4N9VA

High resolution x-ray structure of urate oxidase in complex with 8-azaxanthine
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
295
structure length
295
Chain Sequence
SAVKAARYGKDNVRVYKVHKDEKTGVQTVYEMTVCVLLEGEIETSYTKADNSVIVATDSIKNTIYITAKQNPVTPPELFGSILGTHFIEKYNHIHAAHVNIVCHRWTRMDIDGKPHPHSFIRDSEEKRNVQVDVVEGKGIDIKSSLSGLTVLKSTNSQFWGFLRDEYTTLKETWDRILSTDVDATWQWKNFSGLQEVRSHVPKFDATWATAREVTLKTFAEDNSASVQATMYKMAEQILARQQLIETVEYSLPNKHYFEIDLSWHKGLQNTGKNAEVFAPQSDPNGLIKCTVGRS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Uricase
publication title The neutron structure of urate oxidase resolves a long-standing mechanistic conundrum and reveals unexpected changes in protonation.
pubmed doi rcsb
source organism Aspergillus flavus
total genus 83
structure length 295
sequence length 295
ec nomenclature ec 1.7.3.3: Factor independent urate hydroxylase.
pdb deposition date 2013-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01014 Uricase Uricase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.270.10 Alpha Beta Roll Urate Oxidase Urate Oxidase; 4n9vA00
3PLJA 4FSKA 1XY3A 3PLIA 3P9OA 2IBAA 4R99A 5FRCA 3PK5A 5AYJA 4D13A 1VAXA 4N9MA 1WRRA 1J2GA 3PKHA 2ICQA 3CKSA 2IC0A 3PKGA 3LBGA 3PLEA 3PKKA 4CW2A 3PKUA 1R4UA 2YZCA 3D2OA 2ZKAA 3PK8A 3WLVA 4CW0A 1R56A 3PK3A 4D12A 3OBPA 3PLMA 2PESA 4OP6A 2R5RA 2YZDA 3LD4A 3BK8A 1WS3A 3L8WA 4OQCA 2FUBA 1R4SA 2YZBA 4OP9A 3F2MA 4POEA 4N3MA 1VAYA 3PKSA 4XFPA 5K95A 2YZEA 2FXLA 4PR8A 4CW3A 3PKLA 3P9FA 3CKUA 3PJKA 2ZKBA 1XXJA 4CW6A 3PLHA 4R8XA 4D17A 4PUVA 3PLGA 3PK4A 3PKFA 3PKTA 4N9SA 3BJPA 5K9GA 1WS2A 1R51A 3PK6A 4MB8A 5M98A 3L9GA 4D19A 5LL1A 3GKOA 1XT4A 4N9VA
chains in the Genus database with same CATH superfamily
3PLJA 4FSKA 1XY3A 3PLIA 3P9OA 2IBAA 4R99A 5FRCA 3PK5A 5AYJA 4D13A 1VAXA 4N9MA 1WRRA 1J2GA 3PKHA 2ICQA 3CKSA 2IC0A 3PKGA 3LBGA 3PLEA 3PKKA 4CW2A 3PKUA 1R4UA 2YZCA 3D2OA 2ZKAA 3PK8A 3WLVA 4CW0A 1R56A 3PK3A 4D12A 3OBPA 3PLMA 2PESA 4OP6A 2R5RA 2YZDA 3LD4A 3BK8A 1WS3A 3L8WA 4OQCA 2FUBA 1R4SA 2YZBA 4OP9A 3F2MA 4POEA 4N3MA 1VAYA 3PKSA 4XFPA 5K95A 2YZEA 2FXLA 4PR8A 4CW3A 3PKLA 3P9FA 3CKUA 3PJKA 2ZKBA 1XXJA 4CW6A 3PLHA 4R8XA 4D17A 4PUVA 3PLGA 3PK4A 3PKFA 3PKTA 4N9SA 3BJPA 5K9GA 1WS2A 1R51A 3PK6A 4MB8A 5M98A 3L9GA 4D19A 5LL1A 3GKOA 1XT4A 4N9VA
chains in the Genus database with same CATH topology
3PLJA 4FSKA 1XY3A 3PLIA 3P9OA 2IBAA 4R99A 5FRCA 3PK5A 5AYJA 4D13A 1VAXA 4N9MA 1WRRA 1J2GA 3PKHA 2ICQA 3CKSA 2IC0A 3PKGA 3LBGA 3PLEA 3PKKA 4CW2A 3PKUA 1R4UA 2YZCA 3D2OA 2ZKAA 3PK8A 3WLVA 4CW0A 1R56A 3PK3A 4D12A 3OBPA 3PLMA 2PESA 4OP6A 2R5RA 2YZDA 3LD4A 3BK8A 1WS3A 3L8WA 4OQCA 2FUBA 1R4SA 2YZBA 4OP9A 3F2MA 4POEA 4N3MA 1VAYA 3PKSA 4XFPA 5K95A 2YZEA 2FXLA 4PR8A 4CW3A 3PKLA 3P9FA 3CKUA 3PJKA 2ZKBA 1XXJA 4CW6A 3PLHA 4R8XA 4D17A 4PUVA 3PLGA 3PK4A 3PKFA 3PKTA 4N9SA 3BJPA 5K9GA 1WS2A 1R51A 3PK6A 4MB8A 5M98A 3L9GA 4D19A 5LL1A 3GKOA 1XT4A 4N9VA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3PLJ A;  4FSK A;  1XY3 A;  3PLI A;  3P9O A;  2IBA A;  4R99 A;  5FRC A;  3PK5 A;  5AYJ A;  4D13 A;  1VAX A;  4N9M A;  1WRR A;  1J2G A;  3PKH A;  2ICQ A;  3CKS A;  2IC0 A;  3PKG A;  3LBG A;  3PLE A;  3PKK A;  4CW2 A;  3PKU A;  1R4U A;  2YZC A;  3D2O A;  2ZKA A;  3PK8 A;  3WLV A;  4CW0 A;  1R56 A;  3PK3 A;  4D12 A;  3OBP A;  3PLM A;  2PES A;  4OP6 A;  2R5R A;  2YZD A;  3LD4 A;  3BK8 A;  1WS3 A;  3L8W A;  4OQC A;  2FUB A;  1R4S A;  2YZB A;  4OP9 A;  3F2M A;  4POE A;  4N3M A;  1VAY A;  3PKS A;  4XFP A;  5K95 A;  2YZE A;  2FXL A;  4PR8 A;  4CW3 A;  3PKL A;  3P9F A;  3CKU A;  3PJK A;  2ZKB A;  1XXJ A;  4CW6 A;  3PLH A;  4R8X A;  4D17 A;  4PUV A;  3PLG A;  3PK4 A;  3PKF A;  3PKT A;  4N9S A;  3BJP A;  5K9G A;  1WS2 A;  1R51 A;  3PK6 A;  4MB8 A;  5M98 A;  3L9G A;  4D19 A;  5LL1 A;  3GKO A;  1XT4 A;  4N9V A; 
#chains in the Genus database with same CATH topology
 3PLJ A;  4FSK A;  1XY3 A;  3PLI A;  3P9O A;  2IBA A;  4R99 A;  5FRC A;  3PK5 A;  5AYJ A;  4D13 A;  1VAX A;  4N9M A;  1WRR A;  1J2G A;  3PKH A;  2ICQ A;  3CKS A;  2IC0 A;  3PKG A;  3LBG A;  3PLE A;  3PKK A;  4CW2 A;  3PKU A;  1R4U A;  2YZC A;  3D2O A;  2ZKA A;  3PK8 A;  3WLV A;  4CW0 A;  1R56 A;  3PK3 A;  4D12 A;  3OBP A;  3PLM A;  2PES A;  4OP6 A;  2R5R A;  2YZD A;  3LD4 A;  3BK8 A;  1WS3 A;  3L8W A;  4OQC A;  2FUB A;  1R4S A;  2YZB A;  4OP9 A;  3F2M A;  4POE A;  4N3M A;  1VAY A;  3PKS A;  4XFP A;  5K95 A;  2YZE A;  2FXL A;  4PR8 A;  4CW3 A;  3PKL A;  3P9F A;  3CKU A;  3PJK A;  2ZKB A;  1XXJ A;  4CW6 A;  3PLH A;  4R8X A;  4D17 A;  4PUV A;  3PLG A;  3PK4 A;  3PKF A;  3PKT A;  4N9S A;  3BJP A;  5K9G A;  1WS2 A;  1R51 A;  3PK6 A;  4MB8 A;  5M98 A;  3L9G A;  4D19 A;  5LL1 A;  3GKO A;  1XT4 A;  4N9V A; 
#chains in the Genus database with same CATH homology
 3PLJ A;  4FSK A;  1XY3 A;  3PLI A;  3P9O A;  2IBA A;  4R99 A;  5FRC A;  3PK5 A;  5AYJ A;  4D13 A;  1VAX A;  4N9M A;  1WRR A;  1J2G A;  3PKH A;  2ICQ A;  3CKS A;  2IC0 A;  3PKG A;  3LBG A;  3PLE A;  3PKK A;  4CW2 A;  3PKU A;  1R4U A;  2YZC A;  3D2O A;  2ZKA A;  3PK8 A;  3WLV A;  4CW0 A;  1R56 A;  3PK3 A;  4D12 A;  3OBP A;  3PLM A;  2PES A;  4OP6 A;  2R5R A;  2YZD A;  3LD4 A;  3BK8 A;  1WS3 A;  3L8W A;  4OQC A;  2FUB A;  1R4S A;  2YZB A;  4OP9 A;  3F2M A;  4POE A;  4N3M A;  1VAY A;  3PKS A;  4XFP A;  5K95 A;  2YZE A;  2FXL A;  4PR8 A;  4CW3 A;  3PKL A;  3P9F A;  3CKU A;  3PJK A;  2ZKB A;  1XXJ A;  4CW6 A;  3PLH A;  4R8X A;  4D17 A;  4PUV A;  3PLG A;  3PK4 A;  3PKF A;  3PKT A;  4N9S A;  3BJP A;  5K9G A;  1WS2 A;  1R51 A;  3PK6 A;  4MB8 A;  5M98 A;  3L9G A;  4D19 A;  5LL1 A;  3GKO A;  1XT4 A;  4N9V A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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