4Y10I

Trypsin in complex with with bpti mutant (2s)-2-amino-4,4-difluorobutanoic acid
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
57
structure length
56
Chain Sequence
PDFCLEPPYTGPCARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Cationic trypsin
publication title Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
pubmed doi rcsb
total genus 12
structure length 56
sequence length 57
ec nomenclature
pdb deposition date 2015-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4y10I00
2CA7A 3GYMI 4U32X 2HEXA 1TAWB 4DTGK 3AUBA 2DDJA 1KUNA 1KTHA 1BRBI 1BIKA 3OTJI 4WXVC 4BD9B 1BTIA 4Y0YI 3LDMA 1TCPA 1LD6A 3FP8I 3FP6I 3CI7A 3BTEI 3WNYA 3BTQI 5JB4A 1BZ5A 1OA55 2ZVXA 3AUDA 4WWYC 2JOTA 1P2MB 1T7CB 3T62D 1IRHA 1P2QB 3TGII 2FI3I 1YLCB 5PTIA 1BF0A 1CBWD 2UUXA 6PTIA 3AUEA 2FTLI 3BTTI 3BYBA 4ISLB 1UUAA 1TPAI 1MTND 3P92E 4BQDA 1FANA 1TFXC 5JB6A 4Y11I 1JV9A 1EJMB 2ODYE 1NAGA 2IJOI 1P2OB 1DEMA 2FI4I 1DENA 1FY8I 2M99A 2FTMB 3LDJA 3AUCA 2TGPI 3BTDI 3L3TE 2LFKA 2W8XA 4NTWB 4ISNB 4PTIA 3M7QB 3BTHI 1P2II 1UUBA 1OA65 3P95E 2DDIA 1ADZA 1DTKA 1KNTA 5JB7A 3BTGI 1CA0D 9PTIA 1QLQA 1CO7I 1T8MB 1T8NB 1BPTA 1AAPA 1F7ZI 1JC6A 2R9PE 1F5RI 3BTWI 3LDIA 4ISOB 1K6UA 1DTXA 1T8LB 1ZR0B 3L33E 1PITA 1JV8A 1D0DA 3BTFI 2PTCI 1BRCI 4NTYB 1BTHP 1G6XA 1EAWB 1D0DB 1KIGI 3U1JE 3UOUB 1ZJDB 1YLDB 1P2NB 2TPII 4TPII 4Y10I 5JB5A 1YC0I 4NTXB 1BHCA 5C67C 7PTIA 2M01A 3BTMI 3BTKI 1BPIA 3AUIA 1LD5A 1TOCR 1B0CA 4BNRI 1P2KI 1T8OB 2UUYB 1Y62A 1AALA 2FI5I 1SHPA 2KNTA 3AUHA 2J6DA 3D65I 2ZJXA 3TPII 8PTIA 4DG4C 3UIRC 2KCRA 2LFLA 2RA3C 3AUGA 1FAKI 1BZXI 3TGJI 3TGKI 1YKTB 1TAPA 2KAII 3OFWA 1BUNB 4U30W 1P2JI 4Y0ZI 3FP7J
chains in the Genus database with same CATH superfamily
2CA7A 3GYMI 4U32X 2HEXA 1TAWB 4DTGK 3AUBA 2DDJA 1KUNA 1KTHA 1BRBI 1BIKA 3OTJI 4WXVC 4BD9B 1BTIA 4Y0YI 3LDMA 1TCPA 1LD6A 3FP8I 3FP6I 3CI7A 3BTEI 3WNYA 3BTQI 5JB4A 1BZ5A 1OA55 2ZVXA 3AUDA 4WWYC 2JOTA 1P2MB 1T7CB 3T62D 1IRHA 1P2QB 3TGII 2FI3I 1YLCB 5PTIA 1BF0A 1CBWD 2UUXA 6PTIA 3AUEA 2FTLI 3BTTI 3BYBA 4ISLB 1UUAA 1TPAI 1MTND 3P92E 4BQDA 1FANA 1TFXC 5JB6A 4Y11I 1JV9A 1EJMB 2ODYE 1NAGA 2IJOI 1P2OB 1DEMA 2FI4I 1DENA 1FY8I 2M99A 2FTMB 3LDJA 3AUCA 2TGPI 3BTDI 3L3TE 2LFKA 2W8XA 4NTWB 4ISNB 4PTIA 3M7QB 3BTHI 1P2II 1UUBA 1OA65 3P95E 2DDIA 1ADZA 1DTKA 1KNTA 5JB7A 3BTGI 1CA0D 9PTIA 1QLQA 1CO7I 1T8MB 1T8NB 1BPTA 1AAPA 1F7ZI 1JC6A 2R9PE 1F5RI 3BTWI 3LDIA 4ISOB 1K6UA 1DTXA 1T8LB 1ZR0B 3L33E 1PITA 1JV8A 1D0DA 3BTFI 2PTCI 1BRCI 4NTYB 1BTHP 1G6XA 1EAWB 1D0DB 1KIGI 3U1JE 3UOUB 1ZJDB 1YLDB 1P2NB 2TPII 4TPII 4Y10I 5JB5A 1YC0I 4NTXB 1BHCA 5C67C 7PTIA 2M01A 3BTMI 3BTKI 1BPIA 3AUIA 1LD5A 1TOCR 1B0CA 4BNRI 1P2KI 1T8OB 2UUYB 1Y62A 1AALA 2FI5I 1SHPA 2KNTA 3AUHA 2J6DA 3D65I 2ZJXA 3TPII 8PTIA 4DG4C 3UIRC 2KCRA 2LFLA 2RA3C 3AUGA 1FAKI 1BZXI 3TGJI 3TGKI 1YKTB 1TAPA 2KAII 3OFWA 1BUNB 4U30W 1P2JI 4Y0ZI 3FP7J
chains in the Genus database with same CATH topology
2CA7A 3GYMI 4U32X 2HEXA 1TAWB 4DTGK 3AUBA 2DDJA 1KUNA 1KTHA 1BRBI 1BIKA 3OTJI 4WXVC 4BD9B 1BTIA 4Y0YI 3LDMA 1TCPA 1LD6A 3FP8I 3FP6I 3CI7A 3BTEI 3WNYA 3BTQI 5JB4A 1BZ5A 1OA55 2ZVXA 3AUDA 4WWYC 2JOTA 1P2MB 1T7CB 3T62D 1IRHA 1P2QB 3TGII 2FI3I 1YLCB 5PTIA 1BF0A 1CBWD 2UUXA 6PTIA 3AUEA 2FTLI 3BTTI 3BYBA 4ISLB 1UUAA 1TPAI 1MTND 3P92E 4BQDA 1FANA 1TFXC 5JB6A 4Y11I 1JV9A 1EJMB 2ODYE 1NAGA 2IJOI 1P2OB 1DEMA 2FI4I 1DENA 1FY8I 2M99A 2FTMB 3LDJA 3AUCA 2TGPI 3BTDI 3L3TE 2LFKA 2W8XA 4NTWB 4ISNB 4PTIA 3M7QB 3BTHI 1P2II 1UUBA 1OA65 3P95E 2DDIA 1ADZA 1DTKA 1KNTA 5JB7A 3BTGI 1CA0D 9PTIA 1QLQA 1CO7I 1T8MB 1T8NB 1BPTA 1AAPA 1F7ZI 1JC6A 2R9PE 1F5RI 3BTWI 3LDIA 4ISOB 1K6UA 1DTXA 1T8LB 1ZR0B 3L33E 1PITA 1JV8A 1D0DA 3BTFI 2PTCI 1BRCI 4NTYB 1BTHP 1G6XA 1EAWB 1D0DB 1KIGI 3U1JE 3UOUB 1ZJDB 1YLDB 1P2NB 2TPII 4TPII 4Y10I 5JB5A 1YC0I 4NTXB 1BHCA 5C67C 7PTIA 2M01A 3BTMI 3BTKI 1BPIA 3AUIA 1LD5A 1TOCR 1B0CA 4BNRI 1P2KI 1T8OB 2UUYB 1Y62A 1AALA 2FI5I 1SHPA 2KNTA 3AUHA 2J6DA 3D65I 2ZJXA 3TPII 8PTIA 4DG4C 3UIRC 2KCRA 2LFLA 2RA3C 3AUGA 1FAKI 1BZXI 3TGJI 3TGKI 1YKTB 1TAPA 2KAII 3OFWA 1BUNB 4U30W 1P2JI 4Y0ZI 3FP7J
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2CA7 A;  3GYM I;  4U32 X;  2HEX A;  1TAW B;  4DTG K;  3AUB A;  2DDJ A;  1KUN A;  1KTH A;  1BRB I;  1BIK A;  3OTJ I;  4WXV C;  4BD9 B;  1BTI A;  4Y0Y I;  3LDM A;  1TCP A;  1LD6 A;  3FP8 I;  3FP6 I;  3CI7 A;  3BTE I;  3WNY A;  3BTQ I;  5JB4 A;  1BZ5 A;  1OA5 5;  2ZVX A;  3AUD A;  4WWY C;  2JOT A;  1P2M B;  1T7C B;  3T62 D;  1IRH A;  1P2Q B;  3TGI I;  2FI3 I;  1YLC B;  5PTI A;  1BF0 A;  1CBW D;  2UUX A;  6PTI A;  3AUE A;  2FTL I;  3BTT I;  3BYB A;  4ISL B;  1UUA A;  1TPA I;  1MTN D;  3P92 E;  4BQD A;  1FAN A;  1TFX C;  5JB6 A;  4Y11 I;  1JV9 A;  1EJM B;  2ODY E;  1NAG A;  2IJO I;  1P2O B;  1DEM A;  2FI4 I;  1DEN A;  1FY8 I;  2M99 A;  2FTM B;  3LDJ A;  3AUC A;  2TGP I;  3BTD I;  3L3T E;  2LFK A;  2W8X A;  4NTW B;  4ISN B;  4PTI A;  3M7Q B;  3BTH I;  1P2I I;  1UUB A;  1OA6 5;  3P95 E;  2DDI A;  1ADZ A;  1DTK A;  1KNT A;  5JB7 A;  3BTG I;  1CA0 D;  9PTI A;  1QLQ A;  1CO7 I;  1T8M B;  1T8N B;  1BPT A;  1AAP A;  1F7Z I;  1JC6 A;  2R9P E;  1F5R I;  3BTW I;  3LDI A;  4ISO B;  1K6U A;  1DTX A;  1T8L B;  1ZR0 B;  3L33 E;  1PIT A;  1JV8 A;  1D0D A;  3BTF I;  2PTC I;  1BRC I;  4NTY B;  1BTH P;  1G6X A;  1EAW B;  1D0D B;  1KIG I;  3U1J E;  3UOU B;  1ZJD B;  1YLD B;  1P2N B;  2TPI I;  4TPI I;  4Y10 I;  5JB5 A;  1YC0 I;  4NTX B;  1BHC A;  5C67 C;  7PTI A;  2M01 A;  3BTM I;  3BTK I;  1BPI A;  3AUI A;  1LD5 A;  1TOC R;  1B0C A;  4BNR I;  1P2K I;  1T8O B;  2UUY B;  1Y62 A;  1AAL A;  2FI5 I;  1SHP A;  2KNT A;  3AUH A;  2J6D A;  3D65 I;  2ZJX A;  3TPI I;  8PTI A;  4DG4 C;  3UIR C;  2KCR A;  2LFL A;  2RA3 C;  3AUG A;  1FAK I;  1BZX I;  3TGJ I;  3TGK I;  1YKT B;  1TAP A;  2KAI I;  3OFW A;  1BUN B;  4U30 W;  1P2J I;  4Y0Z I;  3FP7 J; 
#chains in the Genus database with same CATH topology
 2CA7 A;  3GYM I;  4U32 X;  2HEX A;  1TAW B;  4DTG K;  3AUB A;  2DDJ A;  1KUN A;  1KTH A;  1BRB I;  1BIK A;  3OTJ I;  4WXV C;  4BD9 B;  1BTI A;  4Y0Y I;  3LDM A;  1TCP A;  1LD6 A;  3FP8 I;  3FP6 I;  3CI7 A;  3BTE I;  3WNY A;  3BTQ I;  5JB4 A;  1BZ5 A;  1OA5 5;  2ZVX A;  3AUD A;  4WWY C;  2JOT A;  1P2M B;  1T7C B;  3T62 D;  1IRH A;  1P2Q B;  3TGI I;  2FI3 I;  1YLC B;  5PTI A;  1BF0 A;  1CBW D;  2UUX A;  6PTI A;  3AUE A;  2FTL I;  3BTT I;  3BYB A;  4ISL B;  1UUA A;  1TPA I;  1MTN D;  3P92 E;  4BQD A;  1FAN A;  1TFX C;  5JB6 A;  4Y11 I;  1JV9 A;  1EJM B;  2ODY E;  1NAG A;  2IJO I;  1P2O B;  1DEM A;  2FI4 I;  1DEN A;  1FY8 I;  2M99 A;  2FTM B;  3LDJ A;  3AUC A;  2TGP I;  3BTD I;  3L3T E;  2LFK A;  2W8X A;  4NTW B;  4ISN B;  4PTI A;  3M7Q B;  3BTH I;  1P2I I;  1UUB A;  1OA6 5;  3P95 E;  2DDI A;  1ADZ A;  1DTK A;  1KNT A;  5JB7 A;  3BTG I;  1CA0 D;  9PTI A;  1QLQ A;  1CO7 I;  1T8M B;  1T8N B;  1BPT A;  1AAP A;  1F7Z I;  1JC6 A;  2R9P E;  1F5R I;  3BTW I;  3LDI A;  4ISO B;  1K6U A;  1DTX A;  1T8L B;  1ZR0 B;  3L33 E;  1PIT A;  1JV8 A;  1D0D A;  3BTF I;  2PTC I;  1BRC I;  4NTY B;  1BTH P;  1G6X A;  1EAW B;  1D0D B;  1KIG I;  3U1J E;  3UOU B;  1ZJD B;  1YLD B;  1P2N B;  2TPI I;  4TPI I;  4Y10 I;  5JB5 A;  1YC0 I;  4NTX B;  1BHC A;  5C67 C;  7PTI A;  2M01 A;  3BTM I;  3BTK I;  1BPI A;  3AUI A;  1LD5 A;  1TOC R;  1B0C A;  4BNR I;  1P2K I;  1T8O B;  2UUY B;  1Y62 A;  1AAL A;  2FI5 I;  1SHP A;  2KNT A;  3AUH A;  2J6D A;  3D65 I;  2ZJX A;  3TPI I;  8PTI A;  4DG4 C;  3UIR C;  2KCR A;  2LFL A;  2RA3 C;  3AUG A;  1FAK I;  1BZX I;  3TGJ I;  3TGK I;  1YKT B;  1TAP A;  2KAI I;  3OFW A;  1BUN B;  4U30 W;  1P2J I;  4Y0Z I;  3FP7 J; 
#chains in the Genus database with same CATH homology
 2CA7 A;  3GYM I;  4U32 X;  2HEX A;  1TAW B;  4DTG K;  3AUB A;  2DDJ A;  1KUN A;  1KTH A;  1BRB I;  1BIK A;  3OTJ I;  4WXV C;  4BD9 B;  1BTI A;  4Y0Y I;  3LDM A;  1TCP A;  1LD6 A;  3FP8 I;  3FP6 I;  3CI7 A;  3BTE I;  3WNY A;  3BTQ I;  5JB4 A;  1BZ5 A;  1OA5 5;  2ZVX A;  3AUD A;  4WWY C;  2JOT A;  1P2M B;  1T7C B;  3T62 D;  1IRH A;  1P2Q B;  3TGI I;  2FI3 I;  1YLC B;  5PTI A;  1BF0 A;  1CBW D;  2UUX A;  6PTI A;  3AUE A;  2FTL I;  3BTT I;  3BYB A;  4ISL B;  1UUA A;  1TPA I;  1MTN D;  3P92 E;  4BQD A;  1FAN A;  1TFX C;  5JB6 A;  4Y11 I;  1JV9 A;  1EJM B;  2ODY E;  1NAG A;  2IJO I;  1P2O B;  1DEM A;  2FI4 I;  1DEN A;  1FY8 I;  2M99 A;  2FTM B;  3LDJ A;  3AUC A;  2TGP I;  3BTD I;  3L3T E;  2LFK A;  2W8X A;  4NTW B;  4ISN B;  4PTI A;  3M7Q B;  3BTH I;  1P2I I;  1UUB A;  1OA6 5;  3P95 E;  2DDI A;  1ADZ A;  1DTK A;  1KNT A;  5JB7 A;  3BTG I;  1CA0 D;  9PTI A;  1QLQ A;  1CO7 I;  1T8M B;  1T8N B;  1BPT A;  1AAP A;  1F7Z I;  1JC6 A;  2R9P E;  1F5R I;  3BTW I;  3LDI A;  4ISO B;  1K6U A;  1DTX A;  1T8L B;  1ZR0 B;  3L33 E;  1PIT A;  1JV8 A;  1D0D A;  3BTF I;  2PTC I;  1BRC I;  4NTY B;  1BTH P;  1G6X A;  1EAW B;  1D0D B;  1KIG I;  3U1J E;  3UOU B;  1ZJD B;  1YLD B;  1P2N B;  2TPI I;  4TPI I;  4Y10 I;  5JB5 A;  1YC0 I;  4NTX B;  1BHC A;  5C67 C;  7PTI A;  2M01 A;  3BTM I;  3BTK I;  1BPI A;  3AUI A;  1LD5 A;  1TOC R;  1B0C A;  4BNR I;  1P2K I;  1T8O B;  2UUY B;  1Y62 A;  1AAL A;  2FI5 I;  1SHP A;  2KNT A;  3AUH A;  2J6D A;  3D65 I;  2ZJX A;  3TPI I;  8PTI A;  4DG4 C;  3UIR C;  2KCR A;  2LFL A;  2RA3 C;  3AUG A;  1FAK I;  1BZX I;  3TGJ I;  3TGK I;  1YKT B;  1TAP A;  2KAI I;  3OFW A;  1BUN B;  4U30 W;  1P2J I;  4Y0Z I;  3FP7 J; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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