4WB2A

Crystal structure of the mirror-image l-rna/l-dna aptamer nox-d20 in complex with mouse c5a complement anaphylatoxin
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
69
structure length
69
Chain Sequence
ANLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIRAFNECCTIANKIRKES
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
pubmed doi rcsb
molecule tags Dna-rna hybrid
source organism Mus musculus
molecule keywords Complement C5
total genus 27
structure length 69
sequence length 69
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-09-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01821 ANATO Anaphylotoxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.91.20 Mainly Alpha Up-down Bundle Influenza Virus Matrix Protein; Chain A, domain 1 Anaphylotoxins (complement system) 4wb2A00
2B39A 4I6OA 4P39A 4WB3A 3HQBA 1CFAA 4HW5A 4FXKB 3CU7A 4UU9C 2A73B 5JPNB 4HWJA 4P3AA 3HQAA 4WB2A 5B4PB 1KJSA 3KLSA 4P3BA 1C5AA
chains in the Genus database with same CATH superfamily
4FXGB 4ITVA 2B39A 5JPMB 4I6OA 4P39A 4WB3A 3HQBA 3MD2A 1C5AA 1AA7A 1CFAA 4HW5A 4FXKB 3CU7A 4PUSA 3VDXA 4UU9C 4D9JA 2A73B 5JPNB 4P3AA 5CQEA 3HQAA 2Z16A 4WB2A 1EA3A 5B4PB 1KJSA 4IQ4A 3KLSA 4P3BA 4HWJA
chains in the Genus database with same CATH topology
2B39A 4I6OA 4P39A 4WB3A 3HQBA 1CFAA 4HW5A 4FXKB 3CU7A 4UU9C 2A73B 5JPNB 4HWJA 4P3AA 3HQAA 4WB2A 5B4PB 1KJSA 3KLSA 4P3BA 1C5AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B39 A;  4I6O A;  4P39 A;  4WB3 A;  3HQB A;  1CFA A;  4HW5 A;  4FXK B;  3CU7 A;  4UU9 C;  2A73 B;  5JPN B;  4HWJ A;  4P3A A;  3HQA A;  4WB2 A;  5B4P B;  1KJS A;  3KLS A;  4P3B A;  1C5A A; 
#chains in the Genus database with same CATH topology
 4FXG B;  4ITV A;  2B39 A;  5JPM B;  4I6O A;  4P39 A;  4WB3 A;  3HQB A;  3MD2 A;  1C5A A;  1AA7 A;  1CFA A;  4HW5 A;  4FXK B;  3CU7 A;  4PUS A;  3VDX A;  4UU9 C;  4D9J A;  2A73 B;  5JPN B;  4P3A A;  5CQE A;  3HQA A;  2Z16 A;  4WB2 A;  1EA3 A;  5B4P B;  1KJS A;  4IQ4 A;  3KLS A;  4P3B A;  4HWJ A; 
#chains in the Genus database with same CATH homology
 2B39 A;  4I6O A;  4P39 A;  4WB3 A;  3HQB A;  1CFA A;  4HW5 A;  4FXK B;  3CU7 A;  4UU9 C;  2A73 B;  5JPN B;  4HWJ A;  4P3A A;  3HQA A;  4WB2 A;  5B4P B;  1KJS A;  3KLS A;  4P3B A;  1C5A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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