4MJPA

E. coli sliding clamp in complex with (r)-vedaprofen
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
364
structure length
361
Chain Sequence
MKFTVEREHLLKPLQQVSGPLGTLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Escherichia coli
molecule keywords DNA polymerase III subunit beta
total genus 89
structure length 361
sequence length 364
chains with identical sequence B
ec nomenclature ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date 2013-09-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00712 DNA_pol3_beta DNA polymerase III beta subunit, N-terminal domain
A PF02767 DNA_pol3_beta_2 DNA polymerase III beta subunit, central domain
A PF02768 DNA_pol3_beta_3 DNA polymerase III beta subunit, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 4mjpA02
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 4mjpA03
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 4mjpA01
4N97A 1OK7A 3BEPA 1UNNA 4N94A 4N96A 3QSBA 4K3KA 4K3MA 1JQJA 5FVEA 3D1EA 3PGEB 4K3RA 4TR8A 5AGVA 4N99A 4TR7A 4MJPA 3L0XA 4TR6A 1MMIA 4PNUA 2AVTA 2POLA 3QSBB 4N95A 4S3IA 4RKIA 3Q4JA 1JQLA 3F1VA 2XURA 3P16A 3PWEA 3Q4KA 4K74A 4N98A 4OVFA 4OVHA 3L10A 4K3QA 4TRTA 3D1FA 3D1GA 4K3SA 4TSZA 2AWAA 4N9AA 5FRQA 4K3PA 3Q4LA 3RB9A 4OVGA 4MJQA 3L0WA 4K3OA 4PNWA 5AH4A 5AGUA 4PNVA 4K3LA 3T0PA 4MJRA 1VPKA 5AH2A
chains in the Genus database with same CATH superfamily
3L0WB 4N97A 5AH2A 1OK7A 3BEPA 1UNNA 4N94A 4N96A 3QSBA 4K3KA 4K3MA 1JQJA 5FVEA 3D1EA 3PGEB 4K3RA 4TR8A 5AGVA 4N99A 4TR7A 4MJPA 3L0XA 4TR6A 1MMIA 4PNUA 2AVTA 2POLA 3QSBB 4N95A 4S3IA 4RKIA 3Q4JA 1JQLA 3F1VA 2XURA 3P16A 3PWEA 3Q4KA 4K74A 4N98A 4OVFA 4OVHA 3L10A 4K3QA 4TRTA 3D1FA 3D1GA 3L0XB 4K3SA 2AWAA 4N9AA 4TSZA 4K3PA 3Q4LA 5FRQA 3RB9A 4OVGA 4MJQA 3L0WA 4K3OA 4PNWA 5AH4A 5AGUA 4PNVA 4K3LA 3T0PA 4MJRA 3L10B 1VPKA 3PGEA
chains in the Genus database with same CATH topology
4N97A 1OK7A 3BEPA 1UNNA 4N94A 4N96A 3QSBA 4K3KA 4K3MA 1JQJA 5FVEA 3D1EA 3PGEB 4K3RA 4TR8A 5AGVA 4N99A 4TR7A 4MJPA 3L0XA 4TR6A 1MMIA 4PNUA 2AVTA 2POLA 3QSBB 4N95A 4S3IA 4RKIA 3Q4JA 1JQLA 3F1VA 2XURA 3P16A 3PWEA 3Q4KA 4K74A 4N98A 4OVFA 4OVHA 3L10A 4K3QA 4TRTA 3D1FA 3D1GA 4K3SA 4TSZA 2AWAA 4N9AA 5FRQA 4K3PA 3Q4LA 3RB9A 4OVGA 4MJQA 3L0WA 4K3OA 4PNWA 5AH4A 5AGUA 4PNVA 4K3LA 3T0PA 4MJRA 1VPKA 5AH2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4N97 A;  1OK7 A;  3BEP A;  1UNN A;  4N94 A;  4N96 A;  3QSB A;  4K3K A;  4K3M A;  1JQJ A;  5FVE A;  3D1E A;  3PGE B;  4K3R A;  4TR8 A;  5AGV A;  4N99 A;  4TR7 A;  4MJP A;  3L0X A;  4TR6 A;  1MMI A;  4PNU A;  2AVT A;  2POL A;  3QSB B;  4N95 A;  4S3I A;  4RKI A;  3Q4J A;  1JQL A;  3F1V A;  2XUR A;  3P16 A;  3PWE A;  3Q4K A;  4K74 A;  4N98 A;  4OVF A;  4OVH A;  3L10 A;  4K3Q A;  4TRT A;  3D1F A;  3D1G A;  4K3S A;  4TSZ A;  2AWA A;  4N9A A;  5FRQ A;  4K3P A;  3Q4L A;  3RB9 A;  4OVG A;  4MJQ A;  3L0W A;  4K3O A;  4PNW A;  5AH4 A;  5AGU A;  4PNV A;  4K3L A;  3T0P A;  4MJR A;  1VPK A;  5AH2 A; 
#chains in the Genus database with same CATH topology
 3L0W B;  4N97 A;  5AH2 A;  1OK7 A;  3BEP A;  1UNN A;  4N94 A;  4N96 A;  3QSB A;  4K3K A;  4K3M A;  1JQJ A;  5FVE A;  3D1E A;  3PGE B;  4K3R A;  4TR8 A;  5AGV A;  4N99 A;  4TR7 A;  4MJP A;  3L0X A;  4TR6 A;  1MMI A;  4PNU A;  2AVT A;  2POL A;  3QSB B;  4N95 A;  4S3I A;  4RKI A;  3Q4J A;  1JQL A;  3F1V A;  2XUR A;  3P16 A;  3PWE A;  3Q4K A;  4K74 A;  4N98 A;  4OVF A;  4OVH A;  3L10 A;  4K3Q A;  4TRT A;  3D1F A;  3D1G A;  3L0X B;  4K3S A;  2AWA A;  4N9A A;  4TSZ A;  4K3P A;  3Q4L A;  5FRQ A;  3RB9 A;  4OVG A;  4MJQ A;  3L0W A;  4K3O A;  4PNW A;  5AH4 A;  5AGU A;  4PNV A;  4K3L A;  3T0P A;  4MJR A;  3L10 B;  1VPK A;  3PGE A; 
#chains in the Genus database with same CATH homology
 4N97 A;  1OK7 A;  3BEP A;  1UNN A;  4N94 A;  4N96 A;  3QSB A;  4K3K A;  4K3M A;  1JQJ A;  5FVE A;  3D1E A;  3PGE B;  4K3R A;  4TR8 A;  5AGV A;  4N99 A;  4TR7 A;  4MJP A;  3L0X A;  4TR6 A;  1MMI A;  4PNU A;  2AVT A;  2POL A;  3QSB B;  4N95 A;  4S3I A;  4RKI A;  3Q4J A;  1JQL A;  3F1V A;  2XUR A;  3P16 A;  3PWE A;  3Q4K A;  4K74 A;  4N98 A;  4OVF A;  4OVH A;  3L10 A;  4K3Q A;  4TRT A;  3D1F A;  3D1G A;  4K3S A;  4TSZ A;  2AWA A;  4N9A A;  5FRQ A;  4K3P A;  3Q4L A;  3RB9 A;  4OVG A;  4MJQ A;  3L0W A;  4K3O A;  4PNW A;  5AH4 A;  5AGU A;  4PNV A;  4K3L A;  3T0P A;  4MJR A;  1VPK A;  5AH2 A; 
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similar chains in the Genus database (?% sequence similarity)
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