2GTPC

Crystal structure of the heterodimeric complex of human rgs1 and activated gi alpha 1
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
132
structure length
132
Chain Sequence
VLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords Guanine nucleotide-binding protein G(i), alpha-1 subunit
publication title Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
pubmed doi rcsb
source organism Homo sapiens
total genus 46
structure length 132
sequence length 132
chains with identical sequence D
ec nomenclature
pdb deposition date 2006-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2gtpC02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2gtpC01
3UZTA 3NYOA 2AF0A 3PVWA 1EZYA 2DLVA 3KRWA 3PVUA 5HE0A 3KRXA 1EMUA 3NYNA 1FQKB 1AGRE 4MK0A 2IHDA 2OJ4A 1FQJB 2EBZA 3CIKA 2IK8B 3V5WA 1OMWA 1CMZA 3C7LA 2JNUA 2BCJA 1FQIA 5HE1A 5HE3A 3C7KB 2ODEB 2IHBB 5HE2A 2JM5A 4TNDA 2D9JA 2BT2A 1DK8A 4TNBA 2V4ZB 3PSCA 2BV1A 1EZTA 4PNKA 4EKDB 2OWIA 5DO9B 2CRPA 2GTPC
chains in the Genus database with same CATH superfamily
3UZTA 3NYOA 2AF0A 3PVWA 1EZYA 2DLVA 3KRWA 3PVUA 5HE0A 3KRXA 1EMUA 3QYFA 3NYNA 1FQKB 1AGRE 4MK0A 2IHDA 2OJ4A 1FQJB 2EBZA 3CIKA 2IK8B 4HTEA 3V5WA 1OMWA 1CMZA 3C7LA 2JNUA 2BCJA 1FQIA 5HE1A 5HE3A 3C7KB 2ODEB 2IHBB 5HE2A 2JM5A 5REQB 4TNDA 2D9JA 2BT2A 1DK8A 4TNBA 2V4ZB 3I5QA 2BV1A 3PSCA 1EZTA 4PNKA 4EKDB 2OWIA 5DO9B 2CRPA 2GTPC
chains in the Genus database with same CATH topology
3UZTA 3NYOA 2AF0A 3PVWA 1EZYA 2DLVA 3KRWA 3PVUA 5HE0A 3KRXA 1EMUA 3QYFA 3NYNA 1FQKB 1AGRE 4MK0A 2IHDA 2OJ4A 1FQJB 2EBZA 3CIKA 2IK8B 3V5WA 1OMWA 1CMZA 3C7LA 2JNUA 2BCJA 1FQIA 5HE1A 5HE3A 3C7KB 2ODEB 2IHBB 5HE2A 2JM5A 5REQB 4TNDA 2D9JA 2BT2A 1DK8A 4TNBA 2V4ZB 3PSCA 2BV1A 1EZTA 4PNKA 4EKDB 2OWIA 5DO9B 2CRPA 2GTPC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UZT A;  3NYO A;  2AF0 A;  3PVW A;  1EZY A;  2DLV A;  3KRW A;  3PVU A;  5HE0 A;  3KRX A;  1EMU A;  3NYN A;  1FQK B;  1AGR E;  4MK0 A;  2IHD A;  2OJ4 A;  1FQJ B;  2EBZ A;  3CIK A;  2IK8 B;  3V5W A;  1OMW A;  1CMZ A;  3C7L A;  2JNU A;  2BCJ A;  1FQI A;  5HE1 A;  5HE3 A;  3C7K B;  2ODE B;  2IHB B;  5HE2 A;  2JM5 A;  4TND A;  2D9J A;  2BT2 A;  1DK8 A;  4TNB A;  2V4Z B;  3PSC A;  2BV1 A;  1EZT A;  4PNK A;  4EKD B;  2OWI A;  5DO9 B;  2CRP A;  2GTP C; 
#chains in the Genus database with same CATH topology
 3UZT A;  3NYO A;  2AF0 A;  3PVW A;  1EZY A;  2DLV A;  3KRW A;  3PVU A;  5HE0 A;  3KRX A;  1EMU A;  3QYF A;  3NYN A;  1FQK B;  1AGR E;  4MK0 A;  2IHD A;  2OJ4 A;  1FQJ B;  2EBZ A;  3CIK A;  2IK8 B;  4HTE A;  3V5W A;  1OMW A;  1CMZ A;  3C7L A;  2JNU A;  2BCJ A;  1FQI A;  5HE1 A;  5HE3 A;  3C7K B;  2ODE B;  2IHB B;  5HE2 A;  2JM5 A;  5REQ B;  4TND A;  2D9J A;  2BT2 A;  1DK8 A;  4TNB A;  2V4Z B;  3I5Q A;  2BV1 A;  3PSC A;  1EZT A;  4PNK A;  4EKD B;  2OWI A;  5DO9 B;  2CRP A;  2GTP C; 
#chains in the Genus database with same CATH homology
 3UZT A;  3NYO A;  2AF0 A;  3PVW A;  1EZY A;  2DLV A;  3KRW A;  3PVU A;  5HE0 A;  3KRX A;  1EMU A;  3QYF A;  3NYN A;  1FQK B;  1AGR E;  4MK0 A;  2IHD A;  2OJ4 A;  1FQJ B;  2EBZ A;  3CIK A;  2IK8 B;  3V5W A;  1OMW A;  1CMZ A;  3C7L A;  2JNU A;  2BCJ A;  1FQI A;  5HE1 A;  5HE3 A;  3C7K B;  2ODE B;  2IHB B;  5HE2 A;  2JM5 A;  5REQ B;  4TND A;  2D9J A;  2BT2 A;  1DK8 A;  4TNB A;  2V4Z B;  3PSC A;  2BV1 A;  1EZT A;  4PNK A;  4EKD B;  2OWI A;  5DO9 B;  2CRP A;  2GTP C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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