3PIOP

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
126
structure length
126
Chain Sequence
FRNKKQRKQQVKLRKPGFAVAKYVRMSPRKVRLVVDVIRGKSVQDAEDLLRFIPRSASEPVAKVLNSAKANALHNDEMLEDRLFVKEAYVDAGPTLKRLIPRARGSANIIKKRTSHITIIVAEKGN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.
pubmed doi rcsb
molecule tags Ribosome/antibiotic
molecule keywords RIBOSOMAL 23S RNA
total genus 27
structure length 126
sequence length 126
ec nomenclature
pdb deposition date 2010-11-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00237 Ribosomal_L22 Ribosomal protein L22p/L17e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.470.10 Alpha Beta Alpha-Beta Complex Ribosomal Protein L22; Chain A Ribosomal protein L22/L17 3pioP00
3CCJR 1VQLR 3CCLR 3I56R 1YIJR 5DM7P 5GAGT 3PIPP 3J7ZS 1K73S 3CF5P 1YJ9R 1N8RS 1I4JA 5JVHP 1Q7YS 1JJ2Q 1VQ5R 1K8AS 2OTLR 3CCQR 4WCEP 1VQOR 4IO9P 5DM6P 3OW2Q 1VQKR 4V19W 4IOCP 1YJNR 5H1SU 1YHQR 1QVFQ 3G4SR 1K9MS 5GAET 4U67P 3DLLP 3CPWQ 1VQMR 1VQNR 2ZJQP 3CC2R 1QVGQ 1VQ9R 2OTJR 1VQ6R 1VQ4R 5JVGP 1VQ8R 2ZJRP 3CCMR 1M1KS 5GADT 4WFBP 3CMAR 1KD1S 3CMER 1VQPR 4UY8S 3CD6R 2ZJPP 5MLCU 3CCUR 3CXCQ 4WFNP 4WFAP 5HL7P 3CC7R 1VQ7R 1M90S 3G6ER 1W2BQ 1YI2R 1Q86S 2QA4R 3CC4R 4IOAP 1YITR 3I55R 5GAHT 1BXEA 1Q81S 3G71R 1KQSQ 3CCSR 4WF9P 1YJWR 3CCER 3CCVR 3PIOP 2QEXR 3J7YT 1NJIS 1KC8S 1Q82S 1S72R 3CCRR
chains in the Genus database with same CATH superfamily
3CCJR 1VQLR 3CCLR 1F80A 3I56R 1YIJR 5DM7P 5GAGT 3HYKA 3PIPP 2QG8A 4MRTA 3J7ZS 2BYDA 1K73S 3CF5P 1YJ9R 1N8RS 1I4JA 5JVHP 1Q7YS 1JJ2Q 1VQ5R 3NE1A 1Q82S 1K8AS 2OTLR 3CCQR 4WCEP 1VQOR 5DM6P 4IO9P 3OW2Q 1VQKR 4V19W 4IOCP 1YJNR 1FTHA 3NE9A 2WATA 5H1SU 1YHQR 1QVFQ 1FTFA 3G4SR 1K9MS 2D0OA 5GAET 4U67P 2JCAA 2WDSA 3DLLP 3CPWQ 1VQMR 1VQNR 2ZJQP 2WASB 2C43A 3CC2R 3NE3B 1QVGQ 1VQ9R 5CXDA 5CMOA 2OTJR 1VQ6R 5JVGP 1VQ4R 1VQ8R 1FTEA 2ZJRP 3CCMR 5GADT 1M1KS 2BDDA 4WFBP 3CMAR 1KD1S 3NFDA 2D0PA 2WASA 2JBZA 3CMER 1VQPR 3QMNA 4UY8S 3CD6R 1F7TA 3H7QA 2ZJPP 5MLCU 3CCUR 3CXCQ 4WFNP 1QR0A 4WFAP 5HL7P 3CC7R 1VQ7R 1M90S 3G6ER 2WDYA 1W2BQ 4DXEA 1YI2R 1Q86S 3GWMA 2QA4R 4JM7A 3CC4R 4IOAP 1YITR 2CG5A 3I55R 5GAHT 1BXEA 1Q81S 3G71R 1KQSQ 3CCSR 4WF9P 1YJWR 3CCER 3CCVR 3HQJA 3PIOP 2QEXR 2WDOA 3J7YT 1NJIS 1KC8S 1NBWA 4HC6A 1F7LA 1S72R 3CCRR
chains in the Genus database with same CATH topology
3CCJR 1VQLR 3CCLR 3I56R 1YIJR 5DM7P 5GAGT 3PIPP 3J7ZS 1K73S 3CF5P 1YJ9R 1N8RS 1I4JA 5JVHP 1Q7YS 1JJ2Q 1VQ5R 1K8AS 2OTLR 3CCQR 4WCEP 1VQOR 4IO9P 5DM6P 3OW2Q 1VQKR 4V19W 4IOCP 1YJNR 5H1SU 1YHQR 1QVFQ 3G4SR 1K9MS 5GAET 4U67P 3DLLP 3CPWQ 1VQMR 1VQNR 2ZJQP 3CC2R 1QVGQ 1VQ9R 2OTJR 1VQ6R 1VQ4R 5JVGP 1VQ8R 2ZJRP 3CCMR 1M1KS 5GADT 4WFBP 3CMAR 1KD1S 3CMER 1VQPR 4UY8S 3CD6R 2ZJPP 5MLCU 3CCUR 3CXCQ 4WFNP 4WFAP 5HL7P 3CC7R 1VQ7R 1M90S 3G6ER 1W2BQ 1YI2R 1Q86S 2QA4R 3CC4R 4IOAP 1YITR 3I55R 5GAHT 1BXEA 1Q81S 3G71R 1KQSQ 3CCSR 4WF9P 1YJWR 3CCER 3CCVR 3PIOP 2QEXR 3J7YT 1NJIS 1KC8S 1Q82S 1S72R 3CCRR
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CCJ R;  1VQL R;  3CCL R;  3I56 R;  1YIJ R;  5DM7 P;  5GAG T;  3PIP P;  3J7Z S;  1K73 S;  3CF5 P;  1YJ9 R;  1N8R S;  1I4J A;  5JVH P;  1Q7Y S;  1JJ2 Q;  1VQ5 R;  1K8A S;  2OTL R;  3CCQ R;  4WCE P;  1VQO R;  4IO9 P;  5DM6 P;  3OW2 Q;  1VQK R;  4V19 W;  4IOC P;  1YJN R;  5H1S U;  1YHQ R;  1QVF Q;  3G4S R;  1K9M S;  5GAE T;  4U67 P;  3DLL P;  3CPW Q;  1VQM R;  1VQN R;  2ZJQ P;  3CC2 R;  1QVG Q;  1VQ9 R;  2OTJ R;  1VQ6 R;  1VQ4 R;  5JVG P;  1VQ8 R;  2ZJR P;  3CCM R;  1M1K S;  5GAD T;  4WFB P;  3CMA R;  1KD1 S;  3CME R;  1VQP R;  4UY8 S;  3CD6 R;  2ZJP P;  5MLC U;  3CCU R;  3CXC Q;  4WFN P;  4WFA P;  5HL7 P;  3CC7 R;  1VQ7 R;  1M90 S;  3G6E R;  1W2B Q;  1YI2 R;  1Q86 S;  2QA4 R;  3CC4 R;  4IOA P;  1YIT R;  3I55 R;  5GAH T;  1BXE A;  1Q81 S;  3G71 R;  1KQS Q;  3CCS R;  4WF9 P;  1YJW R;  3CCE R;  3CCV R;  3PIO P;  2QEX R;  3J7Y T;  1NJI S;  1KC8 S;  1Q82 S;  1S72 R;  3CCR R; 
#chains in the Genus database with same CATH topology
 3CCJ R;  1VQL R;  3CCL R;  1F80 A;  3I56 R;  1YIJ R;  5DM7 P;  5GAG T;  3HYK A;  3PIP P;  2QG8 A;  4MRT A;  3J7Z S;  2BYD A;  1K73 S;  3CF5 P;  1YJ9 R;  1N8R S;  1I4J A;  5JVH P;  1Q7Y S;  1JJ2 Q;  1VQ5 R;  3NE1 A;  1Q82 S;  1K8A S;  2OTL R;  3CCQ R;  4WCE P;  1VQO R;  5DM6 P;  4IO9 P;  3OW2 Q;  1VQK R;  4V19 W;  4IOC P;  1YJN R;  1FTH A;  3NE9 A;  2WAT A;  5H1S U;  1YHQ R;  1QVF Q;  1FTF A;  3G4S R;  1K9M S;  2D0O A;  5GAE T;  4U67 P;  2JCA A;  2WDS A;  3DLL P;  3CPW Q;  1VQM R;  1VQN R;  2ZJQ P;  2WAS B;  2C43 A;  3CC2 R;  3NE3 B;  1QVG Q;  1VQ9 R;  5CXD A;  5CMO A;  2OTJ R;  1VQ6 R;  5JVG P;  1VQ4 R;  1VQ8 R;  1FTE A;  2ZJR P;  3CCM R;  5GAD T;  1M1K S;  2BDD A;  4WFB P;  3CMA R;  1KD1 S;  3NFD A;  2D0P A;  2WAS A;  2JBZ A;  3CME R;  1VQP R;  3QMN A;  4UY8 S;  3CD6 R;  1F7T A;  3H7Q A;  2ZJP P;  5MLC U;  3CCU R;  3CXC Q;  4WFN P;  1QR0 A;  4WFA P;  5HL7 P;  3CC7 R;  1VQ7 R;  1M90 S;  3G6E R;  2WDY A;  1W2B Q;  4DXE A;  1YI2 R;  1Q86 S;  3GWM A;  2QA4 R;  4JM7 A;  3CC4 R;  4IOA P;  1YIT R;  2CG5 A;  3I55 R;  5GAH T;  1BXE A;  1Q81 S;  3G71 R;  1KQS Q;  3CCS R;  4WF9 P;  1YJW R;  3CCE R;  3CCV R;  3HQJ A;  3PIO P;  2QEX R;  2WDO A;  3J7Y T;  1NJI S;  1KC8 S;  1NBW A;  4HC6 A;  1F7L A;  1S72 R;  3CCR R; 
#chains in the Genus database with same CATH homology
 3CCJ R;  1VQL R;  3CCL R;  3I56 R;  1YIJ R;  5DM7 P;  5GAG T;  3PIP P;  3J7Z S;  1K73 S;  3CF5 P;  1YJ9 R;  1N8R S;  1I4J A;  5JVH P;  1Q7Y S;  1JJ2 Q;  1VQ5 R;  1K8A S;  2OTL R;  3CCQ R;  4WCE P;  1VQO R;  4IO9 P;  5DM6 P;  3OW2 Q;  1VQK R;  4V19 W;  4IOC P;  1YJN R;  5H1S U;  1YHQ R;  1QVF Q;  3G4S R;  1K9M S;  5GAE T;  4U67 P;  3DLL P;  3CPW Q;  1VQM R;  1VQN R;  2ZJQ P;  3CC2 R;  1QVG Q;  1VQ9 R;  2OTJ R;  1VQ6 R;  1VQ4 R;  5JVG P;  1VQ8 R;  2ZJR P;  3CCM R;  1M1K S;  5GAD T;  4WFB P;  3CMA R;  1KD1 S;  3CME R;  1VQP R;  4UY8 S;  3CD6 R;  2ZJP P;  5MLC U;  3CCU R;  3CXC Q;  4WFN P;  4WFA P;  5HL7 P;  3CC7 R;  1VQ7 R;  1M90 S;  3G6E R;  1W2B Q;  1YI2 R;  1Q86 S;  2QA4 R;  3CC4 R;  4IOA P;  1YIT R;  3I55 R;  5GAH T;  1BXE A;  1Q81 S;  3G71 R;  1KQS Q;  3CCS R;  4WF9 P;  1YJW R;  3CCE R;  3CCV R;  3PIO P;  2QEX R;  3J7Y T;  1NJI S;  1KC8 S;  1Q82 S;  1S72 R;  3CCR R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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