1CSIA

A very short hydrogen bond provides only moderate stabilization of an enzyme: inhibitor complex of citrate synthase
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
sequence length
435
structure length
435
Chain Sequence
STNLKDVLASLIPKEQARIKTFRQQHGNTAVGQITVDMSYGGMRGMKGLIYETSVLDPDEGIRFRGFSIPECQKLLPKAGGGEEPLPEGLFWLLVTGQIPTPEQVSWVSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSESNFARAYAEGINRTKYWEFVYEDAMDLIAKLPCVAAKIYRNLYRAGSSIGAIDSKLDWSHNFTNMLGYTDPQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLLWLSQLQKDLGADASDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPSDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTAGLEKLSAGG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A very short hydrogen bond provides only moderate stabilization of an enzyme-inhibitor complex of citrate synthase.
pubmed doi rcsb
molecule tags Lyase(oxo-acid)
source organism Gallus gallus
molecule keywords CITRATE SYNTHASE
total genus 161
structure length 435
sequence length 435
ec nomenclature ec 2.3.3.1: Citrate (Si)-synthase.
pdb deposition date 1994-03-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00285 Citrate_synt Citrate synthase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.230.10 Mainly Alpha Orthogonal Bundle Cytochrome p450-Terp; domain 2 Cytochrome P450-Terp, domain 2 1csiA02
1.10.580.10 Mainly Alpha Orthogonal Bundle Citrate Synthase; domain 1 Citrate Synthase, domain 1 1csiA01
4E6YA 1CTSA 1CSCA 3TQGA 1CSSA 3HWKA 1CSRA 1NXGA 2P2WA 6CTSA 4JAEA 2H12A 3ENJA 6CSCA 1NXEA 1VGPA 1IOMA 4CTSA 3MSUA 4CSCA 2CSCA 4JADA 1CSIA 1VGMA 1CSHA 1OWCA 5CTSA 1OWBA 1IXEA 4TVMA 4XGHA 2IBPA 3CSCA 2R26A 1AMZA 5CSCA 3O8JA 2CTSA 2IFCA 2R9EA 4YBOA 1AL6A 5CSCB 4G6BA 1A59A 1AJ8A 1O7XA 2C6XA 4JAGA 4JAFA
chains in the Genus database with same CATH superfamily
4E6YA 1CTSA 1CSCA 3TQGA 1CSSA 3HWKA 1CSRA 1NXGA 2P2WA 6CTSA 4JAEA 2H12A 3ENJA 6CSCA 1NXEA 1VGPA 1IOMA 4CTSA 3MSUA 4CSCA 2CSCA 4JADA 1CSIA 1VGMA 1CSHA 1OWCA 5CTSA 1OWBA 1IXEA 4TVMA 4XGHA 2IBPA 3CSCA 2R26A 1AMZA 5CSCA 3O8JA 2CTSA 2IFCA 2R9EA 4YBOA 1AL6A 5CSCB 4G6BA 1A59A 1AJ8A 1O7XA 2C6XA 4JAGA 4JAFA
chains in the Genus database with same CATH topology
4E6YA 1CTSA 1CSCA 3TQGA 1CSSA 3HWKA 1CSRA 1NXGA 2P2WA 6CTSA 4JAEA 2H12A 3ENJA 6CSCA 1NXEA 1VGPA 1IOMA 4CTSA 3MSUA 4CSCA 2CSCA 4JADA 1CSIA 1VGMA 1CSHA 1OWCA 5CTSA 1OWBA 1IXEA 4TVMA 4XGHA 2IBPA 3CSCA 2R26A 1AMZA 5CSCA 3O8JA 2CTSA 2IFCA 2R9EA 4YBOA 1AL6A 5CSCB 4G6BA 1A59A 1AJ8A 1O7XA 2C6XA 4JAGA 4JAFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4E6Y A;  1CTS A;  1CSC A;  3TQG A;  1CSS A;  3HWK A;  1CSR A;  1NXG A;  2P2W A;  6CTS A;  4JAE A;  2H12 A;  3ENJ A;  6CSC A;  1NXE A;  1VGP A;  1IOM A;  4CTS A;  3MSU A;  4CSC A;  2CSC A;  4JAD A;  1CSI A;  1VGM A;  1CSH A;  1OWC A;  5CTS A;  1OWB A;  1IXE A;  4TVM A;  4XGH A;  2IBP A;  3CSC A;  2R26 A;  1AMZ A;  5CSC A;  3O8J A;  2CTS A;  2IFC A;  2R9E A;  4YBO A;  1AL6 A;  5CSC B;  4G6B A;  1A59 A;  1AJ8 A;  1O7X A;  2C6X A;  4JAG A;  4JAF A; 
#chains in the Genus database with same CATH topology
 4E6Y A;  1CTS A;  1CSC A;  3TQG A;  1CSS A;  3HWK A;  1CSR A;  1NXG A;  2P2W A;  6CTS A;  4JAE A;  2H12 A;  3ENJ A;  6CSC A;  1NXE A;  1VGP A;  1IOM A;  4CTS A;  3MSU A;  4CSC A;  2CSC A;  4JAD A;  1CSI A;  1VGM A;  1CSH A;  1OWC A;  5CTS A;  1OWB A;  1IXE A;  4TVM A;  4XGH A;  2IBP A;  3CSC A;  2R26 A;  1AMZ A;  5CSC A;  3O8J A;  2CTS A;  2IFC A;  2R9E A;  4YBO A;  1AL6 A;  5CSC B;  4G6B A;  1A59 A;  1AJ8 A;  1O7X A;  2C6X A;  4JAG A;  4JAF A; 
#chains in the Genus database with same CATH homology
 4E6Y A;  1CTS A;  1CSC A;  3TQG A;  1CSS A;  3HWK A;  1CSR A;  1NXG A;  2P2W A;  6CTS A;  4JAE A;  2H12 A;  3ENJ A;  6CSC A;  1NXE A;  1VGP A;  1IOM A;  4CTS A;  3MSU A;  4CSC A;  2CSC A;  4JAD A;  1CSI A;  1VGM A;  1CSH A;  1OWC A;  5CTS A;  1OWB A;  1IXE A;  4TVM A;  4XGH A;  2IBP A;  3CSC A;  2R26 A;  1AMZ A;  5CSC A;  3O8J A;  2CTS A;  2IFC A;  2R9E A;  4YBO A;  1AL6 A;  5CSC B;  4G6B A;  1A59 A;  1AJ8 A;  1O7X A;  2C6X A;  4JAG A;  4JAF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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