4WB3A

Crystal structure of the mirror-image l-rna/l-dna aptamer nox-d20 in complex with mouse c5a-desarg complement anaphylatoxin
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
68
structure length
68
Chain Sequence
NLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIRAFNECCTIANKIRKES
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
pubmed doi rcsb
molecule tags Dna-rna hybrid
source organism Mus musculus
molecule keywords Complement C5
total genus 26
structure length 68
sequence length 68
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-09-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01821 ANATO Anaphylotoxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.91.20 Mainly Alpha Up-down Bundle Influenza Virus Matrix Protein; Chain A, domain 1 Anaphylotoxins (complement system) 4wb3A00
4P3BA 1KJSA 3CU7A 4I6OA 5JPNB 3HQBA 4HWJA 4UU9C 3KLSA 1CFAA 4P3AA 2A73B 3HQAA 4WB2A 1C5AA 4WB3A 5B4PB 4FXKB 4HW5A 4P39A 2B39A
chains in the Genus database with same CATH superfamily
2Z16A 4D9JA 4ITVA 4P3BA 4IQ4A 1KJSA 3CU7A 4I6OA 5CQEA 5JPNB 3HQBA 4HWJA 4FXGB 1EA3A 4UU9C 3KLSA 5JPMB 1CFAA 4P3AA 2A73B 3HQAA 4WB2A 1C5AA 3VDXA 4PUSA 4WB3A 1AA7A 5B4PB 4FXKB 4HW5A 4P39A 2B39A 3MD2A
chains in the Genus database with same CATH topology
4P3BA 1KJSA 3CU7A 4I6OA 5JPNB 3HQBA 4HWJA 4UU9C 3KLSA 1CFAA 4P3AA 2A73B 3HQAA 4WB2A 1C5AA 4WB3A 5B4PB 4FXKB 4HW5A 4P39A 2B39A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4P3B A;  1KJS A;  3CU7 A;  4I6O A;  5JPN B;  3HQB A;  4HWJ A;  4UU9 C;  3KLS A;  1CFA A;  4P3A A;  2A73 B;  3HQA A;  4WB2 A;  1C5A A;  4WB3 A;  5B4P B;  4FXK B;  4HW5 A;  4P39 A;  2B39 A; 
#chains in the Genus database with same CATH topology
 2Z16 A;  4D9J A;  4ITV A;  4P3B A;  4IQ4 A;  1KJS A;  3CU7 A;  4I6O A;  5CQE A;  5JPN B;  3HQB A;  4HWJ A;  4FXG B;  1EA3 A;  4UU9 C;  3KLS A;  5JPM B;  1CFA A;  4P3A A;  2A73 B;  3HQA A;  4WB2 A;  1C5A A;  3VDX A;  4PUS A;  4WB3 A;  1AA7 A;  5B4P B;  4FXK B;  4HW5 A;  4P39 A;  2B39 A;  3MD2 A; 
#chains in the Genus database with same CATH homology
 4P3B A;  1KJS A;  3CU7 A;  4I6O A;  5JPN B;  3HQB A;  4HWJ A;  4UU9 C;  3KLS A;  1CFA A;  4P3A A;  2A73 B;  3HQA A;  4WB2 A;  1C5A A;  4WB3 A;  5B4P B;  4FXK B;  4HW5 A;  4P39 A;  2B39 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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