2FXLA

Urate oxidase from aspergillus flavus complexed with allantoin
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
294
structure length
294
Chain Sequence
AVKAARYGKDNVRVYKVHKDEKTGVQTVYEMTVCVLLEGEIETSYTKADNSVIVATDSIKNTIYITAKQNPVTPPELFGSILGTHFIEKYNHIHAAHVNIVCHRWTRMDIDGKPHPHSFIRDSEEKRNVQVDVVEGKGIDIKSSLSGLTVLKSTNSQFWGFLRDEYTTLKETWDRILSTDVDATWQWKNFSGLQEVRSHVPKFDATWATAREVTLKTFAEDNSASVQATMYKMAEQILARQQLIETVEYSLPNKHYFEIDLSWHKGLQNTGKNAEVFAPQSDPNGLIKCTVGRS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Uricase
publication title Recapture of [S]-allantoin, the product of the two-step degradation of uric acid, by urate oxidase.
pubmed doi rcsb
source organism Aspergillus flavus
total genus 80
structure length 294
sequence length 294
ec nomenclature ec 1.7.3.3: Factor independent urate hydroxylase.
pdb deposition date 2006-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01014 Uricase Uricase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.270.10 Alpha Beta Roll Urate Oxidase Urate Oxidase; 2fxlA00
4CW2A 5LL1A 4D12A 2YZCA 4R8XA 3PK3A 3PK6A 3PKUA 4CW3A 3PKSA 2YZEA 1R51A 4D17A 2R5RA 3BK8A 5M98A 3PLJA 3PLEA 2IC0A 3P9OA 1R4SA 4N9MA 3PLHA 4PR8A 4N9VA 2PESA 3CKUA 1VAXA 3PKTA 4OP9A 2FUBA 4FSKA 1VAYA 3CKSA 2IBAA 4R99A 5AYJA 4N9SA 4POEA 4D19A 3PK4A 2ZKAA 4XFPA 1R56A 3P9FA 3PKLA 3PK8A 3GKOA 3LBGA 4OQCA 2FXLA 2ZKBA 3PJKA 3PKHA 4CW6A 4N3MA 1WRRA 3L9GA 1XT4A 1WS2A 3PKFA 4CW0A 3WLVA 1J2GA 3PLIA 2YZBA 3PKGA 4MB8A 3PLMA 3OBPA 2YZDA 5K9GA 1R4UA 3PK5A 5K95A 3F2MA 1WS3A 3PLGA 4PUVA 3L8WA 3PKKA 5FRCA 1XY3A 3BJPA 3LD4A 1XXJA 4D13A 3D2OA 4OP6A 2ICQA
chains in the Genus database with same CATH superfamily
4CW2A 5LL1A 4D12A 2YZCA 4R8XA 3PK3A 3PK6A 3PKUA 4CW3A 3PKSA 2YZEA 1R51A 4D17A 2R5RA 3BK8A 5M98A 3PLJA 3PLEA 2IC0A 3P9OA 1R4SA 4N9MA 3PLHA 4PR8A 4N9VA 2PESA 3CKUA 1VAXA 3PKTA 4OP9A 2FUBA 4FSKA 1VAYA 3CKSA 2IBAA 4R99A 5AYJA 4N9SA 4POEA 4D19A 3PK4A 2ZKAA 4XFPA 1R56A 3P9FA 3PKLA 3PK8A 3GKOA 3LBGA 4OQCA 2FXLA 2ZKBA 3PJKA 3PKHA 4CW6A 4N3MA 1WRRA 3L9GA 1XT4A 1WS2A 3PKFA 4CW0A 3WLVA 1J2GA 3PLIA 2YZBA 3PKGA 4MB8A 3PLMA 3OBPA 2YZDA 5K9GA 1R4UA 3PK5A 5K95A 3F2MA 1WS3A 3PLGA 4PUVA 3L8WA 3PKKA 5FRCA 1XY3A 3BJPA 3LD4A 1XXJA 4D13A 3D2OA 4OP6A 2ICQA
chains in the Genus database with same CATH topology
4CW2A 5LL1A 4D12A 2YZCA 4R8XA 3PK3A 3PK6A 3PKUA 4CW3A 3PKSA 2YZEA 1R51A 4D17A 2R5RA 3BK8A 5M98A 3PLJA 3PLEA 2IC0A 3P9OA 1R4SA 4N9MA 3PLHA 4PR8A 4N9VA 2PESA 3CKUA 1VAXA 3PKTA 4OP9A 2FUBA 4FSKA 1VAYA 3CKSA 2IBAA 4R99A 5AYJA 4N9SA 4POEA 4D19A 3PK4A 2ZKAA 4XFPA 1R56A 3P9FA 3PKLA 3PK8A 3GKOA 3LBGA 4OQCA 2FXLA 2ZKBA 3PJKA 3PKHA 4CW6A 4N3MA 1WRRA 3L9GA 1XT4A 1WS2A 3PKFA 4CW0A 3WLVA 1J2GA 3PLIA 2YZBA 3PKGA 4MB8A 3PLMA 3OBPA 2YZDA 5K9GA 1R4UA 3PK5A 5K95A 3F2MA 1WS3A 3PLGA 4PUVA 3L8WA 3PKKA 5FRCA 1XY3A 3BJPA 3LD4A 1XXJA 4D13A 3D2OA 4OP6A 2ICQA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4CW2 A;  5LL1 A;  4D12 A;  2YZC A;  4R8X A;  3PK3 A;  3PK6 A;  3PKU A;  4CW3 A;  3PKS A;  2YZE A;  1R51 A;  4D17 A;  2R5R A;  3BK8 A;  5M98 A;  3PLJ A;  3PLE A;  2IC0 A;  3P9O A;  1R4S A;  4N9M A;  3PLH A;  4PR8 A;  4N9V A;  2PES A;  3CKU A;  1VAX A;  3PKT A;  4OP9 A;  2FUB A;  4FSK A;  1VAY A;  3CKS A;  2IBA A;  4R99 A;  5AYJ A;  4N9S A;  4POE A;  4D19 A;  3PK4 A;  2ZKA A;  4XFP A;  1R56 A;  3P9F A;  3PKL A;  3PK8 A;  3GKO A;  3LBG A;  4OQC A;  2FXL A;  2ZKB A;  3PJK A;  3PKH A;  4CW6 A;  4N3M A;  1WRR A;  3L9G A;  1XT4 A;  1WS2 A;  3PKF A;  4CW0 A;  3WLV A;  1J2G A;  3PLI A;  2YZB A;  3PKG A;  4MB8 A;  3PLM A;  3OBP A;  2YZD A;  5K9G A;  1R4U A;  3PK5 A;  5K95 A;  3F2M A;  1WS3 A;  3PLG A;  4PUV A;  3L8W A;  3PKK A;  5FRC A;  1XY3 A;  3BJP A;  3LD4 A;  1XXJ A;  4D13 A;  3D2O A;  4OP6 A;  2ICQ A; 
#chains in the Genus database with same CATH topology
 4CW2 A;  5LL1 A;  4D12 A;  2YZC A;  4R8X A;  3PK3 A;  3PK6 A;  3PKU A;  4CW3 A;  3PKS A;  2YZE A;  1R51 A;  4D17 A;  2R5R A;  3BK8 A;  5M98 A;  3PLJ A;  3PLE A;  2IC0 A;  3P9O A;  1R4S A;  4N9M A;  3PLH A;  4PR8 A;  4N9V A;  2PES A;  3CKU A;  1VAX A;  3PKT A;  4OP9 A;  2FUB A;  4FSK A;  1VAY A;  3CKS A;  2IBA A;  4R99 A;  5AYJ A;  4N9S A;  4POE A;  4D19 A;  3PK4 A;  2ZKA A;  4XFP A;  1R56 A;  3P9F A;  3PKL A;  3PK8 A;  3GKO A;  3LBG A;  4OQC A;  2FXL A;  2ZKB A;  3PJK A;  3PKH A;  4CW6 A;  4N3M A;  1WRR A;  3L9G A;  1XT4 A;  1WS2 A;  3PKF A;  4CW0 A;  3WLV A;  1J2G A;  3PLI A;  2YZB A;  3PKG A;  4MB8 A;  3PLM A;  3OBP A;  2YZD A;  5K9G A;  1R4U A;  3PK5 A;  5K95 A;  3F2M A;  1WS3 A;  3PLG A;  4PUV A;  3L8W A;  3PKK A;  5FRC A;  1XY3 A;  3BJP A;  3LD4 A;  1XXJ A;  4D13 A;  3D2O A;  4OP6 A;  2ICQ A; 
#chains in the Genus database with same CATH homology
 4CW2 A;  5LL1 A;  4D12 A;  2YZC A;  4R8X A;  3PK3 A;  3PK6 A;  3PKU A;  4CW3 A;  3PKS A;  2YZE A;  1R51 A;  4D17 A;  2R5R A;  3BK8 A;  5M98 A;  3PLJ A;  3PLE A;  2IC0 A;  3P9O A;  1R4S A;  4N9M A;  3PLH A;  4PR8 A;  4N9V A;  2PES A;  3CKU A;  1VAX A;  3PKT A;  4OP9 A;  2FUB A;  4FSK A;  1VAY A;  3CKS A;  2IBA A;  4R99 A;  5AYJ A;  4N9S A;  4POE A;  4D19 A;  3PK4 A;  2ZKA A;  4XFP A;  1R56 A;  3P9F A;  3PKL A;  3PK8 A;  3GKO A;  3LBG A;  4OQC A;  2FXL A;  2ZKB A;  3PJK A;  3PKH A;  4CW6 A;  4N3M A;  1WRR A;  3L9G A;  1XT4 A;  1WS2 A;  3PKF A;  4CW0 A;  3WLV A;  1J2G A;  3PLI A;  2YZB A;  3PKG A;  4MB8 A;  3PLM A;  3OBP A;  2YZD A;  5K9G A;  1R4U A;  3PK5 A;  5K95 A;  3F2M A;  1WS3 A;  3PLG A;  4PUV A;  3L8W A;  3PKK A;  5FRC A;  1XY3 A;  3BJP A;  3LD4 A;  1XXJ A;  4D13 A;  3D2O A;  4OP6 A;  2ICQ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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