4N95 | Genus

Total Genus 90

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	90
sequence length	365
structure length	359
Chain Sequence	MKFTVEREHLLKPLQQVSGPLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMR

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 359 atoms

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359 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Transferase
source organism	Escherichia coli
publication title	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. pubmed doi rcsb
molecule keywords	DNA polymerase III subunit beta
total genus	90
structure length	359
sequence length	365
chains with identical sequence	B
ec nomenclature	ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date	2013-10-19

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00712	DNA_pol3_beta	DNA polymerase III beta subunit, N-terminal domain
A	PF02767	DNA_pol3_beta_2	DNA polymerase III beta subunit, central domain
A	PF02768	DNA_pol3_beta_3	DNA polymerase III beta subunit, C-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n95A02
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n95A03
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n95A01

4MJRA 4N96A 4S3IA 4K3LA 1JQLA 4MJQA 4MJPA 2AWAA 3P16A 2POLA 4PNUA 3D1GA 5FRQA 3T0PA 4N97A 5AGVA 3PWEA 4OVGA 4PNWA 4TR6A 4K3RA 3D1EA 3Q4JA 4K3QA 4PNVA 4K3SA 4N99A 3D1FA 1OK7A 3PGEB 4TR8A 1VPKA 3QSBB 4N95A 4RKIA 4K3OA 5AH4A 3RB9A 3L10A 4K74A 4TSZA 5AH2A 3BEPA 1UNNA 3L0WA 4N94A 4TRTA 1MMIA 4K3KA 4OVFA 3Q4LA 4N9AA 5AGUA 3F1VA 4N98A 3L0XA 3Q4KA 4OVHA 2AVTA 2XURA 4TR7A 5FVEA 1JQJA 4K3MA 4K3PA 3QSBA
chains in the Genus database with same CATH superfamily

4MJRA 4N96A 4S3IA 3L0WB 1JQLA 4K3LA 4MJQA 4MJPA 2AWAA 3P16A 2POLA 4PNUA 3D1GA 5FRQA 3T0PA 4N97A 5AGVA 3L0XB 3PWEA 4OVGA 4PNWA 4TR6A 4K3RA 3D1EA 3Q4JA 4K3QA 4PNVA 4K3SA 3QSBA 3D1FA 1OK7A 3PGEB 4N99A 4TR8A 1VPKA 3QSBB 4N95A 4RKIA 4K3OA 5AH4A 3RB9A 3L10A 4K74A 4TSZA 5AH2A 3BEPA 1UNNA 3L0WA 4N94A 4TRTA 1MMIA 4K3KA 4OVFA 3Q4LA 4K3PA 4N9AA 5AGUA 3F1VA 4N98A 3L0XA 3Q4KA 4OVHA 2AVTA 2XURA 4TR7A 5FVEA 1JQJA 4K3MA 3PGEA 3L10B
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4MJR A;  4N96 A;  4S3I A;  4K3L A;  1JQL A;  4MJQ A;  4MJP A;  2AWA A;  3P16 A;  2POL A;  4PNU A;  3D1G A;  5FRQ A;  3T0P A;  4N97 A;  5AGV A;  3PWE A;  4OVG A;  4PNW A;  4TR6 A;  4K3R A;  3D1E A;  3Q4J A;  4K3Q A;  4PNV A;  4K3S A;  4N99 A;  3D1F A;  1OK7 A;  3PGE B;  4TR8 A;  1VPK A;  3QSB B;  4N95 A;  4RKI A;  4K3O A;  5AH4 A;  3RB9 A;  3L10 A;  4K74 A;  4TSZ A;  5AH2 A;  3BEP A;  1UNN A;  3L0W A;  4N94 A;  4TRT A;  1MMI A;  4K3K A;  4OVF A;  3Q4L A;  4N9A A;  5AGU A;  3F1V A;  4N98 A;  3L0X A;  3Q4K A;  4OVH A;  2AVT A;  2XUR A;  4TR7 A;  5FVE A;  1JQJ A;  4K3M A;  4K3P A;  3QSB A; 
#chains in the Genus database with same CATH topology
 4MJR A;  4N96 A;  4S3I A;  3L0W B;  1JQL A;  4K3L A;  4MJQ A;  4MJP A;  2AWA A;  3P16 A;  2POL A;  4PNU A;  3D1G A;  5FRQ A;  3T0P A;  4N97 A;  5AGV A;  3L0X B;  3PWE A;  4OVG A;  4PNW A;  4TR6 A;  4K3R A;  3D1E A;  3Q4J A;  4K3Q A;  4PNV A;  4K3S A;  3QSB A;  3D1F A;  1OK7 A;  3PGE B;  4N99 A;  4TR8 A;  1VPK A;  3QSB B;  4N95 A;  4RKI A;  4K3O A;  5AH4 A;  3RB9 A;  3L10 A;  4K74 A;  4TSZ A;  5AH2 A;  3BEP A;  1UNN A;  3L0W A;  4N94 A;  4TRT A;  1MMI A;  4K3K A;  4OVF A;  3Q4L A;  4K3P A;  4N9A A;  5AGU A;  3F1V A;  4N98 A;  3L0X A;  3Q4K A;  4OVH A;  2AVT A;  2XUR A;  4TR7 A;  5FVE A;  1JQJ A;  4K3M A;  3PGE A;  3L10 B; 
#chains in the Genus database with same CATH homology
 4MJR A;  4N96 A;  4S3I A;  4K3L A;  1JQL A;  4MJQ A;  4MJP A;  2AWA A;  3P16 A;  2POL A;  4PNU A;  3D1G A;  5FRQ A;  3T0P A;  4N97 A;  5AGV A;  3PWE A;  4OVG A;  4PNW A;  4TR6 A;  4K3R A;  3D1E A;  3Q4J A;  4K3Q A;  4PNV A;  4K3S A;  4N99 A;  3D1F A;  1OK7 A;  3PGE B;  4TR8 A;  1VPK A;  3QSB B;  4N95 A;  4RKI A;  4K3O A;  5AH4 A;  3RB9 A;  3L10 A;  4K74 A;  4TSZ A;  5AH2 A;  3BEP A;  1UNN A;  3L0W A;  4N94 A;  4TRT A;  1MMI A;  4K3K A;  4OVF A;  3Q4L A;  4N9A A;  5AGU A;  3F1V A;  4N98 A;  3L0X A;  3Q4K A;  4OVH A;  2AVT A;  2XUR A;  4TR7 A;  5FVE A;  1JQJ A;  4K3M A;  4K3P A;  3QSB A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4N95A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations