3HO5H

Crystal structure of hedgehog-interacting protein (hhip) and sonic hedgehog (shh) complex
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
154
structure length
154
Chain Sequence
KLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Hedgehog-interacting protein
total genus 38
structure length 154
sequence length 154
ec nomenclature
pdb deposition date 2009-06-01
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1380.10 Alpha Beta 2-Layer Sandwich Muramoyl-pentapeptide Carboxypeptidase; domain 2 Muramoyl-pentapeptide Carboxypeptidase; domain 2 3ho5H00
2WFXA 3K7HB 4C4NA 4MUSA 4MPHA 3D1MA 4MUTA 3N1GA 3K7GB 4C4MA 1R44A 4MURA 1LBUA 4NT9A 3MXWA 3N1MB 4D0YA 4OAKA 4F78A 3N1PB 2WFQA 3HO5H 4MUQA 2VO9A 2IBGE 3N1RA 4OX5A 3K7JB 3N1QA 3N1OA 4OXDA 5HNMA 2WFRA 4JIDA 3M1NA 2WG4A 1VHHA 2WG3A 3N1FA 1TZPA 1U10A 3K7IB 4OX3A
chains in the Genus database with same CATH superfamily
2J3RB 2WFXA 3K7HB 4C4NA 4MUSA 2OSOA 2J3WB 2J3TA 3KXCC 4MPHA 1WC8A 2CFHA 3D1MA 3CUEB 4MUTA 3N1GA 3K7GB 4C4MA 1R44A 3K7IB 2J3TB 2OSDA 4MURA 3NJCA 1LBUA 4NT9A 2J3WD 3MXWA 3N1MB 4D0YA 2C0JA 4OAKA 4F78A 3N1PB 1U10A 2WFQA 3HO5H 4MUQA 2VO9A 2IBGE 3CUED 3N1RA 3K7JB 4OX5A 3N1QA 3N1OA 4OXDA 5HNMA 2C0JB 2WFRA 4JIDA 2WG4A 3KXCA 2CFHC 3M1NA 2BJNA 2J3RA 2PWNA 1VHHA 1SZ7A 3N1FA 1TZPA 1WC9A 2WG3A 4OX3A
chains in the Genus database with same CATH topology
2WFXA 3K7HB 4C4NA 4MUSA 4MPHA 3D1MA 4MUTA 3N1GA 3K7GB 4C4MA 1R44A 4MURA 1LBUA 4NT9A 3MXWA 3N1MB 4D0YA 4OAKA 4F78A 3N1PB 2WFQA 3HO5H 4MUQA 2VO9A 2IBGE 3N1RA 4OX5A 3K7JB 3N1QA 3N1OA 4OXDA 5HNMA 2WFRA 4JIDA 3M1NA 2WG4A 1VHHA 2WG3A 3N1FA 1TZPA 1U10A 3K7IB 4OX3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WFX A;  3K7H B;  4C4N A;  4MUS A;  4MPH A;  3D1M A;  4MUT A;  3N1G A;  3K7G B;  4C4M A;  1R44 A;  4MUR A;  1LBU A;  4NT9 A;  3MXW A;  3N1M B;  4D0Y A;  4OAK A;  4F78 A;  3N1P B;  2WFQ A;  3HO5 H;  4MUQ A;  2VO9 A;  2IBG E;  3N1R A;  4OX5 A;  3K7J B;  3N1Q A;  3N1O A;  4OXD A;  5HNM A;  2WFR A;  4JID A;  3M1N A;  2WG4 A;  1VHH A;  2WG3 A;  3N1F A;  1TZP A;  1U10 A;  3K7I B;  4OX3 A; 
#chains in the Genus database with same CATH topology
 2J3R B;  2WFX A;  3K7H B;  4C4N A;  4MUS A;  2OSO A;  2J3W B;  2J3T A;  3KXC C;  4MPH A;  1WC8 A;  2CFH A;  3D1M A;  3CUE B;  4MUT A;  3N1G A;  3K7G B;  4C4M A;  1R44 A;  3K7I B;  2J3T B;  2OSD A;  4MUR A;  3NJC A;  1LBU A;  4NT9 A;  2J3W D;  3MXW A;  3N1M B;  4D0Y A;  2C0J A;  4OAK A;  4F78 A;  3N1P B;  1U10 A;  2WFQ A;  3HO5 H;  4MUQ A;  2VO9 A;  2IBG E;  3CUE D;  3N1R A;  3K7J B;  4OX5 A;  3N1Q A;  3N1O A;  4OXD A;  5HNM A;  2C0J B;  2WFR A;  4JID A;  2WG4 A;  3KXC A;  2CFH C;  3M1N A;  2BJN A;  2J3R A;  2PWN A;  1VHH A;  1SZ7 A;  3N1F A;  1TZP A;  1WC9 A;  2WG3 A;  4OX3 A; 
#chains in the Genus database with same CATH homology
 2WFX A;  3K7H B;  4C4N A;  4MUS A;  4MPH A;  3D1M A;  4MUT A;  3N1G A;  3K7G B;  4C4M A;  1R44 A;  4MUR A;  1LBU A;  4NT9 A;  3MXW A;  3N1M B;  4D0Y A;  4OAK A;  4F78 A;  3N1P B;  2WFQ A;  3HO5 H;  4MUQ A;  2VO9 A;  2IBG E;  3N1R A;  4OX5 A;  3K7J B;  3N1Q A;  3N1O A;  4OXD A;  5HNM A;  2WFR A;  4JID A;  3M1N A;  2WG4 A;  1VHH A;  2WG3 A;  3N1F A;  1TZP A;  1U10 A;  3K7I B;  4OX3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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