3G6ER

Co-crystal structure of homoharringtonine bound to the large ribosomal subunit
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
150
structure length
150
Chain Sequence
GISYSVEADPDTTAKAMLRERQMSFKHSKAIAREIKGKTAGEAVDYLEAVIEGDQPVPFKQHNSGVGHKSKVDGWDAGRYPEKASKAFLDLLENAVGNADHQGFDGEAMTIKHVAAHKVGEQQGRKPRAMGRASAWNSPQVDVELILEEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 38
structure length 150
sequence length 150
ec nomenclature
pdb deposition date 2009-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
R PF00237 Ribosomal_L22 Ribosomal protein L22p/L17e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.470.10 Alpha Beta Alpha-Beta Complex Ribosomal Protein L22; Chain A Ribosomal protein L22/L17 3g6eR00
1YJWR 1VQ4R 4WFNP 1YHQR 4WF9P 3G6ER 1VQNR 4IOCP 1NJIS 3CC2R 2OTLR 1Q7YS 1VQKR 3CCQR 1KD1S 5H1SU 1Q86S 3CCMR 1VQMR 3I56R 3CD6R 1JJ2Q 5DM6P 5MLCU 3CMAR 3J7YT 1YJNR 5HL7P 3CCUR 1VQ7R 5GAGT 2OTJR 3J7ZS 3OW2Q 1YITR 4V19W 4UY8S 5GAET 1QVFQ 4WCEP 4IOAP 3CCER 1KC8S 1M90S 1VQ9R 1Q82S 3CF5P 1N8RS 3PIPP 3CCRR 2ZJPP 1M1KS 2ZJQP 1QVGQ 3CMER 3CC7R 1VQLR 4WFAP 1VQ5R 5GAHT 1Q81S 1VQ6R 3I55R 3CCJR 5JVGP 5JVHP 1YIJR 3PIOP 1K73S 1VQPR 1YJ9R 1VQOR 3CCSR 2QA4R 1S72R 2ZJRP 3CCLR 3CPWQ 1W2BQ 3CCVR 1BXEA 5DM7P 3G71R 3CC4R 4U67P 3G4SR 1I4JA 3CXCQ 4IO9P 1VQ8R 1K9MS 5GADT 2QEXR 1K8AS 3DLLP 1YI2R 4WFBP 1KQSQ
chains in the Genus database with same CATH superfamily
2BDDA 2D0PA 1YJWR 1VQ4R 4WFNP 2WDSA 1YHQR 4WF9P 1QR0A 3NFDA 1NBWA 3G6ER 4DXEA 1VQNR 4IOCP 2C43A 1NJIS 3CC2R 3NE9A 2OTLR 3HYKA 2JCAA 1Q7YS 1VQKR 3CCQR 1KD1S 5H1SU 1Q86S 3CCMR 1VQMR 3I56R 3CD6R 1JJ2Q 1FTHA 5DM6P 5MLCU 3CMAR 3NE1A 3H7QA 3J7YT 1YJNR 5HL7P 2BYDA 3CCUR 5CMOA 1VQ7R 5GAGT 3QMNA 2OTJR 3J7ZS 3OW2Q 4MRTA 1YITR 4V19W 4UY8S 5GAET 1FTFA 1QVFQ 4WCEP 4IOAP 3CCER 1KC8S 2WATA 1M90S 1VQ9R 3NE3B 1Q82S 3CF5P 1N8RS 3PIPP 2JBZA 3CCRR 2ZJPP 2CG5A 1M1KS 2ZJQP 1QVGQ 3CMER 3CC7R 1VQLR 4WFAP 5CXDA 1VQ5R 5GAHT 2QG8A 1F7LA 1Q81S 1F80A 1VQ6R 3I55R 3CCJR 5JVGP 5JVHP 1YIJR 3PIOP 1K73S 1VQPR 1YJ9R 1VQOR 3GWMA 4HC6A 2WDYA 3CCSR 2QA4R 1S72R 2WASA 2ZJRP 2WDOA 3HQJA 3CCLR 3CPWQ 1W2BQ 3CCVR 1F7TA 1BXEA 5DM7P 3G71R 3CC4R 4JM7A 4U67P 2WASB 1I4JA 3G4SR 3CXCQ 4IO9P 1VQ8R 1K9MS 5GADT 2QEXR 1K8AS 3DLLP 2D0OA 1YI2R 4WFBP 1KQSQ 1FTEA
chains in the Genus database with same CATH topology
1YJWR 1VQ4R 4WFNP 1YHQR 4WF9P 3G6ER 1VQNR 4IOCP 1NJIS 3CC2R 2OTLR 1Q7YS 1VQKR 3CCQR 1KD1S 5H1SU 1Q86S 3CCMR 1VQMR 3I56R 3CD6R 1JJ2Q 5DM6P 5MLCU 3CMAR 3J7YT 1YJNR 5HL7P 3CCUR 1VQ7R 5GAGT 2OTJR 3J7ZS 3OW2Q 1YITR 4V19W 4UY8S 5GAET 1QVFQ 4WCEP 4IOAP 3CCER 1KC8S 1M90S 1VQ9R 1Q82S 3CF5P 1N8RS 3PIPP 3CCRR 2ZJPP 1M1KS 2ZJQP 1QVGQ 3CMER 3CC7R 1VQLR 4WFAP 1VQ5R 5GAHT 1Q81S 1VQ6R 3I55R 3CCJR 5JVGP 5JVHP 1YIJR 3PIOP 1K73S 1VQPR 1YJ9R 1VQOR 3CCSR 2QA4R 1S72R 2ZJRP 3CCLR 3CPWQ 1W2BQ 3CCVR 1BXEA 5DM7P 3G71R 3CC4R 4U67P 3G4SR 1I4JA 3CXCQ 4IO9P 1VQ8R 1K9MS 5GADT 2QEXR 1K8AS 3DLLP 1YI2R 4WFBP 1KQSQ
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YJW R;  1VQ4 R;  4WFN P;  1YHQ R;  4WF9 P;  3G6E R;  1VQN R;  4IOC P;  1NJI S;  3CC2 R;  2OTL R;  1Q7Y S;  1VQK R;  3CCQ R;  1KD1 S;  5H1S U;  1Q86 S;  3CCM R;  1VQM R;  3I56 R;  3CD6 R;  1JJ2 Q;  5DM6 P;  5MLC U;  3CMA R;  3J7Y T;  1YJN R;  5HL7 P;  3CCU R;  1VQ7 R;  5GAG T;  2OTJ R;  3J7Z S;  3OW2 Q;  1YIT R;  4V19 W;  4UY8 S;  5GAE T;  1QVF Q;  4WCE P;  4IOA P;  3CCE R;  1KC8 S;  1M90 S;  1VQ9 R;  1Q82 S;  3CF5 P;  1N8R S;  3PIP P;  3CCR R;  2ZJP P;  1M1K S;  2ZJQ P;  1QVG Q;  3CME R;  3CC7 R;  1VQL R;  4WFA P;  1VQ5 R;  5GAH T;  1Q81 S;  1VQ6 R;  3I55 R;  3CCJ R;  5JVG P;  5JVH P;  1YIJ R;  3PIO P;  1K73 S;  1VQP R;  1YJ9 R;  1VQO R;  3CCS R;  2QA4 R;  1S72 R;  2ZJR P;  3CCL R;  3CPW Q;  1W2B Q;  3CCV R;  1BXE A;  5DM7 P;  3G71 R;  3CC4 R;  4U67 P;  3G4S R;  1I4J A;  3CXC Q;  4IO9 P;  1VQ8 R;  1K9M S;  5GAD T;  2QEX R;  1K8A S;  3DLL P;  1YI2 R;  4WFB P;  1KQS Q; 
#chains in the Genus database with same CATH topology
 2BDD A;  2D0P A;  1YJW R;  1VQ4 R;  4WFN P;  2WDS A;  1YHQ R;  4WF9 P;  1QR0 A;  3NFD A;  1NBW A;  3G6E R;  4DXE A;  1VQN R;  4IOC P;  2C43 A;  1NJI S;  3CC2 R;  3NE9 A;  2OTL R;  3HYK A;  2JCA A;  1Q7Y S;  1VQK R;  3CCQ R;  1KD1 S;  5H1S U;  1Q86 S;  3CCM R;  1VQM R;  3I56 R;  3CD6 R;  1JJ2 Q;  1FTH A;  5DM6 P;  5MLC U;  3CMA R;  3NE1 A;  3H7Q A;  3J7Y T;  1YJN R;  5HL7 P;  2BYD A;  3CCU R;  5CMO A;  1VQ7 R;  5GAG T;  3QMN A;  2OTJ R;  3J7Z S;  3OW2 Q;  4MRT A;  1YIT R;  4V19 W;  4UY8 S;  5GAE T;  1FTF A;  1QVF Q;  4WCE P;  4IOA P;  3CCE R;  1KC8 S;  2WAT A;  1M90 S;  1VQ9 R;  3NE3 B;  1Q82 S;  3CF5 P;  1N8R S;  3PIP P;  2JBZ A;  3CCR R;  2ZJP P;  2CG5 A;  1M1K S;  2ZJQ P;  1QVG Q;  3CME R;  3CC7 R;  1VQL R;  4WFA P;  5CXD A;  1VQ5 R;  5GAH T;  2QG8 A;  1F7L A;  1Q81 S;  1F80 A;  1VQ6 R;  3I55 R;  3CCJ R;  5JVG P;  5JVH P;  1YIJ R;  3PIO P;  1K73 S;  1VQP R;  1YJ9 R;  1VQO R;  3GWM A;  4HC6 A;  2WDY A;  3CCS R;  2QA4 R;  1S72 R;  2WAS A;  2ZJR P;  2WDO A;  3HQJ A;  3CCL R;  3CPW Q;  1W2B Q;  3CCV R;  1F7T A;  1BXE A;  5DM7 P;  3G71 R;  3CC4 R;  4JM7 A;  4U67 P;  2WAS B;  1I4J A;  3G4S R;  3CXC Q;  4IO9 P;  1VQ8 R;  1K9M S;  5GAD T;  2QEX R;  1K8A S;  3DLL P;  2D0O A;  1YI2 R;  4WFB P;  1KQS Q;  1FTE A; 
#chains in the Genus database with same CATH homology
 1YJW R;  1VQ4 R;  4WFN P;  1YHQ R;  4WF9 P;  3G6E R;  1VQN R;  4IOC P;  1NJI S;  3CC2 R;  2OTL R;  1Q7Y S;  1VQK R;  3CCQ R;  1KD1 S;  5H1S U;  1Q86 S;  3CCM R;  1VQM R;  3I56 R;  3CD6 R;  1JJ2 Q;  5DM6 P;  5MLC U;  3CMA R;  3J7Y T;  1YJN R;  5HL7 P;  3CCU R;  1VQ7 R;  5GAG T;  2OTJ R;  3J7Z S;  3OW2 Q;  1YIT R;  4V19 W;  4UY8 S;  5GAE T;  1QVF Q;  4WCE P;  4IOA P;  3CCE R;  1KC8 S;  1M90 S;  1VQ9 R;  1Q82 S;  3CF5 P;  1N8R S;  3PIP P;  3CCR R;  2ZJP P;  1M1K S;  2ZJQ P;  1QVG Q;  3CME R;  3CC7 R;  1VQL R;  4WFA P;  1VQ5 R;  5GAH T;  1Q81 S;  1VQ6 R;  3I55 R;  3CCJ R;  5JVG P;  5JVH P;  1YIJ R;  3PIO P;  1K73 S;  1VQP R;  1YJ9 R;  1VQO R;  3CCS R;  2QA4 R;  1S72 R;  2ZJR P;  3CCL R;  3CPW Q;  1W2B Q;  3CCV R;  1BXE A;  5DM7 P;  3G71 R;  3CC4 R;  4U67 P;  3G4S R;  1I4J A;  3CXC Q;  4IO9 P;  1VQ8 R;  1K9M S;  5GAD T;  2QEX R;  1K8A S;  3DLL P;  1YI2 R;  4WFB P;  1KQS Q; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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