4N99 | Genus

Total Genus 86

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	86
sequence length	366
structure length	356
Chain Sequence	MKFTVEREHLLKPLQQVSGPLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Transferase/transferase inhibitor
source organism	Escherichia coli
publication title	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. pubmed doi rcsb
molecule keywords	DNA polymerase III subunit beta
total genus	86
structure length	356
sequence length	366
chains with identical sequence	B
ec nomenclature	ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date	2013-10-19

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00712	DNA_pol3_beta	DNA polymerase III beta subunit, N-terminal domain
A	PF02767	DNA_pol3_beta_2	DNA polymerase III beta subunit, central domain
A	PF02768	DNA_pol3_beta_3	DNA polymerase III beta subunit, C-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n99A02
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n99A03
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n99A01

4OVFA 4N96A 3D1FA 3QSBA 4TSZA 3D1EA 4S3IA 4RKIA 4N98A 4K3KA 1MMIA 2AVTA 2POLA 4K3OA 4OVHA 3Q4KA 3Q4JA 4MJQA 4TRTA 5AH2A 3D1GA 4OVGA 5FVEA 3F1VA 4K3SA 4K3LA 4K3QA 3L0XA 1OK7A 3PWEA 4N95A 5AGVA 4PNWA 4PNUA 4PNVA 5AH4A 4N9AA 4N97A 4MJPA 3PGEB 3QSBB 4TR7A 3BEPA 5FRQA 4N99A 3L0WA 2AWAA 3L10A 4TR8A 4K3RA 3Q4LA 3P16A 4K74A 4TR6A 4K3MA 1VPKA 4MJRA 1UNNA 3RB9A 3T0PA 2XURA 4K3PA 1JQLA 4N94A 5AGUA 1JQJA
chains in the Genus database with same CATH superfamily

4OVFA 4N96A 3D1FA 3QSBA 4TSZA 3D1EA 3PGEA 4S3IA 4RKIA 4N98A 4K3KA 1MMIA 2AVTA 3L10B 2POLA 3L0WB 4K3OA 4OVHA 3Q4KA 3Q4JA 4MJQA 4TRTA 5AH2A 3D1GA 4OVGA 5FVEA 3F1VA 4K3SA 4K3LA 4K3QA 3L0XA 1OK7A 3PWEA 4N95A 5AGVA 4PNWA 4PNUA 4PNVA 5AH4A 4N9AA 4N97A 4MJPA 3PGEB 3QSBB 4TR7A 3BEPA 5FRQA 4N99A 3L0WA 2AWAA 3L10A 4TR8A 4K3RA 3Q4LA 3P16A 4K74A 4TR6A 4K3MA 1VPKA 4MJRA 1UNNA 3RB9A 3T0PA 2XURA 3L0XB 1JQLA 4K3PA 4N94A 5AGUA 1JQJA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4OVF A;  4N96 A;  3D1F A;  3QSB A;  4TSZ A;  3D1E A;  4S3I A;  4RKI A;  4N98 A;  4K3K A;  1MMI A;  2AVT A;  2POL A;  4K3O A;  4OVH A;  3Q4K A;  3Q4J A;  4MJQ A;  4TRT A;  5AH2 A;  3D1G A;  4OVG A;  5FVE A;  3F1V A;  4K3S A;  4K3L A;  4K3Q A;  3L0X A;  1OK7 A;  3PWE A;  4N95 A;  5AGV A;  4PNW A;  4PNU A;  4PNV A;  5AH4 A;  4N9A A;  4N97 A;  4MJP A;  3PGE B;  3QSB B;  4TR7 A;  3BEP A;  5FRQ A;  4N99 A;  3L0W A;  2AWA A;  3L10 A;  4TR8 A;  4K3R A;  3Q4L A;  3P16 A;  4K74 A;  4TR6 A;  4K3M A;  1VPK A;  4MJR A;  1UNN A;  3RB9 A;  3T0P A;  2XUR A;  4K3P A;  1JQL A;  4N94 A;  5AGU A;  1JQJ A; 
#chains in the Genus database with same CATH topology
 4OVF A;  4N96 A;  3D1F A;  3QSB A;  4TSZ A;  3D1E A;  3PGE A;  4S3I A;  4RKI A;  4N98 A;  4K3K A;  1MMI A;  2AVT A;  3L10 B;  2POL A;  3L0W B;  4K3O A;  4OVH A;  3Q4K A;  3Q4J A;  4MJQ A;  4TRT A;  5AH2 A;  3D1G A;  4OVG A;  5FVE A;  3F1V A;  4K3S A;  4K3L A;  4K3Q A;  3L0X A;  1OK7 A;  3PWE A;  4N95 A;  5AGV A;  4PNW A;  4PNU A;  4PNV A;  5AH4 A;  4N9A A;  4N97 A;  4MJP A;  3PGE B;  3QSB B;  4TR7 A;  3BEP A;  5FRQ A;  4N99 A;  3L0W A;  2AWA A;  3L10 A;  4TR8 A;  4K3R A;  3Q4L A;  3P16 A;  4K74 A;  4TR6 A;  4K3M A;  1VPK A;  4MJR A;  1UNN A;  3RB9 A;  3T0P A;  2XUR A;  3L0X B;  1JQL A;  4K3P A;  4N94 A;  5AGU A;  1JQJ A; 
#chains in the Genus database with same CATH homology
 4OVF A;  4N96 A;  3D1F A;  3QSB A;  4TSZ A;  3D1E A;  4S3I A;  4RKI A;  4N98 A;  4K3K A;  1MMI A;  2AVT A;  2POL A;  4K3O A;  4OVH A;  3Q4K A;  3Q4J A;  4MJQ A;  4TRT A;  5AH2 A;  3D1G A;  4OVG A;  5FVE A;  3F1V A;  4K3S A;  4K3L A;  4K3Q A;  3L0X A;  1OK7 A;  3PWE A;  4N95 A;  5AGV A;  4PNW A;  4PNU A;  4PNV A;  5AH4 A;  4N9A A;  4N97 A;  4MJP A;  3PGE B;  3QSB B;  4TR7 A;  3BEP A;  5FRQ A;  4N99 A;  3L0W A;  2AWA A;  3L10 A;  4TR8 A;  4K3R A;  3Q4L A;  3P16 A;  4K74 A;  4TR6 A;  4K3M A;  1VPK A;  4MJR A;  1UNN A;  3RB9 A;  3T0P A;  2XUR A;  4K3P A;  1JQL A;  4N94 A;  5AGU A;  1JQJ A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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4N99A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations