3MXWA

Crystal structure sonic hedgehog bound to the 5e1 fab fragment
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
153
structure length
153
Chain Sequence
LTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Sonic hedgehog protein
total genus 47
structure length 153
sequence length 153
ec nomenclature
pdb deposition date 2010-05-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1380.10 Alpha Beta 2-Layer Sandwich Muramoyl-pentapeptide Carboxypeptidase; domain 2 Muramoyl-pentapeptide Carboxypeptidase; domain 2 3mxwA00
3N1OA 4OAKA 3N1PB 4MPHA 5HNMA 3D1MA 2WG4A 2WFRA 2VO9A 1TZPA 3K7JB 2WG3A 3K7GB 3M1NA 1R44A 4NT9A 4MUSA 3N1MB 4MURA 3N1FA 4D0YA 4JIDA 3HO5H 4OX5A 3N1GA 2WFXA 3N1QA 3MXWA 3K7HB 2IBGE 4MUQA 1LBUA 4C4MA 3K7IB 4C4NA 1VHHA 4F78A 4OX3A 1U10A 2WFQA 4MUTA 4OXDA 3N1RA
chains in the Genus database with same CATH superfamily
3N1OA 2CFHA 4OAKA 1WC8A 3N1PB 4MPHA 2J3RA 2CFHC 3D1MA 2WG4A 2WFRA 2VO9A 5HNMA 1TZPA 3K7JB 2WG3A 1R44A 3K7GB 3M1NA 4NT9A 2OSDA 3KXCA 4MUSA 3N1MB 4MURA 3KXCC 3N1FA 2J3RB 4D0YA 1WC9A 4JIDA 2J3WD 2C0JA 2J3TA 3HO5H 4OX5A 3CUED 3N1GA 2WFXA 3N1QA 2BJNA 3MXWA 2IBGE 3K7HB 1SZ7A 1LBUA 2OSOA 3K7IB 3NJCA 4MUQA 4C4MA 4C4NA 1VHHA 2PWNA 2J3WB 1U10A 2WFQA 2C0JB 2J3TB 4MUTA 4OX3A 4F78A 4OXDA 3CUEB 3N1RA
chains in the Genus database with same CATH topology
3N1OA 4OAKA 3N1PB 4MPHA 5HNMA 3D1MA 2WG4A 2WFRA 2VO9A 1TZPA 3K7JB 2WG3A 3K7GB 3M1NA 1R44A 4NT9A 4MUSA 3N1MB 4MURA 3N1FA 4D0YA 4JIDA 3HO5H 4OX5A 3N1GA 2WFXA 3N1QA 3MXWA 3K7HB 2IBGE 4MUQA 1LBUA 4C4MA 3K7IB 4C4NA 1VHHA 4F78A 4OX3A 1U10A 2WFQA 4MUTA 4OXDA 3N1RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3N1O A;  4OAK A;  3N1P B;  4MPH A;  5HNM A;  3D1M A;  2WG4 A;  2WFR A;  2VO9 A;  1TZP A;  3K7J B;  2WG3 A;  3K7G B;  3M1N A;  1R44 A;  4NT9 A;  4MUS A;  3N1M B;  4MUR A;  3N1F A;  4D0Y A;  4JID A;  3HO5 H;  4OX5 A;  3N1G A;  2WFX A;  3N1Q A;  3MXW A;  3K7H B;  2IBG E;  4MUQ A;  1LBU A;  4C4M A;  3K7I B;  4C4N A;  1VHH A;  4F78 A;  4OX3 A;  1U10 A;  2WFQ A;  4MUT A;  4OXD A;  3N1R A; 
#chains in the Genus database with same CATH topology
 3N1O A;  2CFH A;  4OAK A;  1WC8 A;  3N1P B;  4MPH A;  2J3R A;  2CFH C;  3D1M A;  2WG4 A;  2WFR A;  2VO9 A;  5HNM A;  1TZP A;  3K7J B;  2WG3 A;  1R44 A;  3K7G B;  3M1N A;  4NT9 A;  2OSD A;  3KXC A;  4MUS A;  3N1M B;  4MUR A;  3KXC C;  3N1F A;  2J3R B;  4D0Y A;  1WC9 A;  4JID A;  2J3W D;  2C0J A;  2J3T A;  3HO5 H;  4OX5 A;  3CUE D;  3N1G A;  2WFX A;  3N1Q A;  2BJN A;  3MXW A;  2IBG E;  3K7H B;  1SZ7 A;  1LBU A;  2OSO A;  3K7I B;  3NJC A;  4MUQ A;  4C4M A;  4C4N A;  1VHH A;  2PWN A;  2J3W B;  1U10 A;  2WFQ A;  2C0J B;  2J3T B;  4MUT A;  4OX3 A;  4F78 A;  4OXD A;  3CUE B;  3N1R A; 
#chains in the Genus database with same CATH homology
 3N1O A;  4OAK A;  3N1P B;  4MPH A;  5HNM A;  3D1M A;  2WG4 A;  2WFR A;  2VO9 A;  1TZP A;  3K7J B;  2WG3 A;  3K7G B;  3M1N A;  1R44 A;  4NT9 A;  4MUS A;  3N1M B;  4MUR A;  3N1F A;  4D0Y A;  4JID A;  3HO5 H;  4OX5 A;  3N1G A;  2WFX A;  3N1Q A;  3MXW A;  3K7H B;  2IBG E;  4MUQ A;  1LBU A;  4C4M A;  3K7I B;  4C4N A;  1VHH A;  4F78 A;  4OX3 A;  1U10 A;  2WFQ A;  4MUT A;  4OXD A;  3N1R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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