3CCLR

Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation u2535c. density for anisomycin is visible but not included in model.
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
150
structure length
150
Chain Sequence
GISYSVEADPDTTAKAMLRERQMSFKHSKAIAREIKGKTAGEAVDYLEAVIEGDQPVPFKQHNSGVGHKSKVDGWDAGRYPEKASKAFLDLLENAVGNADHQGFDGEAMTIKHVAAHKVGEQQGRKPRAMGRASAWNSPQVDVELILEEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mutations outside the anisomycin-binding site can make ribosomes drug-resistant.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 50S ribosomal protein L2P
total genus 38
structure length 150
sequence length 150
ec nomenclature
pdb deposition date 2008-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00237 Ribosomal_L22 Ribosomal protein L22p/L17e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.470.10 Alpha Beta Alpha-Beta Complex Ribosomal Protein L22; Chain A Ribosomal protein L22/L17 3cclR00
4IOCP 3I55R 1VQ5R 1VQ7R 5DM7P 2ZJPP 5DM6P 3J7ZS 4IOAP 1YIJR 2QEXR 4V19W 3CCMR 1N8RS 1NJIS 1VQNR 3PIOP 2QA4R 3CCRR 5HL7P 1M90S 3CCQR 3G71R 5JVGP 1Q81S 3CPWQ 4WCEP 1VQPR 4WFNP 1M1KS 1QVFQ 3CD6R 2OTJR 3CXCQ 4WF9P 1QVGQ 3CMER 1Q7YS 1VQ4R 4U67P 2ZJQP 1VQ6R 3CC2R 1BXEA 5JVHP 1VQKR 3CCSR 4WFBP 4IO9P 1VQ9R 5GADT 2ZJRP 3CCER 1K73S 2OTLR 3CCUR 1YJNR 3G4SR 1K8AS 1YI2R 5GAHT 1VQLR 1K9MS 5GAGT 1JJ2Q 5GAET 1Q82S 3CCVR 1KD1S 3CCJR 1YHQR 3CCLR 1YJ9R 3PIPP 1VQ8R 3CMAR 1KC8S 3DLLP 3OW2Q 3I56R 3J7YT 1KQSQ 3CC7R 4UY8S 5H1SU 1YJWR 1Q86S 1S72R 1VQMR 1W2BQ 5MLCU 1I4JA 3CF5P 1VQOR 3CC4R 4WFAP 3G6ER 1YITR
chains in the Genus database with same CATH superfamily
4IOCP 3I55R 1VQ5R 5CMOA 1VQ7R 5DM7P 2ZJPP 5DM6P 3H7QA 3J7ZS 4IOAP 1YIJR 2QEXR 4V19W 3CCMR 1N8RS 1NJIS 1VQNR 2C43A 3PIOP 2QA4R 3CCRR 5HL7P 1M90S 3CCQR 3G71R 5JVGP 1Q81S 3CPWQ 4WCEP 1VQPR 4WFNP 1M1KS 1QVFQ 4JM7A 3CD6R 2BDDA 2OTJR 3CXCQ 1FTEA 4WF9P 3NE3B 2CG5A 1F80A 1QVGQ 2WDOA 3CMER 2WASA 1Q7YS 1VQ4R 4U67P 2ZJQP 1VQ6R 3CC2R 1BXEA 3HYKA 2JBZA 5JVHP 1VQKR 2WDSA 3CCSR 4WFBP 4IO9P 1VQ9R 3NE1A 5GADT 5CXDA 2WASB 3GWMA 2ZJRP 3CCER 1QR0A 2QG8A 1K73S 2OTLR 1F7TA 3CCUR 1YJNR 3G4SR 1K8AS 1NBWA 1YI2R 4HC6A 5GAHT 1VQLR 1F7LA 2JCAA 1K9MS 2WDYA 5GAGT 1JJ2Q 3NFDA 5GAET 1Q82S 3CCVR 2D0PA 1KD1S 3QMNA 3CCJR 1YHQR 3CCLR 1YJ9R 3PIPP 1VQ8R 2BYDA 3CMAR 1FTHA 1KC8S 3DLLP 3OW2Q 3I56R 3J7YT 1KQSQ 1FTFA 3CC7R 4UY8S 5H1SU 2D0OA 4MRTA 1YJWR 1Q86S 2WATA 1S72R 4DXEA 1VQMR 1W2BQ 5MLCU 3HQJA 1I4JA 3CF5P 1VQOR 3CC4R 4WFAP 3G6ER 3NE9A 1YITR
chains in the Genus database with same CATH topology
4IOCP 3I55R 1VQ5R 1VQ7R 5DM7P 2ZJPP 5DM6P 3J7ZS 4IOAP 1YIJR 2QEXR 4V19W 3CCMR 1N8RS 1NJIS 1VQNR 3PIOP 2QA4R 3CCRR 5HL7P 1M90S 3CCQR 3G71R 5JVGP 1Q81S 3CPWQ 4WCEP 1VQPR 4WFNP 1M1KS 1QVFQ 3CD6R 2OTJR 3CXCQ 4WF9P 1QVGQ 3CMER 1Q7YS 1VQ4R 4U67P 2ZJQP 1VQ6R 3CC2R 1BXEA 5JVHP 1VQKR 3CCSR 4WFBP 4IO9P 1VQ9R 5GADT 2ZJRP 3CCER 1K73S 2OTLR 3CCUR 1YJNR 3G4SR 1K8AS 1YI2R 5GAHT 1VQLR 1K9MS 5GAGT 1JJ2Q 5GAET 1Q82S 3CCVR 1KD1S 3CCJR 1YHQR 3CCLR 1YJ9R 3PIPP 1VQ8R 3CMAR 1KC8S 3DLLP 3OW2Q 3I56R 3J7YT 1KQSQ 3CC7R 4UY8S 5H1SU 1YJWR 1Q86S 1S72R 1VQMR 1W2BQ 5MLCU 1I4JA 3CF5P 1VQOR 3CC4R 4WFAP 3G6ER 1YITR
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IOC P;  3I55 R;  1VQ5 R;  1VQ7 R;  5DM7 P;  2ZJP P;  5DM6 P;  3J7Z S;  4IOA P;  1YIJ R;  2QEX R;  4V19 W;  3CCM R;  1N8R S;  1NJI S;  1VQN R;  3PIO P;  2QA4 R;  3CCR R;  5HL7 P;  1M90 S;  3CCQ R;  3G71 R;  5JVG P;  1Q81 S;  3CPW Q;  4WCE P;  1VQP R;  4WFN P;  1M1K S;  1QVF Q;  3CD6 R;  2OTJ R;  3CXC Q;  4WF9 P;  1QVG Q;  3CME R;  1Q7Y S;  1VQ4 R;  4U67 P;  2ZJQ P;  1VQ6 R;  3CC2 R;  1BXE A;  5JVH P;  1VQK R;  3CCS R;  4WFB P;  4IO9 P;  1VQ9 R;  5GAD T;  2ZJR P;  3CCE R;  1K73 S;  2OTL R;  3CCU R;  1YJN R;  3G4S R;  1K8A S;  1YI2 R;  5GAH T;  1VQL R;  1K9M S;  5GAG T;  1JJ2 Q;  5GAE T;  1Q82 S;  3CCV R;  1KD1 S;  3CCJ R;  1YHQ R;  3CCL R;  1YJ9 R;  3PIP P;  1VQ8 R;  3CMA R;  1KC8 S;  3DLL P;  3OW2 Q;  3I56 R;  3J7Y T;  1KQS Q;  3CC7 R;  4UY8 S;  5H1S U;  1YJW R;  1Q86 S;  1S72 R;  1VQM R;  1W2B Q;  5MLC U;  1I4J A;  3CF5 P;  1VQO R;  3CC4 R;  4WFA P;  3G6E R;  1YIT R; 
#chains in the Genus database with same CATH topology
 4IOC P;  3I55 R;  1VQ5 R;  5CMO A;  1VQ7 R;  5DM7 P;  2ZJP P;  5DM6 P;  3H7Q A;  3J7Z S;  4IOA P;  1YIJ R;  2QEX R;  4V19 W;  3CCM R;  1N8R S;  1NJI S;  1VQN R;  2C43 A;  3PIO P;  2QA4 R;  3CCR R;  5HL7 P;  1M90 S;  3CCQ R;  3G71 R;  5JVG P;  1Q81 S;  3CPW Q;  4WCE P;  1VQP R;  4WFN P;  1M1K S;  1QVF Q;  4JM7 A;  3CD6 R;  2BDD A;  2OTJ R;  3CXC Q;  1FTE A;  4WF9 P;  3NE3 B;  2CG5 A;  1F80 A;  1QVG Q;  2WDO A;  3CME R;  2WAS A;  1Q7Y S;  1VQ4 R;  4U67 P;  2ZJQ P;  1VQ6 R;  3CC2 R;  1BXE A;  3HYK A;  2JBZ A;  5JVH P;  1VQK R;  2WDS A;  3CCS R;  4WFB P;  4IO9 P;  1VQ9 R;  3NE1 A;  5GAD T;  5CXD A;  2WAS B;  3GWM A;  2ZJR P;  3CCE R;  1QR0 A;  2QG8 A;  1K73 S;  2OTL R;  1F7T A;  3CCU R;  1YJN R;  3G4S R;  1K8A S;  1NBW A;  1YI2 R;  4HC6 A;  5GAH T;  1VQL R;  1F7L A;  2JCA A;  1K9M S;  2WDY A;  5GAG T;  1JJ2 Q;  3NFD A;  5GAE T;  1Q82 S;  3CCV R;  2D0P A;  1KD1 S;  3QMN A;  3CCJ R;  1YHQ R;  3CCL R;  1YJ9 R;  3PIP P;  1VQ8 R;  2BYD A;  3CMA R;  1FTH A;  1KC8 S;  3DLL P;  3OW2 Q;  3I56 R;  3J7Y T;  1KQS Q;  1FTF A;  3CC7 R;  4UY8 S;  5H1S U;  2D0O A;  4MRT A;  1YJW R;  1Q86 S;  2WAT A;  1S72 R;  4DXE A;  1VQM R;  1W2B Q;  5MLC U;  3HQJ A;  1I4J A;  3CF5 P;  1VQO R;  3CC4 R;  4WFA P;  3G6E R;  3NE9 A;  1YIT R; 
#chains in the Genus database with same CATH homology
 4IOC P;  3I55 R;  1VQ5 R;  1VQ7 R;  5DM7 P;  2ZJP P;  5DM6 P;  3J7Z S;  4IOA P;  1YIJ R;  2QEX R;  4V19 W;  3CCM R;  1N8R S;  1NJI S;  1VQN R;  3PIO P;  2QA4 R;  3CCR R;  5HL7 P;  1M90 S;  3CCQ R;  3G71 R;  5JVG P;  1Q81 S;  3CPW Q;  4WCE P;  1VQP R;  4WFN P;  1M1K S;  1QVF Q;  3CD6 R;  2OTJ R;  3CXC Q;  4WF9 P;  1QVG Q;  3CME R;  1Q7Y S;  1VQ4 R;  4U67 P;  2ZJQ P;  1VQ6 R;  3CC2 R;  1BXE A;  5JVH P;  1VQK R;  3CCS R;  4WFB P;  4IO9 P;  1VQ9 R;  5GAD T;  2ZJR P;  3CCE R;  1K73 S;  2OTL R;  3CCU R;  1YJN R;  3G4S R;  1K8A S;  1YI2 R;  5GAH T;  1VQL R;  1K9M S;  5GAG T;  1JJ2 Q;  5GAE T;  1Q82 S;  3CCV R;  1KD1 S;  3CCJ R;  1YHQ R;  3CCL R;  1YJ9 R;  3PIP P;  1VQ8 R;  3CMA R;  1KC8 S;  3DLL P;  3OW2 Q;  3I56 R;  3J7Y T;  1KQS Q;  3CC7 R;  4UY8 S;  5H1S U;  1YJW R;  1Q86 S;  1S72 R;  1VQM R;  1W2B Q;  5MLC U;  1I4J A;  3CF5 P;  1VQO R;  3CC4 R;  4WFA P;  3G6E R;  1YIT R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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