4KTXA

Crystal structure of the catalytic domain of botulinum neurotoxin bont/a c134s mutant with covalent inhibitor that modifies cys-165 causing disorder in 167-174 stretch
Total Genus 132
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
428
structure length
428
Chain Sequence
GSHMPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNSINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Botulinum neurotoxin A light chain
publication title Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A
rcsb
source organism Clostridium botulinum a
total genus 132
structure length 428
sequence length 428
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2013-05-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 4ktxA00
2ETFA 2QN0A 2ILPA 3DDAA 4HEVA 3BONA 4ZJXA 2G7NA 2G7PA 4KTXA 3ZUSA 2ISHA 3DDBA 2ISEA 1T3AA 2G7KA 3D3XA 4EL4A 5BQMA 1G9BA 3DEBA 3QIYA 3QW6A 1G9DA 1ZKWA 3C88A 3K3QB 2G7QA 3BWIA 3VUOA 3BOKA 3C8BA 4ELCA 1F82A 3QIXA 3C89A 2IMCA 2NP0A 3FIEA 3ZUQA 4KUFA 5BQNA 2NZ9A 3BOOA 1S0CA 1ZN3A 4KS6A 1E1HA 3FIIA 1S0BA 3V0BA 2FPQA 4J1LA 1YVGA 3V0BB 2W2DA 3NF3A 1ZKXA 1S0FA 3QW7A 2NYYA 3FFZA 3V0AA 1I1EA 2IMBA 3QW5A 1S0DA 1ZL6A 2A97A 2XHLA 1G9CA 3QW8A 1XTGA 3V0AB 3QJ0A 1T3CA 3C8AA 3DS9A 1EPWA 2A8AA 4EJ5A 1S0GA 2ISGA 3ZURA 3DSEA 3BTAA 4ZKTB 1G9AA 3QIZA 1Z7HA 1F31A 2IMAA 1ZL5A 1XTFA 1ZB7A 1S0EA
chains in the Genus database with same CATH superfamily
2ETFA 2QN0A 2ILPA 3DDAA 4HEVA 3BONA 4ZJXA 2G7NA 2G7PA 4JIUA 4KTXA 3ZUSA 2ISHA 3DDBA 2ISEA 1T3AA 2G7KA 3D3XA 4EL4A 5BQMA 1G9BA 3DEBA 3QIYA 3QW6A 1G9DA 1ZKWA 3C88A 4IL3A 3K3QB 2G7QA 3BWIA 3VUOA 3BOKA 3C8BA 4ELCA 1F82A 3QIXA 3C89A 2IMCA 2NP0A 3FIEA 3ZUQA 4KUFA 5BQNA 2NZ9A 3BOOA 1S0CA 1ZN3A 4KS6A 1E1HA 3FIIA 1S0BA 3V0BA 2FPQA 4J1LA 1YVGA 3V0BB 2EJQA 2W2DA 3E11A 1ZKXA 3NF3A 1S0FA 3QW7A 2NYYA 3FFZA 3V0AA 1I1EA 2IMBA 4AW6A 3QW5A 1S0DA 1ZL6A 2A97A 2XHLA 4QHFA 1G9CA 3QW8A 1XTGA 3V0AB 3QJ0A 1T3CA 3C8AA 3DS9A 1EPWA 2A8AA 4EJ5A 4JIXA 3CQBA 1S0GA 2ISGA 3ZURA 3DSEA 3BTAA 4ZKTB 2YPTA 1G9AA 3QIZA 1Z7HA 1F31A 2IMAA 1ZL5A 1XTFA 1ZB7A 1S0EA
chains in the Genus database with same CATH topology
2ETFA 2QN0A 2ILPA 3DDAA 4HEVA 3BONA 4ZJXA 2G7NA 2G7PA 4KTXA 3ZUSA 2ISHA 3DDBA 2ISEA 1T3AA 2G7KA 3D3XA 4EL4A 5BQMA 1G9BA 3DEBA 3QIYA 3QW6A 1G9DA 1ZKWA 3C88A 3K3QB 2G7QA 3BWIA 3VUOA 3BOKA 3C8BA 4ELCA 1F82A 3QIXA 3C89A 2IMCA 2NP0A 3FIEA 3ZUQA 4KUFA 5BQNA 2NZ9A 3BOOA 1S0CA 1ZN3A 4KS6A 1E1HA 3FIIA 1S0BA 3V0BA 2FPQA 4J1LA 1YVGA 3V0BB 2W2DA 3NF3A 1ZKXA 1S0FA 3QW7A 2NYYA 3FFZA 3V0AA 1I1EA 2IMBA 3QW5A 1S0DA 1ZL6A 2A97A 2XHLA 1G9CA 3QW8A 1XTGA 3V0AB 3QJ0A 1T3CA 3C8AA 3DS9A 1EPWA 2A8AA 4EJ5A 1S0GA 2ISGA 3ZURA 3DSEA 3BTAA 4ZKTB 1G9AA 3QIZA 1Z7HA 1F31A 2IMAA 1ZL5A 1XTFA 1ZB7A 1S0EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ETF A;  2QN0 A;  2ILP A;  3DDA A;  4HEV A;  3BON A;  4ZJX A;  2G7N A;  2G7P A;  4KTX A;  3ZUS A;  2ISH A;  3DDB A;  2ISE A;  1T3A A;  2G7K A;  3D3X A;  4EL4 A;  5BQM A;  1G9B A;  3DEB A;  3QIY A;  3QW6 A;  1G9D A;  1ZKW A;  3C88 A;  3K3Q B;  2G7Q A;  3BWI A;  3VUO A;  3BOK A;  3C8B A;  4ELC A;  1F82 A;  3QIX A;  3C89 A;  2IMC A;  2NP0 A;  3FIE A;  3ZUQ A;  4KUF A;  5BQN A;  2NZ9 A;  3BOO A;  1S0C A;  1ZN3 A;  4KS6 A;  1E1H A;  3FII A;  1S0B A;  3V0B A;  2FPQ A;  4J1L A;  1YVG A;  3V0B B;  2W2D A;  3NF3 A;  1ZKX A;  1S0F A;  3QW7 A;  2NYY A;  3FFZ A;  3V0A A;  1I1E A;  2IMB A;  3QW5 A;  1S0D A;  1ZL6 A;  2A97 A;  2XHL A;  1G9C A;  3QW8 A;  1XTG A;  3V0A B;  3QJ0 A;  1T3C A;  3C8A A;  3DS9 A;  1EPW A;  2A8A A;  4EJ5 A;  1S0G A;  2ISG A;  3ZUR A;  3DSE A;  3BTA A;  4ZKT B;  1G9A A;  3QIZ A;  1Z7H A;  1F31 A;  2IMA A;  1ZL5 A;  1XTF A;  1ZB7 A;  1S0E A; 
#chains in the Genus database with same CATH topology
 2ETF A;  2QN0 A;  2ILP A;  3DDA A;  4HEV A;  3BON A;  4ZJX A;  2G7N A;  2G7P A;  4JIU A;  4KTX A;  3ZUS A;  2ISH A;  3DDB A;  2ISE A;  1T3A A;  2G7K A;  3D3X A;  4EL4 A;  5BQM A;  1G9B A;  3DEB A;  3QIY A;  3QW6 A;  1G9D A;  1ZKW A;  3C88 A;  4IL3 A;  3K3Q B;  2G7Q A;  3BWI A;  3VUO A;  3BOK A;  3C8B A;  4ELC A;  1F82 A;  3QIX A;  3C89 A;  2IMC A;  2NP0 A;  3FIE A;  3ZUQ A;  4KUF A;  5BQN A;  2NZ9 A;  3BOO A;  1S0C A;  1ZN3 A;  4KS6 A;  1E1H A;  3FII A;  1S0B A;  3V0B A;  2FPQ A;  4J1L A;  1YVG A;  3V0B B;  2EJQ A;  2W2D A;  3E11 A;  1ZKX A;  3NF3 A;  1S0F A;  3QW7 A;  2NYY A;  3FFZ A;  3V0A A;  1I1E A;  2IMB A;  4AW6 A;  3QW5 A;  1S0D A;  1ZL6 A;  2A97 A;  2XHL A;  4QHF A;  1G9C A;  3QW8 A;  1XTG A;  3V0A B;  3QJ0 A;  1T3C A;  3C8A A;  3DS9 A;  1EPW A;  2A8A A;  4EJ5 A;  4JIX A;  3CQB A;  1S0G A;  2ISG A;  3ZUR A;  3DSE A;  3BTA A;  4ZKT B;  2YPT A;  1G9A A;  3QIZ A;  1Z7H A;  1F31 A;  2IMA A;  1ZL5 A;  1XTF A;  1ZB7 A;  1S0E A; 
#chains in the Genus database with same CATH homology
 2ETF A;  2QN0 A;  2ILP A;  3DDA A;  4HEV A;  3BON A;  4ZJX A;  2G7N A;  2G7P A;  4KTX A;  3ZUS A;  2ISH A;  3DDB A;  2ISE A;  1T3A A;  2G7K A;  3D3X A;  4EL4 A;  5BQM A;  1G9B A;  3DEB A;  3QIY A;  3QW6 A;  1G9D A;  1ZKW A;  3C88 A;  3K3Q B;  2G7Q A;  3BWI A;  3VUO A;  3BOK A;  3C8B A;  4ELC A;  1F82 A;  3QIX A;  3C89 A;  2IMC A;  2NP0 A;  3FIE A;  3ZUQ A;  4KUF A;  5BQN A;  2NZ9 A;  3BOO A;  1S0C A;  1ZN3 A;  4KS6 A;  1E1H A;  3FII A;  1S0B A;  3V0B A;  2FPQ A;  4J1L A;  1YVG A;  3V0B B;  2W2D A;  3NF3 A;  1ZKX A;  1S0F A;  3QW7 A;  2NYY A;  3FFZ A;  3V0A A;  1I1E A;  2IMB A;  3QW5 A;  1S0D A;  1ZL6 A;  2A97 A;  2XHL A;  1G9C A;  3QW8 A;  1XTG A;  3V0A B;  3QJ0 A;  1T3C A;  3C8A A;  3DS9 A;  1EPW A;  2A8A A;  4EJ5 A;  1S0G A;  2ISG A;  3ZUR A;  3DSE A;  3BTA A;  4ZKT B;  1G9A A;  3QIZ A;  1Z7H A;  1F31 A;  2IMA A;  1ZL5 A;  1XTF A;  1ZB7 A;  1S0E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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