5AH2A

The sliding clamp of mycobacterium smegmatis in complex with a natural product.
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
388
structure length
380
Chain Sequence
TDLKFRVVREDFADAVAWVARSLPTRPTIPVLAGVLLTGTDEGLTISGFDYEVSAEVKVSAEIASAGSVLVSGRLLSDITKALPAKPVEVSVEGTRVSLTCGSARFSLPTLAVEDYPALPALPEETGVIASDLFAEAIGQVAVAAGRLPMLTGIRVEISGESVVLAATDRFRLAVRELTWVTTAGDVEAAVLVPAKTLAEAAKAGTDGNQVHLALGSGASVGKDGLLGIRSEGKRSTTRLLDAEFPKFRQLLPAEHTAVATIGVAELTEAIKRVALVADRGAQIRMEFSDDTLKLSAGADDVGRAEEDLPVDFAGEPLTIAFNPTYLTDGLGSLHSERVTFGFTTPSRPAVLRPAGEGGSGPFPAAKTDYVYLLMPVRLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins.
pubmed doi rcsb
molecule tags Transferase/antibiotic
source organism Mycobacterium smegmatis
molecule keywords DNA POLYMERASE III SUBUNIT BETA
total genus 85
structure length 380
sequence length 388
chains with identical sequence B, C, D
ec nomenclature ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date 2015-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00712 DNA_pol3_beta DNA polymerase III beta subunit, N-terminal domain
A PF02767 DNA_pol3_beta_2 DNA polymerase III beta subunit, central domain
A PF02768 DNA_pol3_beta_3 DNA polymerase III beta subunit, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 5ah2A01
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 5ah2A02
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 5ah2A03
3D1GA 4N9AA 4TR6A 4MJQA 3T0PA 1UNNA 2AVTA 3L0WA 5AGUA 5FVEA 1MMIA 3P16A 3D1FA 2XURA 4MJPA 3QSBA 4N94A 4N99A 3Q4JA 1VPKA 4PNUA 4MJRA 4RKIA 1OK7A 4S3IA 3BEPA 4TSZA 4OVFA 4K3LA 4PNVA 3QSBB 3D1EA 3RB9A 3PWEA 4OVGA 4N96A 3Q4LA 3L10A 5FRQA 4K3OA 3Q4KA 2POLA 4N98A 4TR7A 5AH4A 3L0XA 4TR8A 4K3SA 4OVHA 4N97A 4N95A 4PNWA 5AGVA 1JQLA 4K3PA 4K3MA 4TRTA 5AH2A 4K3KA 4K74A 4K3RA 2AWAA 3F1VA 1JQJA 3PGEB 4K3QA
chains in the Genus database with same CATH superfamily
3D1GA 4N9AA 4TR6A 4MJQA 3T0PA 1UNNA 2AVTA 3L0WA 5AGUA 5FVEA 1MMIA 3P16A 3D1FA 2XURA 4MJPA 3QSBA 4N94A 4N99A 3Q4JA 1VPKA 4PNUA 4MJRA 4RKIA 3L0WB 1OK7A 4S3IA 3BEPA 4TSZA 4OVFA 4K3LA 4PNVA 3QSBB 3D1EA 3RB9A 3PWEA 4OVGA 4N96A 3Q4LA 3L10A 5FRQA 4K3OA 3Q4KA 2POLA 4N98A 4TR7A 5AH4A 3L0XA 4TR8A 4K3SA 4OVHA 4N97A 4N95A 4PNWA 5AGVA 3PGEA 1JQLA 4K3PA 4K3MA 4TRTA 5AH2A 4K3KA 4K74A 3L10B 4K3RA 3L0XB 2AWAA 3F1VA 1JQJA 3PGEB 4K3QA
chains in the Genus database with same CATH topology
3D1GA 4N9AA 4TR6A 4MJQA 3T0PA 1UNNA 2AVTA 3L0WA 5AGUA 5FVEA 1MMIA 3P16A 3D1FA 2XURA 4MJPA 3QSBA 4N94A 4N99A 3Q4JA 1VPKA 4PNUA 4MJRA 4RKIA 1OK7A 4S3IA 3BEPA 4TSZA 4OVFA 4K3LA 4PNVA 3QSBB 3D1EA 3RB9A 3PWEA 4OVGA 4N96A 3Q4LA 3L10A 5FRQA 4K3OA 3Q4KA 2POLA 4N98A 4TR7A 5AH4A 3L0XA 4TR8A 4K3SA 4OVHA 4N97A 4N95A 4PNWA 5AGVA 1JQLA 4K3PA 4K3MA 4TRTA 5AH2A 4K3KA 4K74A 4K3RA 2AWAA 3F1VA 1JQJA 3PGEB 4K3QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3D1G A;  4N9A A;  4TR6 A;  4MJQ A;  3T0P A;  1UNN A;  2AVT A;  3L0W A;  5AGU A;  5FVE A;  1MMI A;  3P16 A;  3D1F A;  2XUR A;  4MJP A;  3QSB A;  4N94 A;  4N99 A;  3Q4J A;  1VPK A;  4PNU A;  4MJR A;  4RKI A;  1OK7 A;  4S3I A;  3BEP A;  4TSZ A;  4OVF A;  4K3L A;  4PNV A;  3QSB B;  3D1E A;  3RB9 A;  3PWE A;  4OVG A;  4N96 A;  3Q4L A;  3L10 A;  5FRQ A;  4K3O A;  3Q4K A;  2POL A;  4N98 A;  4TR7 A;  5AH4 A;  3L0X A;  4TR8 A;  4K3S A;  4OVH A;  4N97 A;  4N95 A;  4PNW A;  5AGV A;  1JQL A;  4K3P A;  4K3M A;  4TRT A;  5AH2 A;  4K3K A;  4K74 A;  4K3R A;  2AWA A;  3F1V A;  1JQJ A;  3PGE B;  4K3Q A; 
#chains in the Genus database with same CATH topology
 3D1G A;  4N9A A;  4TR6 A;  4MJQ A;  3T0P A;  1UNN A;  2AVT A;  3L0W A;  5AGU A;  5FVE A;  1MMI A;  3P16 A;  3D1F A;  2XUR A;  4MJP A;  3QSB A;  4N94 A;  4N99 A;  3Q4J A;  1VPK A;  4PNU A;  4MJR A;  4RKI A;  3L0W B;  1OK7 A;  4S3I A;  3BEP A;  4TSZ A;  4OVF A;  4K3L A;  4PNV A;  3QSB B;  3D1E A;  3RB9 A;  3PWE A;  4OVG A;  4N96 A;  3Q4L A;  3L10 A;  5FRQ A;  4K3O A;  3Q4K A;  2POL A;  4N98 A;  4TR7 A;  5AH4 A;  3L0X A;  4TR8 A;  4K3S A;  4OVH A;  4N97 A;  4N95 A;  4PNW A;  5AGV A;  3PGE A;  1JQL A;  4K3P A;  4K3M A;  4TRT A;  5AH2 A;  4K3K A;  4K74 A;  3L10 B;  4K3R A;  3L0X B;  2AWA A;  3F1V A;  1JQJ A;  3PGE B;  4K3Q A; 
#chains in the Genus database with same CATH homology
 3D1G A;  4N9A A;  4TR6 A;  4MJQ A;  3T0P A;  1UNN A;  2AVT A;  3L0W A;  5AGU A;  5FVE A;  1MMI A;  3P16 A;  3D1F A;  2XUR A;  4MJP A;  3QSB A;  4N94 A;  4N99 A;  3Q4J A;  1VPK A;  4PNU A;  4MJR A;  4RKI A;  1OK7 A;  4S3I A;  3BEP A;  4TSZ A;  4OVF A;  4K3L A;  4PNV A;  3QSB B;  3D1E A;  3RB9 A;  3PWE A;  4OVG A;  4N96 A;  3Q4L A;  3L10 A;  5FRQ A;  4K3O A;  3Q4K A;  2POL A;  4N98 A;  4TR7 A;  5AH4 A;  3L0X A;  4TR8 A;  4K3S A;  4OVH A;  4N97 A;  4N95 A;  4PNW A;  5AGV A;  1JQL A;  4K3P A;  4K3M A;  4TRT A;  5AH2 A;  4K3K A;  4K74 A;  4K3R A;  2AWA A;  3F1V A;  1JQJ A;  3PGE B;  4K3Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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