4N99 | Genus

Total Genus 86

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	86
sequence length	366
structure length	356
Chain Sequence	MKFTVEREHLLKPLQQVSGPLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 356 atoms

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356 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Transferase/transferase inhibitor
source organism	Escherichia coli
publication title	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. pubmed doi rcsb
molecule keywords	DNA polymerase III subunit beta
total genus	86
structure length	356
sequence length	366
chains with identical sequence	B
ec nomenclature	ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date	2013-10-19

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00712	DNA_pol3_beta	DNA polymerase III beta subunit, N-terminal domain
A	PF02767	DNA_pol3_beta_2	DNA polymerase III beta subunit, central domain
A	PF02768	DNA_pol3_beta_3	DNA polymerase III beta subunit, C-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n99A02
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n99A03
3.10.150.10	Alpha Beta	Roll	DNA Polymerase III; Chain A, domain 2	DNA Polymerase III, subunit A, domain 2	4n99A01

3Q4LA 3D1FA 3L0WA 3L0XA 3Q4JA 3L10A 4N95A 4K74A 3QSBB 3RB9A 4MJQA 3QSBA 4K3SA 4N98A 4RKIA 1UNNA 4PNUA 4TSZA 4PNWA 5AH4A 1JQLA 1JQJA 4MJPA 4K3OA 4OVGA 4TR6A 4N99A 4TR7A 4OVHA 2AWAA 4PNVA 1VPKA 4N94A 1OK7A 4MJRA 4K3KA 5AGUA 5AGVA 5FVEA 5AH2A 4N96A 4K3PA 3F1VA 4K3LA 4N9AA 4OVFA 3D1EA 4S3IA 3BEPA 2POLA 1MMIA 3P16A 4TRTA 5FRQA 2XURA 3D1GA 2AVTA 3PWEA 3Q4KA 3PGEB 4TR8A 3T0PA 4K3MA 4K3RA 4N97A 4K3QA
chains in the Genus database with same CATH superfamily

3L0XB 3PGEA 3Q4LA 3D1FA 3L0WA 3L0XA 3Q4JA 3L10A 4N95A 4K74A 3QSBB 3RB9A 4MJQA 3QSBA 4K3SA 4N98A 4RKIA 1UNNA 4PNUA 4TSZA 4PNWA 5AH4A 1JQLA 1JQJA 4MJPA 4K3OA 4OVGA 4TR6A 4N99A 4TR7A 4OVHA 2AWAA 4PNVA 1VPKA 4N94A 1OK7A 4MJRA 4K3KA 5AGUA 5AGVA 5FVEA 5AH2A 4N96A 4K3PA 3F1VA 4K3LA 4N9AA 4OVFA 3D1EA 4S3IA 3BEPA 2POLA 1MMIA 3P16A 4TRTA 5FRQA 2XURA 3D1GA 2AVTA 3PWEA 3Q4KA 3PGEB 4TR8A 3T0PA 4K3MA 4K3RA 4N97A 3L0WB 3L10B 4K3QA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3Q4L A;  3D1F A;  3L0W A;  3L0X A;  3Q4J A;  3L10 A;  4N95 A;  4K74 A;  3QSB B;  3RB9 A;  4MJQ A;  3QSB A;  4K3S A;  4N98 A;  4RKI A;  1UNN A;  4PNU A;  4TSZ A;  4PNW A;  5AH4 A;  1JQL A;  1JQJ A;  4MJP A;  4K3O A;  4OVG A;  4TR6 A;  4N99 A;  4TR7 A;  4OVH A;  2AWA A;  4PNV A;  1VPK A;  4N94 A;  1OK7 A;  4MJR A;  4K3K A;  5AGU A;  5AGV A;  5FVE A;  5AH2 A;  4N96 A;  4K3P A;  3F1V A;  4K3L A;  4N9A A;  4OVF A;  3D1E A;  4S3I A;  3BEP A;  2POL A;  1MMI A;  3P16 A;  4TRT A;  5FRQ A;  2XUR A;  3D1G A;  2AVT A;  3PWE A;  3Q4K A;  3PGE B;  4TR8 A;  3T0P A;  4K3M A;  4K3R A;  4N97 A;  4K3Q A; 
#chains in the Genus database with same CATH topology
 3L0X B;  3PGE A;  3Q4L A;  3D1F A;  3L0W A;  3L0X A;  3Q4J A;  3L10 A;  4N95 A;  4K74 A;  3QSB B;  3RB9 A;  4MJQ A;  3QSB A;  4K3S A;  4N98 A;  4RKI A;  1UNN A;  4PNU A;  4TSZ A;  4PNW A;  5AH4 A;  1JQL A;  1JQJ A;  4MJP A;  4K3O A;  4OVG A;  4TR6 A;  4N99 A;  4TR7 A;  4OVH A;  2AWA A;  4PNV A;  1VPK A;  4N94 A;  1OK7 A;  4MJR A;  4K3K A;  5AGU A;  5AGV A;  5FVE A;  5AH2 A;  4N96 A;  4K3P A;  3F1V A;  4K3L A;  4N9A A;  4OVF A;  3D1E A;  4S3I A;  3BEP A;  2POL A;  1MMI A;  3P16 A;  4TRT A;  5FRQ A;  2XUR A;  3D1G A;  2AVT A;  3PWE A;  3Q4K A;  3PGE B;  4TR8 A;  3T0P A;  4K3M A;  4K3R A;  4N97 A;  3L0W B;  3L10 B;  4K3Q A; 
#chains in the Genus database with same CATH homology
 3Q4L A;  3D1F A;  3L0W A;  3L0X A;  3Q4J A;  3L10 A;  4N95 A;  4K74 A;  3QSB B;  3RB9 A;  4MJQ A;  3QSB A;  4K3S A;  4N98 A;  4RKI A;  1UNN A;  4PNU A;  4TSZ A;  4PNW A;  5AH4 A;  1JQL A;  1JQJ A;  4MJP A;  4K3O A;  4OVG A;  4TR6 A;  4N99 A;  4TR7 A;  4OVH A;  2AWA A;  4PNV A;  1VPK A;  4N94 A;  1OK7 A;  4MJR A;  4K3K A;  5AGU A;  5AGV A;  5FVE A;  5AH2 A;  4N96 A;  4K3P A;  3F1V A;  4K3L A;  4N9A A;  4OVF A;  3D1E A;  4S3I A;  3BEP A;  2POL A;  1MMI A;  3P16 A;  4TRT A;  5FRQ A;  2XUR A;  3D1G A;  2AVT A;  3PWE A;  3Q4K A;  3PGE B;  4TR8 A;  3T0P A;  4K3M A;  4K3R A;  4N97 A;  4K3Q A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4N99A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations