5AGUA

The sliding clamp of mycobacterium tuberculosis in complex with a natural product.
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
390
structure length
373
Chain Sequence
DLTFRLLRESFADAVSWVAKNLPVLSGVLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHVEGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDTLPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAGIGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMDVAELIEAIKLVALVAAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIAFNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGNGNGPFPAVSTDYVYLLMPVRLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins.
pubmed doi rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis h37rv
molecule keywords DNA POLYMERASE III SUBUNIT BETA
total genus 92
structure length 373
sequence length 390
chains with identical sequence B
ec nomenclature ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date 2015-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00712 DNA_pol3_beta DNA polymerase III beta subunit, N-terminal domain
A PF02767 DNA_pol3_beta_2 DNA polymerase III beta subunit, central domain
A PF02768 DNA_pol3_beta_3 DNA polymerase III beta subunit, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 5aguA01
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 5aguA02
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 5aguA03
3PWEA 1MMIA 4K74A 4K3LA 4PNVA 5AGUA 3L0WA 3D1EA 4TSZA 4OVFA 4OVHA 3Q4KA 4K3SA 4TR7A 4MJQA 3RB9A 3PGEB 4K3QA 3T0PA 4N95A 3D1GA 4K3RA 1JQJA 2POLA 4S3IA 1OK7A 2XURA 5FVEA 1VPKA 4MJPA 4N98A 4K3PA 4PNWA 5AH4A 3F1VA 4OVGA 4RKIA 3QSBB 3P16A 3L10A 2AWAA 4N94A 5FRQA 4N96A 4MJRA 5AGVA 1UNNA 4K3MA 4PNUA 4TR8A 3QSBA 1JQLA 3D1FA 3Q4JA 4TRTA 4TR6A 4N97A 3Q4LA 4K3OA 4K3KA 4N9AA 3L0XA 3BEPA 4N99A 2AVTA 5AH2A
chains in the Genus database with same CATH superfamily
3PWEA 1MMIA 4K74A 4K3LA 4PNVA 5AGUA 3L0WA 3D1EA 4TSZA 4OVFA 4OVHA 3Q4KA 4K3SA 4TR7A 4MJQA 3RB9A 3PGEB 4K3QA 3T0PA 4N95A 3D1GA 4K3RA 1JQJA 2POLA 4S3IA 1OK7A 2XURA 3L10B 5FVEA 1VPKA 4MJPA 4N98A 3PGEA 4K3PA 4PNWA 5AH4A 3F1VA 4OVGA 4RKIA 3QSBB 3P16A 3L10A 2AWAA 4N94A 5FRQA 4N96A 4MJRA 5AGVA 1UNNA 3L0XB 4K3MA 4PNUA 4TR8A 3QSBA 1JQLA 3D1FA 3Q4JA 4TRTA 4TR6A 4N97A 3Q4LA 4K3OA 4K3KA 3L0WB 3L0XA 4N9AA 3BEPA 4N99A 2AVTA 5AH2A
chains in the Genus database with same CATH topology
3PWEA 1MMIA 4K74A 4K3LA 4PNVA 5AGUA 3L0WA 3D1EA 4TSZA 4OVFA 4OVHA 3Q4KA 4K3SA 4TR7A 4MJQA 3RB9A 3PGEB 4K3QA 3T0PA 4N95A 3D1GA 4K3RA 1JQJA 2POLA 4S3IA 1OK7A 2XURA 5FVEA 1VPKA 4MJPA 4N98A 4K3PA 4PNWA 5AH4A 3F1VA 4OVGA 4RKIA 3QSBB 3P16A 3L10A 2AWAA 4N94A 5FRQA 4N96A 4MJRA 5AGVA 1UNNA 4K3MA 4PNUA 4TR8A 3QSBA 1JQLA 3D1FA 3Q4JA 4TRTA 4TR6A 4N97A 3Q4LA 4K3OA 4K3KA 4N9AA 3L0XA 3BEPA 4N99A 2AVTA 5AH2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PWE A;  1MMI A;  4K74 A;  4K3L A;  4PNV A;  5AGU A;  3L0W A;  3D1E A;  4TSZ A;  4OVF A;  4OVH A;  3Q4K A;  4K3S A;  4TR7 A;  4MJQ A;  3RB9 A;  3PGE B;  4K3Q A;  3T0P A;  4N95 A;  3D1G A;  4K3R A;  1JQJ A;  2POL A;  4S3I A;  1OK7 A;  2XUR A;  5FVE A;  1VPK A;  4MJP A;  4N98 A;  4K3P A;  4PNW A;  5AH4 A;  3F1V A;  4OVG A;  4RKI A;  3QSB B;  3P16 A;  3L10 A;  2AWA A;  4N94 A;  5FRQ A;  4N96 A;  4MJR A;  5AGV A;  1UNN A;  4K3M A;  4PNU A;  4TR8 A;  3QSB A;  1JQL A;  3D1F A;  3Q4J A;  4TRT A;  4TR6 A;  4N97 A;  3Q4L A;  4K3O A;  4K3K A;  4N9A A;  3L0X A;  3BEP A;  4N99 A;  2AVT A;  5AH2 A; 
#chains in the Genus database with same CATH topology
 3PWE A;  1MMI A;  4K74 A;  4K3L A;  4PNV A;  5AGU A;  3L0W A;  3D1E A;  4TSZ A;  4OVF A;  4OVH A;  3Q4K A;  4K3S A;  4TR7 A;  4MJQ A;  3RB9 A;  3PGE B;  4K3Q A;  3T0P A;  4N95 A;  3D1G A;  4K3R A;  1JQJ A;  2POL A;  4S3I A;  1OK7 A;  2XUR A;  3L10 B;  5FVE A;  1VPK A;  4MJP A;  4N98 A;  3PGE A;  4K3P A;  4PNW A;  5AH4 A;  3F1V A;  4OVG A;  4RKI A;  3QSB B;  3P16 A;  3L10 A;  2AWA A;  4N94 A;  5FRQ A;  4N96 A;  4MJR A;  5AGV A;  1UNN A;  3L0X B;  4K3M A;  4PNU A;  4TR8 A;  3QSB A;  1JQL A;  3D1F A;  3Q4J A;  4TRT A;  4TR6 A;  4N97 A;  3Q4L A;  4K3O A;  4K3K A;  3L0W B;  3L0X A;  4N9A A;  3BEP A;  4N99 A;  2AVT A;  5AH2 A; 
#chains in the Genus database with same CATH homology
 3PWE A;  1MMI A;  4K74 A;  4K3L A;  4PNV A;  5AGU A;  3L0W A;  3D1E A;  4TSZ A;  4OVF A;  4OVH A;  3Q4K A;  4K3S A;  4TR7 A;  4MJQ A;  3RB9 A;  3PGE B;  4K3Q A;  3T0P A;  4N95 A;  3D1G A;  4K3R A;  1JQJ A;  2POL A;  4S3I A;  1OK7 A;  2XUR A;  5FVE A;  1VPK A;  4MJP A;  4N98 A;  4K3P A;  4PNW A;  5AH4 A;  3F1V A;  4OVG A;  4RKI A;  3QSB B;  3P16 A;  3L10 A;  2AWA A;  4N94 A;  5FRQ A;  4N96 A;  4MJR A;  5AGV A;  1UNN A;  4K3M A;  4PNU A;  4TR8 A;  3QSB A;  1JQL A;  3D1F A;  3Q4J A;  4TRT A;  4TR6 A;  4N97 A;  3Q4L A;  4K3O A;  4K3K A;  4N9A A;  3L0X A;  3BEP A;  4N99 A;  2AVT A;  5AH2 A; 
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similar chains in the Genus database (?% sequence similarity)
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