5JPM B;  1KJS A;  4P3B A;  4PUS A;  1AA7 A;  4I6O A;  4P3A A;  2Z16 A;  1C5A A;  3MD2 A;  4P39 A;  4WB2 A; 
#chains in the Genus database with same CATH homology
 3HQA A;  2B39 A;  4WB3 A;  5JPN B;  4HWJ A;  5B4P B;  3KLS A;  3CU7 A;  4HW5 A;  3HQB A;  4FXK B;  4UU9 C;  1CFA A;  2A73 B;  1KJS A;  4P3B A;  4I6O A;  4P3A A;  1C5A A;  4P39 A;  4WB2 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...