1YI2R

Crystal structure of erythromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
150
structure length
150
Chain Sequence
GISYSVEADPDTTAKAMLRERQMSFKHSKAIAREIKGKTAGEAVDYLEAVIEGDQPVPFKQHNSGVGHKSKVDGWDAGRYPEKASKAFLDLLENAVGNADHQGFDGEAMTIKHVAAHKVGEQQGRKPRAMGRASAWNSPQVDVELILEEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S Ribosomal RNA
total genus 36
structure length 150
sequence length 150
ec nomenclature
pdb deposition date 2005-01-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00237 Ribosomal_L22 Ribosomal protein L22p/L17e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.470.10 Alpha Beta Alpha-Beta Complex Ribosomal Protein L22; Chain A Ribosomal protein L22/L17 1yi2R00
5GAET 2ZJRP 3CC2R 3CCLR 5GADT 2OTJR 3J7ZS 1Q7YS 2OTLR 3CD6R 3G4SR 1VQLR 2QA4R 5MLCU 1YHQR 2ZJPP 1YIJR 5DM6P 4WFNP 1VQNR 1VQ6R 3CMAR 1VQMR 4WCEP 3I56R 1VQ9R 4WF9P 3CCVR 1M90S 5H1SU 1VQ5R 3G71R 3CC7R 3CCER 5JVHP 3CCSR 3CCMR 4WFAP 3OW2Q 3CCJR 5HL7P 1Q86S 1I4JA 3J7YT 1M1KS 1BXEA 1QVFQ 1NJIS 1KD1S 3DLLP 1W2BQ 1VQPR 1VQ7R 1VQ4R 1KC8S 2QEXR 4WFBP 4V19W 1VQ8R 1VQOR 3CMER 5JVGP 3PIOP 3CCRR 1N8RS 1YJNR 3CCQR 1YJWR 3I55R 2ZJQP 3CPWQ 5GAHT 3CF5P 1Q82S 3CCUR 4U67P 1QVGQ 4IOAP 3CC4R 3CXCQ 1VQKR 1S72R 4IO9P 1KQSQ 4UY8S 1YI2R 1K9MS 5DM7P 1K8AS 3PIPP 3G6ER 1YITR 1YJ9R 5GAGT 1Q81S 1JJ2Q 4IOCP 1K73S
chains in the Genus database with same CATH superfamily
5GAET 2BYDA 2ZJRP 3CC2R 3CCLR 5GADT 1K73S 2OTJR 3J7ZS 1Q7YS 2OTLR 3CD6R 1F80A 3G4SR 1VQLR 3NE1A 2BDDA 2QA4R 5MLCU 2QG8A 1YHQR 2ZJPP 1YIJR 5DM6P 4WFNP 2CG5A 1VQNR 2C43A 1VQ6R 3CMAR 1VQMR 3H7QA 4WCEP 3I56R 1F7TA 1VQ9R 4WF9P 3CCVR 1M90S 5H1SU 1VQ5R 3G71R 3CC7R 3CCER 3NE9A 5JVHP 2WDYA 3CCSR 3CCMR 3HQJA 4WFAP 5CMOA 3CCJR 3OW2Q 5HL7P 2WASA 1Q86S 1I4JA 3J7YT 5CXDA 1M1KS 2WASB 1BXEA 1QVFQ 1NJIS 4HC6A 2D0OA 1KD1S 3DLLP 1W2BQ 2WDSA 1FTFA 1VQPR 1VQ7R 1VQ4R 1KC8S 2QEXR 4WFBP 4V19W 1VQ8R 1VQOR 4MRTA 3QMNA 3CMER 5JVGP 3PIOP 3CCRR 1N8RS 1YJNR 3CCQR 1FTEA 1FTHA 3GWMA 3I55R 1YJWR 2ZJQP 2WATA 3NFDA 3CPWQ 5GAHT 3CF5P 1Q82S 2JBZA 3CCUR 4U67P 1QVGQ 4IOAP 2WDOA 3CC4R 4DXEA 3CXCQ 1VQKR 1QR0A 1NBWA 1S72R 4IO9P 1KQSQ 4UY8S 1F7LA 1YI2R 1K9MS 5DM7P 1K8AS 2D0PA 3PIPP 3G6ER 1YITR 3NE3B 1YJ9R 5GAGT 2JCAA 1Q81S 4JM7A 1JJ2Q 4IOCP 3HYKA
chains in the Genus database with same CATH topology
5GAET 2ZJRP 3CC2R 3CCLR 5GADT 2OTJR 3J7ZS 1Q7YS 2OTLR 3CD6R 3G4SR 1VQLR 2QA4R 5MLCU 1YHQR 2ZJPP 1YIJR 5DM6P 4WFNP 1VQNR 1VQ6R 3CMAR 1VQMR 4WCEP 3I56R 1VQ9R 4WF9P 3CCVR 1M90S 5H1SU 1VQ5R 3G71R 3CC7R 3CCER 5JVHP 3CCSR 3CCMR 4WFAP 3OW2Q 3CCJR 5HL7P 1Q86S 1I4JA 3J7YT 1M1KS 1BXEA 1QVFQ 1NJIS 1KD1S 3DLLP 1W2BQ 1VQPR 1VQ7R 1VQ4R 1KC8S 2QEXR 4WFBP 4V19W 1VQ8R 1VQOR 3CMER 5JVGP 3PIOP 3CCRR 1N8RS 1YJNR 3CCQR 1YJWR 3I55R 2ZJQP 3CPWQ 5GAHT 3CF5P 1Q82S 3CCUR 4U67P 1QVGQ 4IOAP 3CC4R 3CXCQ 1VQKR 1S72R 4IO9P 1KQSQ 4UY8S 1YI2R 1K9MS 5DM7P 1K8AS 3PIPP 3G6ER 1YITR 1YJ9R 5GAGT 1Q81S 1JJ2Q 4IOCP 1K73S
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5GAE T;  2ZJR P;  3CC2 R;  3CCL R;  5GAD T;  2OTJ R;  3J7Z S;  1Q7Y S;  2OTL R;  3CD6 R;  3G4S R;  1VQL R;  2QA4 R;  5MLC U;  1YHQ R;  2ZJP P;  1YIJ R;  5DM6 P;  4WFN P;  1VQN R;  1VQ6 R;  3CMA R;  1VQM R;  4WCE P;  3I56 R;  1VQ9 R;  4WF9 P;  3CCV R;  1M90 S;  5H1S U;  1VQ5 R;  3G71 R;  3CC7 R;  3CCE R;  5JVH P;  3CCS R;  3CCM R;  4WFA P;  3OW2 Q;  3CCJ R;  5HL7 P;  1Q86 S;  1I4J A;  3J7Y T;  1M1K S;  1BXE A;  1QVF Q;  1NJI S;  1KD1 S;  3DLL P;  1W2B Q;  1VQP R;  1VQ7 R;  1VQ4 R;  1KC8 S;  2QEX R;  4WFB P;  4V19 W;  1VQ8 R;  1VQO R;  3CME R;  5JVG P;  3PIO P;  3CCR R;  1N8R S;  1YJN R;  3CCQ R;  1YJW R;  3I55 R;  2ZJQ P;  3CPW Q;  5GAH T;  3CF5 P;  1Q82 S;  3CCU R;  4U67 P;  1QVG Q;  4IOA P;  3CC4 R;  3CXC Q;  1VQK R;  1S72 R;  4IO9 P;  1KQS Q;  4UY8 S;  1YI2 R;  1K9M S;  5DM7 P;  1K8A S;  3PIP P;  3G6E R;  1YIT R;  1YJ9 R;  5GAG T;  1Q81 S;  1JJ2 Q;  4IOC P;  1K73 S; 
#chains in the Genus database with same CATH topology
 5GAE T;  2BYD A;  2ZJR P;  3CC2 R;  3CCL R;  5GAD T;  1K73 S;  2OTJ R;  3J7Z S;  1Q7Y S;  2OTL R;  3CD6 R;  1F80 A;  3G4S R;  1VQL R;  3NE1 A;  2BDD A;  2QA4 R;  5MLC U;  2QG8 A;  1YHQ R;  2ZJP P;  1YIJ R;  5DM6 P;  4WFN P;  2CG5 A;  1VQN R;  2C43 A;  1VQ6 R;  3CMA R;  1VQM R;  3H7Q A;  4WCE P;  3I56 R;  1F7T A;  1VQ9 R;  4WF9 P;  3CCV R;  1M90 S;  5H1S U;  1VQ5 R;  3G71 R;  3CC7 R;  3CCE R;  3NE9 A;  5JVH P;  2WDY A;  3CCS R;  3CCM R;  3HQJ A;  4WFA P;  5CMO A;  3CCJ R;  3OW2 Q;  5HL7 P;  2WAS A;  1Q86 S;  1I4J A;  3J7Y T;  5CXD A;  1M1K S;  2WAS B;  1BXE A;  1QVF Q;  1NJI S;  4HC6 A;  2D0O A;  1KD1 S;  3DLL P;  1W2B Q;  2WDS A;  1FTF A;  1VQP R;  1VQ7 R;  1VQ4 R;  1KC8 S;  2QEX R;  4WFB P;  4V19 W;  1VQ8 R;  1VQO R;  4MRT A;  3QMN A;  3CME R;  5JVG P;  3PIO P;  3CCR R;  1N8R S;  1YJN R;  3CCQ R;  1FTE A;  1FTH A;  3GWM A;  3I55 R;  1YJW R;  2ZJQ P;  2WAT A;  3NFD A;  3CPW Q;  5GAH T;  3CF5 P;  1Q82 S;  2JBZ A;  3CCU R;  4U67 P;  1QVG Q;  4IOA P;  2WDO A;  3CC4 R;  4DXE A;  3CXC Q;  1VQK R;  1QR0 A;  1NBW A;  1S72 R;  4IO9 P;  1KQS Q;  4UY8 S;  1F7L A;  1YI2 R;  1K9M S;  5DM7 P;  1K8A S;  2D0P A;  3PIP P;  3G6E R;  1YIT R;  3NE3 B;  1YJ9 R;  5GAG T;  2JCA A;  1Q81 S;  4JM7 A;  1JJ2 Q;  4IOC P;  3HYK A; 
#chains in the Genus database with same CATH homology
 5GAE T;  2ZJR P;  3CC2 R;  3CCL R;  5GAD T;  2OTJ R;  3J7Z S;  1Q7Y S;  2OTL R;  3CD6 R;  3G4S R;  1VQL R;  2QA4 R;  5MLC U;  1YHQ R;  2ZJP P;  1YIJ R;  5DM6 P;  4WFN P;  1VQN R;  1VQ6 R;  3CMA R;  1VQM R;  4WCE P;  3I56 R;  1VQ9 R;  4WF9 P;  3CCV R;  1M90 S;  5H1S U;  1VQ5 R;  3G71 R;  3CC7 R;  3CCE R;  5JVH P;  3CCS R;  3CCM R;  4WFA P;  3OW2 Q;  3CCJ R;  5HL7 P;  1Q86 S;  1I4J A;  3J7Y T;  1M1K S;  1BXE A;  1QVF Q;  1NJI S;  1KD1 S;  3DLL P;  1W2B Q;  1VQP R;  1VQ7 R;  1VQ4 R;  1KC8 S;  2QEX R;  4WFB P;  4V19 W;  1VQ8 R;  1VQO R;  3CME R;  5JVG P;  3PIO P;  3CCR R;  1N8R S;  1YJN R;  3CCQ R;  1YJW R;  3I55 R;  2ZJQ P;  3CPW Q;  5GAH T;  3CF5 P;  1Q82 S;  3CCU R;  4U67 P;  1QVG Q;  4IOA P;  3CC4 R;  3CXC Q;  1VQK R;  1S72 R;  4IO9 P;  1KQS Q;  4UY8 S;  1YI2 R;  1K9M S;  5DM7 P;  1K8A S;  3PIP P;  3G6E R;  1YIT R;  1YJ9 R;  5GAG T;  1Q81 S;  1JJ2 Q;  4IOC P;  1K73 S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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