1YI2R

Crystal structure of erythromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
150
structure length
150
Chain Sequence
GISYSVEADPDTTAKAMLRERQMSFKHSKAIAREIKGKTAGEAVDYLEAVIEGDQPVPFKQHNSGVGHKSKVDGWDAGRYPEKASKAFLDLLENAVGNADHQGFDGEAMTIKHVAAHKVGEQQGRKPRAMGRASAWNSPQVDVELILEEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S Ribosomal RNA
total genus 36
structure length 150
sequence length 150
ec nomenclature
pdb deposition date 2005-01-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00237 Ribosomal_L22 Ribosomal protein L22p/L17e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.470.10 Alpha Beta Alpha-Beta Complex Ribosomal Protein L22; Chain A Ribosomal protein L22/L17 1yi2R00
4WCEP 3PIPP 1JJ2Q 1QVGQ 1VQPR 3G4SR 4IOCP 1Q7YS 5DM6P 1VQOR 2OTLR 5H1SU 3G6ER 3CMER 1M90S 4WFBP 1I4JA 1VQ6R 3CXCQ 1Q86S 3PIOP 3I56R 1YHQR 1K73S 1YJNR 3CCER 2ZJQP 3CCMR 1Q81S 1YITR 3CCUR 3CCJR 3J7ZS 1K9MS 1VQKR 3J7YT 3CMAR 4U67P 3CC2R 3OW2Q 2OTJR 3CCLR 5GAET 4WFNP 3CCRR 3CPWQ 3DLLP 1VQ7R 1YI2R 1VQ4R 5HL7P 5GAHT 1VQNR 1N8RS 1VQLR 3CCSR 3CCVR 1VQ9R 1W2BQ 1YJWR 5GAGT 1VQ5R 2ZJRP 5JVGP 2ZJPP 3G71R 5MLCU 4WFAP 2QA4R 3CC4R 3CD6R 5GADT 1M1KS 4IOAP 1KQSQ 4V19W 4UY8S 3I55R 4WF9P 5DM7P 1YIJR 1VQ8R 1KD1S 5JVHP 1VQMR 1BXEA 1K8AS 1NJIS 4IO9P 3CC7R 3CCQR 1YJ9R 1QVFQ 1S72R 1KC8S 3CF5P 1Q82S 2QEXR
chains in the Genus database with same CATH superfamily
1F7LA 2C43A 2WDYA 4WCEP 3NE9A 3PIPP 2WDOA 1JJ2Q 1QVGQ 1VQPR 3G4SR 4IOCP 1Q7YS 5DM6P 1VQOR 2OTLR 5H1SU 2CG5A 3G6ER 3CMER 1M90S 4WFBP 1I4JA 1VQ6R 2D0OA 3CXCQ 1Q86S 3PIOP 3I56R 1YHQR 1K73S 3H7QA 1YJNR 3CCER 2ZJQP 4JM7A 1F7TA 3NFDA 3CCMR 3QMNA 1Q81S 1YITR 3CCUR 1QR0A 3CCJR 4DXEA 3J7ZS 2JBZA 1K9MS 1VQKR 3J7YT 3CMAR 2WASA 4U67P 2JCAA 4HC6A 3CC2R 3OW2Q 2OTJR 3CCLR 5GAET 4WFNP 3CCRR 3CPWQ 3DLLP 1VQ7R 1YI2R 1VQ4R 5HL7P 2WATA 5GAHT 1VQNR 1N8RS 1VQLR 3CCSR 3CCVR 3GWMA 1W2BQ 1VQ9R 1YJWR 2BDDA 5GAGT 3HYKA 1VQ5R 2ZJRP 2BYDA 1FTHA 2QG8A 2WASB 5JVGP 2ZJPP 3G71R 5MLCU 4WFAP 2QA4R 3CC4R 3CD6R 5GADT 1M1KS 4IOAP 1KQSQ 2WDSA 4V19W 4UY8S 3I55R 4WF9P 2D0PA 5DM7P 1YIJR 1F80A 1FTFA 1VQ8R 5CMOA 1KD1S 5JVHP 1VQMR 1BXEA 1K8AS 1NJIS 1NBWA 4IO9P 3CC7R 4MRTA 3NE1A 3CCQR 1YJ9R 1QVFQ 1FTEA 3NE3B 1S72R 1KC8S 3CF5P 1Q82S 2QEXR 5CXDA 3HQJA
chains in the Genus database with same CATH topology
4WCEP 3PIPP 1JJ2Q 1QVGQ 1VQPR 3G4SR 4IOCP 1Q7YS 5DM6P 1VQOR 2OTLR 5H1SU 3G6ER 3CMER 1M90S 4WFBP 1I4JA 1VQ6R 3CXCQ 1Q86S 3PIOP 3I56R 1YHQR 1K73S 1YJNR 3CCER 2ZJQP 3CCMR 1Q81S 1YITR 3CCUR 3CCJR 3J7ZS 1K9MS 1VQKR 3J7YT 3CMAR 4U67P 3CC2R 3OW2Q 2OTJR 3CCLR 5GAET 4WFNP 3CCRR 3CPWQ 3DLLP 1VQ7R 1YI2R 1VQ4R 5HL7P 5GAHT 1VQNR 1N8RS 1VQLR 3CCSR 3CCVR 1VQ9R 1W2BQ 1YJWR 5GAGT 1VQ5R 2ZJRP 5JVGP 2ZJPP 3G71R 5MLCU 4WFAP 2QA4R 3CC4R 3CD6R 5GADT 1M1KS 4IOAP 1KQSQ 4V19W 4UY8S 3I55R 4WF9P 5DM7P 1YIJR 1VQ8R 1KD1S 5JVHP 1VQMR 1BXEA 1K8AS 1NJIS 4IO9P 3CC7R 3CCQR 1YJ9R 1QVFQ 1S72R 1KC8S 3CF5P 1Q82S 2QEXR
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WCE P;  3PIP P;  1JJ2 Q;  1QVG Q;  1VQP R;  3G4S R;  4IOC P;  1Q7Y S;  5DM6 P;  1VQO R;  2OTL R;  5H1S U;  3G6E R;  3CME R;  1M90 S;  4WFB P;  1I4J A;  1VQ6 R;  3CXC Q;  1Q86 S;  3PIO P;  3I56 R;  1YHQ R;  1K73 S;  1YJN R;  3CCE R;  2ZJQ P;  3CCM R;  1Q81 S;  1YIT R;  3CCU R;  3CCJ R;  3J7Z S;  1K9M S;  1VQK R;  3J7Y T;  3CMA R;  4U67 P;  3CC2 R;  3OW2 Q;  2OTJ R;  3CCL R;  5GAE T;  4WFN P;  3CCR R;  3CPW Q;  3DLL P;  1VQ7 R;  1YI2 R;  1VQ4 R;  5HL7 P;  5GAH T;  1VQN R;  1N8R S;  1VQL R;  3CCS R;  3CCV R;  1VQ9 R;  1W2B Q;  1YJW R;  5GAG T;  1VQ5 R;  2ZJR P;  5JVG P;  2ZJP P;  3G71 R;  5MLC U;  4WFA P;  2QA4 R;  3CC4 R;  3CD6 R;  5GAD T;  1M1K S;  4IOA P;  1KQS Q;  4V19 W;  4UY8 S;  3I55 R;  4WF9 P;  5DM7 P;  1YIJ R;  1VQ8 R;  1KD1 S;  5JVH P;  1VQM R;  1BXE A;  1K8A S;  1NJI S;  4IO9 P;  3CC7 R;  3CCQ R;  1YJ9 R;  1QVF Q;  1S72 R;  1KC8 S;  3CF5 P;  1Q82 S;  2QEX R; 
#chains in the Genus database with same CATH topology
 1F7L A;  2C43 A;  2WDY A;  4WCE P;  3NE9 A;  3PIP P;  2WDO A;  1JJ2 Q;  1QVG Q;  1VQP R;  3G4S R;  4IOC P;  1Q7Y S;  5DM6 P;  1VQO R;  2OTL R;  5H1S U;  2CG5 A;  3G6E R;  3CME R;  1M90 S;  4WFB P;  1I4J A;  1VQ6 R;  2D0O A;  3CXC Q;  1Q86 S;  3PIO P;  3I56 R;  1YHQ R;  1K73 S;  3H7Q A;  1YJN R;  3CCE R;  2ZJQ P;  4JM7 A;  1F7T A;  3NFD A;  3CCM R;  3QMN A;  1Q81 S;  1YIT R;  3CCU R;  1QR0 A;  3CCJ R;  4DXE A;  3J7Z S;  2JBZ A;  1K9M S;  1VQK R;  3J7Y T;  3CMA R;  2WAS A;  4U67 P;  2JCA A;  4HC6 A;  3CC2 R;  3OW2 Q;  2OTJ R;  3CCL R;  5GAE T;  4WFN P;  3CCR R;  3CPW Q;  3DLL P;  1VQ7 R;  1YI2 R;  1VQ4 R;  5HL7 P;  2WAT A;  5GAH T;  1VQN R;  1N8R S;  1VQL R;  3CCS R;  3CCV R;  3GWM A;  1W2B Q;  1VQ9 R;  1YJW R;  2BDD A;  5GAG T;  3HYK A;  1VQ5 R;  2ZJR P;  2BYD A;  1FTH A;  2QG8 A;  2WAS B;  5JVG P;  2ZJP P;  3G71 R;  5MLC U;  4WFA P;  2QA4 R;  3CC4 R;  3CD6 R;  5GAD T;  1M1K S;  4IOA P;  1KQS Q;  2WDS A;  4V19 W;  4UY8 S;  3I55 R;  4WF9 P;  2D0P A;  5DM7 P;  1YIJ R;  1F80 A;  1FTF A;  1VQ8 R;  5CMO A;  1KD1 S;  5JVH P;  1VQM R;  1BXE A;  1K8A S;  1NJI S;  1NBW A;  4IO9 P;  3CC7 R;  4MRT A;  3NE1 A;  3CCQ R;  1YJ9 R;  1QVF Q;  1FTE A;  3NE3 B;  1S72 R;  1KC8 S;  3CF5 P;  1Q82 S;  2QEX R;  5CXD A;  3HQJ A; 
#chains in the Genus database with same CATH homology
 4WCE P;  3PIP P;  1JJ2 Q;  1QVG Q;  1VQP R;  3G4S R;  4IOC P;  1Q7Y S;  5DM6 P;  1VQO R;  2OTL R;  5H1S U;  3G6E R;  3CME R;  1M90 S;  4WFB P;  1I4J A;  1VQ6 R;  3CXC Q;  1Q86 S;  3PIO P;  3I56 R;  1YHQ R;  1K73 S;  1YJN R;  3CCE R;  2ZJQ P;  3CCM R;  1Q81 S;  1YIT R;  3CCU R;  3CCJ R;  3J7Z S;  1K9M S;  1VQK R;  3J7Y T;  3CMA R;  4U67 P;  3CC2 R;  3OW2 Q;  2OTJ R;  3CCL R;  5GAE T;  4WFN P;  3CCR R;  3CPW Q;  3DLL P;  1VQ7 R;  1YI2 R;  1VQ4 R;  5HL7 P;  5GAH T;  1VQN R;  1N8R S;  1VQL R;  3CCS R;  3CCV R;  1VQ9 R;  1W2B Q;  1YJW R;  5GAG T;  1VQ5 R;  2ZJR P;  5JVG P;  2ZJP P;  3G71 R;  5MLC U;  4WFA P;  2QA4 R;  3CC4 R;  3CD6 R;  5GAD T;  1M1K S;  4IOA P;  1KQS Q;  4V19 W;  4UY8 S;  3I55 R;  4WF9 P;  5DM7 P;  1YIJ R;  1VQ8 R;  1KD1 S;  5JVH P;  1VQM R;  1BXE A;  1K8A S;  1NJI S;  4IO9 P;  3CC7 R;  3CCQ R;  1YJ9 R;  1QVF Q;  1S72 R;  1KC8 S;  3CF5 P;  1Q82 S;  2QEX R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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