2AHKA

Crystal structure of the met-form of the copper-bound streptomyces castaneoglobisporus tyrosinase in complex with a caddie protein obtained by soking in cupric sulfate for 6 months
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
273
structure length
273
Chain Sequence
TVRKNQATLTADEKRRFVAAVLELKRSGRYDEFVRTHNEFIMSDTDSGERTGHRSPSFLPWHRRFLLDFEQALQSVDSSVTLPYWDWSADRTVRASLWAPDFLGGTGRSTDGRVMDGPFAASTGNWPINVRVDSRTYLRRSLGGSVAELPTRAEVESVLAISAYDLPPYNSASEGFRNHLEGWRGVNLHNRVHVWVGGQMATGVSPNDPVFWLHHAYVDKLWAEWQRRHPDSAYVPTGGTPDVVDLNETMKPWNTVRPADLLDHTAYYTFDAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic Evidence That the Dinuclear Copper Center of Tyrosinase Is Flexible during Catalysis
pubmed doi rcsb
molecule tags Oxidoreductase/metal transport
source organism Streptomyces castaneoglobisporus
molecule keywords TYROSINASE
total genus 104
structure length 273
sequence length 273
ec nomenclature ec 1.14.18.1: Tyrosinase.
pdb deposition date 2005-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00264 Tyrosinase Common central domain of tyrosinase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1280.10 Mainly Alpha Orthogonal Bundle di-copper center containing domain from catechol oxidase Di-copper center containing domain from catechol oxidase 2ahkA00
3W6WA 2AHKA 2ZWGA 5I3AA 1BUGA 2Y9WA 3GWJA 3NM8A 2P3XA 4Z10A 4HD4A 4P6SA 3AX0A 4J6UA 3AWTA 2ZMYA 2ZMXA 4J3PA 1WX2A 1LLAA 4J3RA 1BT3A 4OUAA 3AWYA 3QJOA 1OXYA 2ZWFA 3HHSA 4HD7A 3WJMA 1WX5A 3AWSA 4OUAB 3AWWA 4L37A 3HHSB 3WJMB 1NOLA 1BT1A 4Z0ZA 3NTMA 4L37B 1WX4A 3NQ5A 2Y9XA 2AHLA 1WXCA 3NQ1A 5I38A 3W6QA 2ZWEA 4J3QA 5CE9A 2ZMZA 3AWXA 4D87A 4P6RA 3AWZA 4J6TA 4YZWA 2ZWDA 1LNLA 3AWVA 4HD6A 4J6VA 5I3BA 3NQ0A 3WKYA 1JS8A 1LL1A 4Z0YA 1HCYA 3AWUA 4P6TA 1HC1A 3NPYA 1BT2A
chains in the Genus database with same CATH superfamily
3W6WA 2AHKA 2ZWGA 5I3AA 1BUGA 2Y9WA 3GWJA 3NM8A 2P3XA 4Z10A 4HD4A 4P6SA 3AX0A 4J6UA 3AWTA 2ZMYA 2ZMXA 4J3PA 1WX2A 1LLAA 4J3RA 1BT3A 4OUAA 3AWYA 3QJOA 1OXYA 2ZWFA 3HHSA 4HD7A 3WJMA 1WX5A 3AWSA 4OUAB 3AWWA 4L37A 3HHSB 3WJMB 1NOLA 1BT1A 4Z0ZA 3NTMA 4L37B 1WX4A 3NQ5A 2Y9XA 2AHLA 1WXCA 3NQ1A 5I38A 3W6QA 2ZWEA 4J3QA 5CE9A 2ZMZA 3AWXA 4D87A 4P6RA 3AWZA 4J6TA 4YZWA 2ZWDA 1LNLA 3AWVA 4HD6A 4J6VA 5I3BA 3NQ0A 3WKYA 1JS8A 1LL1A 4Z0YA 1HCYA 3AWUA 4P6TA 1HC1A 3NPYA 1BT2A
chains in the Genus database with same CATH topology
3W6WA 2AHKA 2ZWGA 5I3AA 1BUGA 2Y9WA 3GWJA 3NM8A 2P3XA 4Z10A 4HD4A 4P6SA 3AX0A 4J6UA 3AWTA 2ZMYA 2ZMXA 4J3PA 1WX2A 1LLAA 4J3RA 1BT3A 4OUAA 3AWYA 3QJOA 1OXYA 2ZWFA 3HHSA 4HD7A 3WJMA 1WX5A 3AWSA 4OUAB 3AWWA 4L37A 3HHSB 3WJMB 1NOLA 1BT1A 4Z0ZA 3NTMA 4L37B 1WX4A 3NQ5A 2Y9XA 2AHLA 1WXCA 3NQ1A 5I38A 3W6QA 2ZWEA 4J3QA 5CE9A 2ZMZA 3AWXA 4D87A 4P6RA 3AWZA 4J6TA 4YZWA 2ZWDA 1LNLA 3AWVA 4HD6A 4J6VA 5I3BA 3NQ0A 3WKYA 1JS8A 1LL1A 4Z0YA 1HCYA 3AWUA 4P6TA 1HC1A 3NPYA 1BT2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3W6W A;  2AHK A;  2ZWG A;  5I3A A;  1BUG A;  2Y9W A;  3GWJ A;  3NM8 A;  2P3X A;  4Z10 A;  4HD4 A;  4P6S A;  3AX0 A;  4J6U A;  3AWT A;  2ZMY A;  2ZMX A;  4J3P A;  1WX2 A;  1LLA A;  4J3R A;  1BT3 A;  4OUA A;  3AWY A;  3QJO A;  1OXY A;  2ZWF A;  3HHS A;  4HD7 A;  3WJM A;  1WX5 A;  3AWS A;  4OUA B;  3AWW A;  4L37 A;  3HHS B;  3WJM B;  1NOL A;  1BT1 A;  4Z0Z A;  3NTM A;  4L37 B;  1WX4 A;  3NQ5 A;  2Y9X A;  2AHL A;  1WXC A;  3NQ1 A;  5I38 A;  3W6Q A;  2ZWE A;  4J3Q A;  5CE9 A;  2ZMZ A;  3AWX A;  4D87 A;  4P6R A;  3AWZ A;  4J6T A;  4YZW A;  2ZWD A;  1LNL A;  3AWV A;  4HD6 A;  4J6V A;  5I3B A;  3NQ0 A;  3WKY A;  1JS8 A;  1LL1 A;  4Z0Y A;  1HCY A;  3AWU A;  4P6T A;  1HC1 A;  3NPY A;  1BT2 A; 
#chains in the Genus database with same CATH topology
 3W6W A;  2AHK A;  2ZWG A;  5I3A A;  1BUG A;  2Y9W A;  3GWJ A;  3NM8 A;  2P3X A;  4Z10 A;  4HD4 A;  4P6S A;  3AX0 A;  4J6U A;  3AWT A;  2ZMY A;  2ZMX A;  4J3P A;  1WX2 A;  1LLA A;  4J3R A;  1BT3 A;  4OUA A;  3AWY A;  3QJO A;  1OXY A;  2ZWF A;  3HHS A;  4HD7 A;  3WJM A;  1WX5 A;  3AWS A;  4OUA B;  3AWW A;  4L37 A;  3HHS B;  3WJM B;  1NOL A;  1BT1 A;  4Z0Z A;  3NTM A;  4L37 B;  1WX4 A;  3NQ5 A;  2Y9X A;  2AHL A;  1WXC A;  3NQ1 A;  5I38 A;  3W6Q A;  2ZWE A;  4J3Q A;  5CE9 A;  2ZMZ A;  3AWX A;  4D87 A;  4P6R A;  3AWZ A;  4J6T A;  4YZW A;  2ZWD A;  1LNL A;  3AWV A;  4HD6 A;  4J6V A;  5I3B A;  3NQ0 A;  3WKY A;  1JS8 A;  1LL1 A;  4Z0Y A;  1HCY A;  3AWU A;  4P6T A;  1HC1 A;  3NPY A;  1BT2 A; 
#chains in the Genus database with same CATH homology
 3W6W A;  2AHK A;  2ZWG A;  5I3A A;  1BUG A;  2Y9W A;  3GWJ A;  3NM8 A;  2P3X A;  4Z10 A;  4HD4 A;  4P6S A;  3AX0 A;  4J6U A;  3AWT A;  2ZMY A;  2ZMX A;  4J3P A;  1WX2 A;  1LLA A;  4J3R A;  1BT3 A;  4OUA A;  3AWY A;  3QJO A;  1OXY A;  2ZWF A;  3HHS A;  4HD7 A;  3WJM A;  1WX5 A;  3AWS A;  4OUA B;  3AWW A;  4L37 A;  3HHS B;  3WJM B;  1NOL A;  1BT1 A;  4Z0Z A;  3NTM A;  4L37 B;  1WX4 A;  3NQ5 A;  2Y9X A;  2AHL A;  1WXC A;  3NQ1 A;  5I38 A;  3W6Q A;  2ZWE A;  4J3Q A;  5CE9 A;  2ZMZ A;  3AWX A;  4D87 A;  4P6R A;  3AWZ A;  4J6T A;  4YZW A;  2ZWD A;  1LNL A;  3AWV A;  4HD6 A;  4J6V A;  5I3B A;  3NQ0 A;  3WKY A;  1JS8 A;  1LL1 A;  4Z0Y A;  1HCY A;  3AWU A;  4P6T A;  1HC1 A;  3NPY A;  1BT2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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