3DSEA

A potent peptidomimetic inhibitor of botulinum neurotoxin serotype a has a very different conformation than snap-25 substrate
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
416
structure length
394
Chain Sequence
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEEGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Botulinum neurotoxin type A
publication title A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate
pubmed doi rcsb
source organism Clostridium botulinum
total genus 123
structure length 394
sequence length 416
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2008-07-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3dseA00
3C88A 3DDBA 1G9DA 3QIXA 3QJ0A 2G7PA 1T3AA 4HEVA 1S0GA 1EPWA 2A8AA 3D3XA 4KTXA 1S0BA 1S0EA 1ZL5A 3QIYA 4EJ5A 2QN0A 3C8AA 2XHLA 2ILPA 3BOOA 3V0AA 1E1HA 2NP0A 1ZKWA 3BOKA 3V0AB 3BWIA 1S0CA 1F31A 3DDAA 2NYYA 3V0BB 2G7KA 1F82A 3ZURA 3FIEA 3C8BA 3VUOA 3BONA 3BTAA 2NZ9A 1YVGA 4ELCA 3QW8A 3FIIA 5BQMA 2IMCA 1S0FA 2G7QA 2ISHA 3V0BA 1ZKXA 3QW6A 3ZUSA 3QW5A 3DEBA 3DSEA 2IMAA 3DS9A 1ZB7A 1XTGA 1Z7HA 3C89A 4KUFA 3FFZA 2G7NA 2A97A 4ZJXA 2FPQA 2IMBA 2W2DA 2ETFA 4J1LA 1S0DA 3K3QB 5BQNA 3ZUQA 1T3CA 4ZKTB 4KS6A 2ISGA 1ZL6A 3QIZA 3NF3A 3QW7A 1XTFA 1G9BA 2ISEA 1G9CA 1G9AA 1I1EA 4EL4A 1ZN3A
chains in the Genus database with same CATH superfamily
3C88A 3DDBA 1G9DA 3QIXA 3QJ0A 2G7PA 1T3AA 4HEVA 1S0GA 1EPWA 2A8AA 3D3XA 4KTXA 1S0BA 1S0EA 4JIXA 1ZL5A 3QIYA 4EJ5A 2QN0A 3C8AA 2XHLA 2ILPA 3BOOA 3V0AA 1E1HA 2NP0A 1ZKWA 3BOKA 3V0AB 3BWIA 1S0CA 1F31A 3DDAA 2NYYA 3V0BB 2G7KA 1F82A 3ZURA 3FIEA 2YPTA 3C8BA 3VUOA 3BONA 3BTAA 2NZ9A 1YVGA 4ELCA 3QW8A 4AW6A 3FIIA 5BQMA 2IMCA 1S0FA 2G7QA 2ISHA 3V0BA 1ZKXA 3QW6A 3ZUSA 3QW5A 3DEBA 3DSEA 4IL3A 2IMAA 3DS9A 1ZB7A 3E11A 1XTGA 1Z7HA 3C89A 4KUFA 3FFZA 2G7NA 2A97A 4ZJXA 2FPQA 2IMBA 2W2DA 2ETFA 4J1LA 1S0DA 3K3QB 5BQNA 3ZUQA 1T3CA 4JIUA 4ZKTB 4KS6A 2ISGA 1ZL6A 3QIZA 3NF3A 3QW7A 1XTFA 1G9BA 2ISEA 1G9CA 1G9AA 1I1EA 4QHFA 2EJQA 4EL4A 1ZN3A 3CQBA
chains in the Genus database with same CATH topology
3C88A 3DDBA 1G9DA 3QIXA 3QJ0A 2G7PA 1T3AA 4HEVA 1S0GA 1EPWA 2A8AA 3D3XA 4KTXA 1S0BA 1S0EA 1ZL5A 3QIYA 4EJ5A 2QN0A 3C8AA 2XHLA 2ILPA 3BOOA 3V0AA 1E1HA 2NP0A 1ZKWA 3BOKA 3V0AB 3BWIA 1S0CA 1F31A 3DDAA 2NYYA 3V0BB 2G7KA 1F82A 3ZURA 3FIEA 3C8BA 3VUOA 3BONA 3BTAA 2NZ9A 1YVGA 4ELCA 3QW8A 3FIIA 5BQMA 2IMCA 1S0FA 2G7QA 2ISHA 3V0BA 1ZKXA 3QW6A 3ZUSA 3QW5A 3DEBA 3DSEA 2IMAA 3DS9A 1ZB7A 1XTGA 1Z7HA 3C89A 4KUFA 3FFZA 2G7NA 2A97A 4ZJXA 2FPQA 2IMBA 2W2DA 2ETFA 4J1LA 1S0DA 3K3QB 5BQNA 3ZUQA 1T3CA 4ZKTB 4KS6A 2ISGA 1ZL6A 3QIZA 3NF3A 3QW7A 1XTFA 1G9BA 2ISEA 1G9CA 1G9AA 1I1EA 4EL4A 1ZN3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C88 A;  3DDB A;  1G9D A;  3QIX A;  3QJ0 A;  2G7P A;  1T3A A;  4HEV A;  1S0G A;  1EPW A;  2A8A A;  3D3X A;  4KTX A;  1S0B A;  1S0E A;  1ZL5 A;  3QIY A;  4EJ5 A;  2QN0 A;  3C8A A;  2XHL A;  2ILP A;  3BOO A;  3V0A A;  1E1H A;  2NP0 A;  1ZKW A;  3BOK A;  3V0A B;  3BWI A;  1S0C A;  1F31 A;  3DDA A;  2NYY A;  3V0B B;  2G7K A;  1F82 A;  3ZUR A;  3FIE A;  3C8B A;  3VUO A;  3BON A;  3BTA A;  2NZ9 A;  1YVG A;  4ELC A;  3QW8 A;  3FII A;  5BQM A;  2IMC A;  1S0F A;  2G7Q A;  2ISH A;  3V0B A;  1ZKX A;  3QW6 A;  3ZUS A;  3QW5 A;  3DEB A;  3DSE A;  2IMA A;  3DS9 A;  1ZB7 A;  1XTG A;  1Z7H A;  3C89 A;  4KUF A;  3FFZ A;  2G7N A;  2A97 A;  4ZJX A;  2FPQ A;  2IMB A;  2W2D A;  2ETF A;  4J1L A;  1S0D A;  3K3Q B;  5BQN A;  3ZUQ A;  1T3C A;  4ZKT B;  4KS6 A;  2ISG A;  1ZL6 A;  3QIZ A;  3NF3 A;  3QW7 A;  1XTF A;  1G9B A;  2ISE A;  1G9C A;  1G9A A;  1I1E A;  4EL4 A;  1ZN3 A; 
#chains in the Genus database with same CATH topology
 3C88 A;  3DDB A;  1G9D A;  3QIX A;  3QJ0 A;  2G7P A;  1T3A A;  4HEV A;  1S0G A;  1EPW A;  2A8A A;  3D3X A;  4KTX A;  1S0B A;  1S0E A;  4JIX A;  1ZL5 A;  3QIY A;  4EJ5 A;  2QN0 A;  3C8A A;  2XHL A;  2ILP A;  3BOO A;  3V0A A;  1E1H A;  2NP0 A;  1ZKW A;  3BOK A;  3V0A B;  3BWI A;  1S0C A;  1F31 A;  3DDA A;  2NYY A;  3V0B B;  2G7K A;  1F82 A;  3ZUR A;  3FIE A;  2YPT A;  3C8B A;  3VUO A;  3BON A;  3BTA A;  2NZ9 A;  1YVG A;  4ELC A;  3QW8 A;  4AW6 A;  3FII A;  5BQM A;  2IMC A;  1S0F A;  2G7Q A;  2ISH A;  3V0B A;  1ZKX A;  3QW6 A;  3ZUS A;  3QW5 A;  3DEB A;  3DSE A;  4IL3 A;  2IMA A;  3DS9 A;  1ZB7 A;  3E11 A;  1XTG A;  1Z7H A;  3C89 A;  4KUF A;  3FFZ A;  2G7N A;  2A97 A;  4ZJX A;  2FPQ A;  2IMB A;  2W2D A;  2ETF A;  4J1L A;  1S0D A;  3K3Q B;  5BQN A;  3ZUQ A;  1T3C A;  4JIU A;  4ZKT B;  4KS6 A;  2ISG A;  1ZL6 A;  3QIZ A;  3NF3 A;  3QW7 A;  1XTF A;  1G9B A;  2ISE A;  1G9C A;  1G9A A;  1I1E A;  4QHF A;  2EJQ A;  4EL4 A;  1ZN3 A;  3CQB A; 
#chains in the Genus database with same CATH homology
 3C88 A;  3DDB A;  1G9D A;  3QIX A;  3QJ0 A;  2G7P A;  1T3A A;  4HEV A;  1S0G A;  1EPW A;  2A8A A;  3D3X A;  4KTX A;  1S0B A;  1S0E A;  1ZL5 A;  3QIY A;  4EJ5 A;  2QN0 A;  3C8A A;  2XHL A;  2ILP A;  3BOO A;  3V0A A;  1E1H A;  2NP0 A;  1ZKW A;  3BOK A;  3V0A B;  3BWI A;  1S0C A;  1F31 A;  3DDA A;  2NYY A;  3V0B B;  2G7K A;  1F82 A;  3ZUR A;  3FIE A;  3C8B A;  3VUO A;  3BON A;  3BTA A;  2NZ9 A;  1YVG A;  4ELC A;  3QW8 A;  3FII A;  5BQM A;  2IMC A;  1S0F A;  2G7Q A;  2ISH A;  3V0B A;  1ZKX A;  3QW6 A;  3ZUS A;  3QW5 A;  3DEB A;  3DSE A;  2IMA A;  3DS9 A;  1ZB7 A;  1XTG A;  1Z7H A;  3C89 A;  4KUF A;  3FFZ A;  2G7N A;  2A97 A;  4ZJX A;  2FPQ A;  2IMB A;  2W2D A;  2ETF A;  4J1L A;  1S0D A;  3K3Q B;  5BQN A;  3ZUQ A;  1T3C A;  4ZKT B;  4KS6 A;  2ISG A;  1ZL6 A;  3QIZ A;  3NF3 A;  3QW7 A;  1XTF A;  1G9B A;  2ISE A;  1G9C A;  1G9A A;  1I1E A;  4EL4 A;  1ZN3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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