1AAPA

X-ray crystal structure of the protease inhibitor domain of alzheimer's amyloid beta-protein precursor
Total Genus 9
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
56
structure length
56
Chain Sequence
VREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Proteinase inhibitor (trypsin)
source organism Homo sapiens
publication title X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
pubmed doi rcsb
molecule keywords ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN
total genus 9
structure length 56
sequence length 56
chains with identical sequence B
ec nomenclature
pdb deposition date 1990-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1aapA00
1JV9A 1FANA 2R9PE 4Y0YI 1DTXA 3LDIA 1MTND 2M99A 2FTMB 3AUCA 1YLCB 1BPIA 3TGKI 2M01A 1EJMB 1FAKI 1QLQA 1P2NB 1JV8A 1PITA 1TAPA 3T62D 1YLDB 2IJOI 2RA3C 1CA0D 1P2KI 3BTMI 3BYBA 1BUNB 3CI7A 1P2MB 1Y62A 2TPII 1K6UA 1P2QB 1TOCR 3BTEI 3LDMA 1DTKA 1AAPA 2JOTA 1AALA 1IRHA 2W8XA 1YC0I 1KUNA 8PTIA 4Y0ZI 1KNTA 1ADZA 3TPII 1BTIA 1BF0A 2FI3I 5JB4A 1DENA 3P95E 2ODYE 1LD6A 1DEMA 1BIKA 1JC6A 1T8LB 3BTGI 4Y10I 5PTIA 3TGJI 4ISNB 3AUEA 4NTYB 3U1JE 1SHPA 4WXVC 2LFKA 1OA65 1YKTB 1BHCA 4TPII 4BD9B 1B0CA 3OTJI 2J6DA 3UOUB 1BRCI 1TFXC 1TCPA 5C67C 1T8MB 2HEXA 4U30W 7PTIA 3FP7J 2PTCI 3D65I 3AUBA 2FI4I 3L3TE 4BQDA 2CA7A 3AUGA 1LD5A 1P2JI 2KNTA 4PTIA 3P92E 1BTHP 1G6XA 1P2OB 1KIGI 2UUYB 2KAII 1UUAA 1CBWD 1T7CB 2DDIA 3BTQI 4ISOB 4BNRI 1EAWB 2DDJA 3LDJA 3OFWA 1KTHA 1F5RI 3BTWI 3TGII 1D0DA 4NTWB 1OA55 2FTLI 3UIRC 1BZ5A 3WNYA 9PTIA 2ZVXA 1TAWB 3BTHI 3BTKI 2FI5I 4Y11I 3GYMI 1T8OB 1P2II 1ZJDB 3FP6I 1F7ZI 3AUHA 1UUBA 1FY8I 5JB5A 4U32X 3BTFI 1NAGA 1T8NB 1TPAI 2LFLA 4ISLB 4NTXB 4WWYC 4DG4C 5JB6A 3M7QB 4DTGK 1BPTA 1BRBI 2KCRA 1D0DB 1CO7I 3AUIA 2UUXA 3FP8I 3BTDI 2TGPI 5JB7A 3BTTI 1ZR0B 3L33E 3AUDA 6PTIA 2ZJXA 1BZXI
chains in the Genus database with same CATH superfamily
1JV9A 1FANA 2R9PE 4Y0YI 1DTXA 3LDIA 1MTND 2M99A 2FTMB 3AUCA 1YLCB 1BPIA 3TGKI 2M01A 1EJMB 1FAKI 1QLQA 1P2NB 1JV8A 1PITA 1TAPA 3T62D 1YLDB 2IJOI 2RA3C 1CA0D 1P2KI 3BTMI 3BYBA 1BUNB 3CI7A 1P2MB 1Y62A 2TPII 1K6UA 1P2QB 1TOCR 3BTEI 3LDMA 1DTKA 1AAPA 2JOTA 1AALA 1IRHA 2W8XA 1YC0I 1KUNA 8PTIA 4Y0ZI 1KNTA 1ADZA 3TPII 1BTIA 1BF0A 2FI3I 5JB4A 1DENA 3P95E 2ODYE 1LD6A 1DEMA 1BIKA 1JC6A 1T8LB 3BTGI 4Y10I 5PTIA 3TGJI 4ISNB 3AUEA 4NTYB 3U1JE 1SHPA 4WXVC 2LFKA 1OA65 1YKTB 1BHCA 4TPII 4BD9B 1B0CA 3OTJI 2J6DA 3UOUB 1BRCI 1TFXC 1TCPA 5C67C 1T8MB 2HEXA 4U30W 7PTIA 3FP7J 2PTCI 3D65I 3AUBA 2FI4I 3L3TE 4BQDA 2CA7A 3AUGA 1LD5A 1P2JI 2KNTA 4PTIA 3P92E 1BTHP 1G6XA 1P2OB 1KIGI 2UUYB 2KAII 1UUAA 1CBWD 1T7CB 2DDIA 3BTQI 4ISOB 4BNRI 1EAWB 2DDJA 3LDJA 3OFWA 1KTHA 1F5RI 3BTWI 3TGII 1D0DA 4NTWB 1OA55 2FTLI 3UIRC 1BZ5A 3WNYA 9PTIA 2ZVXA 1TAWB 3BTHI 3BTKI 2FI5I 4Y11I 3GYMI 1T8OB 1P2II 1ZJDB 3FP6I 1F7ZI 3AUHA 1UUBA 1FY8I 5JB5A 4U32X 3BTFI 1NAGA 1T8NB 1TPAI 2LFLA 4ISLB 4NTXB 4WWYC 4DG4C 5JB6A 3M7QB 4DTGK 1BPTA 1BRBI 2KCRA 1D0DB 1CO7I 3AUIA 2UUXA 3FP8I 3BTDI 2TGPI 5JB7A 3BTTI 1ZR0B 3L33E 3AUDA 6PTIA 2ZJXA 1BZXI
chains in the Genus database with same CATH topology
1JV9A 1FANA 2R9PE 4Y0YI 1DTXA 3LDIA 1MTND 2M99A 2FTMB 3AUCA 1YLCB 1BPIA 3TGKI 2M01A 1EJMB 1FAKI 1QLQA 1P2NB 1JV8A 1PITA 1TAPA 3T62D 1YLDB 2IJOI 2RA3C 1CA0D 1P2KI 3BTMI 3BYBA 1BUNB 3CI7A 1P2MB 1Y62A 2TPII 1K6UA 1P2QB 1TOCR 3BTEI 3LDMA 1DTKA 1AAPA 2JOTA 1AALA 1IRHA 2W8XA 1YC0I 1KUNA 8PTIA 4Y0ZI 1KNTA 1ADZA 3TPII 1BTIA 1BF0A 2FI3I 5JB4A 1DENA 3P95E 2ODYE 1LD6A 1DEMA 1BIKA 1JC6A 1T8LB 3BTGI 4Y10I 5PTIA 3TGJI 4ISNB 3AUEA 4NTYB 3U1JE 1SHPA 4WXVC 2LFKA 1OA65 1YKTB 1BHCA 4TPII 4BD9B 1B0CA 3OTJI 2J6DA 3UOUB 1BRCI 1TFXC 1TCPA 5C67C 1T8MB 2HEXA 4U30W 7PTIA 3FP7J 2PTCI 3D65I 3AUBA 2FI4I 3L3TE 4BQDA 2CA7A 3AUGA 1LD5A 1P2JI 2KNTA 4PTIA 3P92E 1BTHP 1G6XA 1P2OB 1KIGI 2UUYB 2KAII 1UUAA 1CBWD 1T7CB 2DDIA 3BTQI 4ISOB 4BNRI 1EAWB 2DDJA 3LDJA 3OFWA 1KTHA 1F5RI 3BTWI 3TGII 1D0DA 4NTWB 1OA55 2FTLI 3UIRC 1BZ5A 3WNYA 9PTIA 2ZVXA 1TAWB 3BTHI 3BTKI 2FI5I 4Y11I 3GYMI 1T8OB 1P2II 1ZJDB 3FP6I 1F7ZI 3AUHA 1UUBA 1FY8I 5JB5A 4U32X 3BTFI 1NAGA 1T8NB 1TPAI 2LFLA 4ISLB 4NTXB 4WWYC 4DG4C 5JB6A 3M7QB 4DTGK 1BPTA 1BRBI 2KCRA 1D0DB 1CO7I 3AUIA 2UUXA 3FP8I 3BTDI 2TGPI 5JB7A 3BTTI 1ZR0B 3L33E 3AUDA 6PTIA 2ZJXA 1BZXI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JV9 A;  1FAN A;  2R9P E;  4Y0Y I;  1DTX A;  3LDI A;  1MTN D;  2M99 A;  2FTM B;  3AUC A;  1YLC B;  1BPI A;  3TGK I;  2M01 A;  1EJM B;  1FAK I;  1QLQ A;  1P2N B;  1JV8 A;  1PIT A;  1TAP A;  3T62 D;  1YLD B;  2IJO I;  2RA3 C;  1CA0 D;  1P2K I;  3BTM I;  3BYB A;  1BUN B;  3CI7 A;  1P2M B;  1Y62 A;  2TPI I;  1K6U A;  1P2Q B;  1TOC R;  3BTE I;  3LDM A;  1DTK A;  1AAP A;  2JOT A;  1AAL A;  1IRH A;  2W8X A;  1YC0 I;  1KUN A;  8PTI A;  4Y0Z I;  1KNT A;  1ADZ A;  3TPI I;  1BTI A;  1BF0 A;  2FI3 I;  5JB4 A;  1DEN A;  3P95 E;  2ODY E;  1LD6 A;  1DEM A;  1BIK A;  1JC6 A;  1T8L B;  3BTG I;  4Y10 I;  5PTI A;  3TGJ I;  4ISN B;  3AUE A;  4NTY B;  3U1J E;  1SHP A;  4WXV C;  2LFK A;  1OA6 5;  1YKT B;  1BHC A;  4TPI I;  4BD9 B;  1B0C A;  3OTJ I;  2J6D A;  3UOU B;  1BRC I;  1TFX C;  1TCP A;  5C67 C;  1T8M B;  2HEX A;  4U30 W;  7PTI A;  3FP7 J;  2PTC I;  3D65 I;  3AUB A;  2FI4 I;  3L3T E;  4BQD A;  2CA7 A;  3AUG A;  1LD5 A;  1P2J I;  2KNT A;  4PTI A;  3P92 E;  1BTH P;  1G6X A;  1P2O B;  1KIG I;  2UUY B;  2KAI I;  1UUA A;  1CBW D;  1T7C B;  2DDI A;  3BTQ I;  4ISO B;  4BNR I;  1EAW B;  2DDJ A;  3LDJ A;  3OFW A;  1KTH A;  1F5R I;  3BTW I;  3TGI I;  1D0D A;  4NTW B;  1OA5 5;  2FTL I;  3UIR C;  1BZ5 A;  3WNY A;  9PTI A;  2ZVX A;  1TAW B;  3BTH I;  3BTK I;  2FI5 I;  4Y11 I;  3GYM I;  1T8O B;  1P2I I;  1ZJD B;  3FP6 I;  1F7Z I;  3AUH A;  1UUB A;  1FY8 I;  5JB5 A;  4U32 X;  3BTF I;  1NAG A;  1T8N B;  1TPA I;  2LFL A;  4ISL B;  4NTX B;  4WWY C;  4DG4 C;  5JB6 A;  3M7Q B;  4DTG K;  1BPT A;  1BRB I;  2KCR A;  1D0D B;  1CO7 I;  3AUI A;  2UUX A;  3FP8 I;  3BTD I;  2TGP I;  5JB7 A;  3BTT I;  1ZR0 B;  3L33 E;  3AUD A;  6PTI A;  2ZJX A;  1BZX I; 
#chains in the Genus database with same CATH topology
 1JV9 A;  1FAN A;  2R9P E;  4Y0Y I;  1DTX A;  3LDI A;  1MTN D;  2M99 A;  2FTM B;  3AUC A;  1YLC B;  1BPI A;  3TGK I;  2M01 A;  1EJM B;  1FAK I;  1QLQ A;  1P2N B;  1JV8 A;  1PIT A;  1TAP A;  3T62 D;  1YLD B;  2IJO I;  2RA3 C;  1CA0 D;  1P2K I;  3BTM I;  3BYB A;  1BUN B;  3CI7 A;  1P2M B;  1Y62 A;  2TPI I;  1K6U A;  1P2Q B;  1TOC R;  3BTE I;  3LDM A;  1DTK A;  1AAP A;  2JOT A;  1AAL A;  1IRH A;  2W8X A;  1YC0 I;  1KUN A;  8PTI A;  4Y0Z I;  1KNT A;  1ADZ A;  3TPI I;  1BTI A;  1BF0 A;  2FI3 I;  5JB4 A;  1DEN A;  3P95 E;  2ODY E;  1LD6 A;  1DEM A;  1BIK A;  1JC6 A;  1T8L B;  3BTG I;  4Y10 I;  5PTI A;  3TGJ I;  4ISN B;  3AUE A;  4NTY B;  3U1J E;  1SHP A;  4WXV C;  2LFK A;  1OA6 5;  1YKT B;  1BHC A;  4TPI I;  4BD9 B;  1B0C A;  3OTJ I;  2J6D A;  3UOU B;  1BRC I;  1TFX C;  1TCP A;  5C67 C;  1T8M B;  2HEX A;  4U30 W;  7PTI A;  3FP7 J;  2PTC I;  3D65 I;  3AUB A;  2FI4 I;  3L3T E;  4BQD A;  2CA7 A;  3AUG A;  1LD5 A;  1P2J I;  2KNT A;  4PTI A;  3P92 E;  1BTH P;  1G6X A;  1P2O B;  1KIG I;  2UUY B;  2KAI I;  1UUA A;  1CBW D;  1T7C B;  2DDI A;  3BTQ I;  4ISO B;  4BNR I;  1EAW B;  2DDJ A;  3LDJ A;  3OFW A;  1KTH A;  1F5R I;  3BTW I;  3TGI I;  1D0D A;  4NTW B;  1OA5 5;  2FTL I;  3UIR C;  1BZ5 A;  3WNY A;  9PTI A;  2ZVX A;  1TAW B;  3BTH I;  3BTK I;  2FI5 I;  4Y11 I;  3GYM I;  1T8O B;  1P2I I;  1ZJD B;  3FP6 I;  1F7Z I;  3AUH A;  1UUB A;  1FY8 I;  5JB5 A;  4U32 X;  3BTF I;  1NAG A;  1T8N B;  1TPA I;  2LFL A;  4ISL B;  4NTX B;  4WWY C;  4DG4 C;  5JB6 A;  3M7Q B;  4DTG K;  1BPT A;  1BRB I;  2KCR A;  1D0D B;  1CO7 I;  3AUI A;  2UUX A;  3FP8 I;  3BTD I;  2TGP I;  5JB7 A;  3BTT I;  1ZR0 B;  3L33 E;  3AUD A;  6PTI A;  2ZJX A;  1BZX I; 
#chains in the Genus database with same CATH homology
 1JV9 A;  1FAN A;  2R9P E;  4Y0Y I;  1DTX A;  3LDI A;  1MTN D;  2M99 A;  2FTM B;  3AUC A;  1YLC B;  1BPI A;  3TGK I;  2M01 A;  1EJM B;  1FAK I;  1QLQ A;  1P2N B;  1JV8 A;  1PIT A;  1TAP A;  3T62 D;  1YLD B;  2IJO I;  2RA3 C;  1CA0 D;  1P2K I;  3BTM I;  3BYB A;  1BUN B;  3CI7 A;  1P2M B;  1Y62 A;  2TPI I;  1K6U A;  1P2Q B;  1TOC R;  3BTE I;  3LDM A;  1DTK A;  1AAP A;  2JOT A;  1AAL A;  1IRH A;  2W8X A;  1YC0 I;  1KUN A;  8PTI A;  4Y0Z I;  1KNT A;  1ADZ A;  3TPI I;  1BTI A;  1BF0 A;  2FI3 I;  5JB4 A;  1DEN A;  3P95 E;  2ODY E;  1LD6 A;  1DEM A;  1BIK A;  1JC6 A;  1T8L B;  3BTG I;  4Y10 I;  5PTI A;  3TGJ I;  4ISN B;  3AUE A;  4NTY B;  3U1J E;  1SHP A;  4WXV C;  2LFK A;  1OA6 5;  1YKT B;  1BHC A;  4TPI I;  4BD9 B;  1B0C A;  3OTJ I;  2J6D A;  3UOU B;  1BRC I;  1TFX C;  1TCP A;  5C67 C;  1T8M B;  2HEX A;  4U30 W;  7PTI A;  3FP7 J;  2PTC I;  3D65 I;  3AUB A;  2FI4 I;  3L3T E;  4BQD A;  2CA7 A;  3AUG A;  1LD5 A;  1P2J I;  2KNT A;  4PTI A;  3P92 E;  1BTH P;  1G6X A;  1P2O B;  1KIG I;  2UUY B;  2KAI I;  1UUA A;  1CBW D;  1T7C B;  2DDI A;  3BTQ I;  4ISO B;  4BNR I;  1EAW B;  2DDJ A;  3LDJ A;  3OFW A;  1KTH A;  1F5R I;  3BTW I;  3TGI I;  1D0D A;  4NTW B;  1OA5 5;  2FTL I;  3UIR C;  1BZ5 A;  3WNY A;  9PTI A;  2ZVX A;  1TAW B;  3BTH I;  3BTK I;  2FI5 I;  4Y11 I;  3GYM I;  1T8O B;  1P2I I;  1ZJD B;  3FP6 I;  1F7Z I;  3AUH A;  1UUB A;  1FY8 I;  5JB5 A;  4U32 X;  3BTF I;  1NAG A;  1T8N B;  1TPA I;  2LFL A;  4ISL B;  4NTX B;  4WWY C;  4DG4 C;  5JB6 A;  3M7Q B;  4DTG K;  1BPT A;  1BRB I;  2KCR A;  1D0D B;  1CO7 I;  3AUI A;  2UUX A;  3FP8 I;  3BTD I;  2TGP I;  5JB7 A;  3BTT I;  1ZR0 B;  3L33 E;  3AUD A;  6PTI A;  2ZJX A;  1BZX I; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...