The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
76
|
sequence length |
217
|
structure length |
217
|
Chain Sequence |
MKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| molecule tags |
Hydrolase
|
| molecule keywords |
Thymidylate synthase ThyX
|
| publication title |
Identification of inhibitors targeting substrate-binding site in Mycobacterium tuberculosis FAD-dependent Thymidylate synthase (ThyX) through Virtual Screening: A New study de-fining the binding mechanism of Inhibitors
rcsb |
| source organism |
Thermotoga maritima
|
| total genus |
76
|
| structure length |
217
|
| sequence length |
217
|
| ec nomenclature |
ec
2.1.1.148: Thymidylate synthase (FAD). |
| pdb deposition date | 2015-07-10 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF02511 | Thy1 | Thymidylate synthase complementing protein |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 2-Layer Sandwich | Gyrase A; domain 2 | Gyrase A; domain 2 |
#chains in the Genus database with same CATH superfamily 4GTB A; 4KAR A; 4GT9 A; 4GTF A; 4KAT A; 5IOS A; 3G4C A; 1O2B A; 1O24 A; 1O26 A; 3N0C A; 4P5B A; 1O29 A; 2CFA A; 3N3Y A; 4GTD A; 4GTA A; 2CFA B; 3N0B A; 5IOR A; 4GTL A; 4GTE A; 1KQ4 A; 1O28 A; 1O2A A; 4P5A A; 5IOT A; 5JFE A; 3G4A A; 3AH5 A; 5IOQ A; 4FZB A; 5CHP A; 4KAS A; 4GTC A; 1O25 A; 1O27 A; #chains in the Genus database with same CATH topology 2VUM A; 1IE0 A; 1X31 C; 3LPX A; 3HOV C; 3GTP C; 1L0W A; 3ORE A; 3GTL C; 3GTQ K; 1K83 K; 4A3F K; 4OIP A; 4X6A K; 2B63 C; 2JA6 C; 4GTD A; 4KMH A; 3PO2 C; 4A3C K; 1XZP B; 5IP7 C; 5IOQ A; 2O5J A; 2GAG C; 1I3Q A; 2E2I C; 1IW7 A; 5M5W K; 4KAW X; 1TWC C; 4ILD A; 3S1R C; 1RU0 A; 2PA8 L; 2GSO A; 1VH2 A; 3GTM A; 1K83 A; 4LK0 A; 3AD8 C; 2NVX A; 2E2J C; 1EH1 A; 1EFW A; 1VGX A; 1XZP A; 1WOP A; 1TWG A; 4A3K C; 1XPP A; 4YG2 A; 2V6S A; 3GTL A; 3GTK K; 1I6H K; 3IPJ A; 2NVT C; 3S1N K; 2B63 A; 2JA6 A; 4C3H K; 3RZO C; 3CAG A; 1ZBS A; 4Y52 C; 3K7A C; 3SZZ A; 1WOS A; 4WJ4 A; 1SFO C; 1TWF K; 4BBR K; 5IYC K; 4A3M K; 1EK8 A; 2E2I A; 1DCH A; 3M3Y K; 2NVQ C; 4MEX A; 3GEE A; 3HOY C; 3WOD A; 1VJE A; 4BY1 K; 3T01 A; 5EGH A; 4M1X A; 4A93 C; 5IP9 C; 3TTG A; 5C4X K; 3S17 C; 2XCQ A; 5C4J C; 1I6V A; 4A3E C; 4Q5S A; 3AD7 C; 2FQO A; 4KN4 A; 2RGR A; 5D4D A; 3CQZ K; 1F93 A; 4GT9 A; 1DCP A; 2YU9 A; 3HKZ D; 4MQ9 A; 5C44 C; 1WQH A; 2GSU A; 1O2B A; 1IQ0 A; 3GTO K; 3HOU K; 1WIH A; 3I4M C; 4P5B A; 4NOI A; 4C3I K; 4KDD A; 4BLB A; 3A8K A; 1Y1W A; 1XZQ B; 1TWH C; 1JVI A; 3GTJ C; 3PO3 C; 1JQW A; 1XXA A; 1O25 A; 3JST A; 4C2M C; 2XCO A; 2CW0 A; 2NVY A; 5IYB C; 5FJ8 K; 2R92 C; 4KAT A; 3S15 K; 2P8T A; 3GTG C; 3RZD K; 4G0V A; 3S14 C; 3FOE A; 1F7V A; 4GFQ A; 1BJT A; 4GTE A; 3AD9 C; 3S1M K; 1DCO A; 1INN A; 1YNN A; 4FZB A; 3S1Q C; 1WSV A; 1O27 A; 4PAA A; 5C3E K; 2WB1 L; 3HOX C; 2R93 K; 4GTB A; 1I50 A; 4Y7N K; 4P9S A; 2ZFZ A; 4A3B C; 4WIL A; 2R7Z C; 3S0X A; 3GIR A; 4BXX C; 3GTM K; 5IYD K; 3FOF A; 2NVX K; 2P5M A; 1F7U A; 4A3G C; 2A6E A; 3HOV K; 3S2D C; 2R92 A; 3GTP K; 2A69 A; 1TWG K; 4C3J C; 4GTL A; 4C45 A; 3GTL K; 3S2H K; 3BP3 A; 4AYB L; 3S16 C; 4G7H A; 3L4J A; 3AH5 A; 2B63 K; 3H3V D; 2JA6 K; 4LQY A; 1YCL A; 3DXJ A; 4O2D A; 4DDQ A; 5L46 A; 3PO2 K; 2W7V A; 1R9T C; 4X6A C; 4QIW L; 4LLG A; 5IP7 K; 4BBS C; 3H0G A; 4G7Z A; 2E2H C; 2R93 A; 4A3L C; 2E2I K; 4LK1 A; 3I4N K; 1HI9 A; 5IOS A; 3HOZ C; 4LJZ A; 4OIR A; 1O26 A; 1TWC K; 3S1R K; 3FKI C; 2JA7 C; 3GTP A; 4YFK A; 3M4O K; 3LAJ A; 3V4G A; 2JA5 C; 4XCH A; 2E2J K; 1WCM C; 1B4A A; 4A3K K; 1J98 A; 1J6W A; 2PMZ L; 3GTK C; 1YX2 A; 1Y1V C; 2YU9 K; 4Y52 K; 3K7A K; 1R9T A; 2ZUE A; 4A3I C; 4C3H C; 2E2H A; 1EQR A; 4BY7 C; 1TWC A; 1Y1W K; 3NUH A; 2FQT A; 4GTA A; 3T00 A; 3HXA A; 3TFJ A; 2NVQ K; 4G0U A; 3GTM C; 3FKI A; 2A6H A; 2Y0S L; 4Q4Z A; 3HOY K; 5E68 A; 4GTC A; 4XSX A; 1O2A A; 1O2F B; 3L4K A; 2Y3P A; 4A93 K; 1WOR A; 5IP9 K; 2NVY K; 3A8J A; 1WCM A; 2JA8 C; 4YFN A; 4BY1 C; 4BLA A; 3S17 K; 1G51 A; 3MML B; 5C4J K; 4A3E K; 1J6V A; 3FHZ A; 3AQP A; 1SFO A; 3BP8 C; 1Y1V A; 5C44 K; 3A8I A; 4KM8 A; 3CQZ C; 3G4A A; 4G7O A; 4A3D K; 4G0W A; 5JVO A; 3EQL A; 1IL2 A; 4XLP A; 1TWH K; 3HOW C; 3GDZ A; 3ADA C; 4LR2 A; 3H3V L; 1TWA C; 1I50 K; 4J3N A; 5FLM C; 5EGE A; 2V6U A; 1XXB A; 3GTJ K; 1J6X A; 4KMU A; 3PO3 K; 4C2M K; 3VA7 A; 4A3J C; 3Q3Q A; 1O29 A; 5IYB K; 2R92 K; 4XSZ A; 2EBB A; 1WOO A; 1WQF A; 2VUM C; 1KQ4 A; 5JFE A; 2XCR B; 1ZXO A; 2GSN A; 1BGW A; 4JK1 A; 3S14 K; 5M3F K; 4KAS A; 1F9N A; 1TWH A; 3SZY A; 1WQG A; 3TFI A; 1IBA A; 3H0G K; 4LOW A; 4YFX A; 3OEP A; 3GTJ A; 3S1Q K; 3TFH A; 1O24 A; 3RZO K; 3HOX K; 3N0C A; 4KB2 A; 1I3Q C; 4A3B K; 2R7Z K; 2CFA B; 2ZUF A; 2RH6 A; 5TJ3 A; 5TMC A; 4PAB A; 3GTG A; 4A3G K; 4OIO A; 4WJ3 M; 4RMF A; 1PJ5 A; 3OPF A; 4C3J K; 3GTQ C; 1K83 C; 2WAQ D; 4A3F C; 2NVX C; 3S16 K; 1VLO A; 1TWG C; 3S2H C; 3T02 A; 1DD5 A; 4A3C C; 1R9T K; 3GEH A; 4BBS K; 4XLN A; 4MEY A; 2CFA A; 2E2H K; 3HKZ L; 1SMY A; 4A3L K; 2R7Z A; 3HOZ K; 4P5A A; 1UV7 A; 2KWA A; 4KMD A; 1V5V A; 1AB4 A; 5CHP A; 3FKI K; 3I4N C; 2JA7 K; 1ISE A; 5M5X K; 2JA5 K; 1C0A A; 2NVT K; 1WCM K; 3M4O C; 2BE5 A; 3GTQ A; 1I6H C; 3S1N C; 1SFO K; 1PJ6 A; 4BKW A; 3QX3 A; 3N0B A; 4OIQ A; 1Y1V K; 1WSR A; 1ZYR A; 5IOT A; 4A3I K; 1TWF C; 4BBR C; 2D6F C; 2WB1 D; 5IYC C; 4BY7 K; 2YU9 C; 3LAP A; 4A3M C; 2JA7 A; 5CJ9 A; 3M3Y C; 4KB4 A; 1Y1W C; 2JA5 A; 1GE9 A; 4FM9 A; 1JOE A; 4OIN A; 5M3M K; 1USO A; 3G4C A; 4KM9 A; 2PPB A; 2V6T A; 4AYB D; 2JA8 K; 5C4X C; 3GTK A; 1BDF A; 4QJV B; 1B4B A; 2NVY C; 4QIW D; 1YNJ A; 1ZVU A; 3I4M K; 1EI6 A; 1XXC A; 2PA8 D; 3GTO C; 3HOU C; 1TWF A; 2PHC B; 4KAR A; 4C3I C; 4GZY A; 2WAQ L; 4AH6 A; 3BUE A; 3HOW K; 3ERE D; 4A3D C; 1TWA K; 4KN7 A; 3AQO A; 3N3Y A; 5FLM K; 4QJV A; 1USM A; 5TMF A; 4KC6 A; 1O28 A; 4KMA A; 1I50 C; 4A3J K; 2GAH C; 3GTG K; 3GSI A; 2JH3 A; 3S15 C; 2VUM K; 2PMZ D; 3RZD C; 3CQZ A; 2A68 A; 4GTF A; 1HQM A; 1IS1 A; 1BS2 A; 1VRQ C; 1XZQ A; 3GTO A; 3S1M C; 2O5I A; 1TWA A; 1PJ7 A; 5HL8 A; 5IOR A; 4ZH4 A; 2Y0S D; 3H0G C; 4BXX K; 5M5Y K; 5C3E C; 2R93 C; 4Y7N C; 3GEI A; 3S2D K; 1I3Q K; 1ZQ1 C; 5IYD C; #chains in the Genus database with same CATH homology 2VUM A; 3L4K A; 2Y3P A; 3LPX A; 2NVY A; 1WCM A; 4BLA A; 3ORE A; 4KAT A; 3GTQ A; 3MML B; 3FHZ A; 4G0V A; 3AQP A; 1SFO A; 4BKW A; 4GTD A; 3FOE A; 3N0B A; 4KMH A; 3QX3 A; 1Y1V A; 4GFQ A; 1BJT A; 4GTE A; 5IOT A; 4KM8 A; 3G4A A; 5IOQ A; 4FZB A; 4G0W A; 5JVO A; 3LAP A; 1I3Q A; 2JA7 A; 5CJ9 A; 1O27 A; 4LR2 A; 4GTB A; 1I50 A; 4KB4 A; 4KAW X; 4J3N A; 4ILD A; 5EGE A; 2JA5 A; 1GE9 A; 1XXB A; 2ZFZ A; 4FM9 A; 3S0X A; 2GSO A; 3G4C A; 4KM9 A; 3GTM A; 1O25 A; 1K83 A; 3VA7 A; 3FOF A; 2NVX A; 2P5M A; 3Q3Q A; 1O29 A; 1EH1 A; 2R92 A; 1TWG A; 4C3J C; 1WQF A; 4GTL A; 3GTL A; 3GTK A; 1KQ4 A; 1B4B A; 5JFE A; 2XCR B; 1ZXO A; 3AH5 A; 3L4J A; 2B63 A; 1ZVU A; 2GSN A; 2JA6 A; 1BGW A; 4LQY A; 3CAG A; 4DDQ A; 4KAS A; 1XXC A; 1ZBS A; 1F9N A; 1TWH A; 1WQG A; 3H0G A; 1TWF A; 2PHC B; 2R93 A; 4KAR A; 4C3I C; 3BUE A; 3OEP A; 3GTJ A; 2E2I A; 1EK8 A; 5IOS A; 1O24 A; 3ERE D; 1O26 A; 3N0C A; 4KB2 A; 3AQO A; 3N3Y A; 3GTP A; 4C2M C; 2CFA B; 2RH6 A; 5TJ3 A; 4KC6 A; 1O28 A; 5EGH A; 4KMA A; 4M1X A; 3V4G A; 3LAJ A; 3GTG A; 2JH3 A; 1B4A A; 3OPF A; 2XCQ A; 2RGR A; 3CQZ A; 4GT9 A; 4GTF A; 1IS1 A; 1DD5 A; 2YU9 A; 1WQH A; 2GSU A; 1O2B A; 1R9T A; 3GTO A; 1WIH A; 4C3H C; 4P5B A; 2E2H A; 2CFA A; 1TWA A; 4KDD A; 4BLB A; 1TWC A; 1Y1W A; 4GTA A; 3NUH A; 2R7Z A; 5IOR A; 4P5A A; 2KWA A; 4KMD A; 4G0U A; 5CHP A; 1AB4 A; 3FKI A; 4GTC A; 1XXA A; 1O2A A; 1ISE A; 2XCO A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
