4P6SA

Crystal structure of tyrosinase from bacillus megaterium with l-dopa in the active site
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
286
structure length
286
Chain Sequence
YRVRKNVLHLTDTEKRDFVRTVLILKEKGIYDRYIAWHGAAGKFHTPPGSDRNAAHMSSAFLPWHREYLLRFERDLQSINPEVTLPYWEWETDAQMQDPSQSQIWSADFMGGNGNPIKDFIVDTGPFAAGRWTTIDEQGNPSGGLKRNFGATKEAPTLPTRDDVLNALKITQYDTPPWDMTSQNSFRNQLEGFINGPQLHNRVHRWVGGQMGVVPTAPNDPVFFLHHANVDRIWAVWQIIHRNQNYQPMKNGPFGQNFRDPMYPWNTTPEDVMNHRKLGYVYDIEL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
pubmed doi rcsb
molecule keywords Tyrosinase
molecule tags Oxidoreductase
source organism Bacillus megaterium
total genus 109
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature ec 1.14.18.1: Tyrosinase.
pdb deposition date 2014-03-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00264 Tyrosinase Common central domain of tyrosinase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1280.10 Mainly Alpha Orthogonal Bundle di-copper center containing domain from catechol oxidase Di-copper center containing domain from catechol oxidase 4p6sA00
1HC1A 5I3BA 2ZWDA 1WX5A 4J3RA 2ZMXA 2ZWEA 3NQ5A 4J6VA 3NQ1A 2ZWFA 2AHLA 3NPYA 5CE9A 1BT1A 1OXYA 3WJMA 4P6SA 1BUGA 4P6TA 3NTMA 4J3PA 3AWXA 5I38A 1BT2A 4HD7A 3AWWA 4HD4A 3AWZA 3AWVA 4Z0YA 3GWJA 3QJOA 3HHSB 3AWUA 3WKYA 4J6TA 2P3XA 3NQ0A 2ZWGA 4L37B 2Y9XA 3AWSA 4J3QA 2Y9WA 3W6QA 4J6UA 1WXCA 3AX0A 1LL1A 4HD6A 3AWTA 3HHSA 1BT3A 1HCYA 1LLAA 4OUAA 4OUAB 4L37A 3W6WA 1WX2A 4D87A 4Z10A 2ZMYA 2AHKA 2ZMZA 1WX4A 3NM8A 4YZWA 4Z0ZA 4P6RA 1NOLA 3AWYA 1JS8A 1LNLA 3WJMB 5I3AA
chains in the Genus database with same CATH superfamily
1HC1A 5I3BA 2ZWDA 1WX5A 4J3RA 2ZMXA 2ZWEA 3NQ5A 4J6VA 3NQ1A 2ZWFA 2AHLA 3NPYA 5CE9A 1BT1A 1OXYA 3WJMA 4P6SA 1BUGA 4P6TA 3NTMA 4J3PA 3AWXA 5I38A 1BT2A 4HD7A 3AWWA 4HD4A 3AWZA 3AWVA 4Z0YA 3GWJA 3QJOA 3HHSB 3AWUA 3WKYA 4J6TA 2P3XA 3NQ0A 2ZWGA 4L37B 2Y9XA 3AWSA 4J3QA 2Y9WA 3W6QA 4J6UA 1WXCA 3AX0A 1LL1A 4HD6A 3AWTA 3HHSA 1BT3A 1HCYA 1LLAA 4OUAA 4OUAB 4L37A 3W6WA 1WX2A 4D87A 4Z10A 2ZMYA 2AHKA 2ZMZA 1WX4A 3NM8A 4YZWA 4Z0ZA 4P6RA 1NOLA 3AWYA 1JS8A 1LNLA 3WJMB 5I3AA
chains in the Genus database with same CATH topology
1HC1A 5I3BA 2ZWDA 1WX5A 4J3RA 2ZMXA 2ZWEA 3NQ5A 4J6VA 3NQ1A 2ZWFA 2AHLA 3NPYA 5CE9A 1BT1A 1OXYA 3WJMA 4P6SA 1BUGA 4P6TA 3NTMA 4J3PA 3AWXA 5I38A 1BT2A 4HD7A 3AWWA 4HD4A 3AWZA 3AWVA 4Z0YA 3GWJA 3QJOA 3HHSB 3AWUA 3WKYA 4J6TA 2P3XA 3NQ0A 2ZWGA 4L37B 2Y9XA 3AWSA 4J3QA 2Y9WA 3W6QA 4J6UA 1WXCA 3AX0A 1LL1A 4HD6A 3AWTA 3HHSA 1BT3A 1HCYA 1LLAA 4OUAA 4OUAB 4L37A 3W6WA 1WX2A 4D87A 4Z10A 2ZMYA 2AHKA 2ZMZA 1WX4A 3NM8A 4YZWA 4Z0ZA 4P6RA 1NOLA 3AWYA 1JS8A 1LNLA 3WJMB 5I3AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HC1 A;  5I3B A;  2ZWD A;  1WX5 A;  4J3R A;  2ZMX A;  2ZWE A;  3NQ5 A;  4J6V A;  3NQ1 A;  2ZWF A;  2AHL A;  3NPY A;  5CE9 A;  1BT1 A;  1OXY A;  3WJM A;  4P6S A;  1BUG A;  4P6T A;  3NTM A;  4J3P A;  3AWX A;  5I38 A;  1BT2 A;  4HD7 A;  3AWW A;  4HD4 A;  3AWZ A;  3AWV A;  4Z0Y A;  3GWJ A;  3QJO A;  3HHS B;  3AWU A;  3WKY A;  4J6T A;  2P3X A;  3NQ0 A;  2ZWG A;  4L37 B;  2Y9X A;  3AWS A;  4J3Q A;  2Y9W A;  3W6Q A;  4J6U A;  1WXC A;  3AX0 A;  1LL1 A;  4HD6 A;  3AWT A;  3HHS A;  1BT3 A;  1HCY A;  1LLA A;  4OUA A;  4OUA B;  4L37 A;  3W6W A;  1WX2 A;  4D87 A;  4Z10 A;  2ZMY A;  2AHK A;  2ZMZ A;  1WX4 A;  3NM8 A;  4YZW A;  4Z0Z A;  4P6R A;  1NOL A;  3AWY A;  1JS8 A;  1LNL A;  3WJM B;  5I3A A; 
#chains in the Genus database with same CATH topology
 1HC1 A;  5I3B A;  2ZWD A;  1WX5 A;  4J3R A;  2ZMX A;  2ZWE A;  3NQ5 A;  4J6V A;  3NQ1 A;  2ZWF A;  2AHL A;  3NPY A;  5CE9 A;  1BT1 A;  1OXY A;  3WJM A;  4P6S A;  1BUG A;  4P6T A;  3NTM A;  4J3P A;  3AWX A;  5I38 A;  1BT2 A;  4HD7 A;  3AWW A;  4HD4 A;  3AWZ A;  3AWV A;  4Z0Y A;  3GWJ A;  3QJO A;  3HHS B;  3AWU A;  3WKY A;  4J6T A;  2P3X A;  3NQ0 A;  2ZWG A;  4L37 B;  2Y9X A;  3AWS A;  4J3Q A;  2Y9W A;  3W6Q A;  4J6U A;  1WXC A;  3AX0 A;  1LL1 A;  4HD6 A;  3AWT A;  3HHS A;  1BT3 A;  1HCY A;  1LLA A;  4OUA A;  4OUA B;  4L37 A;  3W6W A;  1WX2 A;  4D87 A;  4Z10 A;  2ZMY A;  2AHK A;  2ZMZ A;  1WX4 A;  3NM8 A;  4YZW A;  4Z0Z A;  4P6R A;  1NOL A;  3AWY A;  1JS8 A;  1LNL A;  3WJM B;  5I3A A; 
#chains in the Genus database with same CATH homology
 1HC1 A;  5I3B A;  2ZWD A;  1WX5 A;  4J3R A;  2ZMX A;  2ZWE A;  3NQ5 A;  4J6V A;  3NQ1 A;  2ZWF A;  2AHL A;  3NPY A;  5CE9 A;  1BT1 A;  1OXY A;  3WJM A;  4P6S A;  1BUG A;  4P6T A;  3NTM A;  4J3P A;  3AWX A;  5I38 A;  1BT2 A;  4HD7 A;  3AWW A;  4HD4 A;  3AWZ A;  3AWV A;  4Z0Y A;  3GWJ A;  3QJO A;  3HHS B;  3AWU A;  3WKY A;  4J6T A;  2P3X A;  3NQ0 A;  2ZWG A;  4L37 B;  2Y9X A;  3AWS A;  4J3Q A;  2Y9W A;  3W6Q A;  4J6U A;  1WXC A;  3AX0 A;  1LL1 A;  4HD6 A;  3AWT A;  3HHS A;  1BT3 A;  1HCY A;  1LLA A;  4OUA A;  4OUA B;  4L37 A;  3W6W A;  1WX2 A;  4D87 A;  4Z10 A;  2ZMY A;  2AHK A;  2ZMZ A;  1WX4 A;  3NM8 A;  4YZW A;  4Z0Z A;  4P6R A;  1NOL A;  3AWY A;  1JS8 A;  1LNL A;  3WJM B;  5I3A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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