4HW5A

Crystal structure of the human c3a anaphylatoxin
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
77
structure length
77
Chain Sequence
SVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEACKKVFLDCCNYITELRRQHARASHLGLAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement C3
total genus 24
structure length 77
sequence length 77
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-11-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01821 ANATO Anaphylotoxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.91.20 Mainly Alpha Up-down Bundle Influenza Virus Matrix Protein; Chain A, domain 1 Anaphylotoxins (complement system) 4hw5A00
4I6OA 4P39A 4HWJA 3HQAA 4WB2A 4FXKB 3HQBA 5JPNB 5B4PB 4P3BA 1C5AA 2B39A 3CU7A 3KLSA 4HW5A 4P3AA 1CFAA 1KJSA 2A73B 4UU9C 4WB3A
chains in the Genus database with same CATH superfamily
4IQ4A 4D9JA 4I6OA 4ITVA 4P39A 4HWJA 4PUSA 3HQAA 4FXKB 2Z16A 4WB2A 3HQBA 3MD2A 5JPNB 5B4PB 5CQEA 4P3BA 1C5AA 2B39A 3CU7A 3KLSA 4FXGB 4HW5A 4P3AA 1CFAA 1AA7A 1KJSA 2A73B 5JPMB 1EA3A 4UU9C 3VDXA 4WB3A
chains in the Genus database with same CATH topology
4I6OA 4P39A 4HWJA 3HQAA 4WB2A 4FXKB 3HQBA 5JPNB 5B4PB 4P3BA 1C5AA 2B39A 3CU7A 3KLSA 4HW5A 4P3AA 1CFAA 1KJSA 2A73B 4UU9C 4WB3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4I6O A;  4P39 A;  4HWJ A;  3HQA A;  4WB2 A;  4FXK B;  3HQB A;  5JPN B;  5B4P B;  4P3B A;  1C5A A;  2B39 A;  3CU7 A;  3KLS A;  4HW5 A;  4P3A A;  1CFA A;  1KJS A;  2A73 B;  4UU9 C;  4WB3 A; 
#chains in the Genus database with same CATH topology
 4IQ4 A;  4D9J A;  4I6O A;  4ITV A;  4P39 A;  4HWJ A;  4PUS A;  3HQA A;  4FXK B;  2Z16 A;  4WB2 A;  3HQB A;  3MD2 A;  5JPN B;  5B4P B;  5CQE A;  4P3B A;  1C5A A;  2B39 A;  3CU7 A;  3KLS A;  4FXG B;  4HW5 A;  4P3A A;  1CFA A;  1AA7 A;  1KJS A;  2A73 B;  5JPM B;  1EA3 A;  4UU9 C;  3VDX A;  4WB3 A; 
#chains in the Genus database with same CATH homology
 4I6O A;  4P39 A;  4HWJ A;  3HQA A;  4WB2 A;  4FXK B;  3HQB A;  5JPN B;  5B4P B;  4P3B A;  1C5A A;  2B39 A;  3CU7 A;  3KLS A;  4HW5 A;  4P3A A;  1CFA A;  1KJS A;  2A73 B;  4UU9 C;  4WB3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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