4N95 | Genus

Total Genus 90

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	90
sequence length	365
structure length	359
Chain Sequence	MKFTVEREHLLKPLQQVSGPLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMR

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Transferase
source organism	Escherichia coli
publication title	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. pubmed doi rcsb
molecule keywords	DNA polymerase III subunit beta
total genus	90
structure length	359
sequence length	365
chains with identical sequence	B
ec nomenclature	ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date	2013-10-19

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00712	DNA_pol3_beta	DNA polymerase III beta subunit, N-terminal domain
A	PF02767	DNA_pol3_beta_2	DNA polymerase III beta subunit, central domain
A	PF02768	DNA_pol3_beta_3	DNA polymerase III beta subunit, C-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n95A02
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n95A03
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n95A01

4TR7A 4K3KA 4K74A 4OVHA 3Q4JA 3L0XA 4N98A 5FVEA 3F1VA 4PNUA 3Q4KA 4N95A 4N9AA 4K3QA 4N96A 4K3OA 4K3MA 1OK7A 4S3IA 3QSBA 4K3LA 1MMIA 4N94A 4PNVA 3RB9A 4TR8A 5AGUA 3L10A 1JQLA 4MJQA 4MJPA 4PNWA 3PWEA 2AWAA 5AH4A 4TR6A 2XURA 3D1GA 1UNNA 3T0PA 4K3SA 3PGEB 4OVGA 4N97A 4TRTA 4OVFA 3D1FA 4K3PA 1JQJA 1VPKA 3QSBB 3P16A 3Q4LA 3L0WA 2AVTA 4MJRA 4TSZA 2POLA 4N99A 3D1EA 4K3RA 5AGVA 5AH2A 3BEPA 4RKIA 5FRQA
chains in the Genus database with same CATH superfamily

4TR7A 4K3KA 4K74A 4OVHA 3Q4JA 3L0XA 4N98A 5FVEA 3F1VA 4PNUA 3Q4KA 4N95A 4N9AA 3PGEA 4K3QA 3L0WB 4N96A 4K3OA 4K3MA 1OK7A 4S3IA 3QSBA 4K3LA 1MMIA 4N94A 4PNVA 3RB9A 4TR8A 5AGUA 3L10A 1JQLA 4MJQA 4MJPA 4PNWA 3L0XB 3PWEA 2AWAA 5AH4A 4TR6A 2XURA 3D1GA 1UNNA 3T0PA 4K3SA 3PGEB 4OVGA 4N97A 4TRTA 4OVFA 3D1FA 4K3PA 1JQJA 1VPKA 3QSBB 3P16A 3Q4LA 3L0WA 2AVTA 4MJRA 4TSZA 2POLA 3L10B 3D1EA 4K3RA 4N99A 5AGVA 5AH2A 3BEPA 4RKIA 5FRQA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4TR7 A;  4K3K A;  4K74 A;  4OVH A;  3Q4J A;  3L0X A;  4N98 A;  5FVE A;  3F1V A;  4PNU A;  3Q4K A;  4N95 A;  4N9A A;  4K3Q A;  4N96 A;  4K3O A;  4K3M A;  1OK7 A;  4S3I A;  3QSB A;  4K3L A;  1MMI A;  4N94 A;  4PNV A;  3RB9 A;  4TR8 A;  5AGU A;  3L10 A;  1JQL A;  4MJQ A;  4MJP A;  4PNW A;  3PWE A;  2AWA A;  5AH4 A;  4TR6 A;  2XUR A;  3D1G A;  1UNN A;  3T0P A;  4K3S A;  3PGE B;  4OVG A;  4N97 A;  4TRT A;  4OVF A;  3D1F A;  4K3P A;  1JQJ A;  1VPK A;  3QSB B;  3P16 A;  3Q4L A;  3L0W A;  2AVT A;  4MJR A;  4TSZ A;  2POL A;  4N99 A;  3D1E A;  4K3R A;  5AGV A;  5AH2 A;  3BEP A;  4RKI A;  5FRQ A; 
#chains in the Genus database with same CATH topology
 4TR7 A;  4K3K A;  4K74 A;  4OVH A;  3Q4J A;  3L0X A;  4N98 A;  5FVE A;  3F1V A;  4PNU A;  3Q4K A;  4N95 A;  4N9A A;  3PGE A;  4K3Q A;  3L0W B;  4N96 A;  4K3O A;  4K3M A;  1OK7 A;  4S3I A;  3QSB A;  4K3L A;  1MMI A;  4N94 A;  4PNV A;  3RB9 A;  4TR8 A;  5AGU A;  3L10 A;  1JQL A;  4MJQ A;  4MJP A;  4PNW A;  3L0X B;  3PWE A;  2AWA A;  5AH4 A;  4TR6 A;  2XUR A;  3D1G A;  1UNN A;  3T0P A;  4K3S A;  3PGE B;  4OVG A;  4N97 A;  4TRT A;  4OVF A;  3D1F A;  4K3P A;  1JQJ A;  1VPK A;  3QSB B;  3P16 A;  3Q4L A;  3L0W A;  2AVT A;  4MJR A;  4TSZ A;  2POL A;  3L10 B;  3D1E A;  4K3R A;  4N99 A;  5AGV A;  5AH2 A;  3BEP A;  4RKI A;  5FRQ A; 
#chains in the Genus database with same CATH homology
 4TR7 A;  4K3K A;  4K74 A;  4OVH A;  3Q4J A;  3L0X A;  4N98 A;  5FVE A;  3F1V A;  4PNU A;  3Q4K A;  4N95 A;  4N9A A;  4K3Q A;  4N96 A;  4K3O A;  4K3M A;  1OK7 A;  4S3I A;  3QSB A;  4K3L A;  1MMI A;  4N94 A;  4PNV A;  3RB9 A;  4TR8 A;  5AGU A;  3L10 A;  1JQL A;  4MJQ A;  4MJP A;  4PNW A;  3PWE A;  2AWA A;  5AH4 A;  4TR6 A;  2XUR A;  3D1G A;  1UNN A;  3T0P A;  4K3S A;  3PGE B;  4OVG A;  4N97 A;  4TRT A;  4OVF A;  3D1F A;  4K3P A;  1JQJ A;  1VPK A;  3QSB B;  3P16 A;  3Q4L A;  3L0W A;  2AVT A;  4MJR A;  4TSZ A;  2POL A;  4N99 A;  3D1E A;  4K3R A;  5AGV A;  5AH2 A;  3BEP A;  4RKI A;  5FRQ A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4N95A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations