5AH2A

The sliding clamp of mycobacterium smegmatis in complex with a natural product.
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
388
structure length
380
Chain Sequence
TDLKFRVVREDFADAVAWVARSLPTRPTIPVLAGVLLTGTDEGLTISGFDYEVSAEVKVSAEIASAGSVLVSGRLLSDITKALPAKPVEVSVEGTRVSLTCGSARFSLPTLAVEDYPALPALPEETGVIASDLFAEAIGQVAVAAGRLPMLTGIRVEISGESVVLAATDRFRLAVRELTWVTTAGDVEAAVLVPAKTLAEAAKAGTDGNQVHLALGSGASVGKDGLLGIRSEGKRSTTRLLDAEFPKFRQLLPAEHTAVATIGVAELTEAIKRVALVADRGAQIRMEFSDDTLKLSAGADDVGRAEEDLPVDFAGEPLTIAFNPTYLTDGLGSLHSERVTFGFTTPSRPAVLRPAGEGGSGPFPAAKTDYVYLLMPVRLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins.
pubmed doi rcsb
molecule tags Transferase/antibiotic
source organism Mycobacterium smegmatis
molecule keywords DNA POLYMERASE III SUBUNIT BETA
total genus 85
structure length 380
sequence length 388
chains with identical sequence B, C, D
ec nomenclature ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date 2015-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00712 DNA_pol3_beta DNA polymerase III beta subunit, N-terminal domain
A PF02767 DNA_pol3_beta_2 DNA polymerase III beta subunit, central domain
A PF02768 DNA_pol3_beta_3 DNA polymerase III beta subunit, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 5ah2A01
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 5ah2A02
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 5ah2A03
3L0WA 4PNVA 2AWAA 4TR8A 4MJQA 4OVHA 5FRQA 4RKIA 3QSBA 3Q4LA 3T0PA 3Q4JA 4K3KA 4MJPA 3D1EA 5FVEA 3D1FA 3PGEB 4K3OA 1JQLA 5AH2A 4K3LA 3BEPA 3L0XA 4K3QA 2POLA 4N94A 4N97A 1VPKA 4TR7A 1MMIA 1UNNA 4K3MA 4TR6A 5AGUA 4OVGA 4K74A 3P16A 4N99A 4K3SA 3QSBB 1JQJA 3L10A 4N98A 4N95A 3RB9A 3D1GA 2XURA 4PNUA 4N96A 4MJRA 5AH4A 4OVFA 4N9AA 4K3RA 4S3IA 4PNWA 3Q4KA 4K3PA 3PWEA 2AVTA 4TSZA 4TRTA 3F1VA 1OK7A 5AGVA
chains in the Genus database with same CATH superfamily
3L0WA 4PNVA 2AWAA 4TR8A 4MJQA 4OVHA 5FRQA 3L10B 3QSBA 4RKIA 4TSZA 3Q4LA 3T0PA 3Q4JA 4K3KA 4MJPA 3D1EA 5FVEA 3D1FA 3PGEB 4K3OA 1JQLA 5AH2A 4K3LA 3BEPA 3L0XA 4K3QA 2POLA 3L0WB 4N94A 1VPKA 4N97A 4TR7A 1MMIA 1UNNA 4K3MA 4TR6A 5AGUA 4OVGA 4K74A 3P16A 4N99A 4K3SA 3QSBB 1JQJA 3L10A 4N98A 4N95A 3RB9A 3D1GA 2XURA 4PNUA 4N96A 4MJRA 5AH4A 4OVFA 4N9AA 4K3RA 3PGEA 4PNWA 3Q4KA 4K3PA 3PWEA 4S3IA 2AVTA 3L0XB 4TRTA 3F1VA 1OK7A 5AGVA
chains in the Genus database with same CATH topology
3L0WA 4PNVA 2AWAA 4TR8A 4MJQA 4OVHA 5FRQA 4RKIA 3QSBA 3Q4LA 3T0PA 3Q4JA 4K3KA 4MJPA 3D1EA 5FVEA 3D1FA 3PGEB 4K3OA 1JQLA 5AH2A 4K3LA 3BEPA 3L0XA 4K3QA 2POLA 4N94A 4N97A 1VPKA 4TR7A 1MMIA 1UNNA 4K3MA 4TR6A 5AGUA 4OVGA 4K74A 3P16A 4N99A 4K3SA 3QSBB 1JQJA 3L10A 4N98A 4N95A 3RB9A 3D1GA 2XURA 4PNUA 4N96A 4MJRA 5AH4A 4OVFA 4N9AA 4K3RA 4S3IA 4PNWA 3Q4KA 4K3PA 3PWEA 2AVTA 4TSZA 4TRTA 3F1VA 1OK7A 5AGVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3L0W A;  4PNV A;  2AWA A;  4TR8 A;  4MJQ A;  4OVH A;  5FRQ A;  4RKI A;  3QSB A;  3Q4L A;  3T0P A;  3Q4J A;  4K3K A;  4MJP A;  3D1E A;  5FVE A;  3D1F A;  3PGE B;  4K3O A;  1JQL A;  5AH2 A;  4K3L A;  3BEP A;  3L0X A;  4K3Q A;  2POL A;  4N94 A;  4N97 A;  1VPK A;  4TR7 A;  1MMI A;  1UNN A;  4K3M A;  4TR6 A;  5AGU A;  4OVG A;  4K74 A;  3P16 A;  4N99 A;  4K3S A;  3QSB B;  1JQJ A;  3L10 A;  4N98 A;  4N95 A;  3RB9 A;  3D1G A;  2XUR A;  4PNU A;  4N96 A;  4MJR A;  5AH4 A;  4OVF A;  4N9A A;  4K3R A;  4S3I A;  4PNW A;  3Q4K A;  4K3P A;  3PWE A;  2AVT A;  4TSZ A;  4TRT A;  3F1V A;  1OK7 A;  5AGV A; 
#chains in the Genus database with same CATH topology
 3L0W A;  4PNV A;  2AWA A;  4TR8 A;  4MJQ A;  4OVH A;  5FRQ A;  3L10 B;  3QSB A;  4RKI A;  4TSZ A;  3Q4L A;  3T0P A;  3Q4J A;  4K3K A;  4MJP A;  3D1E A;  5FVE A;  3D1F A;  3PGE B;  4K3O A;  1JQL A;  5AH2 A;  4K3L A;  3BEP A;  3L0X A;  4K3Q A;  2POL A;  3L0W B;  4N94 A;  1VPK A;  4N97 A;  4TR7 A;  1MMI A;  1UNN A;  4K3M A;  4TR6 A;  5AGU A;  4OVG A;  4K74 A;  3P16 A;  4N99 A;  4K3S A;  3QSB B;  1JQJ A;  3L10 A;  4N98 A;  4N95 A;  3RB9 A;  3D1G A;  2XUR A;  4PNU A;  4N96 A;  4MJR A;  5AH4 A;  4OVF A;  4N9A A;  4K3R A;  3PGE A;  4PNW A;  3Q4K A;  4K3P A;  3PWE A;  4S3I A;  2AVT A;  3L0X B;  4TRT A;  3F1V A;  1OK7 A;  5AGV A; 
#chains in the Genus database with same CATH homology
 3L0W A;  4PNV A;  2AWA A;  4TR8 A;  4MJQ A;  4OVH A;  5FRQ A;  4RKI A;  3QSB A;  3Q4L A;  3T0P A;  3Q4J A;  4K3K A;  4MJP A;  3D1E A;  5FVE A;  3D1F A;  3PGE B;  4K3O A;  1JQL A;  5AH2 A;  4K3L A;  3BEP A;  3L0X A;  4K3Q A;  2POL A;  4N94 A;  4N97 A;  1VPK A;  4TR7 A;  1MMI A;  1UNN A;  4K3M A;  4TR6 A;  5AGU A;  4OVG A;  4K74 A;  3P16 A;  4N99 A;  4K3S A;  3QSB B;  1JQJ A;  3L10 A;  4N98 A;  4N95 A;  3RB9 A;  3D1G A;  2XUR A;  4PNU A;  4N96 A;  4MJR A;  5AH4 A;  4OVF A;  4N9A A;  4K3R A;  4S3I A;  4PNW A;  3Q4K A;  4K3P A;  3PWE A;  2AVT A;  4TSZ A;  4TRT A;  3F1V A;  1OK7 A;  5AGV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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