3DSEA

A potent peptidomimetic inhibitor of botulinum neurotoxin serotype a has a very different conformation than snap-25 substrate
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
416
structure length
394
Chain Sequence
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEEGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Botulinum neurotoxin type A
publication title A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate
pubmed doi rcsb
source organism Clostridium botulinum
total genus 123
structure length 394
sequence length 416
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2008-07-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3dseA00
3QIXA 3FIEA 3C8BA 1ZKXA 1S0GA 4HEVA 4ZKTB 2A8AA 4ZJXA 3DEBA 1G9AA 1ZN3A 2ETFA 1XTGA 3VUOA 1ZL6A 2NP0A 1S0FA 1ZKWA 2G7QA 3C88A 4KS6A 3K3QB 2IMAA 4KTXA 3NF3A 1G9DA 1XTFA 4EL4A 1T3AA 3DDAA 3BOKA 3QIZA 4ELCA 1S0DA 1ZB7A 2ISEA 1G9BA 3QW8A 1YVGA 1Z7HA 5BQNA 1S0CA 3BONA 2IMCA 3FFZA 3QW7A 2FPQA 3BOOA 3ZUQA 1T3CA 3DSEA 3QW6A 3ZUSA 2NZ9A 3V0BA 3QIYA 2G7NA 2W2DA 1S0BA 2QN0A 3ZURA 3C8AA 4J1LA 2A97A 3FIIA 3DS9A 2G7PA 2ISHA 3D3XA 3BWIA 3DDBA 5BQMA 4EJ5A 3QW5A 1G9CA 1EPWA 3BTAA 2G7KA 3V0BB 2NYYA 2ILPA 1F31A 1F82A 3V0AB 1S0EA 2IMBA 4KUFA 3QJ0A 3V0AA 3C89A 2ISGA 1ZL5A 1I1EA 2XHLA 1E1HA
chains in the Genus database with same CATH superfamily
3QIXA 3FIEA 2YPTA 3C8BA 1ZKXA 1S0GA 4HEVA 4ZKTB 2A8AA 4ZJXA 3DEBA 1G9AA 3E11A 1ZN3A 2ETFA 4JIXA 1XTGA 3VUOA 1ZL6A 2NP0A 1S0FA 1ZKWA 2G7QA 3C88A 4KS6A 3K3QB 2IMAA 2EJQA 4KTXA 3NF3A 1G9DA 1XTFA 4EL4A 1T3AA 3DDAA 3BOKA 3QIZA 4IL3A 4ELCA 1S0DA 1ZB7A 2ISEA 1G9BA 3QW8A 1YVGA 1Z7HA 5BQNA 1S0CA 3BONA 2IMCA 3FFZA 3QW7A 2FPQA 3BOOA 3ZUQA 1T3CA 3DSEA 3QW6A 3ZUSA 2NZ9A 3V0BA 3QIYA 2G7NA 2W2DA 1S0BA 2QN0A 4JIUA 3ZURA 3C8AA 4J1LA 2A97A 3FIIA 3DS9A 2G7PA 3CQBA 2ISHA 3D3XA 3BWIA 3DDBA 5BQMA 4EJ5A 3QW5A 1G9CA 1EPWA 3BTAA 2G7KA 4QHFA 2NYYA 2ILPA 3V0BB 1F31A 1F82A 3V0AB 1S0EA 2IMBA 4KUFA 3QJ0A 3V0AA 3C89A 2ISGA 1ZL5A 1I1EA 4AW6A 2XHLA 1E1HA
chains in the Genus database with same CATH topology
3QIXA 3FIEA 3C8BA 1ZKXA 1S0GA 4HEVA 4ZKTB 2A8AA 4ZJXA 3DEBA 1G9AA 1ZN3A 2ETFA 1XTGA 3VUOA 1ZL6A 2NP0A 1S0FA 1ZKWA 2G7QA 3C88A 4KS6A 3K3QB 2IMAA 4KTXA 3NF3A 1G9DA 1XTFA 4EL4A 1T3AA 3DDAA 3BOKA 3QIZA 4ELCA 1S0DA 1ZB7A 2ISEA 1G9BA 3QW8A 1YVGA 1Z7HA 5BQNA 1S0CA 3BONA 2IMCA 3FFZA 3QW7A 2FPQA 3BOOA 3ZUQA 1T3CA 3DSEA 3QW6A 3ZUSA 2NZ9A 3V0BA 3QIYA 2G7NA 2W2DA 1S0BA 2QN0A 3ZURA 3C8AA 4J1LA 2A97A 3FIIA 3DS9A 2G7PA 2ISHA 3D3XA 3BWIA 3DDBA 5BQMA 4EJ5A 3QW5A 1G9CA 1EPWA 3BTAA 2G7KA 3V0BB 2NYYA 2ILPA 1F31A 1F82A 3V0AB 1S0EA 2IMBA 4KUFA 3QJ0A 3V0AA 3C89A 2ISGA 1ZL5A 1I1EA 2XHLA 1E1HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QIX A;  3FIE A;  3C8B A;  1ZKX A;  1S0G A;  4HEV A;  4ZKT B;  2A8A A;  4ZJX A;  3DEB A;  1G9A A;  1ZN3 A;  2ETF A;  1XTG A;  3VUO A;  1ZL6 A;  2NP0 A;  1S0F A;  1ZKW A;  2G7Q A;  3C88 A;  4KS6 A;  3K3Q B;  2IMA A;  4KTX A;  3NF3 A;  1G9D A;  1XTF A;  4EL4 A;  1T3A A;  3DDA A;  3BOK A;  3QIZ A;  4ELC A;  1S0D A;  1ZB7 A;  2ISE A;  1G9B A;  3QW8 A;  1YVG A;  1Z7H A;  5BQN A;  1S0C A;  3BON A;  2IMC A;  3FFZ A;  3QW7 A;  2FPQ A;  3BOO A;  3ZUQ A;  1T3C A;  3DSE A;  3QW6 A;  3ZUS A;  2NZ9 A;  3V0B A;  3QIY A;  2G7N A;  2W2D A;  1S0B A;  2QN0 A;  3ZUR A;  3C8A A;  4J1L A;  2A97 A;  3FII A;  3DS9 A;  2G7P A;  2ISH A;  3D3X A;  3BWI A;  3DDB A;  5BQM A;  4EJ5 A;  3QW5 A;  1G9C A;  1EPW A;  3BTA A;  2G7K A;  3V0B B;  2NYY A;  2ILP A;  1F31 A;  1F82 A;  3V0A B;  1S0E A;  2IMB A;  4KUF A;  3QJ0 A;  3V0A A;  3C89 A;  2ISG A;  1ZL5 A;  1I1E A;  2XHL A;  1E1H A; 
#chains in the Genus database with same CATH topology
 3QIX A;  3FIE A;  2YPT A;  3C8B A;  1ZKX A;  1S0G A;  4HEV A;  4ZKT B;  2A8A A;  4ZJX A;  3DEB A;  1G9A A;  3E11 A;  1ZN3 A;  2ETF A;  4JIX A;  1XTG A;  3VUO A;  1ZL6 A;  2NP0 A;  1S0F A;  1ZKW A;  2G7Q A;  3C88 A;  4KS6 A;  3K3Q B;  2IMA A;  2EJQ A;  4KTX A;  3NF3 A;  1G9D A;  1XTF A;  4EL4 A;  1T3A A;  3DDA A;  3BOK A;  3QIZ A;  4IL3 A;  4ELC A;  1S0D A;  1ZB7 A;  2ISE A;  1G9B A;  3QW8 A;  1YVG A;  1Z7H A;  5BQN A;  1S0C A;  3BON A;  2IMC A;  3FFZ A;  3QW7 A;  2FPQ A;  3BOO A;  3ZUQ A;  1T3C A;  3DSE A;  3QW6 A;  3ZUS A;  2NZ9 A;  3V0B A;  3QIY A;  2G7N A;  2W2D A;  1S0B A;  2QN0 A;  4JIU A;  3ZUR A;  3C8A A;  4J1L A;  2A97 A;  3FII A;  3DS9 A;  2G7P A;  3CQB A;  2ISH A;  3D3X A;  3BWI A;  3DDB A;  5BQM A;  4EJ5 A;  3QW5 A;  1G9C A;  1EPW A;  3BTA A;  2G7K A;  4QHF A;  2NYY A;  2ILP A;  3V0B B;  1F31 A;  1F82 A;  3V0A B;  1S0E A;  2IMB A;  4KUF A;  3QJ0 A;  3V0A A;  3C89 A;  2ISG A;  1ZL5 A;  1I1E A;  4AW6 A;  2XHL A;  1E1H A; 
#chains in the Genus database with same CATH homology
 3QIX A;  3FIE A;  3C8B A;  1ZKX A;  1S0G A;  4HEV A;  4ZKT B;  2A8A A;  4ZJX A;  3DEB A;  1G9A A;  1ZN3 A;  2ETF A;  1XTG A;  3VUO A;  1ZL6 A;  2NP0 A;  1S0F A;  1ZKW A;  2G7Q A;  3C88 A;  4KS6 A;  3K3Q B;  2IMA A;  4KTX A;  3NF3 A;  1G9D A;  1XTF A;  4EL4 A;  1T3A A;  3DDA A;  3BOK A;  3QIZ A;  4ELC A;  1S0D A;  1ZB7 A;  2ISE A;  1G9B A;  3QW8 A;  1YVG A;  1Z7H A;  5BQN A;  1S0C A;  3BON A;  2IMC A;  3FFZ A;  3QW7 A;  2FPQ A;  3BOO A;  3ZUQ A;  1T3C A;  3DSE A;  3QW6 A;  3ZUS A;  2NZ9 A;  3V0B A;  3QIY A;  2G7N A;  2W2D A;  1S0B A;  2QN0 A;  3ZUR A;  3C8A A;  4J1L A;  2A97 A;  3FII A;  3DS9 A;  2G7P A;  2ISH A;  3D3X A;  3BWI A;  3DDB A;  5BQM A;  4EJ5 A;  3QW5 A;  1G9C A;  1EPW A;  3BTA A;  2G7K A;  3V0B B;  2NYY A;  2ILP A;  1F31 A;  1F82 A;  3V0A B;  1S0E A;  2IMB A;  4KUF A;  3QJ0 A;  3V0A A;  3C89 A;  2ISG A;  1ZL5 A;  1I1E A;  2XHL A;  1E1H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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