5FVEA

Crystal structure of helicobacter pylori beta clamp in complex with 3, 4-difluorobenzamide
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
374
structure length
367
Chain Sequence
MKISVSKNDLENALRYLQAFLDKKDASSIASHIHLEVIKEKLFLKASDSDIGLKSYIFTQSSDKEGVGTINGKKFLDIISCLKDSNIILETKDDSLAIKQNKSSFKLPMFDADEFPEFPVIDPKVSIEVNAPFLVDAFKKIAPVIEQTSHKRELAGILMQFDQKHQTLSVVGTDTKRLSYTQLEKISIHSTEEDISCILPKRALLEILKLFYENFSFKSDGMLAVIENEMHTFFTKLIDGNYPDYQKILPKEYISSFTLGKEEFKESIKLCSSLSSTIKLTLEKNNALFESLDSEHSETAKTSVEIEKGLDIEKAFHLGVNAKFFLEALNALGTTQFVLRCNEPSSPFLIQESLNAKISTLMMPITL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Screening of E. coli beta-clamp Inhibitors Revealed that Few Inhibit Helicobacter pylori More Effectively: Structural and Functional Characterization.
pubmed doi rcsb
molecule tags Transferase
source organism Helicobacter pylori
molecule keywords DNA POLYMERASE III SUBUNIT BETA
total genus 87
structure length 367
sequence length 374
ec nomenclature ec 2.7.7.7: DNA-directed DNA polymerase.
pdb deposition date 2016-02-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00712 DNA_pol3_beta DNA polymerase III beta subunit, N-terminal domain
A PF02767 DNA_pol3_beta_2 DNA polymerase III beta subunit, central domain
A PF02768 DNA_pol3_beta_3 DNA polymerase III beta subunit, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.150.10 Alpha Beta Roll DNA Polymerase III; Chain A, domain 2 DNA Polymerase III, subunit A, domain 2 5fveA02
3T0PA 3Q4LA 4N98A 5FVEA 4TR8A 4N97A 4PNUA 3F1VA 3QSBB 4N94A 4K3LA 3BEPA 3D1GA 4TR6A 3L0XA 5AGUA 2XURA 1MMIA 3P16A 4K3KA 4K3OA 4MJRA 4PNWA 4OVGA 3PGEB 1JQJA 3PWEA 4PNVA 4RKIA 4K3RA 4K3MA 4MJQA 4K3PA 2AWAA 3L10A 4N96A 3L0WA 4OVFA 1UNNA 4MJPA 5AGVA 2POLA 3D1EA 3Q4JA 1JQLA 4S3IA 4K74A 1VPKA 3QSBA 4TR7A 3Q4KA 1OK7A 4TRTA 5AH2A 4TSZA 4OVHA 4N95A 3RB9A 5FRQA 5AH4A 4K3QA 3D1FA 4N99A 2AVTA 4K3SA 4N9AA
chains in the Genus database with same CATH superfamily
3T0PA 3Q4LA 4N98A 5FVEA 4TR8A 4N97A 4PNUA 3F1VA 3QSBB 4N94A 4K3LA 3BEPA 3D1GA 4TR6A 3L0XA 5AGUA 2XURA 1MMIA 3P16A 4K3KA 4K3OA 4MJRA 4PNWA 4OVGA 3PGEB 1JQJA 3PWEA 4PNVA 4RKIA 4K3RA 4K3MA 4MJQA 4K3PA 2AWAA 3L10A 4N96A 3L0WA 4OVFA 1UNNA 4MJPA 5AGVA 2POLA 3D1EA 3Q4JA 1JQLA 4S3IA 4K74A 1VPKA 3L0XB 3QSBA 3Q4KA 1OK7A 4TR7A 4TRTA 5AH2A 4TSZA 4OVHA 4N95A 3RB9A 5FRQA 5AH4A 4K3QA 3D1FA 4N99A 3L10B 3PGEA 2AVTA 3L0WB 4K3SA 4N9AA
chains in the Genus database with same CATH topology
3T0PA 3Q4LA 4N98A 5FVEA 4TR8A 4N97A 4PNUA 3F1VA 3QSBB 4N94A 4K3LA 3BEPA 3D1GA 4TR6A 3L0XA 5AGUA 2XURA 1MMIA 3P16A 4K3KA 4K3OA 4MJRA 4PNWA 4OVGA 3PGEB 1JQJA 3PWEA 4PNVA 4RKIA 4K3RA 4K3MA 4MJQA 4K3PA 2AWAA 3L10A 4N96A 3L0WA 4OVFA 1UNNA 4MJPA 5AGVA 2POLA 3D1EA 3Q4JA 1JQLA 4S3IA 4K74A 1VPKA 3QSBA 4TR7A 3Q4KA 1OK7A 4TRTA 5AH2A 4TSZA 4OVHA 4N95A 3RB9A 5FRQA 5AH4A 4K3QA 3D1FA 4N99A 2AVTA 4K3SA 4N9AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T0P A;  3Q4L A;  4N98 A;  5FVE A;  4TR8 A;  4N97 A;  4PNU A;  3F1V A;  3QSB B;  4N94 A;  4K3L A;  3BEP A;  3D1G A;  4TR6 A;  3L0X A;  5AGU A;  2XUR A;  1MMI A;  3P16 A;  4K3K A;  4K3O A;  4MJR A;  4PNW A;  4OVG A;  3PGE B;  1JQJ A;  3PWE A;  4PNV A;  4RKI A;  4K3R A;  4K3M A;  4MJQ A;  4K3P A;  2AWA A;  3L10 A;  4N96 A;  3L0W A;  4OVF A;  1UNN A;  4MJP A;  5AGV A;  2POL A;  3D1E A;  3Q4J A;  1JQL A;  4S3I A;  4K74 A;  1VPK A;  3QSB A;  4TR7 A;  3Q4K A;  1OK7 A;  4TRT A;  5AH2 A;  4TSZ A;  4OVH A;  4N95 A;  3RB9 A;  5FRQ A;  5AH4 A;  4K3Q A;  3D1F A;  4N99 A;  2AVT A;  4K3S A;  4N9A A; 
#chains in the Genus database with same CATH topology
 3T0P A;  3Q4L A;  4N98 A;  5FVE A;  4TR8 A;  4N97 A;  4PNU A;  3F1V A;  3QSB B;  4N94 A;  4K3L A;  3BEP A;  3D1G A;  4TR6 A;  3L0X A;  5AGU A;  2XUR A;  1MMI A;  3P16 A;  4K3K A;  4K3O A;  4MJR A;  4PNW A;  4OVG A;  3PGE B;  1JQJ A;  3PWE A;  4PNV A;  4RKI A;  4K3R A;  4K3M A;  4MJQ A;  4K3P A;  2AWA A;  3L10 A;  4N96 A;  3L0W A;  4OVF A;  1UNN A;  4MJP A;  5AGV A;  2POL A;  3D1E A;  3Q4J A;  1JQL A;  4S3I A;  4K74 A;  1VPK A;  3L0X B;  3QSB A;  3Q4K A;  1OK7 A;  4TR7 A;  4TRT A;  5AH2 A;  4TSZ A;  4OVH A;  4N95 A;  3RB9 A;  5FRQ A;  5AH4 A;  4K3Q A;  3D1F A;  4N99 A;  3L10 B;  3PGE A;  2AVT A;  3L0W B;  4K3S A;  4N9A A; 
#chains in the Genus database with same CATH homology
 3T0P A;  3Q4L A;  4N98 A;  5FVE A;  4TR8 A;  4N97 A;  4PNU A;  3F1V A;  3QSB B;  4N94 A;  4K3L A;  3BEP A;  3D1G A;  4TR6 A;  3L0X A;  5AGU A;  2XUR A;  1MMI A;  3P16 A;  4K3K A;  4K3O A;  4MJR A;  4PNW A;  4OVG A;  3PGE B;  1JQJ A;  3PWE A;  4PNV A;  4RKI A;  4K3R A;  4K3M A;  4MJQ A;  4K3P A;  2AWA A;  3L10 A;  4N96 A;  3L0W A;  4OVF A;  1UNN A;  4MJP A;  5AGV A;  2POL A;  3D1E A;  3Q4J A;  1JQL A;  4S3I A;  4K74 A;  1VPK A;  3QSB A;  4TR7 A;  3Q4K A;  1OK7 A;  4TRT A;  5AH2 A;  4TSZ A;  4OVH A;  4N95 A;  3RB9 A;  5FRQ A;  5AH4 A;  4K3Q A;  3D1F A;  4N99 A;  2AVT A;  4K3S A;  4N9A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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