3PIOP

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
126
structure length
126
Chain Sequence
FRNKKQRKQQVKLRKPGFAVAKYVRMSPRKVRLVVDVIRGKSVQDAEDLLRFIPRSASEPVAKVLNSAKANALHNDEMLEDRLFVKEAYVDAGPTLKRLIPRARGSANIIKKRTSHITIIVAEKGN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.
pubmed doi rcsb
molecule tags Ribosome/antibiotic
molecule keywords RIBOSOMAL 23S RNA
total genus 27
structure length 126
sequence length 126
ec nomenclature
pdb deposition date 2010-11-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00237 Ribosomal_L22 Ribosomal protein L22p/L17e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.470.10 Alpha Beta Alpha-Beta Complex Ribosomal Protein L22; Chain A Ribosomal protein L22/L17 3pioP00
4UY8S 3CCLR 1VQMR 3PIOP 1K73S 1KD1S 1VQPR 1W2BQ 3CCJR 4IOAP 3CC7R 1KC8S 4IO9P 4WF9P 1YJ9R 4WFBP 5JVHP 3J7ZS 1VQNR 5JVGP 2OTJR 2OTLR 5MLCU 5H1SU 3J7YT 1YHQR 3OW2Q 1YJNR 1K9MS 1QVGQ 4WFNP 3CPWQ 4IOCP 3CC2R 5GAHT 1YIJR 1YI2R 1I4JA 1VQ4R 1S72R 3CCER 1VQLR 3G6ER 3CCSR 3DLLP 3CC4R 3CMER 3CF5P 5HL7P 3CCRR 4U67P 1QVFQ 4V19W 4WFAP 1Q7YS 3G4SR 1JJ2Q 3CCVR 5GAET 2QA4R 2ZJRP 1M90S 3CCMR 1VQ8R 1VQ9R 5GADT 3I55R 1M1KS 1Q86S 1KQSQ 1VQOR 1Q82S 1YJWR 3CCQR 3PIPP 1VQKR 1VQ6R 3CD6R 1N8RS 2ZJQP 1BXEA 3I56R 2QEXR 1Q81S 1K8AS 4WCEP 2ZJPP 3CCUR 1VQ5R 3CXCQ 1VQ7R 5DM7P 1YITR 5DM6P 3CMAR 1NJIS 5GAGT 3G71R
chains in the Genus database with same CATH superfamily
4UY8S 1QR0A 3CCLR 4DXEA 1VQMR 1F7LA 3PIOP 1K73S 1KD1S 2JCAA 1VQPR 3NE1A 1W2BQ 3CCJR 4IOAP 5CMOA 3CC7R 1KC8S 4IO9P 2BYDA 4WF9P 1YJ9R 4WFBP 5JVHP 3J7ZS 1VQNR 5JVGP 2OTJR 2OTLR 3H7QA 5MLCU 5H1SU 3J7YT 1YHQR 3OW2Q 1YJNR 1K9MS 1QVGQ 2WASB 3NFDA 4WFNP 3CPWQ 4IOCP 2BDDA 5GAHT 3CC2R 1YIJR 1YI2R 1I4JA 1VQ4R 2WATA 1S72R 3CCER 2C43A 1VQLR 2WASA 3G6ER 3CCSR 3DLLP 3CC4R 3CMER 3CF5P 5HL7P 3CCRR 3HYKA 4U67P 1QVFQ 4V19W 2CG5A 4WFAP 1Q7YS 3G4SR 1JJ2Q 3GWMA 3CCVR 5CXDA 2QG8A 1F7TA 5GAET 2QA4R 2ZJRP 1M90S 3CCMR 1VQ8R 1F80A 1VQ9R 2D0PA 3QMNA 5GADT 3I55R 2WDSA 1M1KS 1Q86S 3NE3B 1KQSQ 2JBZA 1VQOR 1FTEA 1Q82S 4HC6A 1YJWR 3CCQR 3PIPP 1FTFA 1VQKR 2WDYA 1VQ6R 3CD6R 2D0OA 2ZJQP 1N8RS 1BXEA 4JM7A 3I56R 4MRTA 3HQJA 3NE9A 2QEXR 1Q81S 1K8AS 1FTHA 4WCEP 2ZJPP 3CCUR 1VQ5R 2WDOA 3CXCQ 1VQ7R 5DM7P 1YITR 5DM6P 3CMAR 1NJIS 5GAGT 3G71R 1NBWA
chains in the Genus database with same CATH topology
4UY8S 3CCLR 1VQMR 3PIOP 1K73S 1KD1S 1VQPR 1W2BQ 3CCJR 4IOAP 3CC7R 1KC8S 4IO9P 4WF9P 1YJ9R 4WFBP 5JVHP 3J7ZS 1VQNR 5JVGP 2OTJR 2OTLR 5MLCU 5H1SU 3J7YT 1YHQR 3OW2Q 1YJNR 1K9MS 1QVGQ 4WFNP 3CPWQ 4IOCP 3CC2R 5GAHT 1YIJR 1YI2R 1I4JA 1VQ4R 1S72R 3CCER 1VQLR 3G6ER 3CCSR 3DLLP 3CC4R 3CMER 3CF5P 5HL7P 3CCRR 4U67P 1QVFQ 4V19W 4WFAP 1Q7YS 3G4SR 1JJ2Q 3CCVR 5GAET 2QA4R 2ZJRP 1M90S 3CCMR 1VQ8R 1VQ9R 5GADT 3I55R 1M1KS 1Q86S 1KQSQ 1VQOR 1Q82S 1YJWR 3CCQR 3PIPP 1VQKR 1VQ6R 3CD6R 1N8RS 2ZJQP 1BXEA 3I56R 2QEXR 1Q81S 1K8AS 4WCEP 2ZJPP 3CCUR 1VQ5R 3CXCQ 1VQ7R 5DM7P 1YITR 5DM6P 3CMAR 1NJIS 5GAGT 3G71R
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UY8 S;  3CCL R;  1VQM R;  3PIO P;  1K73 S;  1KD1 S;  1VQP R;  1W2B Q;  3CCJ R;  4IOA P;  3CC7 R;  1KC8 S;  4IO9 P;  4WF9 P;  1YJ9 R;  4WFB P;  5JVH P;  3J7Z S;  1VQN R;  5JVG P;  2OTJ R;  2OTL R;  5MLC U;  5H1S U;  3J7Y T;  1YHQ R;  3OW2 Q;  1YJN R;  1K9M S;  1QVG Q;  4WFN P;  3CPW Q;  4IOC P;  3CC2 R;  5GAH T;  1YIJ R;  1YI2 R;  1I4J A;  1VQ4 R;  1S72 R;  3CCE R;  1VQL R;  3G6E R;  3CCS R;  3DLL P;  3CC4 R;  3CME R;  3CF5 P;  5HL7 P;  3CCR R;  4U67 P;  1QVF Q;  4V19 W;  4WFA P;  1Q7Y S;  3G4S R;  1JJ2 Q;  3CCV R;  5GAE T;  2QA4 R;  2ZJR P;  1M90 S;  3CCM R;  1VQ8 R;  1VQ9 R;  5GAD T;  3I55 R;  1M1K S;  1Q86 S;  1KQS Q;  1VQO R;  1Q82 S;  1YJW R;  3CCQ R;  3PIP P;  1VQK R;  1VQ6 R;  3CD6 R;  1N8R S;  2ZJQ P;  1BXE A;  3I56 R;  2QEX R;  1Q81 S;  1K8A S;  4WCE P;  2ZJP P;  3CCU R;  1VQ5 R;  3CXC Q;  1VQ7 R;  5DM7 P;  1YIT R;  5DM6 P;  3CMA R;  1NJI S;  5GAG T;  3G71 R; 
#chains in the Genus database with same CATH topology
 4UY8 S;  1QR0 A;  3CCL R;  4DXE A;  1VQM R;  1F7L A;  3PIO P;  1K73 S;  1KD1 S;  2JCA A;  1VQP R;  3NE1 A;  1W2B Q;  3CCJ R;  4IOA P;  5CMO A;  3CC7 R;  1KC8 S;  4IO9 P;  2BYD A;  4WF9 P;  1YJ9 R;  4WFB P;  5JVH P;  3J7Z S;  1VQN R;  5JVG P;  2OTJ R;  2OTL R;  3H7Q A;  5MLC U;  5H1S U;  3J7Y T;  1YHQ R;  3OW2 Q;  1YJN R;  1K9M S;  1QVG Q;  2WAS B;  3NFD A;  4WFN P;  3CPW Q;  4IOC P;  2BDD A;  5GAH T;  3CC2 R;  1YIJ R;  1YI2 R;  1I4J A;  1VQ4 R;  2WAT A;  1S72 R;  3CCE R;  2C43 A;  1VQL R;  2WAS A;  3G6E R;  3CCS R;  3DLL P;  3CC4 R;  3CME R;  3CF5 P;  5HL7 P;  3CCR R;  3HYK A;  4U67 P;  1QVF Q;  4V19 W;  2CG5 A;  4WFA P;  1Q7Y S;  3G4S R;  1JJ2 Q;  3GWM A;  3CCV R;  5CXD A;  2QG8 A;  1F7T A;  5GAE T;  2QA4 R;  2ZJR P;  1M90 S;  3CCM R;  1VQ8 R;  1F80 A;  1VQ9 R;  2D0P A;  3QMN A;  5GAD T;  3I55 R;  2WDS A;  1M1K S;  1Q86 S;  3NE3 B;  1KQS Q;  2JBZ A;  1VQO R;  1FTE A;  1Q82 S;  4HC6 A;  1YJW R;  3CCQ R;  3PIP P;  1FTF A;  1VQK R;  2WDY A;  1VQ6 R;  3CD6 R;  2D0O A;  2ZJQ P;  1N8R S;  1BXE A;  4JM7 A;  3I56 R;  4MRT A;  3HQJ A;  3NE9 A;  2QEX R;  1Q81 S;  1K8A S;  1FTH A;  4WCE P;  2ZJP P;  3CCU R;  1VQ5 R;  2WDO A;  3CXC Q;  1VQ7 R;  5DM7 P;  1YIT R;  5DM6 P;  3CMA R;  1NJI S;  5GAG T;  3G71 R;  1NBW A; 
#chains in the Genus database with same CATH homology
 4UY8 S;  3CCL R;  1VQM R;  3PIO P;  1K73 S;  1KD1 S;  1VQP R;  1W2B Q;  3CCJ R;  4IOA P;  3CC7 R;  1KC8 S;  4IO9 P;  4WF9 P;  1YJ9 R;  4WFB P;  5JVH P;  3J7Z S;  1VQN R;  5JVG P;  2OTJ R;  2OTL R;  5MLC U;  5H1S U;  3J7Y T;  1YHQ R;  3OW2 Q;  1YJN R;  1K9M S;  1QVG Q;  4WFN P;  3CPW Q;  4IOC P;  3CC2 R;  5GAH T;  1YIJ R;  1YI2 R;  1I4J A;  1VQ4 R;  1S72 R;  3CCE R;  1VQL R;  3G6E R;  3CCS R;  3DLL P;  3CC4 R;  3CME R;  3CF5 P;  5HL7 P;  3CCR R;  4U67 P;  1QVF Q;  4V19 W;  4WFA P;  1Q7Y S;  3G4S R;  1JJ2 Q;  3CCV R;  5GAE T;  2QA4 R;  2ZJR P;  1M90 S;  3CCM R;  1VQ8 R;  1VQ9 R;  5GAD T;  3I55 R;  1M1K S;  1Q86 S;  1KQS Q;  1VQO R;  1Q82 S;  1YJW R;  3CCQ R;  3PIP P;  1VQK R;  1VQ6 R;  3CD6 R;  1N8R S;  2ZJQ P;  1BXE A;  3I56 R;  2QEX R;  1Q81 S;  1K8A S;  4WCE P;  2ZJP P;  3CCU R;  1VQ5 R;  3CXC Q;  1VQ7 R;  5DM7 P;  1YIT R;  5DM6 P;  3CMA R;  1NJI S;  5GAG T;  3G71 R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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