1TWQA

Crystal structure of the c-terminal pgn-binding domain of human pgrp-ialpha in complex with pgn analog muramyl tripeptide
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
165
structure length
165
Chain Sequence
VCPNIIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDIGYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQCAVVEGYLTPNYLLMGHSDVVNILSPGQALYNIISTWPHFKH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Immune system, membrane protein
source organism Homo sapiens
publication title Structural basis for peptidoglycan binding by peptidoglycan recognition proteins
pubmed doi rcsb
molecule keywords peptidoglycan recognition protein-I-alpha
total genus 53
structure length 165
sequence length 165
ec nomenclature
pdb deposition date 2004-07-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01510 Amidase_2 N-acetylmuramoyl-L-alanine amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.80.10 Alpha Beta 3-Layer(aba) Sandwich Lysozyme-like Peptidoglycan recognition protein-like 1twqA00
2Y2DA 3QV4A 3HMBA 3C2XA 2Y28A 2WKXA 4BJ4A 2XZ4A 2R90A 3CG9A 2Y2BA 3CORA 4BPAA 1J3GA 3T39A 2BH7A 3D2YA 2R2KA 4OUGA 4BXJA 3OGXA 4BXEA 3O4KA 3CXAA 4OPPA 1YCKA 2AR3A 2APHA 5E0BA 4BXDA 1SXRA 3NNOA 5DWFA 5E0AA 4KNLA 2XZ8A 1S2JA 1TWQA 3NG4A 4BOLA 4KNKA 2RKQA 2EAXA 2Y2CA 4GF9A 2Z9NA 3USXA 2F2LA 4X36A 2Y2EA 3EP1A 2L47A 3D2ZA 4Z8IA 3T2VA 4ZXMA 4Q9EA 3UILA 1AROL 2F2LX 3QS0A 3RT4A 4Q8SA 1YB0A 4IVVA 1SK4A 1Z6IA 1LBAA 3UMQA 4ORVA 5CTVA 2CB3A 4OLSA 3RDRA 3LATA 3TRUA 3UMLA 1SK3A 3NW3A 2EAVA 1OHTA 3QJ1A 4FNNA
chains in the Genus database with same CATH superfamily
2Y2DA 3QV4A 3HMBA 3C2XA 2Y28A 2WKXA 4BJ4A 2XZ4A 2R90A 3CG9A 2Y2BA 3CORA 4BPAA 1J3GA 3T39A 2BH7A 3D2YA 2R2KA 4OUGA 4BXJA 3OGXA 4BXEA 3O4KA 3CXAA 4OPPA 1YCKA 2AR3A 2APHA 5E0BA 4BXDA 1SXRA 3NNOA 5DWFA 5E0AA 4KNLA 2XZ8A 1S2JA 1TWQA 3NG4A 4BOLA 4KNKA 2RKQA 2EAXA 2Y2CA 4GF9A 2Z9NA 3USXA 2F2LA 4X36A 2Y2EA 3EP1A 2L47A 3D2ZA 4Z8IA 3T2VA 4ZXMA 4Q9EA 3UILA 1AROL 2F2LX 3QS0A 3RT4A 4Q8SA 1YB0A 4IVVA 1SK4A 1Z6IA 1LBAA 3UMQA 4ORVA 5CTVA 2CB3A 4OLSA 3RDRA 3LATA 3TRUA 3UMLA 1SK3A 3NW3A 2EAVA 1OHTA 3QJ1A 4FNNA
chains in the Genus database with same CATH topology
2Y2DA 3QV4A 3HMBA 3C2XA 2Y28A 2WKXA 4BJ4A 2XZ4A 2R90A 3CG9A 2Y2BA 3CORA 4BPAA 1J3GA 3T39A 2BH7A 3D2YA 2R2KA 4OUGA 4BXJA 3OGXA 4BXEA 3O4KA 3CXAA 4OPPA 1YCKA 2AR3A 2APHA 5E0BA 4BXDA 1SXRA 3NNOA 5DWFA 5E0AA 4KNLA 2XZ8A 1S2JA 1TWQA 3NG4A 4BOLA 4KNKA 2RKQA 2EAXA 2Y2CA 4GF9A 2Z9NA 3USXA 2F2LA 4X36A 2Y2EA 3EP1A 2L47A 3D2ZA 4Z8IA 3T2VA 4ZXMA 4Q9EA 3UILA 1AROL 2F2LX 3QS0A 3RT4A 4Q8SA 1YB0A 4IVVA 1SK4A 1Z6IA 1LBAA 3UMQA 4ORVA 5CTVA 2CB3A 4OLSA 3RDRA 3LATA 3TRUA 3UMLA 1SK3A 3NW3A 2EAVA 1OHTA 3QJ1A 4FNNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Y2D A;  3QV4 A;  3HMB A;  3C2X A;  2Y28 A;  2WKX A;  4BJ4 A;  2XZ4 A;  2R90 A;  3CG9 A;  2Y2B A;  3COR A;  4BPA A;  1J3G A;  3T39 A;  2BH7 A;  3D2Y A;  2R2K A;  4OUG A;  4BXJ A;  3OGX A;  4BXE A;  3O4K A;  3CXA A;  4OPP A;  1YCK A;  2AR3 A;  2APH A;  5E0B A;  4BXD A;  1SXR A;  3NNO A;  5DWF A;  5E0A A;  4KNL A;  2XZ8 A;  1S2J A;  1TWQ A;  3NG4 A;  4BOL A;  4KNK A;  2RKQ A;  2EAX A;  2Y2C A;  4GF9 A;  2Z9N A;  3USX A;  2F2L A;  4X36 A;  2Y2E A;  3EP1 A;  2L47 A;  3D2Z A;  4Z8I A;  3T2V A;  4ZXM A;  4Q9E A;  3UIL A;  1ARO L;  2F2L X;  3QS0 A;  3RT4 A;  4Q8S A;  1YB0 A;  4IVV A;  1SK4 A;  1Z6I A;  1LBA A;  3UMQ A;  4ORV A;  5CTV A;  2CB3 A;  4OLS A;  3RDR A;  3LAT A;  3TRU A;  3UML A;  1SK3 A;  3NW3 A;  2EAV A;  1OHT A;  3QJ1 A;  4FNN A; 
#chains in the Genus database with same CATH topology
 2Y2D A;  3QV4 A;  3HMB A;  3C2X A;  2Y28 A;  2WKX A;  4BJ4 A;  2XZ4 A;  2R90 A;  3CG9 A;  2Y2B A;  3COR A;  4BPA A;  1J3G A;  3T39 A;  2BH7 A;  3D2Y A;  2R2K A;  4OUG A;  4BXJ A;  3OGX A;  4BXE A;  3O4K A;  3CXA A;  4OPP A;  1YCK A;  2AR3 A;  2APH A;  5E0B A;  4BXD A;  1SXR A;  3NNO A;  5DWF A;  5E0A A;  4KNL A;  2XZ8 A;  1S2J A;  1TWQ A;  3NG4 A;  4BOL A;  4KNK A;  2RKQ A;  2EAX A;  2Y2C A;  4GF9 A;  2Z9N A;  3USX A;  2F2L A;  4X36 A;  2Y2E A;  3EP1 A;  2L47 A;  3D2Z A;  4Z8I A;  3T2V A;  4ZXM A;  4Q9E A;  3UIL A;  1ARO L;  2F2L X;  3QS0 A;  3RT4 A;  4Q8S A;  1YB0 A;  4IVV A;  1SK4 A;  1Z6I A;  1LBA A;  3UMQ A;  4ORV A;  5CTV A;  2CB3 A;  4OLS A;  3RDR A;  3LAT A;  3TRU A;  3UML A;  1SK3 A;  3NW3 A;  2EAV A;  1OHT A;  3QJ1 A;  4FNN A; 
#chains in the Genus database with same CATH homology
 2Y2D A;  3QV4 A;  3HMB A;  3C2X A;  2Y28 A;  2WKX A;  4BJ4 A;  2XZ4 A;  2R90 A;  3CG9 A;  2Y2B A;  3COR A;  4BPA A;  1J3G A;  3T39 A;  2BH7 A;  3D2Y A;  2R2K A;  4OUG A;  4BXJ A;  3OGX A;  4BXE A;  3O4K A;  3CXA A;  4OPP A;  1YCK A;  2AR3 A;  2APH A;  5E0B A;  4BXD A;  1SXR A;  3NNO A;  5DWF A;  5E0A A;  4KNL A;  2XZ8 A;  1S2J A;  1TWQ A;  3NG4 A;  4BOL A;  4KNK A;  2RKQ A;  2EAX A;  2Y2C A;  4GF9 A;  2Z9N A;  3USX A;  2F2L A;  4X36 A;  2Y2E A;  3EP1 A;  2L47 A;  3D2Z A;  4Z8I A;  3T2V A;  4ZXM A;  4Q9E A;  3UIL A;  1ARO L;  2F2L X;  3QS0 A;  3RT4 A;  4Q8S A;  1YB0 A;  4IVV A;  1SK4 A;  1Z6I A;  1LBA A;  3UMQ A;  4ORV A;  5CTV A;  2CB3 A;  4OLS A;  3RDR A;  3LAT A;  3TRU A;  3UML A;  1SK3 A;  3NW3 A;  2EAV A;  1OHT A;  3QJ1 A;  4FNN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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