3BOKA

Structure of the c. botulinum neurotoxin serotype a apo-enzyme
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
423
structure length
416
Chain Sequence
MQFVNKQFNYKDPVNGVDIAYIKIPQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Toxin
molecule keywords Neurotoxin A
publication title Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex.
pubmed doi rcsb
source organism Clostridium botulinum
total genus 148
structure length 416
sequence length 423
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2007-12-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3bokA00
1S0CA 3ZUSA 4KS6A 1ZB7A 3NF3A 3QW5A 1ZL6A 2ETFA 3BOOA 1ZL5A 1EPWA 3QIZA 3DDAA 1ZN3A 3QIYA 1S0EA 1G9CA 2ILPA 3C8BA 2NP0A 1F31A 3C8AA 4J1LA 3QW6A 3FIIA 1S0GA 2G7PA 4KTXA 2ISEA 1ZKXA 3V0BB 2NZ9A 3BOKA 3DS9A 1G9AA 3K3QB 3QW7A 1YVGA 4EL4A 4ZKTB 3BTAA 2G7KA 3BONA 1E1HA 4KUFA 3V0BA 3QJ0A 3QIXA 3DDBA 1XTFA 2IMBA 2A97A 1G9BA 2W2DA 4EJ5A 5BQNA 1I1EA 3VUOA 3ZUQA 3ZURA 1Z7HA 1S0FA 2FPQA 2ISGA 3QW8A 3DEBA 2IMAA 1S0BA 1ZKWA 2G7NA 4ZJXA 3DSEA 3V0AA 1T3AA 2A8AA 4ELCA 2IMCA 1XTGA 2XHLA 3FFZA 1T3CA 2QN0A 3C88A 3C89A 5BQMA 2G7QA 4HEVA 3V0AB 3D3XA 1G9DA 3BWIA 3FIEA 1S0DA 2ISHA 1F82A 2NYYA
chains in the Genus database with same CATH superfamily
1S0CA 3ZUSA 4KS6A 1ZB7A 3NF3A 3QW5A 1ZL6A 2ETFA 3BOOA 1ZL5A 4IL3A 1EPWA 3QIZA 3DDAA 1ZN3A 2EJQA 3QIYA 1S0EA 1G9CA 2ILPA 3C8BA 2NP0A 1F31A 3C8AA 4J1LA 3QW6A 3FIIA 1S0GA 2G7PA 4KTXA 2ISEA 1ZKXA 3V0BB 2NZ9A 3BOKA 3DS9A 1G9AA 3K3QB 3QW7A 1YVGA 4EL4A 4ZKTB 3BTAA 2G7KA 3E11A 4QHFA 3BONA 1E1HA 4KUFA 3V0BA 4JIXA 3QJ0A 3QIXA 3DDBA 1XTFA 2IMBA 2A97A 1G9BA 2W2DA 4EJ5A 5BQNA 1I1EA 3VUOA 3ZUQA 3ZURA 1Z7HA 1S0FA 2FPQA 2YPTA 2ISGA 3QW8A 3DEBA 2IMAA 1S0BA 1ZKWA 2G7NA 4ZJXA 3DSEA 3V0AA 1T3AA 2A8AA 4ELCA 2IMCA 1XTGA 2XHLA 3FFZA 1T3CA 2QN0A 3C88A 3C89A 5BQMA 2G7QA 4HEVA 4AW6A 3V0AB 3D3XA 1G9DA 3BWIA 3CQBA 3FIEA 1S0DA 2ISHA 1F82A 2NYYA 4JIUA
chains in the Genus database with same CATH topology
1S0CA 3ZUSA 4KS6A 1ZB7A 3NF3A 3QW5A 1ZL6A 2ETFA 3BOOA 1ZL5A 1EPWA 3QIZA 3DDAA 1ZN3A 3QIYA 1S0EA 1G9CA 2ILPA 3C8BA 2NP0A 1F31A 3C8AA 4J1LA 3QW6A 3FIIA 1S0GA 2G7PA 4KTXA 2ISEA 1ZKXA 3V0BB 2NZ9A 3BOKA 3DS9A 1G9AA 3K3QB 3QW7A 1YVGA 4EL4A 4ZKTB 3BTAA 2G7KA 3BONA 1E1HA 4KUFA 3V0BA 3QJ0A 3QIXA 3DDBA 1XTFA 2IMBA 2A97A 1G9BA 2W2DA 4EJ5A 5BQNA 1I1EA 3VUOA 3ZUQA 3ZURA 1Z7HA 1S0FA 2FPQA 2ISGA 3QW8A 3DEBA 2IMAA 1S0BA 1ZKWA 2G7NA 4ZJXA 3DSEA 3V0AA 1T3AA 2A8AA 4ELCA 2IMCA 1XTGA 2XHLA 3FFZA 1T3CA 2QN0A 3C88A 3C89A 5BQMA 2G7QA 4HEVA 3V0AB 3D3XA 1G9DA 3BWIA 3FIEA 1S0DA 2ISHA 1F82A 2NYYA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1S0C A;  3ZUS A;  4KS6 A;  1ZB7 A;  3NF3 A;  3QW5 A;  1ZL6 A;  2ETF A;  3BOO A;  1ZL5 A;  1EPW A;  3QIZ A;  3DDA A;  1ZN3 A;  3QIY A;  1S0E A;  1G9C A;  2ILP A;  3C8B A;  2NP0 A;  1F31 A;  3C8A A;  4J1L A;  3QW6 A;  3FII A;  1S0G A;  2G7P A;  4KTX A;  2ISE A;  1ZKX A;  3V0B B;  2NZ9 A;  3BOK A;  3DS9 A;  1G9A A;  3K3Q B;  3QW7 A;  1YVG A;  4EL4 A;  4ZKT B;  3BTA A;  2G7K A;  3BON A;  1E1H A;  4KUF A;  3V0B A;  3QJ0 A;  3QIX A;  3DDB A;  1XTF A;  2IMB A;  2A97 A;  1G9B A;  2W2D A;  4EJ5 A;  5BQN A;  1I1E A;  3VUO A;  3ZUQ A;  3ZUR A;  1Z7H A;  1S0F A;  2FPQ A;  2ISG A;  3QW8 A;  3DEB A;  2IMA A;  1S0B A;  1ZKW A;  2G7N A;  4ZJX A;  3DSE A;  3V0A A;  1T3A A;  2A8A A;  4ELC A;  2IMC A;  1XTG A;  2XHL A;  3FFZ A;  1T3C A;  2QN0 A;  3C88 A;  3C89 A;  5BQM A;  2G7Q A;  4HEV A;  3V0A B;  3D3X A;  1G9D A;  3BWI A;  3FIE A;  1S0D A;  2ISH A;  1F82 A;  2NYY A; 
#chains in the Genus database with same CATH topology
 1S0C A;  3ZUS A;  4KS6 A;  1ZB7 A;  3NF3 A;  3QW5 A;  1ZL6 A;  2ETF A;  3BOO A;  1ZL5 A;  4IL3 A;  1EPW A;  3QIZ A;  3DDA A;  1ZN3 A;  2EJQ A;  3QIY A;  1S0E A;  1G9C A;  2ILP A;  3C8B A;  2NP0 A;  1F31 A;  3C8A A;  4J1L A;  3QW6 A;  3FII A;  1S0G A;  2G7P A;  4KTX A;  2ISE A;  1ZKX A;  3V0B B;  2NZ9 A;  3BOK A;  3DS9 A;  1G9A A;  3K3Q B;  3QW7 A;  1YVG A;  4EL4 A;  4ZKT B;  3BTA A;  2G7K A;  3E11 A;  4QHF A;  3BON A;  1E1H A;  4KUF A;  3V0B A;  4JIX A;  3QJ0 A;  3QIX A;  3DDB A;  1XTF A;  2IMB A;  2A97 A;  1G9B A;  2W2D A;  4EJ5 A;  5BQN A;  1I1E A;  3VUO A;  3ZUQ A;  3ZUR A;  1Z7H A;  1S0F A;  2FPQ A;  2YPT A;  2ISG A;  3QW8 A;  3DEB A;  2IMA A;  1S0B A;  1ZKW A;  2G7N A;  4ZJX A;  3DSE A;  3V0A A;  1T3A A;  2A8A A;  4ELC A;  2IMC A;  1XTG A;  2XHL A;  3FFZ A;  1T3C A;  2QN0 A;  3C88 A;  3C89 A;  5BQM A;  2G7Q A;  4HEV A;  4AW6 A;  3V0A B;  3D3X A;  1G9D A;  3BWI A;  3CQB A;  3FIE A;  1S0D A;  2ISH A;  1F82 A;  2NYY A;  4JIU A; 
#chains in the Genus database with same CATH homology
 1S0C A;  3ZUS A;  4KS6 A;  1ZB7 A;  3NF3 A;  3QW5 A;  1ZL6 A;  2ETF A;  3BOO A;  1ZL5 A;  1EPW A;  3QIZ A;  3DDA A;  1ZN3 A;  3QIY A;  1S0E A;  1G9C A;  2ILP A;  3C8B A;  2NP0 A;  1F31 A;  3C8A A;  4J1L A;  3QW6 A;  3FII A;  1S0G A;  2G7P A;  4KTX A;  2ISE A;  1ZKX A;  3V0B B;  2NZ9 A;  3BOK A;  3DS9 A;  1G9A A;  3K3Q B;  3QW7 A;  1YVG A;  4EL4 A;  4ZKT B;  3BTA A;  2G7K A;  3BON A;  1E1H A;  4KUF A;  3V0B A;  3QJ0 A;  3QIX A;  3DDB A;  1XTF A;  2IMB A;  2A97 A;  1G9B A;  2W2D A;  4EJ5 A;  5BQN A;  1I1E A;  3VUO A;  3ZUQ A;  3ZUR A;  1Z7H A;  1S0F A;  2FPQ A;  2ISG A;  3QW8 A;  3DEB A;  2IMA A;  1S0B A;  1ZKW A;  2G7N A;  4ZJX A;  3DSE A;  3V0A A;  1T3A A;  2A8A A;  4ELC A;  2IMC A;  1XTG A;  2XHL A;  3FFZ A;  1T3C A;  2QN0 A;  3C88 A;  3C89 A;  5BQM A;  2G7Q A;  4HEV A;  3V0A B;  3D3X A;  1G9D A;  3BWI A;  3FIE A;  1S0D A;  2ISH A;  1F82 A;  2NYY A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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