4UU9C

Crystal structure of the human c5a in complex with medi7814 a neutralising antibody
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
65
structure length
65
Chain Sequence
STLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRAN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords MEDI7814
total genus 24
structure length 65
sequence length 65
chains with identical sequence D
ec nomenclature
pdb deposition date 2014-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01821 ANATO Anaphylotoxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.91.20 Mainly Alpha Up-down Bundle Influenza Virus Matrix Protein; Chain A, domain 1 Anaphylotoxins (complement system) 4uu9C00
4WB3A 4P3BA 1KJSA 1C5AA 4P3AA 4UU9C 4P39A 3KLSA 3HQAA 1CFAA 3HQBA 2B39A 4I6OA 4FXKB 5JPNB 4HWJA 5B4PB 3CU7A 2A73B 4HW5A 4WB2A
chains in the Genus database with same CATH superfamily
4IQ4A 4WB3A 1AA7A 5JPMB 4P3BA 1KJSA 1C5AA 4WB2A 4P3AA 4PUSA 3MD2A 4D9JA 4UU9C 5CQEA 4P39A 3KLSA 3HQAA 1CFAA 3HQBA 4FXGB 2B39A 2Z16A 4ITVA 4I6OA 4FXKB 4HWJA 5JPNB 5B4PB 3CU7A 2A73B 4HW5A 1EA3A 3VDXA
chains in the Genus database with same CATH topology
4WB3A 4P3BA 1KJSA 1C5AA 4P3AA 4UU9C 4P39A 3KLSA 3HQAA 1CFAA 3HQBA 2B39A 4I6OA 4FXKB 5JPNB 4HWJA 5B4PB 3CU7A 2A73B 4HW5A 4WB2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WB3 A;  4P3B A;  1KJS A;  1C5A A;  4P3A A;  4UU9 C;  4P39 A;  3KLS A;  3HQA A;  1CFA A;  3HQB A;  2B39 A;  4I6O A;  4FXK B;  5JPN B;  4HWJ A;  5B4P B;  3CU7 A;  2A73 B;  4HW5 A;  4WB2 A; 
#chains in the Genus database with same CATH topology
 4IQ4 A;  4WB3 A;  1AA7 A;  5JPM B;  4P3B A;  1KJS A;  1C5A A;  4WB2 A;  4P3A A;  4PUS A;  3MD2 A;  4D9J A;  4UU9 C;  5CQE A;  4P39 A;  3KLS A;  3HQA A;  1CFA A;  3HQB A;  4FXG B;  2B39 A;  2Z16 A;  4ITV A;  4I6O A;  4FXK B;  4HWJ A;  5JPN B;  5B4P B;  3CU7 A;  2A73 B;  4HW5 A;  1EA3 A;  3VDX A; 
#chains in the Genus database with same CATH homology
 4WB3 A;  4P3B A;  1KJS A;  1C5A A;  4P3A A;  4UU9 C;  4P39 A;  3KLS A;  3HQA A;  1CFA A;  3HQB A;  2B39 A;  4I6O A;  4FXK B;  5JPN B;  4HWJ A;  5B4P B;  3CU7 A;  2A73 B;  4HW5 A;  4WB2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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