4MJQ | Genus

Total Genus 90

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	90
sequence length	366
structure length	362
Chain Sequence	MKFTVEREHLLKPLQQVSGRPTLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Transferase/transferase inhibitor
source organism	Escherichia coli
publication title	DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. pubmed doi rcsb
molecule keywords	DNA polymerase III subunit beta
total genus	90
structure length	362
sequence length	366
chains with identical sequence	B
ec nomenclature	ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date	2013-09-04

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00712	DNA_pol3_beta	DNA polymerase III beta subunit, N-terminal domain
A	PF02767	DNA_pol3_beta_2	DNA polymerase III beta subunit, central domain
A	PF02768	DNA_pol3_beta_3	DNA polymerase III beta subunit, C-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4mjqA02
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4mjqA03
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4mjqA01

4K3QA 3D1GA 4MJRA 3T0PA 4K3MA 2AVTA 3L0WA 1OK7A 3L0XA 3L10A 4N99A 2XURA 3Q4JA 4PNWA 5AGVA 4TRTA 4TSZA 4TR7A 4RKIA 3Q4LA 4K3KA 4K3SA 4OVFA 3D1EA 3PGEB 4OVGA 4S3IA 3QSBB 1JQJA 4K3RA 1MMIA 4N96A 5AH2A 1UNNA 4MJPA 5AGUA 4K3PA 3PWEA 4OVHA 5FRQA 4MJQA 3F1VA 4N98A 4K74A 2POLA 3QSBA 4N97A 5FVEA 4PNUA 4N95A 1VPKA 4TR8A 5AH4A 3D1FA 4N9AA 3BEPA 3Q4KA 4K3OA 1JQLA 3P16A 2AWAA 4PNVA 4N94A 4TR6A 4K3LA 3RB9A
chains in the Genus database with same CATH superfamily

4K3QA 3D1GA 4MJRA 3T0PA 4K3MA 2AVTA 3L0WA 1OK7A 3L0XA 3L10A 4N99A 2XURA 3Q4JA 4PNWA 5AGVA 4TRTA 4TSZA 4TR7A 4RKIA 3Q4LA 4K3KA 4K3SA 4OVFA 3D1EA 3PGEB 4OVGA 4S3IA 3QSBB 1JQJA 4K3RA 1MMIA 4N96A 5AH2A 1UNNA 4MJPA 5AGUA 4K3PA 3PWEA 4OVHA 5FRQA 4MJQA 3PGEA 3F1VA 4N98A 4K74A 2POLA 3QSBA 4N97A 5FVEA 4PNUA 4N95A 1VPKA 3L0XB 3L0WB 4TR8A 5AH4A 3D1FA 4N9AA 3L10B 3BEPA 3Q4KA 4K3OA 1JQLA 3P16A 2AWAA 4PNVA 4N94A 4TR6A 4K3LA 3RB9A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4K3Q A;  3D1G A;  4MJR A;  3T0P A;  4K3M A;  2AVT A;  3L0W A;  1OK7 A;  3L0X A;  3L10 A;  4N99 A;  2XUR A;  3Q4J A;  4PNW A;  5AGV A;  4TRT A;  4TSZ A;  4TR7 A;  4RKI A;  3Q4L A;  4K3K A;  4K3S A;  4OVF A;  3D1E A;  3PGE B;  4OVG A;  4S3I A;  3QSB B;  1JQJ A;  4K3R A;  1MMI A;  4N96 A;  5AH2 A;  1UNN A;  4MJP A;  5AGU A;  4K3P A;  3PWE A;  4OVH A;  5FRQ A;  4MJQ A;  3F1V A;  4N98 A;  4K74 A;  2POL A;  3QSB A;  4N97 A;  5FVE A;  4PNU A;  4N95 A;  1VPK A;  4TR8 A;  5AH4 A;  3D1F A;  4N9A A;  3BEP A;  3Q4K A;  4K3O A;  1JQL A;  3P16 A;  2AWA A;  4PNV A;  4N94 A;  4TR6 A;  4K3L A;  3RB9 A; 
#chains in the Genus database with same CATH topology
 4K3Q A;  3D1G A;  4MJR A;  3T0P A;  4K3M A;  2AVT A;  3L0W A;  1OK7 A;  3L0X A;  3L10 A;  4N99 A;  2XUR A;  3Q4J A;  4PNW A;  5AGV A;  4TRT A;  4TSZ A;  4TR7 A;  4RKI A;  3Q4L A;  4K3K A;  4K3S A;  4OVF A;  3D1E A;  3PGE B;  4OVG A;  4S3I A;  3QSB B;  1JQJ A;  4K3R A;  1MMI A;  4N96 A;  5AH2 A;  1UNN A;  4MJP A;  5AGU A;  4K3P A;  3PWE A;  4OVH A;  5FRQ A;  4MJQ A;  3PGE A;  3F1V A;  4N98 A;  4K74 A;  2POL A;  3QSB A;  4N97 A;  5FVE A;  4PNU A;  4N95 A;  1VPK A;  3L0X B;  3L0W B;  4TR8 A;  5AH4 A;  3D1F A;  4N9A A;  3L10 B;  3BEP A;  3Q4K A;  4K3O A;  1JQL A;  3P16 A;  2AWA A;  4PNV A;  4N94 A;  4TR6 A;  4K3L A;  3RB9 A; 
#chains in the Genus database with same CATH homology
 4K3Q A;  3D1G A;  4MJR A;  3T0P A;  4K3M A;  2AVT A;  3L0W A;  1OK7 A;  3L0X A;  3L10 A;  4N99 A;  2XUR A;  3Q4J A;  4PNW A;  5AGV A;  4TRT A;  4TSZ A;  4TR7 A;  4RKI A;  3Q4L A;  4K3K A;  4K3S A;  4OVF A;  3D1E A;  3PGE B;  4OVG A;  4S3I A;  3QSB B;  1JQJ A;  4K3R A;  1MMI A;  4N96 A;  5AH2 A;  1UNN A;  4MJP A;  5AGU A;  4K3P A;  3PWE A;  4OVH A;  5FRQ A;  4MJQ A;  3F1V A;  4N98 A;  4K74 A;  2POL A;  3QSB A;  4N97 A;  5FVE A;  4PNU A;  4N95 A;  1VPK A;  4TR8 A;  5AH4 A;  3D1F A;  4N9A A;  3BEP A;  3Q4K A;  4K3O A;  1JQL A;  3P16 A;  2AWA A;  4PNV A;  4N94 A;  4TR6 A;  4K3L A;  3RB9 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4MJQA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations