2KYGA

Structure of the aml1-eto nervy domain - pka(riia) complex and its contribution to aml1-eto activity
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
50
structure length
50
Chain Sequence
GAMGSMSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding
molecule keywords cAMP-dependent protein kinase type II-alpha regulatory subun
publication title Structure of the AML1-ETO NHR3-PKA(RIIalpha) complex and its contribution to AML1-ETO activity.
pubmed doi rcsb
source organism Homo sapiens
total genus 13
structure length 50
sequence length 50
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-05-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02197 RIIa Regulatory subunit of type II PKA R-subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.890.10 Mainly Alpha Up-down Bundle cAMP-dependent Protein Kinase, Chain A cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain 2kygA00
4ZP3A 2H9RA 2IZYA 5HVZA 2EZWA 1R2AA 3IM3A 4RTAA 4F9KA 3IM4A 3G36A 4RIQA 1L6EA 2KYGA 2DRNA 4RT4A
chains in the Genus database with same CATH superfamily
3S4BA 3QDEA 4ZP3A 3ACTA 3QFZA 2EZWA 3GWHA 3UFEA 2CQTA 2DRNA 3S4AA 3QFYA 2OUTA 2RQYA 3PMIA 3S4DA 5HVZA 1R2AA 3IM3A 4RTAA 3IM4A 4RIQA 3ACSA 4RT4A 2I15A 2CQSA 3QG0A 2IZYA 3AFJA 3S4CA 4F9KA 2CBGA 2KNGA 1L6EA 3RSYA 2K9QA 2H9RA 3RRSA 3G36A 2KYGA 2CB9A
chains in the Genus database with same CATH topology
4ZP3A 2H9RA 2IZYA 5HVZA 2EZWA 1R2AA 3IM3A 4RTAA 4F9KA 3IM4A 3G36A 4RIQA 1L6EA 2KYGA 2DRNA 4RT4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZP3 A;  2H9R A;  2IZY A;  5HVZ A;  2EZW A;  1R2A A;  3IM3 A;  4RTA A;  4F9K A;  3IM4 A;  3G36 A;  4RIQ A;  1L6E A;  2KYG A;  2DRN A;  4RT4 A; 
#chains in the Genus database with same CATH topology
 3S4B A;  3QDE A;  4ZP3 A;  3ACT A;  3QFZ A;  2EZW A;  3GWH A;  3UFE A;  2CQT A;  2DRN A;  3S4A A;  3QFY A;  2OUT A;  2RQY A;  3PMI A;  3S4D A;  5HVZ A;  1R2A A;  3IM3 A;  4RTA A;  3IM4 A;  4RIQ A;  3ACS A;  4RT4 A;  2I15 A;  2CQS A;  3QG0 A;  2IZY A;  3AFJ A;  3S4C A;  4F9K A;  2CBG A;  2KNG A;  1L6E A;  3RSY A;  2K9Q A;  2H9R A;  3RRS A;  3G36 A;  2KYG A;  2CB9 A; 
#chains in the Genus database with same CATH homology
 4ZP3 A;  2H9R A;  2IZY A;  5HVZ A;  2EZW A;  1R2A A;  3IM3 A;  4RTA A;  4F9K A;  3IM4 A;  3G36 A;  4RIQ A;  1L6E A;  2KYG A;  2DRN A;  4RT4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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