3MXWA

Crystal structure sonic hedgehog bound to the 5e1 fab fragment
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
153
structure length
153
Chain Sequence
LTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Sonic hedgehog protein
total genus 47
structure length 153
sequence length 153
ec nomenclature
pdb deposition date 2010-05-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1380.10 Alpha Beta 2-Layer Sandwich Muramoyl-pentapeptide Carboxypeptidase; domain 2 Muramoyl-pentapeptide Carboxypeptidase; domain 2 3mxwA00
3N1MB 1R44A 2IBGE 3HO5H 3K7HB 2WG4A 3N1QA 1TZPA 3K7JB 4JIDA 2WG3A 2WFXA 3N1GA 4OAKA 4D0YA 4C4NA 4F78A 2WFRA 1U10A 5HNMA 3D1MA 3N1OA 1LBUA 3MXWA 3N1FA 4OX3A 2VO9A 3M1NA 4MPHA 3K7GB 3K7IB 4MUSA 4NT9A 4MURA 4C4MA 3N1PB 4MUQA 4MUTA 3N1RA 1VHHA 4OX5A 4OXDA 2WFQA
chains in the Genus database with same CATH superfamily
3N1MB 1R44A 2IBGE 3HO5H 3K7HB 2WG4A 2J3WD 3N1QA 1TZPA 3CUEB 3K7JB 4JIDA 1WC8A 2WG3A 2WFXA 2PWNA 3N1GA 4OAKA 4C4NA 4D0YA 4F78A 2OSOA 2WFRA 1U10A 5HNMA 3D1MA 3N1OA 1LBUA 3MXWA 3N1FA 4OX3A 2VO9A 3M1NA 4MPHA 3K7GB 3K7IB 3CUED 4MUSA 2C0JA 4NT9A 2C0JB 2J3TA 1SZ7A 2J3RA 2CFHA 2CFHC 2J3TB 2OSDA 4MURA 4C4MA 3N1PB 4MUQA 2J3RB 4MUTA 2BJNA 3N1RA 3KXCA 3KXCC 2J3WB 1VHHA 3NJCA 4OX5A 4OXDA 2WFQA 1WC9A
chains in the Genus database with same CATH topology
3N1MB 1R44A 2IBGE 3HO5H 3K7HB 2WG4A 3N1QA 1TZPA 3K7JB 4JIDA 2WG3A 2WFXA 3N1GA 4OAKA 4D0YA 4C4NA 4F78A 2WFRA 1U10A 5HNMA 3D1MA 3N1OA 1LBUA 3MXWA 3N1FA 4OX3A 2VO9A 3M1NA 4MPHA 3K7GB 3K7IB 4MUSA 4NT9A 4MURA 4C4MA 3N1PB 4MUQA 4MUTA 3N1RA 1VHHA 4OX5A 4OXDA 2WFQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3N1M B;  1R44 A;  2IBG E;  3HO5 H;  3K7H B;  2WG4 A;  3N1Q A;  1TZP A;  3K7J B;  4JID A;  2WG3 A;  2WFX A;  3N1G A;  4OAK A;  4D0Y A;  4C4N A;  4F78 A;  2WFR A;  1U10 A;  5HNM A;  3D1M A;  3N1O A;  1LBU A;  3MXW A;  3N1F A;  4OX3 A;  2VO9 A;  3M1N A;  4MPH A;  3K7G B;  3K7I B;  4MUS A;  4NT9 A;  4MUR A;  4C4M A;  3N1P B;  4MUQ A;  4MUT A;  3N1R A;  1VHH A;  4OX5 A;  4OXD A;  2WFQ A; 
#chains in the Genus database with same CATH topology
 3N1M B;  1R44 A;  2IBG E;  3HO5 H;  3K7H B;  2WG4 A;  2J3W D;  3N1Q A;  1TZP A;  3CUE B;  3K7J B;  4JID A;  1WC8 A;  2WG3 A;  2WFX A;  2PWN A;  3N1G A;  4OAK A;  4C4N A;  4D0Y A;  4F78 A;  2OSO A;  2WFR A;  1U10 A;  5HNM A;  3D1M A;  3N1O A;  1LBU A;  3MXW A;  3N1F A;  4OX3 A;  2VO9 A;  3M1N A;  4MPH A;  3K7G B;  3K7I B;  3CUE D;  4MUS A;  2C0J A;  4NT9 A;  2C0J B;  2J3T A;  1SZ7 A;  2J3R A;  2CFH A;  2CFH C;  2J3T B;  2OSD A;  4MUR A;  4C4M A;  3N1P B;  4MUQ A;  2J3R B;  4MUT A;  2BJN A;  3N1R A;  3KXC A;  3KXC C;  2J3W B;  1VHH A;  3NJC A;  4OX5 A;  4OXD A;  2WFQ A;  1WC9 A; 
#chains in the Genus database with same CATH homology
 3N1M B;  1R44 A;  2IBG E;  3HO5 H;  3K7H B;  2WG4 A;  3N1Q A;  1TZP A;  3K7J B;  4JID A;  2WG3 A;  2WFX A;  3N1G A;  4OAK A;  4D0Y A;  4C4N A;  4F78 A;  2WFR A;  1U10 A;  5HNM A;  3D1M A;  3N1O A;  1LBU A;  3MXW A;  3N1F A;  4OX3 A;  2VO9 A;  3M1N A;  4MPH A;  3K7G B;  3K7I B;  4MUS A;  4NT9 A;  4MUR A;  4C4M A;  3N1P B;  4MUQ A;  4MUT A;  3N1R A;  1VHH A;  4OX5 A;  4OXD A;  2WFQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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