4N9AA

E. coli sliding clamp in complex with (r)-6-chloro-2,3,4,9-tetrahydro-1h-carbazole-1-carboxylic acid
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
364
structure length
356
Chain Sequence
MKFTVEREHLLKPLQQVSLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/transferase inhibitor
source organism Escherichia coli
publication title Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.
pubmed doi rcsb
molecule keywords DNA polymerase III subunit beta
total genus 89
structure length 356
sequence length 364
chains with identical sequence B
ec nomenclature ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date 2013-10-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00712 DNA_pol3_beta DNA polymerase III beta subunit, N-terminal domain
A PF02767 DNA_pol3_beta_2 DNA polymerase III beta subunit, central domain
A PF02768 DNA_pol3_beta_3 DNA polymerase III beta subunit, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 4n9aA02
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 4n9aA03
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 4n9aA01
4K3RA 4PNVA 4K3SA 3L0XA 3T0PA 5AH2A 4K3KA 3L0WA 3Q4LA 1MMIA 4OVGA 4OVFA 3QSBB 3D1GA 4K3LA 2POLA 5AGUA 5FVEA 4S3IA 4PNUA 1OK7A 3QSBA 4MJRA 4K74A 1JQJA 3D1EA 4N9AA 3L10A 4TR7A 4N98A 3PGEB 4OVHA 1VPKA 4RKIA 4TR6A 4MJPA 3F1VA 2AVTA 3D1FA 3Q4JA 4N99A 4N97A 3PWEA 4N95A 5FRQA 3BEPA 4MJQA 2XURA 4PNWA 4TR8A 5AGVA 2AWAA 3P16A 1UNNA 3Q4KA 4N96A 4K3PA 4TRTA 4K3MA 4TSZA 3RB9A 4N94A 1JQLA 5AH4A 4K3QA 4K3OA
chains in the Genus database with same CATH superfamily
4K3RA 4PNVA 3L0WB 3L0XA 4K3SA 3T0PA 5AH2A 4K3KA 3L0WA 3Q4LA 1MMIA 4OVGA 4OVFA 3QSBB 3D1GA 4K3LA 2POLA 5AGUA 5FVEA 4S3IA 3L10B 4PNUA 1OK7A 3QSBA 4MJRA 4K74A 1JQJA 3D1EA 4N9AA 3L10A 4TR7A 4N98A 3PGEB 4OVHA 1VPKA 4RKIA 4TR6A 3PGEA 4MJPA 3F1VA 2AVTA 3D1FA 3Q4JA 4N99A 4N97A 3PWEA 4N95A 5FRQA 3BEPA 4MJQA 2XURA 4PNWA 4TR8A 5AGVA 2AWAA 3P16A 1UNNA 3Q4KA 4N96A 4K3PA 4TRTA 4K3MA 4TSZA 3RB9A 4N94A 1JQLA 5AH4A 3L0XB 4K3QA 4K3OA
chains in the Genus database with same CATH topology
4K3RA 4PNVA 4K3SA 3L0XA 3T0PA 5AH2A 4K3KA 3L0WA 3Q4LA 1MMIA 4OVGA 4OVFA 3QSBB 3D1GA 4K3LA 2POLA 5AGUA 5FVEA 4S3IA 4PNUA 1OK7A 3QSBA 4MJRA 4K74A 1JQJA 3D1EA 4N9AA 3L10A 4TR7A 4N98A 3PGEB 4OVHA 1VPKA 4RKIA 4TR6A 4MJPA 3F1VA 2AVTA 3D1FA 3Q4JA 4N99A 4N97A 3PWEA 4N95A 5FRQA 3BEPA 4MJQA 2XURA 4PNWA 4TR8A 5AGVA 2AWAA 3P16A 1UNNA 3Q4KA 4N96A 4K3PA 4TRTA 4K3MA 4TSZA 3RB9A 4N94A 1JQLA 5AH4A 4K3QA 4K3OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4K3R A;  4PNV A;  4K3S A;  3L0X A;  3T0P A;  5AH2 A;  4K3K A;  3L0W A;  3Q4L A;  1MMI A;  4OVG A;  4OVF A;  3QSB B;  3D1G A;  4K3L A;  2POL A;  5AGU A;  5FVE A;  4S3I A;  4PNU A;  1OK7 A;  3QSB A;  4MJR A;  4K74 A;  1JQJ A;  3D1E A;  4N9A A;  3L10 A;  4TR7 A;  4N98 A;  3PGE B;  4OVH A;  1VPK A;  4RKI A;  4TR6 A;  4MJP A;  3F1V A;  2AVT A;  3D1F A;  3Q4J A;  4N99 A;  4N97 A;  3PWE A;  4N95 A;  5FRQ A;  3BEP A;  4MJQ A;  2XUR A;  4PNW A;  4TR8 A;  5AGV A;  2AWA A;  3P16 A;  1UNN A;  3Q4K A;  4N96 A;  4K3P A;  4TRT A;  4K3M A;  4TSZ A;  3RB9 A;  4N94 A;  1JQL A;  5AH4 A;  4K3Q A;  4K3O A; 
#chains in the Genus database with same CATH topology
 4K3R A;  4PNV A;  3L0W B;  3L0X A;  4K3S A;  3T0P A;  5AH2 A;  4K3K A;  3L0W A;  3Q4L A;  1MMI A;  4OVG A;  4OVF A;  3QSB B;  3D1G A;  4K3L A;  2POL A;  5AGU A;  5FVE A;  4S3I A;  3L10 B;  4PNU A;  1OK7 A;  3QSB A;  4MJR A;  4K74 A;  1JQJ A;  3D1E A;  4N9A A;  3L10 A;  4TR7 A;  4N98 A;  3PGE B;  4OVH A;  1VPK A;  4RKI A;  4TR6 A;  3PGE A;  4MJP A;  3F1V A;  2AVT A;  3D1F A;  3Q4J A;  4N99 A;  4N97 A;  3PWE A;  4N95 A;  5FRQ A;  3BEP A;  4MJQ A;  2XUR A;  4PNW A;  4TR8 A;  5AGV A;  2AWA A;  3P16 A;  1UNN A;  3Q4K A;  4N96 A;  4K3P A;  4TRT A;  4K3M A;  4TSZ A;  3RB9 A;  4N94 A;  1JQL A;  5AH4 A;  3L0X B;  4K3Q A;  4K3O A; 
#chains in the Genus database with same CATH homology
 4K3R A;  4PNV A;  4K3S A;  3L0X A;  3T0P A;  5AH2 A;  4K3K A;  3L0W A;  3Q4L A;  1MMI A;  4OVG A;  4OVF A;  3QSB B;  3D1G A;  4K3L A;  2POL A;  5AGU A;  5FVE A;  4S3I A;  4PNU A;  1OK7 A;  3QSB A;  4MJR A;  4K74 A;  1JQJ A;  3D1E A;  4N9A A;  3L10 A;  4TR7 A;  4N98 A;  3PGE B;  4OVH A;  1VPK A;  4RKI A;  4TR6 A;  4MJP A;  3F1V A;  2AVT A;  3D1F A;  3Q4J A;  4N99 A;  4N97 A;  3PWE A;  4N95 A;  5FRQ A;  3BEP A;  4MJQ A;  2XUR A;  4PNW A;  4TR8 A;  5AGV A;  2AWA A;  3P16 A;  1UNN A;  3Q4K A;  4N96 A;  4K3P A;  4TRT A;  4K3M A;  4TSZ A;  3RB9 A;  4N94 A;  1JQL A;  5AH4 A;  4K3Q A;  4K3O A; 
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similar chains in the Genus database (?% sequence similarity)
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