3G4SR

Co-crystal structure of tiamulin bound to the large ribosomal subunit
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
150
structure length
150
Chain Sequence
GISYSVEADPDTTAKAMLRERQMSFKHSKAIAREIKGKTAGEAVDYLEAVIEGDQPVPFKQHNSGVGHKSKVDGWDAGRYPEKASKAFLDLLENAVGNADHQGFDGEAMTIKHVAAHKVGEQQGRKPRAMGRASAWNSPQVDVELILEEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 38
structure length 150
sequence length 150
ec nomenclature
pdb deposition date 2009-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00237 Ribosomal_L22 Ribosomal protein L22p/L17e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.470.10 Alpha Beta Alpha-Beta Complex Ribosomal Protein L22; Chain A Ribosomal protein L22/L17 3g4sR00
3CXCQ 1Q82S 3CPWQ 4U67P 1K9MS 5MLCU 1KC8S 1VQ5R 3PIPP 4IOAP 2QEXR 1YJNR 1VQ7R 5GAHT 5HL7P 3CCJR 2ZJRP 3CMAR 3CCVR 1Q81S 1K73S 1YJWR 2OTLR 5JVGP 1QVFQ 4WCEP 5JVHP 2ZJPP 5DM6P 3CCLR 1KD1S 1KQSQ 1M1KS 1YI2R 3CF5P 1YIJR 1VQ9R 4WFAP 5DM7P 3G4SR 1QVGQ 1N8RS 2OTJR 1VQPR 2QA4R 2ZJQP 5GAET 4V19W 1I4JA 3G6ER 1NJIS 3CCUR 3CCER 3J7ZS 1VQOR 4WF9P 3CC7R 5H1SU 1VQMR 4WFBP 1S72R 1VQ4R 3CC2R 1JJ2Q 1VQKR 3CMER 1BXEA 1K8AS 3J7YT 3CC4R 3DLLP 3PIOP 4WFNP 3CD6R 1W2BQ 1VQ6R 3OW2Q 1VQNR 1Q86S 4UY8S 1YJ9R 3CCQR 4IO9P 4IOCP 5GAGT 1M90S 3I55R 3G71R 1VQ8R 5GADT 1YHQR 3I56R 1YITR 1VQLR 3CCMR 1Q7YS 3CCRR 3CCSR
chains in the Genus database with same CATH superfamily
3CXCQ 1Q82S 3CPWQ 4U67P 1K9MS 2BYDA 5MLCU 1KC8S 1VQ5R 3PIPP 3QMNA 4IOAP 2QEXR 1YJNR 1VQ7R 1FTFA 3NE9A 5GAHT 5HL7P 2C43A 2WASA 2ZJRP 3CCJR 3CMAR 3CCVR 1Q81S 1K73S 3HYKA 1YJWR 1NBWA 2OTLR 5JVGP 1QVFQ 4WCEP 5JVHP 2ZJPP 3GWMA 4MRTA 5DM6P 3CCLR 1KD1S 1KQSQ 1M1KS 1YI2R 3CF5P 5CXDA 3NE3B 2CG5A 1YIJR 1VQ9R 4WFAP 2JCAA 5DM7P 3G4SR 1QVGQ 1N8RS 2OTJR 1VQPR 2QA4R 2ZJQP 3NE1A 5GAET 1F7TA 2D0OA 4V19W 1I4JA 3G6ER 1NJIS 3CCUR 3CCER 3J7ZS 1VQOR 4WF9P 3CC7R 5H1SU 1F7LA 1QR0A 2BDDA 4WFBP 2WDSA 1VQMR 1S72R 1VQ4R 3CC2R 1F80A 1JJ2Q 1VQKR 3H7QA 3CMER 2WDYA 1BXEA 1K8AS 3J7YT 3CC4R 3HQJA 3PIOP 3DLLP 4HC6A 4WFNP 2D0PA 1FTEA 3CD6R 1W2BQ 1VQ6R 3OW2Q 2QG8A 1VQNR 1Q86S 4UY8S 1YJ9R 3CCQR 4IO9P 4IOCP 5GAGT 1M90S 3I55R 3G71R 1VQ8R 4JM7A 5GADT 1YHQR 3I56R 1YITR 1VQLR 5CMOA 3NFDA 2WASB 3CCMR 2WATA 4DXEA 1FTHA 1Q7YS 3CCRR 2WDOA 3CCSR 2JBZA
chains in the Genus database with same CATH topology
3CXCQ 1Q82S 3CPWQ 4U67P 1K9MS 5MLCU 1KC8S 1VQ5R 3PIPP 4IOAP 2QEXR 1YJNR 1VQ7R 5GAHT 5HL7P 3CCJR 2ZJRP 3CMAR 3CCVR 1Q81S 1K73S 1YJWR 2OTLR 5JVGP 1QVFQ 4WCEP 5JVHP 2ZJPP 5DM6P 3CCLR 1KD1S 1KQSQ 1M1KS 1YI2R 3CF5P 1YIJR 1VQ9R 4WFAP 5DM7P 3G4SR 1QVGQ 1N8RS 2OTJR 1VQPR 2QA4R 2ZJQP 5GAET 4V19W 1I4JA 3G6ER 1NJIS 3CCUR 3CCER 3J7ZS 1VQOR 4WF9P 3CC7R 5H1SU 1VQMR 4WFBP 1S72R 1VQ4R 3CC2R 1JJ2Q 1VQKR 3CMER 1BXEA 1K8AS 3J7YT 3CC4R 3DLLP 3PIOP 4WFNP 3CD6R 1W2BQ 1VQ6R 3OW2Q 1VQNR 1Q86S 4UY8S 1YJ9R 3CCQR 4IO9P 4IOCP 5GAGT 1M90S 3I55R 3G71R 1VQ8R 5GADT 1YHQR 3I56R 1YITR 1VQLR 3CCMR 1Q7YS 3CCRR 3CCSR
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CXC Q;  1Q82 S;  3CPW Q;  4U67 P;  1K9M S;  5MLC U;  1KC8 S;  1VQ5 R;  3PIP P;  4IOA P;  2QEX R;  1YJN R;  1VQ7 R;  5GAH T;  5HL7 P;  3CCJ R;  2ZJR P;  3CMA R;  3CCV R;  1Q81 S;  1K73 S;  1YJW R;  2OTL R;  5JVG P;  1QVF Q;  4WCE P;  5JVH P;  2ZJP P;  5DM6 P;  3CCL R;  1KD1 S;  1KQS Q;  1M1K S;  1YI2 R;  3CF5 P;  1YIJ R;  1VQ9 R;  4WFA P;  5DM7 P;  3G4S R;  1QVG Q;  1N8R S;  2OTJ R;  1VQP R;  2QA4 R;  2ZJQ P;  5GAE T;  4V19 W;  1I4J A;  3G6E R;  1NJI S;  3CCU R;  3CCE R;  3J7Z S;  1VQO R;  4WF9 P;  3CC7 R;  5H1S U;  1VQM R;  4WFB P;  1S72 R;  1VQ4 R;  3CC2 R;  1JJ2 Q;  1VQK R;  3CME R;  1BXE A;  1K8A S;  3J7Y T;  3CC4 R;  3DLL P;  3PIO P;  4WFN P;  3CD6 R;  1W2B Q;  1VQ6 R;  3OW2 Q;  1VQN R;  1Q86 S;  4UY8 S;  1YJ9 R;  3CCQ R;  4IO9 P;  4IOC P;  5GAG T;  1M90 S;  3I55 R;  3G71 R;  1VQ8 R;  5GAD T;  1YHQ R;  3I56 R;  1YIT R;  1VQL R;  3CCM R;  1Q7Y S;  3CCR R;  3CCS R; 
#chains in the Genus database with same CATH topology
 3CXC Q;  1Q82 S;  3CPW Q;  4U67 P;  1K9M S;  2BYD A;  5MLC U;  1KC8 S;  1VQ5 R;  3PIP P;  3QMN A;  4IOA P;  2QEX R;  1YJN R;  1VQ7 R;  1FTF A;  3NE9 A;  5GAH T;  5HL7 P;  2C43 A;  2WAS A;  2ZJR P;  3CCJ R;  3CMA R;  3CCV R;  1Q81 S;  1K73 S;  3HYK A;  1YJW R;  1NBW A;  2OTL R;  5JVG P;  1QVF Q;  4WCE P;  5JVH P;  2ZJP P;  3GWM A;  4MRT A;  5DM6 P;  3CCL R;  1KD1 S;  1KQS Q;  1M1K S;  1YI2 R;  3CF5 P;  5CXD A;  3NE3 B;  2CG5 A;  1YIJ R;  1VQ9 R;  4WFA P;  2JCA A;  5DM7 P;  3G4S R;  1QVG Q;  1N8R S;  2OTJ R;  1VQP R;  2QA4 R;  2ZJQ P;  3NE1 A;  5GAE T;  1F7T A;  2D0O A;  4V19 W;  1I4J A;  3G6E R;  1NJI S;  3CCU R;  3CCE R;  3J7Z S;  1VQO R;  4WF9 P;  3CC7 R;  5H1S U;  1F7L A;  1QR0 A;  2BDD A;  4WFB P;  2WDS A;  1VQM R;  1S72 R;  1VQ4 R;  3CC2 R;  1F80 A;  1JJ2 Q;  1VQK R;  3H7Q A;  3CME R;  2WDY A;  1BXE A;  1K8A S;  3J7Y T;  3CC4 R;  3HQJ A;  3PIO P;  3DLL P;  4HC6 A;  4WFN P;  2D0P A;  1FTE A;  3CD6 R;  1W2B Q;  1VQ6 R;  3OW2 Q;  2QG8 A;  1VQN R;  1Q86 S;  4UY8 S;  1YJ9 R;  3CCQ R;  4IO9 P;  4IOC P;  5GAG T;  1M90 S;  3I55 R;  3G71 R;  1VQ8 R;  4JM7 A;  5GAD T;  1YHQ R;  3I56 R;  1YIT R;  1VQL R;  5CMO A;  3NFD A;  2WAS B;  3CCM R;  2WAT A;  4DXE A;  1FTH A;  1Q7Y S;  3CCR R;  2WDO A;  3CCS R;  2JBZ A; 
#chains in the Genus database with same CATH homology
 3CXC Q;  1Q82 S;  3CPW Q;  4U67 P;  1K9M S;  5MLC U;  1KC8 S;  1VQ5 R;  3PIP P;  4IOA P;  2QEX R;  1YJN R;  1VQ7 R;  5GAH T;  5HL7 P;  3CCJ R;  2ZJR P;  3CMA R;  3CCV R;  1Q81 S;  1K73 S;  1YJW R;  2OTL R;  5JVG P;  1QVF Q;  4WCE P;  5JVH P;  2ZJP P;  5DM6 P;  3CCL R;  1KD1 S;  1KQS Q;  1M1K S;  1YI2 R;  3CF5 P;  1YIJ R;  1VQ9 R;  4WFA P;  5DM7 P;  3G4S R;  1QVG Q;  1N8R S;  2OTJ R;  1VQP R;  2QA4 R;  2ZJQ P;  5GAE T;  4V19 W;  1I4J A;  3G6E R;  1NJI S;  3CCU R;  3CCE R;  3J7Z S;  1VQO R;  4WF9 P;  3CC7 R;  5H1S U;  1VQM R;  4WFB P;  1S72 R;  1VQ4 R;  3CC2 R;  1JJ2 Q;  1VQK R;  3CME R;  1BXE A;  1K8A S;  3J7Y T;  3CC4 R;  3DLL P;  3PIO P;  4WFN P;  3CD6 R;  1W2B Q;  1VQ6 R;  3OW2 Q;  1VQN R;  1Q86 S;  4UY8 S;  1YJ9 R;  3CCQ R;  4IO9 P;  4IOC P;  5GAG T;  1M90 S;  3I55 R;  3G71 R;  1VQ8 R;  5GAD T;  1YHQ R;  3I56 R;  1YIT R;  1VQL R;  3CCM R;  1Q7Y S;  3CCR R;  3CCS R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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