2V4ZB

The crystal structure of the human g-protein subunit alpha (gnai3) in complex with an engineered regulator of g-protein signaling type 2 domain (rgs2)
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
128
structure length
122
Chain Sequence
PSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFSEENIEFWLACEDFKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNATSGCFTTAQKRVYSLMENDSYPRFLKSEFYQDLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords GUANINE NUCLEOTIDE-BINDING PROTEIN G(K) SUBUNIT ALPHA
publication title Structural Determinants of G-Protein Alpha Subunit Selectivity by Regulator of G-Protein Signaling 2(Rgs2).
pubmed doi rcsb
source organism Homo sapiens
total genus 41
structure length 122
sequence length 128
ec nomenclature
pdb deposition date 2008-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00615 RGS Regulator of G protein signaling domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.167.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 2 Regulator of G-protein Signalling 4, domain 2 2v4zB02
1.10.196.10 Mainly Alpha Orthogonal Bundle Regulator of G-protein Signalling 4; domain 1 Regulator of G-protein Signalling 4; domain 1 2v4zB01
2IHDA 1DK8A 2JNUA 4TNDA 3V5WA 1EMUA 1FQIA 2EBZA 2BCJA 1EZYA 4TNBA 2OJ4A 1OMWA 5DO9B 3PSCA 2IHBB 5HE3A 3C7LA 2AF0A 2CRPA 5HE1A 2D9JA 3C7KB 4PNKA 5HE2A 1CMZA 1EZTA 2GTPC 3KRXA 2BV1A 3NYOA 3PVUA 4EKDB 1FQJB 5HE0A 1AGRE 3KRWA 2BT2A 3UZTA 2ODEB 3PVWA 2DLVA 2OWIA 3CIKA 2JM5A 1FQKB 4MK0A 2IK8B 3NYNA 2V4ZB
chains in the Genus database with same CATH superfamily
2IHDA 5REQB 1DK8A 2JNUA 4TNDA 3V5WA 1EMUA 1FQIA 2EBZA 2BCJA 1EZYA 4TNBA 2OJ4A 1OMWA 5DO9B 3PSCA 2IHBB 5HE3A 3C7LA 2AF0A 2CRPA 5HE1A 2D9JA 3C7KB 4PNKA 5HE2A 1CMZA 1EZTA 2GTPC 3KRXA 2BV1A 3NYOA 3PVUA 4EKDB 3I5QA 1FQJB 5HE0A 1AGRE 3KRWA 2BT2A 3UZTA 2ODEB 3PVWA 2DLVA 2OWIA 3CIKA 2JM5A 4HTEA 1FQKB 3QYFA 4MK0A 2IK8B 3NYNA 2V4ZB
chains in the Genus database with same CATH topology
2IHDA 5REQB 1DK8A 2JNUA 4TNDA 3V5WA 1EMUA 1FQIA 2EBZA 2BCJA 1EZYA 4TNBA 2OJ4A 1OMWA 5DO9B 3PSCA 2IHBB 5HE3A 3C7LA 2AF0A 2CRPA 5HE1A 2D9JA 3C7KB 4PNKA 5HE2A 1CMZA 1EZTA 2GTPC 3KRXA 2BV1A 3NYOA 3PVUA 4EKDB 1FQJB 5HE0A 1AGRE 3KRWA 2BT2A 3UZTA 2ODEB 3PVWA 2DLVA 2OWIA 3CIKA 2JM5A 1FQKB 3QYFA 4MK0A 2IK8B 3NYNA 2V4ZB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IHD A;  1DK8 A;  2JNU A;  4TND A;  3V5W A;  1EMU A;  1FQI A;  2EBZ A;  2BCJ A;  1EZY A;  4TNB A;  2OJ4 A;  1OMW A;  5DO9 B;  3PSC A;  2IHB B;  5HE3 A;  3C7L A;  2AF0 A;  2CRP A;  5HE1 A;  2D9J A;  3C7K B;  4PNK A;  5HE2 A;  1CMZ A;  1EZT A;  2GTP C;  3KRX A;  2BV1 A;  3NYO A;  3PVU A;  4EKD B;  1FQJ B;  5HE0 A;  1AGR E;  3KRW A;  2BT2 A;  3UZT A;  2ODE B;  3PVW A;  2DLV A;  2OWI A;  3CIK A;  2JM5 A;  1FQK B;  4MK0 A;  2IK8 B;  3NYN A;  2V4Z B; 
#chains in the Genus database with same CATH topology
 2IHD A;  5REQ B;  1DK8 A;  2JNU A;  4TND A;  3V5W A;  1EMU A;  1FQI A;  2EBZ A;  2BCJ A;  1EZY A;  4TNB A;  2OJ4 A;  1OMW A;  5DO9 B;  3PSC A;  2IHB B;  5HE3 A;  3C7L A;  2AF0 A;  2CRP A;  5HE1 A;  2D9J A;  3C7K B;  4PNK A;  5HE2 A;  1CMZ A;  1EZT A;  2GTP C;  3KRX A;  2BV1 A;  3NYO A;  3PVU A;  4EKD B;  3I5Q A;  1FQJ B;  5HE0 A;  1AGR E;  3KRW A;  2BT2 A;  3UZT A;  2ODE B;  3PVW A;  2DLV A;  2OWI A;  3CIK A;  2JM5 A;  4HTE A;  1FQK B;  3QYF A;  4MK0 A;  2IK8 B;  3NYN A;  2V4Z B; 
#chains in the Genus database with same CATH homology
 2IHD A;  5REQ B;  1DK8 A;  2JNU A;  4TND A;  3V5W A;  1EMU A;  1FQI A;  2EBZ A;  2BCJ A;  1EZY A;  4TNB A;  2OJ4 A;  1OMW A;  5DO9 B;  3PSC A;  2IHB B;  5HE3 A;  3C7L A;  2AF0 A;  2CRP A;  5HE1 A;  2D9J A;  3C7K B;  4PNK A;  5HE2 A;  1CMZ A;  1EZT A;  2GTP C;  3KRX A;  2BV1 A;  3NYO A;  3PVU A;  4EKD B;  1FQJ B;  5HE0 A;  1AGR E;  3KRW A;  2BT2 A;  3UZT A;  2ODE B;  3PVW A;  2DLV A;  2OWI A;  3CIK A;  2JM5 A;  1FQK B;  3QYF A;  4MK0 A;  2IK8 B;  3NYN A;  2V4Z B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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