4P6RA

Crystal structure of tyrosinase from bacillus megaterium with tyrosine in the active site
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
287
structure length
287
Chain Sequence
KYRVRKNVLHLTDTEKRDFVRTVLILKEKGIYDRYIAWHGAAGKFHTPPGSDRNAAHMSSAFLPWHREYLLRFERDLQSINPEVTLPYWEWETDAQMQDPSQSQIWSADFMGGNGNPIKDFIVDTGPFAAGRWTTIDEQGNPSGGLKRNFGATKEAPTLPTRDDVLNALKITQYDTPPWDMTSQNSFRNQLEGFINGPQLHNRVHRWVGGQMGVVPTAPNDPVFFLHHANVDRIWAVWQIIHRNQNYQPMKNGPFGQNFRDPMYPWNTTPEDVMNHRKLGYVYDIEL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Bacillus megaterium
molecule keywords Tyrosinase
total genus 107
structure length 287
sequence length 287
chains with identical sequence B
ec nomenclature ec 1.14.18.1: Tyrosinase.
pdb deposition date 2014-03-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00264 Tyrosinase Common central domain of tyrosinase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1280.10 Mainly Alpha Orthogonal Bundle di-copper center containing domain from catechol oxidase Di-copper center containing domain from catechol oxidase 4p6rA00
4J3RA 3AWVA 3WJMA 3NQ5A 3GWJA 1OXYA 3NQ0A 2P3XA 1BUGA 5I38A 4J6TA 2AHLA 3QJOA 2Y9XA 4HD4A 4YZWA 2ZWFA 3AWSA 5I3AA 4J3QA 1NOLA 3NQ1A 1WXCA 4OUAA 3AX0A 3AWWA 3AWYA 4P6TA 3HHSB 1BT3A 3NTMA 4P6SA 4L37A 2ZMXA 3AWZA 3AWXA 1HC1A 1BT2A 4Z0YA 3WJMB 4Z0ZA 4P6RA 4J3PA 2ZMZA 3NPYA 3W6WA 5CE9A 3HHSA 1WX4A 2Y9WA 2ZWEA 1LNLA 2AHKA 4D87A 5I3BA 1WX5A 1LLAA 1LL1A 2ZWGA 4OUAB 4Z10A 1HCYA 1WX2A 1BT1A 3NM8A 4J6UA 4L37B 4HD6A 4HD7A 2ZWDA 3AWUA 3WKYA 1JS8A 2ZMYA 3W6QA 3AWTA 4J6VA
chains in the Genus database with same CATH superfamily
4J3RA 3AWVA 3WJMA 3NQ5A 3GWJA 1OXYA 3NQ0A 2P3XA 1BUGA 5I38A 4J6TA 2AHLA 3QJOA 2Y9XA 4HD4A 4YZWA 2ZWFA 3AWSA 5I3AA 4J3QA 1NOLA 3NQ1A 1WXCA 4OUAA 3AX0A 3AWWA 3AWYA 4P6TA 3HHSB 1BT3A 3NTMA 4P6SA 4L37A 2ZMXA 3AWZA 3AWXA 1HC1A 1BT2A 4Z0YA 3WJMB 4Z0ZA 4P6RA 4J3PA 2ZMZA 3NPYA 3W6WA 5CE9A 3HHSA 1WX4A 2Y9WA 2ZWEA 1LNLA 2AHKA 4D87A 5I3BA 1WX5A 1LLAA 1LL1A 2ZWGA 4OUAB 4Z10A 1HCYA 1WX2A 1BT1A 3NM8A 4J6UA 4L37B 4HD6A 4HD7A 2ZWDA 3AWUA 3WKYA 1JS8A 2ZMYA 3W6QA 3AWTA 4J6VA
chains in the Genus database with same CATH topology
4J3RA 3AWVA 3WJMA 3NQ5A 3GWJA 1OXYA 3NQ0A 2P3XA 1BUGA 5I38A 4J6TA 2AHLA 3QJOA 2Y9XA 4HD4A 4YZWA 2ZWFA 3AWSA 5I3AA 4J3QA 1NOLA 3NQ1A 1WXCA 4OUAA 3AX0A 3AWWA 3AWYA 4P6TA 3HHSB 1BT3A 3NTMA 4P6SA 4L37A 2ZMXA 3AWZA 3AWXA 1HC1A 1BT2A 4Z0YA 3WJMB 4Z0ZA 4P6RA 4J3PA 2ZMZA 3NPYA 3W6WA 5CE9A 3HHSA 1WX4A 2Y9WA 2ZWEA 1LNLA 2AHKA 4D87A 5I3BA 1WX5A 1LLAA 1LL1A 2ZWGA 4OUAB 4Z10A 1HCYA 1WX2A 1BT1A 3NM8A 4J6UA 4L37B 4HD6A 4HD7A 2ZWDA 3AWUA 3WKYA 1JS8A 2ZMYA 3W6QA 3AWTA 4J6VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J3R A;  3AWV A;  3WJM A;  3NQ5 A;  3GWJ A;  1OXY A;  3NQ0 A;  2P3X A;  1BUG A;  5I38 A;  4J6T A;  2AHL A;  3QJO A;  2Y9X A;  4HD4 A;  4YZW A;  2ZWF A;  3AWS A;  5I3A A;  4J3Q A;  1NOL A;  3NQ1 A;  1WXC A;  4OUA A;  3AX0 A;  3AWW A;  3AWY A;  4P6T A;  3HHS B;  1BT3 A;  3NTM A;  4P6S A;  4L37 A;  2ZMX A;  3AWZ A;  3AWX A;  1HC1 A;  1BT2 A;  4Z0Y A;  3WJM B;  4Z0Z A;  4P6R A;  4J3P A;  2ZMZ A;  3NPY A;  3W6W A;  5CE9 A;  3HHS A;  1WX4 A;  2Y9W A;  2ZWE A;  1LNL A;  2AHK A;  4D87 A;  5I3B A;  1WX5 A;  1LLA A;  1LL1 A;  2ZWG A;  4OUA B;  4Z10 A;  1HCY A;  1WX2 A;  1BT1 A;  3NM8 A;  4J6U A;  4L37 B;  4HD6 A;  4HD7 A;  2ZWD A;  3AWU A;  3WKY A;  1JS8 A;  2ZMY A;  3W6Q A;  3AWT A;  4J6V A; 
#chains in the Genus database with same CATH topology
 4J3R A;  3AWV A;  3WJM A;  3NQ5 A;  3GWJ A;  1OXY A;  3NQ0 A;  2P3X A;  1BUG A;  5I38 A;  4J6T A;  2AHL A;  3QJO A;  2Y9X A;  4HD4 A;  4YZW A;  2ZWF A;  3AWS A;  5I3A A;  4J3Q A;  1NOL A;  3NQ1 A;  1WXC A;  4OUA A;  3AX0 A;  3AWW A;  3AWY A;  4P6T A;  3HHS B;  1BT3 A;  3NTM A;  4P6S A;  4L37 A;  2ZMX A;  3AWZ A;  3AWX A;  1HC1 A;  1BT2 A;  4Z0Y A;  3WJM B;  4Z0Z A;  4P6R A;  4J3P A;  2ZMZ A;  3NPY A;  3W6W A;  5CE9 A;  3HHS A;  1WX4 A;  2Y9W A;  2ZWE A;  1LNL A;  2AHK A;  4D87 A;  5I3B A;  1WX5 A;  1LLA A;  1LL1 A;  2ZWG A;  4OUA B;  4Z10 A;  1HCY A;  1WX2 A;  1BT1 A;  3NM8 A;  4J6U A;  4L37 B;  4HD6 A;  4HD7 A;  2ZWD A;  3AWU A;  3WKY A;  1JS8 A;  2ZMY A;  3W6Q A;  3AWT A;  4J6V A; 
#chains in the Genus database with same CATH homology
 4J3R A;  3AWV A;  3WJM A;  3NQ5 A;  3GWJ A;  1OXY A;  3NQ0 A;  2P3X A;  1BUG A;  5I38 A;  4J6T A;  2AHL A;  3QJO A;  2Y9X A;  4HD4 A;  4YZW A;  2ZWF A;  3AWS A;  5I3A A;  4J3Q A;  1NOL A;  3NQ1 A;  1WXC A;  4OUA A;  3AX0 A;  3AWW A;  3AWY A;  4P6T A;  3HHS B;  1BT3 A;  3NTM A;  4P6S A;  4L37 A;  2ZMX A;  3AWZ A;  3AWX A;  1HC1 A;  1BT2 A;  4Z0Y A;  3WJM B;  4Z0Z A;  4P6R A;  4J3P A;  2ZMZ A;  3NPY A;  3W6W A;  5CE9 A;  3HHS A;  1WX4 A;  2Y9W A;  2ZWE A;  1LNL A;  2AHK A;  4D87 A;  5I3B A;  1WX5 A;  1LLA A;  1LL1 A;  2ZWG A;  4OUA B;  4Z10 A;  1HCY A;  1WX2 A;  1BT1 A;  3NM8 A;  4J6U A;  4L37 B;  4HD6 A;  4HD7 A;  2ZWD A;  3AWU A;  3WKY A;  1JS8 A;  2ZMY A;  3W6Q A;  3AWT A;  4J6V A; 
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similar chains in the Genus database (?% sequence similarity)
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